Glucocorticoid Receptor 

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  • ||||||||||  Multifocal Strokes in a Patient with Suspected Cns Vasculitis: a Case () -  Feb 8, 2024 - Abstract #CRAAHPA2024CRA_AHPA_209;    
    A 45-year-old female patient was diagnosed with pemphigus vulgaris in February 2023, treated with 50 mg prednisone daily with taper, CellCept 1 g BID, and monthly IVIG...Pulse solumedrol 1 g IV daily x 5 was initiated...IV acyclovir was initiated, glucocorticoids were discontinued after 5 days, and a 3-month course of antiviral therapy was planned...Diagnosis is based on presence of CSF VZV DNA or anti-VZV IgG antibody. VZV infection can also be associated with a transient hypercoagulable state with antiphospholipid antibodies.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Checkpoint Inhibitor Immunotherapy Induced Inflammatory Arthritis Secondary to Nivolumab and Ipilumab: a Pediatric First () -  Feb 8, 2024 - Abstract #CRAAHPA2024CRA_AHPA_172;    
    Her initial presentation was consistent with a grade 1 irAE with mild pain with clinical arthritis.1 She was initially treated with Naproxen with good improvement in pain; however, with each subsequent cycle of immunotherapy, her inflammatory arthritis worsened despite escalating naproxen doses. Her symptoms worsened to a grade 2 irAE with moderate pain and limitations in activities of daily living, resulting in her being started on oral prednisolone 0.5mg/kg/day, and her Naproxen was changed to Celebrex due to GI intolerance.1 As of her last follow-up, she had achieved clinical remission of her mesothelioma following six cycles of Nivolumab and Ipilumab and had control of her inflammatory arthritis on Celebrex monotherapy.
  • ||||||||||  Kineret (anakinra) / SOBI
    An Unusual Case of Pediatric Systemic Lupus Erythematosus Complicated by Sialadenitis, Pancreatitis and Hemophagocytic Lymphohistiocytosis () -  Feb 8, 2024 - Abstract #CRAAHPA2024CRA_AHPA_142;    
    A 16-year-old female had a 3-year history of polyarticular juvenile idiopathic arthritis (antinuclear antibody (ANA) and rheumatoid factor negative) that resolved with naproxen and remained inactive off therapy for 8 months...Her fevers, arthritis (other than left elbow arthritis), sialadenitis, pancreatitis, and laboratory markers of HLH improved after switching to dexamethasone and anakinra was weaned...Repeat brain MRI showed bilateral asymmetric cerebral white matter hyperintensities. She started intravenous cyclophosphamide and is now clinically well other than ongoing behaviour disinhibition.
  • ||||||||||  betamethasone / Generic mfg.
    Trial completion:  Efficacy of Pulse Radiofrequency Treatment in Patients With Coxarthrosis (clinicaltrials.gov) -  Feb 8, 2024   
    P=N/A,  N=28, Completed, 
    This experience suggests that corticosteroids could be a treatment option for drug-resistant seizures and status epilepticus in preterm neonates, particularly those with bacterial meningitis. Recruiting --> Completed
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion, Enrollment change:  Effect of Submucosal Cryotherapy on Postoperative Endodontic Pain (clinicaltrials.gov) -  Feb 7, 2024   
    P=N/A,  N=52, Completed, 
    Recruiting --> Completed Recruiting --> Completed | N=40 --> 52
  • ||||||||||  Oncaspar liquid (pegaspargase) / Servier
    Journal:  Development of osteonecrosis and improved survival in B-ALL: results of Children's Oncology Group Trial AALL0232. (Pubmed Central) -  Feb 7, 2024   
    Patients were randomized to induction dexamethasone vs prednisone, and interim maintenance high-dose methotrexate vs escalating-dose Capizzi methotrexate/pegaspargase...Patients with osteonecrosis had higher 5-year event-free (HR, 0.51; P?<?0.0001) and overall survival (HR, 0.42; P?<?0.0001), and this was directly attributable to reduced relapse rates (HR, 0.57; P?=?0.0014). Osteonecrosis in high-risk B-ALL patients is associated with improved survival, suggesting an important role for host factors in mediating both toxicity and enhanced efficacy of specific therapies.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., cyclophosphamide / Generic mfg.
    Journal:  A case report: Nonsecretory multiple myeloma presenting with bone pain. (Pubmed Central) -  Feb 6, 2024   
    Active, not recruiting --> Completed | Trial completion date: Aug 2024 --> Feb 2024 | Trial primary completion date: Aug 2024 --> Feb 2024 This case shows that NSMM is easily missed or misdiagnosed.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Ornidazole induced Stevens-Johnson syndrome without body surface involved: A case report. (Pubmed Central) -  Feb 6, 2024   
    In order to avoid severe adverse effect, the patient should not use metronidazole ether orally or vaginally. The case emphasized the importance of rapid and accurate diagnosis of Steven-Johnson syndrome induced by ornidazole vaginal plug, especially when the eye symptoms were the chief complaint without body skin involved.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Resolution of Pityriasis rubra pilaris induced ectropion with oral dexamethasone. A case report. (Pubmed Central) -  Feb 6, 2024   
    A head injury resulting in subacute subdural haematoma, managed with a week course of low dose oral dexamethasone, resulted in the improvement of his skin condition and complete resolution of the cicatricial ectropion within a few weeks. Thus, systemic treatment of PRP with oral dexamethasone may be considered sooner in the treatment of cicatricial ectropion in similar cases.
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Trial completion, Trial primary completion date:  Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia (clinicaltrials.gov) -  Feb 6, 2024   
    P1,  N=35, Completed, 
    Although there were no significant changes in the CGM metrics, four patients developed CGM-measured hyperglycemia after STTA for DME. Active, not recruiting --> Completed | Trial primary completion date: Nov 2022 --> Dec 2023
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Triamcinolone Acetonide Injections in Nail Psoriasis: A Pragmatic Analysis. (Pubmed Central) -  Feb 5, 2024   
    Adverse effects included pain (30%), subungual haematoma (1.7%), and proximal nail fold hypopigmentation with mild atrophy (1.1%). TA (5 mg/mL) injections are effective in nail psoriasis and associated with minimal adverse effects.
  • ||||||||||  Lantus (insulin glargine) / Sanofi
    Journal:  Prescription drug spending by payer: Implications for managed care. (Pubmed Central) -  Feb 5, 2024   
    The findings highlight the significant impact of the top 10 selling prescription drugs on U.S. prescription drug spending. The wide variation in per prescription cost as well as contribution to each payer's prescription drug burden emphasizes how policies targeting top-selling drugs may differentially impact payers as well as how payer-specific policies may differ substantially even for top selling drugs.
  • ||||||||||  epinephrine / Generic mfg.
    Journal, HEOR, Cost-effectiveness, Cost effectiveness:  Cost-effectiveness of budesonide-formoterol versus inhaled epinephrine in United States adults with mild asthma. (Pubmed Central) -  Feb 5, 2024   
    Therefore, it is recommended to incorporate ultrasonography as a routine examination for keloid patients to aid in better decision making in clinical practice. If made available, OTC as-needed budesonide-formoterol for treating mild asthma in underinsured adults without HCP management improves asthma outcomes, prevents fatalities, and is cost-saving.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone Decreased Postoperative Complications in Tonsillotomy. (Pubmed Central) -  Feb 5, 2024   
    The rate of postoperative bleeding between the dexamethasone group and the control group had no significant difference, suggesting the high safety of dexamethasone use in TT. Dexamethasone use in TT improved postoperative pain, nausea, and vomiting significantly.
  • ||||||||||  Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
    NECROTIZING STROMAL KERATITIS IN AN IMMUNOCOMPETENT PATIENT SECONDARY TO HERPES SIMPLEX VIRUS INFECTION. () -  Feb 5, 2024 - Abstract #ESCRSWM2024ESCRS_WM_93;    
    Stromal HSV infection has infective and immune components and is often a recurrent and potentially blinding corneal disease, especially necrotizing stromal HSV keratitis. Necrotizing keratitis is characterized by distorted corneal architecture, substantial stromal inflammatory infiltration, and thinning.
  • ||||||||||  dexamethasone / Generic mfg., methotrexate / Generic mfg.
    Review, Journal:  Primary testicular NK/T cell lymphoma. Case report and review of literature (Pubmed Central) -  Feb 4, 2024   
    Classified as stage IEA, the patient received involved-field irradiation to contralateral testis (45 Gy), followed by systemic chemotherapy with a combination regimen ofL-asparaginase, methotrexate and dexamethasone. Relevant literature is reviewed, and the clinicopathologic features, natural history, and treatment options for primary testicular NK/T cell lymphoma are discussed.
  • ||||||||||  Vaxzevria (ChAdOx1-S recombinant) / University of Oxford, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca
    Journal:  Anti-N-methyl D-aspartate Receptor Encephalitis Following ChAdOx1 nCoV-19 Vaccination: A Case Report. (Pubmed Central) -  Feb 4, 2024   
    The patient responded to intravenous dexamethasone very well and experienced no other complications in 6 months of follow-up. Scientific reports of neurological side effects such as anti-NMDAR encephalitis after vaccination are necessary to optimize the safety and effectiveness of SARS-CoV-2 vaccines.
  • ||||||||||  Budenofalk (budesonide gastro-resistant) / Dr Falk
    Journal:  ONSET OF NONSPECIFIC ULCERATIVE COLITIS POST COVID-19 (CASE STUDY). (Pubmed Central) -  Feb 3, 2024   
    The patient started treatment with Salofalk first at a dose of 2 mg and then 4 mg per day. Due to the insufficient clinical effect, the patient was additionally prescribed Budenofalk in a daily dose of 9 mg with a positive clinical effect.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Primary Systemic Amyloidosis: A Case Report. (Pubmed Central) -  Feb 3, 2024   
    Further studies are needed to understand the proper pathophysiology and treatment of the disease. cardiomyopathies; case reports; primary amyloidosis.
  • ||||||||||  carboplatin / Generic mfg., olanzapine / Generic mfg., paclitaxel / Generic mfg.
    Olanzapine versus neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced () -  Feb 3, 2024 - Abstract #SGO2024SGO_726;    
    This study found similar rates of control of CINV between olanzapine and fosaprepitant in gynecologic oncology patients receiving carboplatin/paclitaxel every three weeks. Given the similar efficacy and the cost-saving implications, primary utilization of olanzapine, rather than a NK1-RA, as part of a prophylactic antiemetic regimen should be considered.