Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


«12...7576777879808182838485...10641065»
  • ||||||||||  A Luminating Reaction: Anaphylactic Shock Following Lumason Administration (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_978;    
    She required several days of vasopressor support in the intensive care unit and was treated with methylprednisolone, diphenhydramine and famotidine prior to recovering...The reactions were secondary to immediate hypersensivity reactions. Therefore, it important to discuss PEG-related allergies with patients and have anaphylaxis kits readily available.
  • ||||||||||  fluconazole oral / Generic mfg.
    Fluconazole Associated DRESS Syndrome in Patient With Coccidioidomycosis Pneumonia (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_976;    
    Regarding fluconazole as an offending agent, there has been limited literature that demonstrates systemic adverse effects with eosinophilia. In the context of the timing, symptoms, and lesion biopsy, fluconazole likely led to the exhibited immune response of the patient.
  • ||||||||||  Rituxan (rituximab) / Roche
    Iris Associated HLH: Determining Appropriate Treatment Based on Underlying Etiology (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_975;    
    As his infectious workup was unrevealing, he was initiated on an institutional protocol similar to HLH-94 and HLH-2004 protocols including etoposide, steroids, and rituximab with rapid improvement in symptoms. This case helps illustrate that when there is no clear underlying infection in IRIS associated HLH, standardized HLH care may remain the gold standard treatment.
  • ||||||||||  hydrocortisone / Generic mfg.
    Opening the Pandora's Box: Unveiling Severe Immune Dysregulation and Coinfections in an HIV-positive Male (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_973;    
    A multidisciplinary approach, including ART optimization, tailored antimicrobial therapy, and careful consideration of chemotherapy, is crucial to establish a delicate balance in care. The patient's recurrent admissions further underscore the multifaceted nature of managing advanced HIV and its complications.
  • ||||||||||  Rituxan (rituximab) / Roche
    Where Are the Antibodies? A Case of Prolonged COVID19 Infection in an Immunocompromised Patient Status Post Rituximab Therapy (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_967;    
    Over the next 6 weeks (weeks 2-8 from initial presentation), he was readmitted twice for recurrent respiratory symptoms and was treated with Remdesivir, systemic steroids, and trimethoprim-sulfamethoxazole for pneumocystis prophylaxis...This case highlights the importance of tailoring therapeutic approaches for immunocompromised patients with COVID19 not responding to standard therapies. Further investigation is needed to clarify the role of extended nirmatrelvir-ritonavir treatment in such cases.
  • ||||||||||  ceftriaxone / Generic mfg., acyclovir / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Aseptic Meningitis Unmasking a Diagnosis Common Variable Immunodeficiency (CVID) and Granulomatous Interstitial Lung Disease (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_962;    
    He was commenced on empirical treatment for presumed meningitis with acyclovir and ceftriaxone...A few weeks later, he represented with hallucinations and an inguinal rash consistent with molluscum contagiosum was pulsed with intravenous methylprednisolone for presumed neurosarcoidosis...Baseline immunoglobulin screening should therefore be undertaken in any patient presenting with recurrent infection to avoid a delay in diagnosis. In the context of widespread parenchymal lung changes, once infection is excluded, a diagnosis of granulomatous interstitial lung disease should also be considered.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Utilizing Flow Profiles to Monitor and Improve pMDI Drug Delivery in Patients With COPD and Asthma (San Diego Convention Center, Room 33A-C (Upper Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_833;    
    Conclusions Flow profiles generated by a novel flow sensor quantified drug delivery during in-office and at-home pMDI use and demonstrated that training improved drug delivery in the office with modest reductions thereafter at-home. Nonetheless, another training session was required to reverse decreases in delivery at home.
  • ||||||||||  acetazolamide / Generic mfg., nimodipine / Generic mfg., dexamethasone injection / Generic mfg.
    Prone Positioning for ARDS: A Double-Edged Sword (San Diego Convention Center, Room 5A-B (Upper Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_769;    
    She was started on intravenous dexamethasone and diamox...Only a superior hemianopic field deficit remained, and she was eventually discharged home with a course of nimodipine, steroid taper, and follow-up appointment with ophthalmology...Retinal vascular occlusions may be related to external ocular pressure, thrombosis, emboli, vasospasm, or local compression from adjacent atherosclerotic arteries, all exacerbated by prone positioning. Therefore, we hope this case further emphasizes the importance of standard eye care and protection in the ICU setting, especially with prone positioning to prevent catastrophic vision-threatening complications.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Rodent Invasion! A Case of Hantavirus in an Immunocompromised Patient Causing Hantavirus Pulmonary Syndrome (San Diego Convention Center, Room 5A-B (Upper Level)) -  Feb 20, 2024 - Abstract #ATS2024ATS_762;    
    Case Presentation A 69-year-old female with history of orthotopic liver transplantation on Cellcept and tacrolimus with transplant failure, breast cancer, and melanoma presented with a one-month history of shortness of breath, intermittent headaches, body aches, malaise, fevers, night sweats, and fatigue...After consultation with Infectious disease, she was started on caspofungin, atovaquone, and decadron for possible pneumocystis (PCP) given history of immunosuppression...There were 850 cases nationwide and 78 in California over two decades. Although rare, this case highlights the importance of maintaining a wide differential as well as the importance of taking a detailed history given the high mortality.
  • ||||||||||  prednisolone / Generic mfg., prednisone / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date, Head-to-Head:  ADAPTinMCN: Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy (clinicaltrials.gov) -  Feb 20, 2024   
    P4,  N=71, Active, not recruiting, 
    Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial completion date: Dec 2025 --> May 2025 | Trial primary completion date: Dec 2024 --> Feb 2024
  • ||||||||||  dexamethasone / Generic mfg., carfilzomib / Generic mfg., bendamustine / Generic mfg.
    Trial completion, Combination therapy:  Carfilzomib In Combination With Bendamustine And Dexamethasone In Refractory Or Relapsed Multiple Myeloma (clinicaltrials.gov) -  Feb 20, 2024   
    P1/2,  N=63, Completed, 
    Recruiting --> Active, not recruiting | Trial completion date: Dec 2025 --> May 2025 | Trial primary completion date: Dec 2024 --> Feb 2024 Active, not recruiting --> Completed
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Autoimmune Disorders Associated With Surgical Remission of Cushing's Disease : A Cohort Study. (Pubmed Central) -  Feb 19, 2024   
    Assessment for hypercortisolemia included late-night salivary cortisol levels, 24-hour urine free cortisol (UFC) ratio (UFC value divided by the upper limit of the normal range for the assay), and dexamethasone suppression tests...Adrenal insufficiency may be a trigger. Recordati Rare Diseases Inc.
  • ||||||||||  dexamethasone / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block (clinicaltrials.gov) -  Feb 19, 2024   
    P4,  N=60, Recruiting, 
    Neither intravenous immunoglobulin nor anakinra had any effect on duration of hospital stay compared with usual care. Trial completion date: Dec 2023 --> Feb 2025 | Initiation date: Apr 2022 --> Feb 2024 | Trial primary completion date: Dec 2023 --> Feb 2025
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date, Surgery:  Opioid Free Anesthesia in Obese Patients. (clinicaltrials.gov) -  Feb 19, 2024   
    P=N/A,  N=76, Completed, 
    Trial completion date: Dec 2023 --> Feb 2025 | Initiation date: Apr 2022 --> Feb 2024 | Trial primary completion date: Dec 2023 --> Feb 2025 Not yet recruiting --> Completed | Trial completion date: Dec 2022 --> Nov 2023 | Trial primary completion date: Nov 2022 --> Aug 2023
  • ||||||||||  Melflufen (melphalan flufenamide) / Oncopeptides
    Journal:  Melflufen in relapsed/refractory multiple myeloma refractory to prior alkylators: A subgroup analysis from the OCEAN study. (Pubmed Central) -  Feb 19, 2024   
    Melphalan flufenamide (melflufen), a first-in-class alkylating peptide-drug conjugate, plus dexamethasone demonstrated superior progression-free survival (PFS), but not overall survival (OS), versus pomalidomide plus dexamethasone in relapsed/refractory multiple myeloma in the OCEAN study...This post hoc exploratory analysis evaluated patients refractory to prior alkylators (e.g., cyclophosphamide and melphalan) in OCEAN...The safety profile of melflufen was consistent with previous reports. These results suggest that melflufen is safe and effective in patients with alkylator-refractory disease, suggesting differentiated activity from other alkylators.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Trial primary completion date:  DEXA-REFINE: Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions (clinicaltrials.gov) -  Feb 19, 2024   
    P4,  N=980, Recruiting, 
    These results suggest that melflufen is safe and effective in patients with alkylator-refractory disease, suggesting differentiated activity from other alkylators. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging. (Pubmed Central) -  Feb 16, 2024   
    To understand the role of diffusion and partition coefficient on drug permeation, four drugs, namely hydrocortisone, trans-cinnamic acid, caffeine, and benzoic acid, are considered...Desirable drug characteristic is inferred to be a lower value of partition coefficient and a higher value of diffusion coefficient. This study could lead to real-time assessment of drugs reaching the bloodstream and beyond.
  • ||||||||||  Clinical, Review, Journal:  Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. (Pubmed Central) -  Feb 16, 2024   
    On the other hand, neither neuraxial morphine nor epidural dexamethasone showed promising results...Epidural blood patches remain the more invasive but the gold standard and ultimate solution in patients resisting medical therapy. This study highlights the need for larger research to define the best approach to prevent and treat PDPH.
  • ||||||||||  prednisone / Generic mfg., dexamethasone injection / Generic mfg., acetylcysteine solution / Generic mfg.
    Journal:  Functional Hearing Preservation in Cochlear Implantation: The Miami Cocktail Effect. (Pubmed Central) -  Feb 16, 2024   
    Resistance of P. aeruginosa against gentamicin and ciprofloxacin may be affected by combining these antibiotics with dexamethasone or tenoxicam. Perioperative STE + NAC, "The Miami Cocktail," was safe and superior to intraoperative steroids alone in functional hearing preservation 1-year after cochlear implantation.