Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A double-layer thin oral film for wet oral mucosa adhesion and efficient treatment of oral ulcers. (Pubmed Central) -  Mar 1, 2024   
    Animal experiments confirmed that the double-layer oral film carrying dexamethasone sodium phosphate achieved satisfactory efficacy in the SD rat oral ulcer model. Hence, this biologically friendly double-layer thin oral film holds great promise for clinical application in topical drug therapy for oral mucosal conditions.
  • ||||||||||  hydrocortisone / Generic mfg.
    The Long Reach of Prematurity - New Findings (Metro Toronto Convention Centre: 201 F) -  Mar 1, 2024 - Abstract #PAS2024PAS_1935;    
    Learning Objectives: Upon completion, participants will be able to describe various outcomes of preterm infants Upon completion, participants will be able to develop a procedure for predicting academic performance in late preterm infants. Upon completion, participants will be able to weigh the benefits versus the costs of prophylactic hydrocortisone use in extremely preterm infants.
  • ||||||||||  dexamethasone / Generic mfg.
    Dexamethasone to Prevent Chronic Lung Disease (Metro Toronto Convention Centre: 105) -  Mar 1, 2024 - Abstract #PAS2024PAS_536;    
    Upon completion, participants will be able to weigh the benefits versus the costs of prophylactic hydrocortisone use in extremely preterm infants. Selected By: Neonatal.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Systemic Corticosteroid Use in Neonates: Contemporary Controversies and Current Evidence (Metro Toronto Convention Centre: 105) -  Mar 1, 2024 - Abstract #PAS2024PAS_531;    
    Recent trends suggest growing use of hydrocortisone (HCTZ) among preterm infants...Moreover, renewed interest in the potential value of dexamethasone as an alternative to HCTZ warrants careful consideration...Determine the strengths and limitations of evidence for systemic corticosteroid use among preterm infants. Discuss the need for clinical equipoise regarding treatment options, highlighting the value of pragmatic clinical trials to inform the practice of equity-focused, evidence-based medicine.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis. (Pubmed Central) -  Feb 29, 2024   
    She was treated acutely with intravenous methylprednisolone...The co-occurrence of the two conditions is unlikely to be coincidental, suggesting that there may be a shared or overlapping immunological pathway involved. The patient's recovery was impressive, which could partially relate to the acute treatment with corticosteroids.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Comparison of the effects of two different styles of orally prescribing prednisolone on postoperative sequelae of surgical extraction of an impacted mandibular third molar: a single-blind randomized study. (Pubmed Central) -  Feb 29, 2024   
    A randomized, split-mouth clinical study was conducted to investigate the efficacy of two different styles of preoral prednisolone in mitigating postoperative sequelae following surgical extraction of impacted mandibular third molars...Group A included those who received a single dose of prednisolone 25 mg, while group B received prednisolone 5 mg postoperatively for a period of three days (5 mg three times/day on the first postoperative day, 5 mg twice/day on the second postoperative day; 5 mg once/day on the third postoperative day). There was a significant difference in the distance between the corner of the mouth and tragus, which decreased with the time interval with respect to group B when compared to group A. The present study showed that a three-day tapered dose of prednisolone postoperatively was more effective in reducing post-extraction sequelae than a single-dose regimen.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Coordinated inflammatory responses dictate Marburg virus control by reservoir bats. (Pubmed Central) -  Feb 28, 2024   
    Here, we use dexamethasone to attenuate ERB pro-inflammatory responses and assess MARV replication, shedding and disease...When pro-inflammatory responses are diminished, ERBs display heightened MARV replication, oral/rectal shedding and severe MVD-like liver pathology, demonstrating that ERBs balance immunoprotective tolerance with discreet MARV-resistant pro-inflammatory responses. These data further suggest that natural ERB immunomodulatory stressors like food scarcity and habitat disruption may potentiate viral shedding, transmission and therefore outbreak risk.
  • ||||||||||  pentoxifylline / Generic mfg., hydrocortisone / Generic mfg., dexamethasone injection / Generic mfg.
    Review, Journal:  Interventions for managing oral submucous fibrosis. (Pubmed Central) -  Feb 28, 2024   
    High-quality, adequately powered intervention trials with a low risk of bias that compare biologically plausible treatments for OSF are needed. It is important that relevant participant-reported outcomes are evaluated.
  • ||||||||||  prednisone / Generic mfg., budesonide / Generic mfg., mycophenolate mofetil / Generic mfg.
    Journal:  Refractory IgA Nephropathy: A Challenge for Future Nephrologists. (Pubmed Central) -  Feb 28, 2024   
    Despite these therapies, some patients have a disease refractory to treatment, defined as individuals that present a 24 h urinary protein persistently >1 g after at least two rounds of regular steroids (methylprednisolone or prednisone) and/or immunosuppressant therapy (e.g., mycophenolate mofetil), or who do not tolerate regular steroids and/or immunosuppressant therapy. The aim of this Systematic Review is to revise the current literature, using the biomedical database PubMed, to investigate possible therapeutic strategies, including SGLT2 inhibitors, endothelin receptor blockers, targeted-release budesonide, B cell proliferation and differentiation inhibitors, fecal microbiota transplantation, as well as blockade of complement components.
  • ||||||||||  New P4 trial:  ANTES B+ Clinical Trial (clinicaltrials.gov) -  Feb 28, 2024   
    P4,  N=1028, Not yet recruiting, 
  • ||||||||||  Enrollment change:  REMAP-CAP: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (clinicaltrials.gov) -  Feb 28, 2024   
    P3,  N=20000, Recruiting, 
    The aim of this Systematic Review is to revise the current literature, using the biomedical database PubMed, to investigate possible therapeutic strategies, including SGLT2 inhibitors, endothelin receptor blockers, targeted-release budesonide, B cell proliferation and differentiation inhibitors, fecal microbiota transplantation, as well as blockade of complement components. N=10000 --> 20000
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats. (Pubmed Central) -  Feb 28, 2024   
    DEX in combination with MLT demonstrated a synergistic efficacy in RA treatment, showing advantages in detumescence reduction, pro-inflammatory cytokine inhibition, and joint internal pathological improvement. Thus, MLT promoted the efficacy of DEX in adjuvant RA treatment in rats, offering an approach to reduce the use dosage and side effects of DEX.
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  Effect of Systematic Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Pediatric Ankle Surgery (clinicaltrials.gov) -  Feb 28, 2024   
    P4,  N=90, Completed, 
    Phase classification: P1b/2a --> P1/2 | Trial completion date: Oct 2029 --> Feb 2028 | Trial primary completion date: Oct 2029 --> Mar 2024 Recruiting --> Completed | Trial completion date: Aug 2024 --> Feb 2024 | Trial primary completion date: Jul 2024 --> Feb 2024
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., thalidomide / Generic mfg.
    New trial:  Two Schemes Response in Multiple Myeloma (clinicaltrials.gov) -  Feb 28, 2024   
    P=N/A,  N=83, Recruiting, 
  • ||||||||||  carboplatin / Generic mfg., olanzapine / Generic mfg., paclitaxel / Generic mfg.
    Enrollment closed, Enrollment change:  Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology Patients (clinicaltrials.gov) -  Feb 28, 2024   
    P3,  N=62, Active, not recruiting, 
    Recruiting --> Completed | Trial completion date: Aug 2024 --> Feb 2024 | Trial primary completion date: Jul 2024 --> Feb 2024 Recruiting --> Active, not recruiting | N=170 --> 62
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Severe COVID-19 in Vaccinated Adults With Hematologic Cancers in the Veterans Health Administration. (Pubmed Central) -  Feb 27, 2024   
    Severe COVID-19 was defined as death within 28 days, mechanical ventilation, or hospitalization with use of dexamethasone or evidence of hypoxemia or use of supplemental oxygen...After oral antiviral drugs became widely used in March 2022, 20 of 538 patients (3.7%) with SARS-CoV-2 infection during this period had progression to severe COVID-19. In this case-control study of patients with hematologic cancers, odds of severe COVID-19 remained high through mid-2022 despite vaccination, especially in patients requiring treatment.
  • ||||||||||  dexamethasone / Generic mfg., temozolomide / Generic mfg.
    Retrospective data, Review, Journal, Oncolytic virus:  The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy. (Pubmed Central) -  Feb 27, 2024   
    Steroid use, high neutrophil-to-lymphocyte ratio (NLR), and low post-treatment total lymphocyte count (TLC) are significant prognostic factors for shorter survival in patients with glioblastoma in retrospective studies; however, these clinically relevant variables are rarely reported and correlated with response and survival in immunotherapy studies (e.g., immune checkpoint inhibitors, vaccines, and oncolytic viruses). Our analysis should help in the development of a more rational clinical trial design and decision-making regarding the treatment to potentially improve the efficacy of immunotherapy or oncolytic virotherapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  3,4',5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways. (Pubmed Central) -  Feb 27, 2024   
    Insulin-resistant HepG2 cells (IR-HepG2) were induced by high glucose plus dexamethasone whilst six-week-old male C57BL/6J mice received a 60 kcal% fat diet for 14 weeks to establish an obese diabetic model...3,4',5-TMS suppressed oxidative stress by increasing the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H?:?quinone oxidoreductase 1 (NQO1) and antioxidant enzyme activity. In summary, 3,4',5-TMS alleviated hepatic insulin resistance in vitro and in vivo, by the activation of the insulin signaling pathway, accomplished by the suppression of oxidative stress.
  • ||||||||||  Kenalog-40 (triamcinolone acetonide injection suspension) / BMS
    Journal:  Medial Epicanthal Fold Correction Using a Y-W Epicanthoplasty in Asian Eyelids. (Pubmed Central) -  Feb 27, 2024   
    One patient had a hypertrophic scar that was successfully managed with triamcinolone acetonide injections...Moreover, an acutely shaped or webbed medial canthus after epicanthoplasty can be prevented by adding a small triangular flap. The Y-W epicanthoplasty procedure is simple and straightforward, and it is appropriate for moderate-to-severe epicanthal fold correction.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Immortal Time Bias Possibly Affecting Fludrocortisone-Hydrocortisone Findings. (Pubmed Central) -  Feb 27, 2024   
    To compare the outcomes of early or late switching from intravitreal (IV) anti-vascular endothelial growth factor (anti-VEGF) injection to IV Dexamethasone (DEX) implant injection in treatment-na No abstract available
  • ||||||||||  budesonide / Generic mfg.
    Review, Journal:  A Literature Review of Microscopic Colitis. (Pubmed Central) -  Feb 26, 2024   
    Although budesonide is an effective treatment in most cases, budesonide-refractory MC represents a significant clinical challenge. Therefore, immunomodulators and biologics are now well-thought to be the second-line choice for treatment.