Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


«12...6667686970717273747576...10641065»
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Acute Transverse Myelitis Due to Neuroborreliosis: A Case Report (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_2543;    
    Two months prior, he developed a round, erythematous rash with central clearing and tested positive for Borrelia burgdorferi serum antibodies, treated with oral doxycycline. Our case report shows a case of ATM due to neuroborreliosis, an uncommon etiology, highlighting the importance of a broad infectious differential to identify treatable causes of ATM.
  • ||||||||||  Noxafil (posaconazole) / Merck (MSD), Cresemba (isavuconazonium sulfate) / Astellas, Basilea
    Management and Outcome in a Case of Cerebral Phaeohyphomycosis Due to Rhinocladiella Mackenziei in an Immunocompetent Individual (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_2242;    
    Initial management involved empirical therapy for brain abscess including antibiotics (ceftriaxone, vancomycin, metronidazole) and dexamethasone, along with antiseizure medication (levetiracetam)...The treatment protocol was then adjusted based on fungal culture results to targeted therapy with intravenous liposomal amphotericin B. Subsequent MRI showed recurrence of the right parietal lesion and the emergence of a smaller lesion...This case highlights the potential for successful management of cerebral phaeohyphomycosis with a combination of surgical and medical therapies, including the use of triazole-class antifungal drugs like posaconazole and isavuconazole. Given its rarity, with only 42 cases reported globally, further research is needed to inform strategies for managing this severe infection.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinicopathologic Correlation of Paraneoplastic Neuronal Intermediate Filament (NIF) Autoimmunity (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_2108;    
    Given its rarity, with only 42 cases reported globally, further research is needed to inform strategies for managing this severe infection. The patient was treated with a trial of high-dose intravenous methylprednisolone and plasma exchange with moderate clinical improvement...Our case highlights neuropathological findings seen in paraneoplastic NIF autoimmunity and a possible association with CLL recurrence.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Parainfectious Hemorrhagic Longitudinally-extensive Transverse Myelitis Secondary to COVID-19 (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_2032;    
    However, this case is differentiated by good clinical recovery despite longitudinally-extensive involvement. We highlight the importance of extensive workup for other causes of acute myelitis including neuroinflammatory, metabolic, neoplastic, and vascular etiologies (including acute ischemia and dural AV fistula).
  • ||||||||||  dapsone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Systemic manifestation of necrotic erythema nodosum leprosum: A case report of a fatal leprosy. (Pubmed Central) -  Mar 7, 2024   
    Multidrug therapy mulitbacillary (MDT-MB) without dapsone, and ofloxacin 400 mg was initiated...The patient became unconscious and experienced death. This case highlights that medical professionals should be aware of the various manifestations of necrotic ENL to correctly diagnose and provide treatment as soon as possible to prevent mortality, especially in leprosy-endemic country, Indonesia.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Preclinical, Journal:  CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in the murine model of the acute respiratory distress syndrome. (Pubmed Central) -  Mar 7, 2024   
    Computed tomography revealed rapid recovery of the density and volume of the affected lung in TAK-779-treated animals. Our pre-clinical data suggest that TAK-779 is more effective than the administration of dexamethasone or the anti-IL6R therapeutic antibody tocilizumab, which brings novel therapeutic modality to TAK-779 and other CCR5 inhibitors for the treatment of virus-induced hyperinflammation syndromes, including COVID-19.
  • ||||||||||  Cingal (hyaluronic acid/triamcinolone) / Anika Therap
    Phase classification:  Study of Cingal (clinicaltrials.gov) -  Mar 7, 2024   
    P=N/A,  N=25, Completed, 
    Not yet recruiting --> Recruiting | Trial completion date: Feb 2025 --> Sep 2026 | Initiation date: Feb 2024 --> Nov 2024 | Trial primary completion date: Feb 2025 --> Sep 2026 Phase classification: P3 --> P=N/A
  • ||||||||||  Cingal (hyaluronic acid/triamcinolone) / Anika Therap
    Phase classification:  Study of Cingal (clinicaltrials.gov) -  Mar 7, 2024   
    P=N/A,  N=25, Completed, 
    Phase classification: P3 --> P=N/A Phase classification: P3 --> P=N/A
  • ||||||||||  Cingal (hyaluronic acid/triamcinolone) / Anika Therap
    Phase classification:  Study of Cingal (clinicaltrials.gov) -  Mar 7, 2024   
    P=N/A,  N=25, Completed, 
    Not yet recruiting --> Recruiting Phase classification: P3 --> P=N/A
  • ||||||||||  LY294002 / Eli Lilly
    Preclinical, Journal:  Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway. (Pubmed Central) -  Mar 6, 2024   
    Validation of the PI3K inhibitor (LY294002) and molecular docking of Ech and PI3K/AKT further indicated that Ech could directly enhance PI3K/AKT activity to alleviate Dex-induced inhibition...Our results provide robust evidence that PI3K/AKT/FOXO1 plays a crucial role in the development of SONFH. Moreover, Ech may be a promising candidate drug for the treatment of SONFH.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion date, Trial primary completion date:  Short-Term Efficacy of Triamcinolone Acetonide (Aristocort (clinicaltrials.gov) -  Mar 5, 2024   
    P4,  N=20, Recruiting, 
    Trial completion date: May 2025 --> Mar 2026 | Trial primary completion date: May 2025 --> Mar 2026 Trial completion date: Dec 2023 --> May 2024 | Trial primary completion date: Sep 2023 --> Apr 2024
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Clinical Trial to Evaluate the Efficacy of Different Treatments in Patients With COVID-19 (clinicaltrials.gov) -  Mar 5, 2024   
    P3,  N=356, Completed, 
    Trial completion date: Dec 2023 --> May 2024 | Trial primary completion date: Sep 2023 --> Apr 2024 Recruiting --> Completed | N=2193 --> 356 | Trial completion date: Nov 2022 --> Jul 2023 | Trial primary completion date: Nov 2021 --> Jul 2023
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment. (Pubmed Central) -  Mar 5, 2024   
    Hydrocortisone was chosen as model drug...The drug release profile of the arrays was evaluated, suggesting that the developed PCL arrays can offer efficient drug delivery for up to two days, while the AUP-PCL arrays can provide a release up to three weeks. Finally, the insertion of MN arrays into skin samples was performed, followed by histological analysis demonstrating the AUP-PCL MNs outperforming the PCL arrays upon providing pyramidical-shaped perforations through the epidermal layer of the skin.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Epidermoid Cyst of the Brainstem in 3-Year-Old Child: A Rare Case Report. (Pubmed Central) -  Mar 5, 2024   
    After completing the surgery, the cavity was irrigated using a solution containing hydrocortisone and Ringer lactate to prevent the occurrence of aseptic meningitis. In the postoperative, the patient recovered without any complications, as all symptoms showed immediate improvement, and the lower cranial nerves returned to normal functioning.
  • ||||||||||  Enrollment open:  ANTES B+ Clinical Trial (clinicaltrials.gov) -  Mar 5, 2024   
    P4,  N=1028, Recruiting, 
    IGNS supplements endoscopic visualization with localization of target lesion by real time stereotactic feedback using preset preoperative imaging data, thus increasing accuracy, safety and effectiveness of minimally invasive surgery. Not yet recruiting --> Recruiting