- |||||||||| triamcinolone acetonide / Generic mfg.
Review, Journal: Vitreoschisis-induced vitreous cortex remnants in proliferative vitreoretinopathy: A comprehensive review from basic research to clinical practice. (Pubmed Central) - Sep 12, 2024
These remnants are difficult to visualise without triamcinolone acetonide (TA) staining, leading to their frequent lack of recognition in clinical practice...The review also discusses epidemiological data, surgical management strategies and potential future directions, including improved visualisation techniques and the development of new surgical tools and methods. This review aims to improve surgical outcomes and reduce the frequency and burden of RRD-related complications by addressing VCR as a critical factor in PVR.
- |||||||||| budesonide ER / Generic mfg.
Review, Journal: Practical management of mild-to-moderate ulcerative colitis: an international expert consensus. (Pubmed Central) - Sep 11, 2024
Furthermore, noninvasive tools for patient monitoring such as fecal calprotectin and intestinal ultrasound are now available. Their implementation in clinical practice will allow clinicians to tightly monitor disease activity and promptly adapt treatment, avoiding complications and disease progression and targeting better disease control.
- |||||||||| dexamethasone / Generic mfg., cisplatin / Generic mfg.
Journal: Ototoxicity-Alleviating and Cytoprotective Allomelanin Nanomedicine for Efficient Sensorineural Hearing Loss Treatment. (Pubmed Central) - Sep 11, 2024
The therapeutic benefits of AMNPs are attributed to mitigating oxidative stress and inflammation within the cochlea, with transcriptome analysis indicating downregulated gene expression related to these processes post-AMNPs treatment. The pronounced antioxidative and anti-inflammatory effects of AMNPs position them as a promising alternative to DEX for SNHL treatment.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: Contractile regulation of the glucocorticoid-sensitive transcriptome in young and aged skeletal muscle. (Pubmed Central) - Sep 11, 2024
To answer this, young (4-month-old) and aged (24-25-month-old) male C57BL/6 mice were randomized to receive either an intraperitoneal (IP) injection of dexamethasone (DEX; 2 mg/kg) or saline as a control...Increasing PPARG expression in the TA of aged mice using Adeno-associated virus serotype 9 partially counteracted the glucocorticoid-induced reduction in Runt-related transcription factor 1 (Runx1) mRNA content, recapitulating the effects observed by contractions. Overall, these data contribute to our understanding of the contractile regulation of the glucocorticoid transcriptome in aged skeletal muscle.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Efficacy and Systemic Effects of a Single Deep Orbital Triamcinolone Injection for Thyroid Eye Disease. (Pubmed Central) - Sep 11, 2024
A total of 1 mL of triamcinolone acetonide (40 mg/mL) was administered posterior to the orbital septum at both the medial and lateral aspects of both the upper and lower eyelids...No severe adverse ophthalmic or systemic effects, including IOP increases or liver damage, were observed. Bilateral single orbital triamcinolone injections provided relief from TED symptoms through both direct effects on orbital soft tissue and systemic effects by decreasing antibody reactions.
- |||||||||| A RARE CASE OF ACUTE EPIGLOTTITIS FROM PASTEURELLA MULTOCIDA IN AN IMMUNOCOMPETENT PATIENT (Convention Center Exhibit Hall: Rapid Fire Area 2A) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7107;
Although rare, P. multocida should be considered as a potential causative pathogen in acute epiglottitis, particularly in those with a history of dog or cat exposure. The prompt diagnosis and management of P. multocida epiglottitis is interdisciplinary and reliant on a thorough exposure history to pets with relevant laboratory and diagnostic findings.
- |||||||||| hydrocortisone / Generic mfg.
UNMASKING THE CONNECTION: ADRENAL INSUFFICIENCY AND INHALED CORTICOSTEROIDS IN RESPIRATORY MEDICINE (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7075;
This case report illuminates the rare complication of adrenal insufficiency induced by ICS and highlights the importance of an injectable monoclonal antibody as a potential treatment strategy game-changer, bridging these insights by promising a treatment approach for patients with severe asthma dependent on ICS-LABA, as well as those on maintenance oral steroids who are navigating the balance of managing chronic disease while avoiding potential steroid-induced complications. This case sems to connect the dots between complex medical challenge and a potential innovative therapeutic approach.
- |||||||||| A CRITICAL INSIGHT INTO MULTIFOCAL BRAIN ABSCESS: DIAGNOSIS, MANAGEMENT, AND PROGNOSIS (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7022;
Further research is needed to validate HLH diagnostic criteria in the context of hematologic malignancies for enhanced patient care through early detection and treatment strategies. Following an urgent lumbar puncture, an external ventricular drain (EVD) was placed, and empirical treatment with vancomycin, ceftriaxone, and metronidazole was initiated...Repeat blood culture grew streptococcus anginosus in one of the bottles, leading to an antibiotic switch to merrem and dexamethasone...
- |||||||||| dexamethasone / Generic mfg., etoposide IV / Generic mfg.
UNCOVERING THE TRUE CULPRIT: HLH MIMICKING SEPSIS IN AN HIV PATIENT (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7010;
It has a high mortality rate, especially when immunosuppressive therapy is not initiated. Thus, it is crucial for every intensivist to be aware of this diagnosis and maintain a high clinical index of suspicion.
- |||||||||| ketamine / Generic mfg.
KETAMINE USE IN MANAGING STATUS ASTHMATICUS IN A PREGNANT PATIENT: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7001;
Its bronchodilatory effects and ability to provide cardiovascular and respiratory stability make it a valuable asset in emergency situations. Further research is needed to fully understand its efficacy and safety profile, especially in specific populations such as pregnant individuals.
- |||||||||| Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
LESSONS FROM BENCH TO BEDSIDE: EXPLORING GENOMIC AND NONGENOMIC MECHANISMS OF ALBUTEROL-BUDESONIDE AS NEEDED FOR TREATMENT AND PREVENTION OF ACUTE AIRWAY OBSTRUCTION (ALTA) (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6896;
P3
While there is in vitro understanding of the mechanisms by which a fast-acting beta2-agonist and ICS may interact to effect bronchoconstriction and airway inflammation, ALTA is the first study to explore potential in vivo inflammatory and genomic mechanisms of SABA-ICS in the treatment and prevention of acute airway obstruction on lung function, symptoms, airway hyperresponsiveness, and airway inflammation. CLINICAL IMPLICATIONS: ALTA will provide patient-based, mechanistic data across asthma endotypes that will inform decisions by practicing clinicians to use combination rescue therapy.
- |||||||||| PROPYLTHYOURACIL-INDUCED CENTRAL NERVOUS SYSTEM ANCA-VASCULITIS PRESENTING AS APHASIA, HEMI-PARESIS, AND SEIZURE (Convention Center Exhibit Hall: Rapid Fire Area 2C) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6886;
If left untreated ANCA-associated vasculitis can be life threatening, and delay in diagnosis or subsequent treatment can lead to poor prognosis. This rare case serves as a reminder that ANCA-vasculitis should be considered in the differential when patients being treated with PTU present with otherwise unexplained neurologic deficits.
- |||||||||| Januvia (sitagliptin) / Merck (MSD)
ANAPHYLACTIC SHOCK SECONDARY TO DPP-4 AND ACE-I USE (Convention Center Exhibit Hall: Rapid Fire Area 1A) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6696;
With the increasing use of DPP-4, careful consideration of life-threatening adverse reactions should be considered. Hemodynamic support and prompt diagnosis of angioedema with stabilization of the airway are necessary to achieve a good outcome.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
DIAGNOSTIC DILEMMA: UNMASKING GLIOBLASTOMA IN HIV WITH FOCAL BRAIN LESION MIMICKING OPPORTUNISTIC INFECTIONS (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6567;
Consequently, the pt was started a therapeutic regimen consistent with decadron, and broad-spectrum antibiotics... This patient's presentation highlights the importance of keeping a broad differential diagnosis in HIV patients with brain masses as these pathologies may have overlapping clinical features.
- |||||||||| THE KNOWN TO THE UNKNOWN: A RARE CASE OF UPPER GI BLEEDING (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6562;
The patient received Dexamethasone and Allopurinol therapy and was discharged home with outpatient oncology follow-up...(3) Therapeutic advances in multiple myeloma management now include the use of antiangiogenic thalidomide and protease inhibitor bortezomib. Although rare in presentation, PCM should be considered in the differential diagnosis with GI bleeding and presence of systemic hematological malignancy.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
A RARE CASE OF PERIPARTUM MYXEDEMA COMA (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6558;
Myxedema coma is an endocrine emergency, that left untreated, carries a high mortality. Early recognition and multidisciplinary efforts are essential for prompt treatment.
- |||||||||| Kineret (anakinra) / SOBI
AN ATYPICAL CASE OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS PRESENTING WITH RAPIDLY PROGRESSIVE ENCEPHALOPATHY (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6557;
This case represents an unusual presentation due to the lack of fever and an unclear etiology, and reinforces the importance of maintaining a high level of suspicion. It also emphasizes the need for more effective treatments for HLH and may inform a clinician's judgement on initiating empiric treatment for HLH at an early stage.
- |||||||||| Taltz (ixekizumab) / Eli Lilly, Japan Tobacco
CYTOMEGALOVIRUS-INDUCED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH) IN A CRITICALLY ILL PATIENT WITH PSORIATIC ARTHRITIS (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6553;
This case highlights the importance of including HLH on the differential in patients with spondyloarthropathies especially those who are chronically immunosuppressed, who present with pancytopenia and nonspecific symptoms. Early initiation of HLH workup and, if appropriate, empiric treatment, has the potential to reduce mortality in this rare but potentially fatal condition.
- |||||||||| POST-COVID PNEUMOCYSTIS JIROVECII PNEUMONIA IN A PATIENT UNDERGOING CHEMOTHERAPY FOR DIFFUSE LARGE B-CELL LYMPHOMA (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6547;
The patient received five days of remdesivir and 10 days of dexamethasone for COVID-19 pneumonia and also completed a treatment course for Staphylococcus epidermidis bacteremia likely due to line infection...Given sulfa allergy and acute kidney injury, the patient did not receive Bactrim and was initiated on atovaquone with adjunctive solumedrol for PJP...She was discharged on long steroid taper along with clindamycin and primaquine for 21 days followed by 2 months of atovaquone... Given the similarity in presentation of COVID-19 pneumonia and Pneumocystis jirovecii pneumonia, it is imperative to perform a comprehensive workup (including fungal evaluation for patients on chemotherapy or with immunocompromise) to ensure early diagnosis and treatment.
- |||||||||| bamlanivimab (LY-CoV555) / Eli Lilly, AbCellera, National Institute of Allergy and Infectious Diseases, Lokelma (sodium zirconium cyclosilicate) / AstraZeneca
COVID-ASSOCIATED ORGANIZING PNEUMONIA WITH CLAD IN A LUNG TRANSPLANT PATIENT (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6542;
Patients with post COVID pneumonia must be evaluated for organizing pneumonia in order to initiate early treatment. In addition, lung transplant patients who develop COVID infection must be monitored for decline in their lung function.
- |||||||||| Firazyr (icatibant) / Takeda
IT'S AT THE TIP OF MY TONGUE: A CASE OF PERSISTENT ACE-INHIBITOR INDUCED ANGIOEDEMA (Convention Center Exhibit Hall: Poster Area 1) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6517;
Throughout admission to the MICU, patient was treated with a total of 6 units FFP, multiple doses of methylprednisolone and dexamethasone, and tranexamic acid...With the help of the MICU pharmacy team, generic vs. brand name icatibant, at 91% reduction of cost, was obtained, and the patient was able to be treated with 3-doses of generic icatibant... This case emphasizes the importance of establishing better guidelines for treating ACE-induced angioedema, access to medications that may be involved, and exploration of treatment options to reduce length of stay, cost of care, and prolonged intubation.
- |||||||||| hydrocortisone / Generic mfg.
THE UNEXPECTED HERO: HOW SEMEN ANALYSIS SAVED THE DAY IN A DIFFICULT PRIMARY CILIARY DYSKINESIA CASE (Convention Center Exhibit Hall: Poster Area 4) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6446;
PCD remains under-recognised due to lack of awareness of its clinical features, commonality of symptoms, variability of severity, number of clinicians involved, limitations of diagnostic tests and lack of consistent standards. Accurate diagnosis early on in life is crucial in overall prognosis, as its long-term complications can be prevented if timely management is instituted.
- |||||||||| Juluca (dolutegravir/rilpivirine) / ViiV Healthcare, J&J
PNEUMOCYSTIC JIROVECII: ALWAYS A DIFFERENTIAL (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6439;
CASE PRESENTATION: A 52-year-old woman with a history of HIV on antiretroviral therapy (dolutegravir and rilpivirine), previously treated latent tuberculosis, tracheal stenosis and COPD on high dose inhaled fluticasone/salmeterol and tiotropium was evaluated for 3 weeks of progressive dyspnea...Given the acuity of her dyspnea which only partially improved with balloon dilatation, she was treated with oral trimethoprim-sulfamethoxazole for 21 days and ciprofloxacin for 14 days... PJP is an ubiquitous colonizer in the respiratory tract which may become pathogenic and cause clinical pneumonia in the setting of prolonged use of inhaled steroids, especially in HIV patients on protease-inhibitors, even in the setting of immune reconstitution and undetectable viral load.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Imfinzi (durvalumab) / AstraZeneca
THE LAST BREATH: CONFRONTING MORTALITY IN CHECKPOINT INHIBITORS (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6433;
Physicians should be aware of the varied features of checkpoint inhibitor pneumonitis (CIP) and consider the use of immunosuppressive agents when necessary. CIP signifies the role of interdisciplinary collaboration in managing it, and palliative care plays a significant role in providing comfort and support to patients with poor prognosis.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
CHECK YOURSELF BEFORE YOU WRECK YOURSELF: A CASE OF PEMBROLIZUMAB-INDUCED PNEUMONITIS (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6423;
If recognized early and treated appropriately, the vast majority of patients recover. Unfortunately, patients with multiple comorbidities or poor functional baseline may not do as well or may need additional treatment such as IVIG or biologics such as rituximab.
- |||||||||| prednisone / Generic mfg., hydrocortisone / Generic mfg.
NICOTINE VAPE-ASSOCIATED PULMONARY INJURY WITH EOSINOPHILIA (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6369;
It is paramount to note the many etiologies of respiratory damage that can occur as a consequence of vaping various substances. Majority of presentations are consistent with a true ARDS clinical scenario, but the prudent clinician must utilize laboratory investigations, bronchoscopic evaluation, and microbiologic workup in addition to excellent history taking in order to make the diagnosis and rapidly reverse the injury when possible.
- |||||||||| DECOMPENSATED HYPOTHYROIDISM IN A CIRRHOTIC PATIENT: A RARE PRESENTATION OF SEVERE HYPOTHYROIDISM WITH HYPERTENSION (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6361;
Majority of presentations are consistent with a true ARDS clinical scenario, but the prudent clinician must utilize laboratory investigations, bronchoscopic evaluation, and microbiologic workup in addition to excellent history taking in order to make the diagnosis and rapidly reverse the injury when possible. CASE PRESENTATION: A 79-year-old cirrhotic woman with multiple HE admissions presented with worsening AMS and cold intolerance despite lactulose compliance...She was not given hydrocortisone as the stimulation test was robust...
- |||||||||| QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva, Cresemba (isavuconazonium sulfate) / Astellas, Basilea
HAVING A BALL: HEMOPTYSIS AS A PRESENTATION OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS (ABPA) WITH AN ASPERGILLOMA (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6339;
Prior to this, she endorsed a one month history of dry cough and dyspnea on exertion but reported abruptly stopping her Qvar inhaler after running out...Respiratory symptoms improved with an inhaled corticosteroid, treatment of bacterial infections, Cresemba for Aspergillus, IVIG for immunodeficiency, and bronchopulmonary clearance with hypertonic saline and albuterol... This case is significant as it demonstrates a complex diagnostic process leading to the diagnosis of a rare Pulmonary Aspergillus Overlap Syndrome; AGPA with an Aspergilloma.
- |||||||||| Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
A BROKEN HEART: A CASE OF IPILIMUMAB AND NIVOLUMAB-INDUCED MYOCARDITIS (Convention Center Exhibit Hall: Poster Area 1) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6317;
Immune checkpoint inhibitors may cause several immune-related side effects; one rare side effect is cardiac toxicity, including myocarditis. Though these side effects are rare, they have a high mortality rate; As a result a high index of suspicion is imperative for early diagnosis and treatment of these cohorts of patients.
- |||||||||| fentanyl citrate / Generic mfg., prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
NONINFECTIOUS COMPLICATIONS OF AIDS-RELATED PULMONARY KAPOSI'S SARCOMA (KS): A FORGOTTEN YET NOTEWORTHY ENTITY IN THE ANTIRETROVIRAL THERAPY (ART) ERA (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6154;
He was started on prednisone 40 mg daily for suspected drug reaction and experienced a significant decrease in peripheral eosinophilia (4 cells/mL)...Methylprednisolone 40 mg IV twice a day was initiated for persistent hypoxic respiratory failure due to presumed acute illicit drug-induced pneumonitis... While most signs and symptoms of acute drug-induced pulmonary toxicity typically manifest within 48 hours, delayed presentation beyond 1 week may occur, and should remain high on the differential in patients with history of inhaled substances such as cocaine, fentanyl, and xylazine.
- |||||||||| Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
IMMUNOTHERAPY-INDUCED DIABETIC KETOACIDOSIS (Convention Center 256) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6023;
All patients who are started on ICI's should be educated on signs and symptoms of DKA and the need to seek urgent medical attention if symptoms arise. For patients with pre-existing diabetes, insulin therapy for be initiated immediately.
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