Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg., ribavirin / Generic mfg., rifampicin / Generic mfg.
    Interface visualization on the biosynthesis of iron-based nanoparticles via cryo-S/TEM combined with EELS (Virtual; Virtual Session (Virtual Only)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_13028;    
    The results of in-situ visualization study on microorganism synthesis of nanoparticles have theoretical significance for precise regulation of nanoparticles synthesis. Results also show that the M- n Fe has high environmental remediation ability to remove three kinds of COVID-19-specific drugs, ribavirin (RIB) (76.0%), dexamethasone (DXMS) (89.2%), and rifampicin (RIF) (92.0%) in aqueous solution.
  • ||||||||||  Zilretta (triamcinolone acetonide ER) / Pacira, Bydureon (exenatide XR once-weekly) / AstraZeneca
    Mapping the drug-loading design space of long-acting cross-linked microparticles (In-person; Galerie 6 (New Orleans Marriott)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_11653;    
    Results also show that the M- n Fe has high environmental remediation ability to remove three kinds of COVID-19-specific drugs, ribavirin (RIB) (76.0%), dexamethasone (DXMS) (89.2%), and rifampicin (RIF) (92.0%) in aqueous solution. Polymeric microparticles (MPs) are clinically well-established formulations (e.g., Lupron Depot
  • ||||||||||  hydrocortisone / Generic mfg.
    Switchable DNA photocatalysts for radical polymerization controlled by chemical stimuli | Poster Board #M54 (In-person; Poster Board #M54; Studio 3 - 10 (New Orleans Marriott)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_7833;    
    We show these photocatalysts can initiate free-radical polymerization to form bulk hydrogels in response to complementary DNA, a metal ion (Zn 2+ ), or small molecules (glucose and hydrocortisone)...These results demonstrate that DNA conformational changes triggered by chemically diverse stimuli can regulate the activity of radical polymerization photocatalysts. This platform offers new capabilities in spatially and temporally controlled polymer synthesis, with potential applications in diagnostics, sensing, and environmentally responsive materials.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  A One-Stone-Two-Birds Strategy of Targeting Microbubbles with "Dual" Anti-Inflammatory and Blood-Brain Barrier "Switch" Function for Ischemic Stroke Treatment. (Pubmed Central) -  Mar 12, 2024   
    In this study, we constructed hydrocortisone-phosphatidylserine microbubbles and combined them with ultrasound (US)-targeted microbubble destruction technology to successfully open the BBB to achieve targeted drug delivery...A confocal microendoscope was used to directly observe the polarization of microglial cells in living animal models for dynamic microscopic visualization detection showing the advantage of being closer to clinical work. Taken together, this study constructed a multifunctional targeted US contrast agent with the function of "one-stone-two-birds", which can not only "on-off" the BBB but also have "two" anti-inflammatory functions, providing a new strategy of integrated anti-inflammatory targeted delivery and imaging monitoring for ischemic stroke treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Depletion of dexamethasone in cattle: Food safety study in dairy and beef cattle. (Pubmed Central) -  Mar 12, 2024   
    Muscle and fat had no detectable dexamethasone residues while kidney and liver had detectable residues only on day 3 post-dose. A withdrawal interval of 48?h for milk in Canadian dairy cattle and 7?days for meat in Canadian beef cattle are suggested for the dexamethasone treatment regimen most commonly requested to CgFARAD
  • ||||||||||  Trial completion date, Trial primary completion date:  Effects of Pharmacological Stress and RTMS on Executive Function in Opioid Use Disorder (clinicaltrials.gov) -  Mar 11, 2024   
    P2,  N=20, Not yet recruiting, 
    aureus metabolised HCHS to cortisol and reduced poly (I:C) induced IL-6 secretion. Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Oct 2025 --> Oct 2026
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Korean Red Ginseng suppresses emphysematous lesions induced by cigarette smoke condensate through inhibition of macrophage-driven apoptosis pathways. (Pubmed Central) -  Mar 11, 2024   
    Mice were instilled with 50 mg/kg of CSC intranasally once a week for 4 weeks, KRG was administered to the mice once daily for 4 weeks at doses of 100 or 300 mg/kg, and dexamethasone (DEX, positive control) was administered to the mice once daily for 2 weeks at 3 mg/kg...Taken together, KRG effectively inhibits macrophage-mediated emphysema induced by CSC exposure, possibly via the suppression of pro-apoptotic signaling, which results in cell survival pathway activation. These findings suggest that KRG has therapeutic potential for the prevention of emphysema in COPD patients.
  • ||||||||||  Translarna (ataluren) / PTC Therap, Agamree (vamorolone) / Santhera
    Journal:  The Early Care (0-3 Years) In Duchenne Muscular Dystrophy Meeting Report. (Pubmed Central) -  Mar 11, 2024   
    The meeting emphasized the need for early diagnosis, evidence-based guidelines, and comprehensive care and support for affected children and their families. Further research, collaboration, and the development of consensus guidelines are needed to improve early diagnosis, treatment, and outcomes in this population.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal, Video, Surgery:  Intravenous dexamethasone in pain treatment after video-assisted thoracoscopic surgery. (Pubmed Central) -  Mar 10, 2024   
    P=N/A
    Those with elevated TSI may benefit from dual therapy (IVMP and MMF) and require closer monitoring. This study suggests that addition of IV dexamethasone in VATS may reduce the need for opioids and facilitate early mobilisation.
  • ||||||||||  Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
    Review, Journal, IO biomarker:  Selinexor for the treatment of patients with relapsed or refractory multiple myeloma. (Pubmed Central) -  Mar 8, 2024   
    However, more RCTs should be conducted to determine the effects of varied dexamethasone dosages, particularly 4-5 mg, on the incidence of PONV and pain. To improve the outcome of patients with relapsed/refractory multiple myeloma, it is critical to develop new therapies, assess potential therapeutic synergies, and overcome drug resistance by determining the efficacy of multiple myeloma therapies across multiple disease subgroups.
  • ||||||||||  Oncaspar liquid (pegaspargase) / Servier
    Retrospective data, Journal:  Vomiting in children and adolescents receiving intravenous pegaspargase: a retrospective study. (Pubmed Central) -  Mar 8, 2024   
    Of 44 patients who received IV pegaspargase between 2011 and 2020, 13 received a serotonin receptor antagonist plus dexamethasone or palonosetron alone and all experienced a CR. We, therefore, recommend classifying IV pegaspargase as moderately emetogenic.
  • ||||||||||  Rituxan (rituximab) / Roche
    Journal:  Spinal Meningeal Mass Lesion: A Rare Presentation of Primary Dural Follicular Lymphoma. (Pubmed Central) -  Mar 8, 2024   
    Lymphoma can rarely present as an isolated dural lesion and should be considered in the differential diagnosis of intradural extramedullary spinal mass lesions. Prompt diagnosis and initiation of treatment can lead to complete response and resolution of symptoms.
  • ||||||||||  Rituxan (rituximab) / Roche
    GLOMERULOPATIA COLAPSANTE (SAT-297; Exhibition Hall and Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1725;    
    There is no literature that relates it to neuroendocrine tumors of the digestive tract, but it does relate to neoplasms in general, which is why the histopathological study of the appendix is important, given that even intraoperatively this disease is not suspected, which leads to a late diagnosis. Historia de la enfermedad actual: acude refiriendo que el d
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    COMPARING HORSE VS RABBIT ATG AS INDUCTION THERAPY IN KIDNEY TRANSPLANT (MON-301; Exhibition Hall and Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1638;    
    We randomised all immunologically high risk patients(cadaver, spousal and approved unrelated transplants)to receive either Horse or Rabbit ATG from June 2023 to December 2023.They received Injection Horse ATG at the dose of 10 mg/kg body weight or 5mg/kg of Rabbit ATG.After induction ,maintenance therapy was continued with tablet prednisolone, mycophenolate mofetil and Tacrolimus.Patients were monitored for any infusion reactions and followed for a period of 3 months till March 2024 .Biopsy proven rejections, infections episodes were recorded. Till now the data analysed shows that patients receiving Horse ATG were performing well.There is no statistically significant difference in patients receiving horse vs rabbit ATG.If proven good horse ATG can replace rabbit ATG as a cheaper alternative as the overall cost of induction can be reduced upto one thirds.
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
    KIDNEY TRANSPLANTATION IN A TRANSGENDER PATIENT LIVING WITH HIV: A CASE OF SUCCESS (TUE-204; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1626;    
    Given the social marginalization and limited access to healthcare services faced by this population, and considering that, with exceptions in immunosuppression management, kidney transplantation is indicated and radically improves the quality of life, reduces mortality, and fully integrates them into the public healthcare system. Abstract presented in poster format at the 2023 S
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    CASE REPORT: RENAL ARTERY STENOSIS POST KIDNEY TRASPLANT (TUE-179; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1601;    
    Abstract presented in poster format at the 2023 S It is important to recognize and prevent this pathology in patients who receive a renal transplant associated with risk factors prior to transplantation, during the explant and the implant of the graft and that in turn according to clinical characteristics of the patient an intervention should be made according to clinical characteristics of each patient to improve the long-term survival of the graft
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, Actemra IV (tocilizumab) / Roche, JW Pharma, Rituxan (rituximab) / Roche
    REJECTION MEDIATED BY NON-HLA ANTIBODY AND THROMBOTIC MICROANGIOPATHY. CLINICAL CASE (SAT-242; Exhibition Hall and Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1517;    
    This clinical case of a TMA phenotype associated with Non-HLA Ab and clinical ABMR; shows the relevance of non-HLA antibodies in early graft rejection, especially in sensitized, retransplanted patients and with a history of preeclampsia. The evaluation of Non- HLA (AT1R-Ab and ETAR-Ab) and HLA-DSA could provide a complementary and integrated assessment of immunological risk, guiding an individual therapeutic immunosupression.
  • ||||||||||  lamivudine / Generic mfg.
    TOLERANCE OF HIGH DOSE LAMIVUDINE IN PATIENTS WITH CHRONIC KIDNEY DISEASE LIVING WITH HIV (TUE-122; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1164;    
    Challenges of accessibility of lamivudine tabs of various strengths have raised questions on the need for renal-dose adjustments. More studies are needed to shed light to confirm the safety and possible mechanism of lamivudine tolerance in renal impairment.
  • ||||||||||  ivermectin oral / Generic mfg.
    DRUGS USED FOR COVID-19, IMPLICATIONS TO THE RENAL FUNCTION, AND PROSPECTS (TUE-092; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_984;    
    Medicines used without proof may have had negative consequences for the population, not just by the nephrologic diseases, but to the other areas of health, including the drop in supply. Furthermore, research has evolved to reduce mortality rates through the most diverse pharmacological routes, however, the only safe way to combat the disease still remains prevention.
  • ||||||||||  dexamethasone / Generic mfg.
    Acute kidney injury in COVID-19: prevalence and associated factors (MON-120; Exhibition Hall and Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_970;    
    Acute kidney injury is common in COVID-19. Its presence is correlated with disease severity and the presence of comorbidities.
  • ||||||||||  Tavneos (avacopan) / Amgen
    AVACOPAN IN MPO-ANCA VASCULITIS: WHEN CORTICOSTEROIDS CAN NOT BE THE LONG TERM ANSWER (TUE-084; Main Foyer) -  Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_960;    
    Avacopan, as a C5aR antagonist that blocks the effects of C5a, may reduce AAV-induced lesions, and is a new strategy to reduce drug side effects including CCT toxicity. Due to its incidence in older patients, these tend to have more comorbidities that may be aggravated with the current therapies, namely CCT.Avacopan has been used as an alternative in maintaining MPO-ANCA vasculitis remission, particularly in patients with an increased risk of CCT toxicity as was the case of our patient with several cardiovascular risk factors, besides the vasculitis itself, which was successfully treated with this approach.