- |||||||||| Remicade (infliximab) / J&J, Rituxan (rituximab) / Roche
Journal: Advancements in autoimmune hepatitis management: Perspectives for future guidelines. (Pubmed Central) - Mar 18, 2024
However, these interesting findings have yet to be replicated by other research groups. Additionally, second-line drugs, such as tacrolimus, rituximab, and infliximab, should be subjected to controlled trials for further evaluation.
- |||||||||| fentanyl citrate / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal, Surgery: An atypical case of bilateral optic neuritis after strabismus surgery under general anesthesia. (Pubmed Central) - Mar 18, 2024
She underwent uneventful bilateral inferior oblique recession surgery under general anesthesia with Propofol 60?mg, Atracurium 30?mg, and Fentanyl 70 mcg...She received intravenous methylprednisolone pulse therapy followed by oral steroids and responded to the medical treatment with improvement in vision but developed steroid-induced glaucoma requiring medical management over several weeks...This possibility should be kept in mind if any patient presents with similar symptoms. This report also highlights IOP monitoring in pediatric patients receiving systemic steroids to prevent loss of vision due to steroid-induced glaucoma.
- |||||||||| dexamethasone / Generic mfg.
Journal, Surgery: The effect of local dexamethasone on stapedotomy surgery outcomes in patients with otosclerosis. (Pubmed Central) - Mar 18, 2024
Since local dexamethasone had a positive effect on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery's success rate. If local dexamethasone had a positive influence on the results of stapedotomy surgery, it can be used instead of systemic corticosteroids to reduce the side effects and increasing surgery's success rate.
- |||||||||| fluticasone / Generic mfg.
Preclinical, Journal: In Vivo Fluticasone Absorption in Surgical Patients. (Pubmed Central) - Mar 18, 2024
Computation fluid dynamic models of the nasal passage are useful models to help predict intranasal particle flow. However, these models do not incorporate or consider the important mucociliary clearance system, leading to absorption of fluticasone throughout the sinonasal cavity far beyond that predicted by these models.
- |||||||||| foscarnet / Generic mfg., dexamethasone injection / Generic mfg.
CMV RETINITIS FOLLOWING INJECTION OF INTRAVITREAL DEXAMETHASONE IMPLANT () - Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_292;
Contrariwise, in the presenting case, patient was immunocompetent with no history of CMV infection. Monotherapy with intravitreal foscarnet injection proved sufficient to control the disease.
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
POSTERIOR SCLERITIS SIMULATING NEURORETINITIS: A CASE REPORT () - Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_288;
About 60% of cases are idiopathic. Systemic corticosteroids are frequently used, but in refractory cases immunosuppressants can be added.
- |||||||||| UNUSUAL PRESENTATION OF A BILATERAL ACUTE IRIS PATHOLOGY () - Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_256;
Conclusion : While both pathologies commonly manifest sudden-onset symptomatic pigment dispersion, this case displays an atypical presentation. It emphasizes the importance of exercising caution when prescribing fluoroquinolone antibiotics to individuals with a history of BADI/BAIT.
- |||||||||| dexamethasone / Generic mfg., acetazolamide / Generic mfg.
COMMOTIO RETINAE AFTER BLUNT TRAUMA () - Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_231;
We included 240 adult dexamethasone-naive patients with DMO treated at Moorfields Eye Hospital (London, UK) with a 700 ?g intravitreal dexamethasone implant (Ozurdex Despite the initial alarming presentation evolving the macula area, the edema resolved within 3 days without any remaining structural or functional alteration.
- |||||||||| niclosamide nasal spray (UNI91103) / UNION Therap, Institut Pasteur Korea, Alvesco (ciclesonide) / Covis Pharma, Teijin, Korea University Medical Center, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Trial primary completion date: PROTECT-V: PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V (clinicaltrials.gov) - Mar 17, 2024
P2/3, N=5000, Recruiting,
Trial completion date: May 2026 --> Sep 2026 | Trial primary completion date: May 2025 --> Jun 2026 Trial primary completion date: Jul 2023 --> Jul 2024
- |||||||||| triamcinolone acetonide topical / Generic mfg.
Journal: The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study. (Pubmed Central) - Mar 17, 2024
This study substantiates that the increase in the mitochondrial translocation of GRs mediated by GCs exacerbates oxidative stress and pyroptosis in microglia, which indicates that the regulation of mitochondrial pathways by GCs is pathogenic to microglia. The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Opioid-induced adrenal insufficiency: diagnostic and management considerations. (Pubmed Central) - Mar 17, 2024
Once a diagnosis of adrenal insufficiency has been made, glucocorticoid replacement in the form of hydrocortisone is likely the mainstay of treatment, and effort should be made to taper down opioids where possible...In this review, we provide context for diagnostic challenges in OAI, suggest diagnostic tools for this population based on available data, and offer recommendations for the management of this disorder. There is a paucity of literature in this field; given the widespread use of opioids in the general population, more investigation into the effects of opioids on the HPA axis is sorely needed.
- |||||||||| dexamethasone / Generic mfg.
Journal: Potential Anti-Inflammatory Constituents from Aesculus wilsonii Seeds. (Pubmed Central) - Mar 17, 2024
as well. In conclusion, this study enriches the spectra of compounds with potential anti-inflammatory effects in A. wilsonii and provides new references for the discovery of anti-inflammatory lead compounds, but further mechanistic research is still needed.
- |||||||||| budesonide / Generic mfg.
Journal: Thermodynamic and Structural Study of Budesonide-Exogenous Lung Surfactant System. (Pubmed Central) - Mar 17, 2024
In conclusion, this study enriches the spectra of compounds with potential anti-inflammatory effects in A. wilsonii and provides new references for the discovery of anti-inflammatory lead compounds, but further mechanistic research is still needed. The changes in the lateral pressure of the Curosurf
- |||||||||| dexamethasone / Generic mfg.
Journal: Dexamethasone Inhibits White Adipose Tissue Browning. (Pubmed Central) - Mar 17, 2024
gene expressions and mitochondrial respiration). Overall, our data strongly suggest that DXM can inhibit the thermogenic program of both retroperitoneal and inguinal WAT depots, an effect that could be exerted, at least partially, by inhibiting de novo cell generation and the thermogenic response in beige adipocytes.
- |||||||||| dexamethasone / Generic mfg., gemfibrozil / Generic mfg.
MANAGEMENT OF SEVERE HYPERTRIGLYCERIDAEMIA IN PREGNANCY: REPORT OF TWO CASES () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_1136;
Hypoglycaemia was avoided with the use of high-volume dextrose-containing fluids, and the use of dexamethasone for foetal lung maturation (which might worsen hypertriglyceridaemia) was not precluded in either case. The latter is especially relevant, as patients with hypertriglyceridaemia are at increased risk of preterm delivery.
- |||||||||| dexamethasone / Generic mfg.
NON-ISLET CELL TUMOUR HYPOGLYCEMIA IN A RECURRENT RETROPERITONEAL LIPOSARCOMA () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_1054;
It is described in several solid organ tumours of mesenchymal and epidermal origin, both malignant and benign with paraneoplastic IGF-2 secretion which cause hypoglycemia. The commonly implicated mesenchymal tumours are fibrosarcoma mesothelioma, liposarcoma and rhabdomyosarcoma.
- |||||||||| prednisolone / Generic mfg.
VITAMIN D TOXICITY () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_874;
Although our patient was only consuming 5000IU/day of Vitamin D for a year, we were concerned whether use of droplet formulations may lead to inconsistent dose administration. As hypervitaminosis D is rare, no consensus evidence-based guidelines are available.
- |||||||||| dexamethasone / Generic mfg., spironolactone / Generic mfg.
PRIMARY HYPERALDOSTERONISM PRESENTING AS BARTTER/GITELMAN SYNDROME MIMIC IN A PATIENT WITH UNCONTROLLED DIABETES () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_842;
The probable mechanism is thought to be related to expansion of the extravascular space, resulting in decreased proximal tubular reabsorption and thereby increased distal delivery of Mg2+ and Ca2+. Though primary hyperaldosteronism has been associated with increased risk of developing diabetes mellitus, a chronic state of hypokalemia through decrease in insulin secretion, and hypomagnesemia by affecting the insulin signaling pathway may contribute to worsening glycemic control.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
THE PUZZLE OF HYPOKALEMIA IN ADRENAL INSUFFICIENCY: A CASE OF AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 2 () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_834;
Severe anorexia, resulting in a prolonged malnourished state causing body depletion of potassium stores, is believed to have played a significant role, likely compounded by gastrointestinal potassium losses due to vomiting. In patients with primary AI, negative feedback causes the release of high levels of corticotropin releasing hormone (CRH), which then causes increased production of a prohormone proopiomelanocortin (POMC).
- |||||||||| dexamethasone / Generic mfg.
CUSHING'S SYNDROME PRESENTING AS AMENORRHEA: AN UNSUAL PRESENTATION () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_829;
Further investigation for Cushing's syndrome revealed non-suppressed cortisol levels after a 1mg dexamethasone suppression test and positive 24-hour urine cortisol, along with suppressed Adrenocorticotrophic Hormone (ACTH)... It is a clinical case
- |||||||||| dexamethasone / Generic mfg.
ECTOPIC GHRH SECRETION FROM ACC (ADRENOCORTICAL CARCINOMA): A CASE REPORT (Station 01) - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_764;
Cortisol level failed to supress with overnight dexamethasone suppression test,favouring adrenal to be the cause of raised cortisol... -Ectopic secretion of GHRH can occur from adrenal tumors.In case of more than one raised hormones, following diagnostic pathways properly for assessing patients can lead to diagnose even rare conditions.
- |||||||||| hydrocortisone / Generic mfg.
AGRESSIVE BILATERAL ADRENAL LYMPHOMAS : ABOUT THREE CASE REPORTS (Station 01) - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_762;
-Ectopic secretion of GHRH can occur from adrenal tumors.In case of more than one raised hormones, following diagnostic pathways properly for assessing patients can lead to diagnose even rare conditions. The prognosis of PAL is usually poor,it grows progressively throughout the adrenal glands.Thus early diagnosis and treatment is the key to saving patients.
- |||||||||| NEUROSARCOIDOSIS PRESENTING WITH HYPOTHALAMIC-PITUITARY DYSFUNCTION () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_731;
Hormonal changes secondary to hypothalamic-pituitary involvement of sarcoidosis are often irreversible especially with delayed presentation. Although data on hormonal reversibility are minimal, early diagonsis and prompt treatment will increase the chance of recovery.
- |||||||||| AN INTERESTING CASE OF MULTIPLE PITUITARY HORMONE DEFICIENCY WITH STALK INTERRUPTION () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_726;
Early identification of hormonal deficiencies and hormonal replacement influences both the prognosis and the quality of life in patients with hypopituitarism. If PSIS patients are identified before the fusion of epiphyses, they have an excellent opportunity to reach their normal height, prevent short stature and optimize quality of life.
- |||||||||| A RARE CASE OF PITUITARY METASTASIS FROM COLONIC ADENOCARCINOMA () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_704;
Biochemistry confirmed anterior hypopituitarism with disconnection hyperprolactinemia but no evidence of diabetes insipidus (DI); commenced on hydrocortisone, levothyroxine...Post-operatively, he developed DI and commenced on desmopressin, but no improvement in vision...He received adjuvant radiotherapy to the brain with high dose dexamethasone, developed steroid induced diabetes mellitus and myopathy... Pituitary gland should not be overlooked as a site of metastasis and sellar symptoms could be the first presentation of neoplastic disease.
- |||||||||| hydrocortisone / Generic mfg.
PITUITARY STALK INTERRUPTION SYNDROME, CASE SERIES WITH VARIABLE PRESENTATION. () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_700;
To conclude this syndrome have variable presentation could present as isolated growth hormone deficiency or multiple pituitary hormone deficiency. It also have progressive course which indicate the need for long-term follow up.
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