Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


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  • ||||||||||  dexamethasone / Generic mfg., tropisetron / Generic mfg.
    Phase classification:  Efficacy of Three Antiemetics in Preventing Nausea and Vomiting (clinicaltrials.gov) -  Apr 4, 2024   
    P4,  N=200, Completed, 
    N=55 --> 80 Phase classification: P=N/A --> P4
  • ||||||||||  Atgam (equine anti-thymocyte globulin) / Pfizer
    Phase classification, Trial completion date, Trial primary completion date:  TRIUMPH: TReatment for ImmUne Mediated PathopHysiology (clinicaltrials.gov) -  Apr 4, 2024   
    P2,  N=163, Recruiting, 
    Phase classification: P=N/A --> P4 Phase classification: P2b --> P2 | Trial completion date: Jan 2026 --> Jan 2027 | Trial primary completion date: Apr 2025 --> Jan 2026
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Cryptobuchanosides A-G: seven previously undescribed triterpene glycosides from Cryptolepis buchananii R.Br. ex Roem. and Schult. with nitric oxide production inhibition activity. (Pubmed Central) -  Apr 4, 2024   
    The chemical structures of the compounds were elucidated to be 3-O-?-D-glucopyranosyl-(1???6)-?-D-glucopyranosyluncargenin C 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (1), 3-O-?-D-glucopyranosyl-(1???2)-?-D-glucopyranosyluncargenin C 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (2), 3-O-?-D-glucopyranosyl-(1???2)-?-D-glucopyranosyluncargenin C 28-O-?-D-glucopyranosyl-(1???4)-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (3), 3-O-?-D-glucopyranosyl-(1???2)-?-D-glucopyranosylhederagenin 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (4), 3-O-?-D-glucopyranosylarjunolic acid 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (5), 3-O-?-D-glucopyranosyl-(1???2)-?- D-glucopyranosyl-6?,23-dihydroxyursolic acid 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (6), 3-O-?-D-glucopyranosyl-6?,23-dihydroxyursolic acid 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (7), asiatic acid 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (8), and 3-O-?-D-glucopyranosylasiatic acid 28-O-?-L-rhamnopyranosyl-(1???2)-?-D-glucopyranosyl ester (9), through infrared, high-resolution electrospray ionization mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectral analyses. The isolates inhibited nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells, with half-maximal inhibitory concentration (IC50) values of 18.8-58.5
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Persistent Fever after COVID-19 Vaccination in a Patient with Ulcerative Colitis: A Call for Attention. (Pubmed Central) -  Apr 4, 2024   
    Diagnosis was made according to HLH-2004 criteria and the patient was treated with dexamethasone with response. Our report aimed to draw attention to the potential relation between COVID-19 vaccines and HLH and the necessity of continued surveillance, especially in at-risk populations such as those with underlying immune dysregulation.
  • ||||||||||  mometasone furoate / Generic mfg., levocetirizine / Generic mfg.
    Review, Journal:  Follicular Psoriasis: A Case Report and Review of Literature. (Pubmed Central) -  Apr 4, 2024   
    Dermoscopy can help distinguish it by revealing typical features including perifollicular white scales and vascular structures. Further epidemiological studies and long-term follow-up are needed for a comprehensive understanding of FP.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., cyclophosphamide / Generic mfg.
    Journal, Pleural effusion:  Myelomatous pleural effusion in multiple myeloma- A rare presentation. (Pubmed Central) -  Apr 3, 2024   
    Despite a positive response to treatment, the patient's condition worsened over the course of following month and he eventually passed away. Myelomatous pleural effusion indicates poor prognosis and early consideration helps in quick diagnosis and initiation of treatment which may help in improving prognosis.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells. (Pubmed Central) -  Apr 3, 2024   
    Mifepristone-induced adipocytes are closer to the in situ adipocytes than those induced by the conventional protocol. The present study proposes a single treatment with mifepristone as a novel protocol to induce more physiologically relevant adipocytes in 3T3-L1 cells than the conventional protocol.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Revolutionizing Back Pain Management: Is Epidural Platelet-Rich Plasma the Superior Choice Over Steroids? (Pubmed Central) -  Apr 3, 2024   
    The results were comparable to those who received methylprednisolone injections. There was a statistically significant difference in VAS scores between the two groups, with the PRP group reporting a higher degree of pain reduction, showing that PRP is an effective alternative to epidural steroid infiltration in managing chronic LBP.
  • ||||||||||  cabergoline / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Pituitary Adenoma Prevalence and Characteristics of Omani Patients: A Single Center Experience. (Pubmed Central) -  Apr 3, 2024   
    The most common presentation symptom was headaches; most female patients had menstrual irregularities. Medical treatment was the primary approach for the applicable types of PAs, while surgery and radiotherapy were found to be secondary and tertiary treatment options, respectively.
  • ||||||||||  dexamethasone / Generic mfg.
    PK/PD data, Preclinical, Journal:  In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis- (Pubmed Central) -  Apr 2, 2024   
    In addition, the study also explored the antioxidant and anti-inflammatory potency of crude extract of SMG and purified signature phytocompounds (i.e., SMC, SAC, and alliin) in comparison with normal garlic and dexamethasone in LPS-stimulated RAW264.7 macrophage cells...Significantly higher plasma concentrations (Cmax), half-life (t1/2), and area under curve (AUC) of SAC following SMG extract administration than normal garlic validated the proposed hypothesis. Thus, the abundance of bioactive phytocompounds and their better pharmacokinetics in SMG extract might be underlying its medicinal merits over normal garlic.
  • ||||||||||  morphine sulphate / Generic mfg., ondansetron intravenous / Generic mfg., dexamethasone injection / Generic mfg.
    Enrollment open:  Bilateral Erector Spinae Plane Block for Postoperative Chronic Pain After Open Heart Surgery (clinicaltrials.gov) -  Apr 2, 2024   
    P=N/A,  N=50, Recruiting, 
    Thus, the abundance of bioactive phytocompounds and their better pharmacokinetics in SMG extract might be underlying its medicinal merits over normal garlic. Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Nonclinical Investigation of Cytokine Mitigation Strategies for T-cell-Engaging Bispecifics in the Cynomolgus Macaque. (Pubmed Central) -  Apr 2, 2024   
    All interventions allowed for functional T-cell responses and expected damage to target-bearing tissues, but the JAK1/TYK2 inhibitor prevented the upregulation of activation markers on T cells, suggesting the potential for suppression of T-cell responses. Our results suggest that short-term prophylactic dexamethasone treatment may be an effective option for blocking cytokine responses without affecting desired T-cell responses to TCBs.
  • ||||||||||  dexamethasone / Generic mfg.
    3D bioengineered liver for the study of acute and chronic hepatic damage (Brown 1+2) -  Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_1811;    
    Its ability to reproduce critical features of liver pathophysiology, including hepatocyte functionality impairment, HSC activation, and inflammation, makes it a valuable tool for studying liver diseases and evaluating potential therapeutic interventions. Furthermore, the adaptability of this model for high- throughput screening provides an opportunity to accelerate the drug discovery process and improve patient outcomes in liver damage-related conditions.
  • ||||||||||  dexamethasone / Generic mfg.
    PNEUMOCOCCAL MENINGITIS IN CHILDREN  (STATION 3) -  Apr 2, 2024 - Abstract #ESPID2024ESPID_540;    
    Conclusions/Learning Points Among children with pneumococcal meningitis, adjuvant therapy by dexamethasone within 12 hours of the start of antibiotics was associated with a lower risk of death. Interpretation of the results is limited by the observational design.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Whey Peptide Alleviates Muscle Atrophy by Strongly Regulating Myocyte Differentiation in Mice. (Pubmed Central) -  Apr 1, 2024   
    The aim of the current study was to evaluate the effect of whey peptide (WP) on muscle atrophy induced by dexamethasone (DEX) in mice...Additionally, it is believed that it helps to relieve muscle atrophy by regulating the expression of myocyte differentiation factors. Therefore, we propose that WP plays a significant role in preventing and treating muscle wasting by functioning as a supplement to counteract muscle atrophy.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., dexamethasone injection / Generic mfg.
    Review, Journal:  Caesarean Delivery: A Narrative Review on the Choice of Neuraxially Administered Opioid and Its Implications for the Multimodal Peripartum Pain Concept. (Pubmed Central) -  Apr 1, 2024   
    Long-acting lipophobic opioids (diamorphine and morphine) have a significant analgesic advantage over short-acting lipophilic opioids (sufentanil and fentanyl)...The question remains as to whether a pain concept that is ideally adapted to a neuraxial short-acting opioid shows benefit to a pain concept that is optimally adapted to neuraxial morphine. If long-acting opioids are used, the timing of each additional component of the multimodal analgesia strategy could ideally be adjusted to this longer duration of action.
  • ||||||||||  Retrospective data, Review, Journal, Surgery:  Prevention of postoperative nausea and vomiting after orthognathic surgery: a scoping review. (Pubmed Central) -  Apr 1, 2024   
    For the non-pharmacological methods, throat packs are not recommended for routine use because of their poor effect and serious complications. More prospective RCTs are required to confirm whether gastric aspiration can prevent PONV effectively for patients undergoing orthognathic surgery.
  • ||||||||||  Rezurock (belumosudil) / Romeck Pharma, Sanofi, Jakafi (ruxolitinib) / Incyte, Imbruvica (ibrutinib) / AbbVie, J&J
    Clinical guideline, Journal:  ERS/EBMT clinical practice guideline on treatment of pulmonary chronic graft-versus-host disease in adults. (Pubmed Central) -  Apr 1, 2024   
    Following the ERS standardised methodology, we conducted systematic reviews to address these questions and used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to develop recommendations.The resulting guideline addresses common therapeutic options (inhalation therapy, fluticasone-azithromycin-montelukast, imatinib, ibrutinib, ruxolitinib, belumosudil, extracorporeal photopheresis and lung transplantation), as well as other aspects of general management, such as lung functional and radiological follow-up and pulmonary rehabilitation, for adults with pulmonary cGvHD phenotype bronchiolitis obliterans syndrome. These recommendations include important advancements that could be incorporated in the management of adults with pulmonary cGvHD, primarily aimed at improving and standardising treatment and improving outcomes.