Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Zwitterionic polymer-dexamethasone conjugates penetrate and protect cartilage from inflammation. (Pubmed Central) -  Apr 24, 2024   
    The conjugates elicited no oxidative stress on chondrocytes compared to dose-matched free DEX and protected bovine cartilage explants from the inflammatory response after treatment with IL-1?. By combining cartilage targeting and sustained drug release properties, the pCBAA-co-DEX conjugates solve many issues of today's intra-articular therapeutics, which could ultimately enable better long-term clinical outcomes with fewer side effects.
  • ||||||||||  prednisolone / Generic mfg.
    Review, Journal:  Skin necrosis after intradermal injection of lyophilized exosome: A case report and a review of the literature. (Pubmed Central) -  Apr 24, 2024   
    IRd appeared to be effective in RRMM patients in routine clinical practice regardless of prior lenalidomide or PI exposure, with better outcomes seen in lenalidomide- and/or PI-nonrefractory versus refractory patients. Utilizing exosomes through unapproved methods should be avoided due to the possibility of adverse reactions that could cause aesthetic issues.
  • ||||||||||  bortezomib / Generic mfg.
    Journal:  Peripheral Ulcerative Keratopathy following Systemic Treatment with Bortezomib: A Case Report. (Pubmed Central) -  Apr 24, 2024   
    Tear break-up time was shortened bilaterally. In addition to palpebral hygiene and oral treatment with doxycycline 100 mg every 24 hours, the patient was prescribed the following topical treatment without preservatives: artificial tears with lipid emulsion, netilmicin 0,3% 0,4 ml eye drops every 6 hours and dexamethasone 1 mg/ml every 8 hours.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Trial completion date, Trial primary completion date:  CHOROS ORION: Outcomes in Real-life After Initation of Treatment With Trixeo (Budesonide / Glycopyrronium / Formoterol) (clinicaltrials.gov) -  Apr 24, 2024   
    P=N/A,  N=250, Recruiting, 
    In addition to palpebral hygiene and oral treatment with doxycycline 100 mg every 24 hours, the patient was prescribed the following topical treatment without preservatives: artificial tears with lipid emulsion, netilmicin 0,3% 0,4 ml eye drops every 6 hours and dexamethasone 1 mg/ml every 8 hours. Trial completion date: Feb 2025 --> Jun 2025 | Trial primary completion date: Feb 2025 --> Jun 2025
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Beef peptides mitigate skeletal muscle atrophy in C2C12 myotubes through protein degradation, protein synthesis, and the oxidative stress pathway. (Pubmed Central) -  Apr 23, 2024   
    This study aimed to investigate the potential of beef peptides (BPs) in mitigating muscle atrophy induced by dexamethasone (DEX) with underlying three mechanisms in vitro (protein degradation, protein synthesis, and the oxidative stress pathway)...Specifically, peptides GAGAAGAPAGGA (MW 924.5) and AFRSSTKK (MW 826.4) were identified from fractionated peptides of BPs. These findings suggest that BPs, specifically the peptide fractions GAGAAGAPAGGA and AFRSSTKK, could be a potential strategy to mitigate glucocorticoid-induced skeletal muscle atrophy by reducing the E3 ubiquitin ligase activity.
  • ||||||||||  dexamethasone / Generic mfg., vancomycin / Generic mfg.
    Journal:  Hair Transplantation Complicated by Methicillin-resistant Staphylococcus Aureus Sepsis and Endogenous Endophthalmitis. (Pubmed Central) -  Apr 23, 2024   
    Hair transplantation is associated with minimal systemic complications, but in rare cases, sepsis is possible and can result in intraocular seeding causing endophthalmitis. MRSA endogenous endophthalmitis frequently results in negative vitreous taps and treatment outcomes in the literature have been shown to vary widely including a return to baseline vision as in the described case.
  • ||||||||||  Kenalog-40 (triamcinolone acetonide injection suspension) / BMS
    Journal:  Pollybeak deformity in rhinoplasty: prevention and treatment. (Pubmed Central) -  Apr 23, 2024   
    Tip support should be provided to prevent inefficient tip support from causing an under-projected tip. However, efforts should be made to minimize supra-tip dead space and possibly proceeding pollybeak formation through proper bandaging.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hair cortisol and changes in cortisol dynamics in chronic kidney disease. (Pubmed Central) -  Apr 23, 2024   
    Reduced cortisol suppression after 1-mg dexamethasone suppression (DST) (p < 0.001), a higher noon (12:00 h pm) salivary cortisol (p = 0.042), and salivary cortisol AUC (p = 0.008) were seen in CKD...Changes in cortisol excretion and HPA dynamics in CKD are not accompanied by significant changes in long-term exposure to cortisol evaluated by HC. The clinical significance and pathophysiological mechanisms explaining the associations between HPA parameters, body composition, and kidney damage warrant further study.
  • ||||||||||  Trial completion date:  Hormonal Mechanisms of Sleep Restriction - Axis Study (clinicaltrials.gov) -  Apr 23, 2024   
    P1,  N=80, Active, not recruiting, 
    The clinical significance and pathophysiological mechanisms explaining the associations between HPA parameters, body composition, and kidney damage warrant further study. Trial completion date: Dec 2024 --> Mar 2025
  • ||||||||||  betamethasone / Generic mfg.
    Trial completion, Trial completion date:  KIDS-STEP_Betamethasone Therapy in Hospitalised Children With CAP (clinicaltrials.gov) -  Apr 23, 2024   
    P3,  N=510, Completed, 
    Recruiting --> Completed | Initiation date: Jul 2023 --> Dec 2023 Recruiting --> Completed | Trial completion date: Dec 2024 --> Mar 2024
  • ||||||||||  triamcinolone acetonide / Generic mfg., minoxidil / Generic mfg.
    Retrospective data, Journal:  Effect of minoxidil combined with triamcinolone acetonide on alopecia areata by microneedle injection. (Pubmed Central) -  Apr 22, 2024   
    Addition of dexmedetomidine to ropivacaine for UKA effectively prolonged the duration of nerve block and decreased c-reactive protein levels, but increased the incidence of rebound pain and rebound pain score, and had no beneficial effects on the postoperative analgesia. Microneedle introduction of minoxidil and triamcinolone acetonide in the treatment of AA is a safe, effective, economical, and convenient method, with few adverse reactions, and has a good application prospect.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Defining Incidental Versus Non-incidental COVID-19 Hospitalizations. (Pubmed Central) -  Apr 22, 2024   
    Results Of the 153,325 patients diagnosed with COVID-19 at 112 general EDs in 17 US states, and admitted or transferred, our preferred measure classified 108,243 (70.6%) as non-incidental, compared to 71,066 (46.3%) using the dexamethasone measure and 77,399 (50.5%) using the CDC measure. Conclusions Identifying non-incidental COVID-19 hospitalizations using ED administration of dexamethasone or the CDC measure provides substantially lower estimates than our preferred measure.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Flexible multifunctional titania nanotube array platform for biological interfacing. (Pubmed Central) -  Apr 22, 2024   
    The release profile of an anti-inflammatory drug, dexamethasone from TNAs-on-polyimide substrates, was then evaluated under different bending modes...This work opens new opportunities for developing novel and more effective implanted devices that can significantly improve patient outcomes and quality of life. The online version contains supplementary material available at 10.1557/s43577-023-00628-y.
  • ||||||||||  hydrocortisone / Generic mfg., acetylcysteine solution / Generic mfg.
    Journal:  The effects of antioxidant supplementation on short-term mortality in sepsis patients. (Pubmed Central) -  Apr 22, 2024   
    Antioxidant supplements can be a single-drug or multi-drug combination: HAT (hydrocortisone, ascorbic acid, and thiamine), ascorbic acid, thiamine, N-acetylcysteine and selenium. However, the meta-analysis of RCTs found that antioxidant therapy drugs, especially ascorbic acid, did substantially reduce short-term mortality(OR
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Steroids After Spine Fusion Surgery (clinicaltrials.gov) -  Apr 22, 2024   
    P4,  N=420, Not yet recruiting, 
    This study was funded by the Septodont company (Saint Maur des Foss??s, France) and registered at ClinicalTrials.gov # NCT04885686. Trial completion date: Oct 2023 --> Oct 2026 | Trial primary completion date: Oct 2023 --> Oct 2026
  • ||||||||||  Cortone (cortisone acetate) / Merck (MSD)
    Journal:  Monitoring adrenal insufficiency through salivary steroids: a pilot study. (Pubmed Central) -  Apr 22, 2024   
    SalE, SalF, and Z-score may be useful markers for monitoring and comparing different GRTs. Excess glucocorticoid in early afternoon best associated with depressive symptoms and worse life and sleep quality.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Effects of prophylactic hydrocortisone in a tertiary Canadian NICU. (Pubmed Central) -  Apr 22, 2024   
    In patients undergoing laparoscopic sleeve gastrectomy, preoperative dexamethasone administration was associated with improved the recovery quality after discharge and reduced early postoperative need for antiemetic medications. No abstract available
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
    Clinical and atopic features of patients with primary eosinophilic colitis: an Italian multicentre study (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2689;    
    Phase classification: P2a --> P2 Therapeutical agents prescribed in patients with EC were as follows: rifaximin (n=4, 10%), mesalazine (n=15, 37.5%), probiotics (n=10, 25%), budesonide (n=16, 60%), systemic corticosteroids (n=5, 12.5%), antidiarrheal agents (n=8, 20%), combination therapy (budesonide
  • ||||||||||  dexamethasone / Generic mfg., ibuprofen / Generic mfg.
    Intraoperative anaphylactic reactions by metamizole (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2487;    
    The second case corresponds to an 84-year-old male with a previous history of an anaphylactic reaction to Ibuprofen, that reacted immediately during the intravenous administration of paracetamol, tramadol, metamizole, ondansetron, and pantoprazole...Despite there being more common causes of allergic reactions during surgery, and although NSAIDs may not be the leading cause of such reactions, they still play a significant role. Therefore, it would be interesting to consider limiting their routine use.
  • ||||||||||  Advantan (methylprednisolone aceponate) / Bayer
    INTERESTING FACT: Delayed systemic allergic reactions to corticosteroids: Clinical symptoms y cross-reactivity (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2472;    
    The ST were diagnostic in 37% of cases, two patients by PT with positive readings at D2 and D4 for the culprit drugs (hydrocortisone, budesonide, and methylprednisolone aceponate respectively), IDT were positive in only one patient with the culprit drug (dexamethasone)...The most commonly was intravenous hydrocortisone and oral methylprednisolone, both belonging to group 1...We considered necessary to prove CS from different groups to offer safe alternatives to the patients. None of them presented reactions to two or more groups of CS and although cross-reactivity exists between CS of the same group, all of our patients presented good tolerance.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    SDRIFE induced by four different iodinated contrast media: an atypical presentation (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2465;    
    The lesions resolved within 5 days after intramuscular methylprednisolone and dexchlorpheniramine administration...This fact could be related to the presence of the carbamoyl side chain, as it has been suggested in the literature. Furthermore, it is worth highlighting the atypical presentation in sock distribution of our patient.
  • ||||||||||  dexamethasone / Generic mfg.
    Perioperative reaction due to chlorhexidine and succinylated gelatin (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2456;    
    Topical chlorhexidine and povidone-iodine applications, cefazolin, dexamethasone, bupivacaine, fentanyl, mepivacaine, tranexamic acid, succinylated gelatin and midazolam were used sequentially in the procedure...Around 7% of POH has been reported to exhibit double sensitization. Therefore, even if a culprit agent is found, it is important to discard all of the agents implicated.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Immediate hypersensitivity reactions to corticosteroids: Clinical symptoms and cross-reactivity (Poster Zone) -  Apr 21, 2024 - Abstract #EAACI2024EAACI_2454;    
    Some patients reacted to more than one CS preparation but there are no cases of patients failing to tolerate at least one CS for each route of administration. We consider necessary to establish and validate protocols for testing of both CS themselves as well as the excipient used in various formulations.