- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
A case of Pembrolizumab induced adrenal insufficiency and thyrotoxicosis (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1275;
It is very uncommon for pembrolizumab to cause adrenal insufficiency coexisting with thyroiditis. Also, these adverse events occurred after she finished 8 cycles of pembrolizumab.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Hypoglycemia as an Unusual Presentation of Panhypopituitarism (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1274;
Intriguingly, this patient's initial clinical presentation centered around hypoglycemia, and further evaluation led to the identification of a sellar mass and new diagnosis of panhypopituitarism. This case demonstrates the need to include hypopituitarism in the differential when evaluating hypoglycemic patients.
- |||||||||| dexamethasone / Generic mfg.
ACTH NETs and the Role for Bilateral Adrenalectomy (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1266;
The other routine biochemistry and brain imaging were unremarkable.Further evaluation of the cause of hypokalaemia was carried out, and the morning cortisol and ACTH were inappropriately elevated and did not suppress with dexamethasone (both low and high doses), and the 24-hour urine cortisol was high...No history of fractures, but the bone mineral density scan demonstrated osteoporosis (T-score of -3 in the lumbar spine, and a T-score -2.7 in the left total proximal femur). To date he has received conservative management, with ongoing discussion regarding the utility of bilateral adrenalectomy.Clinical Lesson
- |||||||||| prednisone / Generic mfg., hydrocortisone / Generic mfg.
Hydrocortisone vs Prednisone During Recovery Following Surgical Cure for Endogenous Hypercortisolism: A Longitudinal Observational Study (258ABC - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_953;
No differences in age (median age 51 vs 53 years, P=0.62), sex (84 vs 85% women, P=0.83), etiology of hypercortisolism (ACTH-dependent: 44% vs 48%, P=0.26), clinical severity of hypercortisolism (median score 13 vs 12, P=0.97), or biochemical severity of hypercortisolism (median score of 6 in both, P=0.31) were noted between groups. When assessed at 4-, 8-, and 12-weeks post-surgery, the prevalence and trajectory of symptoms (fatigue, myalgias/arthralgias, sleep, headaches, nausea, weakness) were similar in patients treated with hydrocortisone and prednisone (P>0.05 for all).
- |||||||||| Retevmo (selpercatinib) / Eli Lilly
Remission of Ectopic Cushing Syndrome due to Medullary Thyroid Cancer with Selpercatinib (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_823;
Serum cortisol following overnight - 1 mg dexamethasone suppression test (DST) was 50.1 mcg/dL, with baseline ACTH of 500 pg/mL (nl 7-63)...He was diagnosed with ectopic CS due to MTC and started on ketoconazole which was later switched to metyrapone due to uptrending liver enzymes...There are multiple reported management strategies for ectopic CS in patients with MTC including surgical debulking, steroidogenesis inhibitors, bilateral adrenalectomies, and more recently the use of tyrosine kinase inhibitors. As demonstrated in our patient, the use of selpercatinib in patients with RET positive metastatic MTC can act as a non-invasive therapeutic option to treat ectopic CS, a rare associated paraneoplastic syndrome.
- |||||||||| methimazole / Generic mfg., hydrocortisone / Generic mfg., propranolol / Generic mfg.
The Storm In A Healthy 26-year-old Hispanic Female (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_769;
She was transferred to the ICU and treatment was initiated with fluids, Propranolol 60 mg PO q4hrs, PTU 250 mg PO q4hrs, and Hydrocortisone 300 mg IV as loading dose then 100mg IV q8hrs...Five days after treatment started, the patient continued symptom-free and was discharged with Propranolol 60 mg PO q6hrs and Methimazole 15 mg PO BID...This case could potentially help physicians identify hyperthyroidism in an earlier phase, reducing incidence, mortality, and hospitalizations of thyroid storm since a variety of mimics make the diagnosis challenging. Furthermore, we could contribute to updated statistical knowledge regarding the risk of patients with thyrotoxicosis developing thyroid storm which despite advancements in technology, are currently lacking.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Myxedema Coma- A Rare and Fatal Manifestation of Severe Hypothyroidism (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_739;
Early detection and quick intervention are crucial for survival. Patient education on medication compliance, regular testing, and reporting new medication to prevent interference with thyroid metabolism is crucial.
- |||||||||| finasteride / Generic mfg.
Case: The Sexual, Physical and Psychological Effects of Post-Finasteride Syndrome (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_731;
A large retrospective study revealed 0.8% of patients developed sexual dysfunction with persistence in 33% of these cases after drug suspension, the main independent risk factor being drug treatment for longer than 7 months.Neuropsychiatric symptoms are likely related to the presence of 5-alpha-reductase isoforms in the brain with resulting alterations in CSF and plasma neuroactive steroid levels and metabolites.Evidence-based treatment options for PFS are limited.PFS is a rare but debilitating syndrome to which a subset of patients appears to be predisposed, but of which the pathophysiology is poorly understood. Further studies in this regard, as well as an exploration of effective treatment options are required.
- |||||||||| Hypopituitarism in Pregnancy (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_699;
Further studies in this regard, as well as an exploration of effective treatment options are required. Ultimately, the management of hypopituitarism in pregnancy requires a personalized approach to hormone replacement and obstetric care and this is done through multidisciplinary care involving endocrinologists and obstetricians to optimize outcomes for both the mother and the baby.
- |||||||||| hydrocortisone / Generic mfg.
A Unique Case of Infertility in a Patient with NCCAH (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_696;
Subfertility in patients in NCCAH is thought to be due to menstrual irregularities including oligomenorrhea or secondary amenorrhea. We report the first case of a woman with diagnosis of NCCAH who is experiencing infertility despite having normal menstrual cycles.
- |||||||||| Padcev (enfortumab vedotin-ejfv) / Astellas, Pfizer
The Sugar Saga: A Profound Case of Diabetic Ketoacidosis due to Enfortumab Vedotin (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_659;
Patient eventually was able to be discharged to rehabilitation with just a correctional humalog insulin...The exact mechanism for hyperglycemia is unknown but it is likely immunomodulatory and therefore treatment with pulse dose steroids may help with overcoming insulin resistance in this setting like in our patient. More research needs to be done to understand mechanisms and establish treatment guidelines for severe insulin resistance and hyperglycemia caused by this medication.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Pembrolizimab Induced Hypophysitis: Uncommon Side Effect Leading to Late Diagnosis (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_657;
Due to non-specific symptoms at onset, hypophysitis can be undiagnosed or misdiagnosed therefore it is important to have a high clinical suspicion with patients on PD-1 inhibitors presenting with such symptoms. It is also imperative to order a full set of hormones as this patient had concomitant primary hypothyroidism.
- |||||||||| Metopirone (metyrapone) / Perrigo Company
Pregnancy-induced ACTH-independent Cushing Syndrome: A Rare Phenomenon Secondary to Aberrant Receptors on Adrenal Glands (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_642;
She was referred to the Endocrinology clinic post-delivery, and screening for Cushing syndrome was negative at that time: 24-hour urinary free cortisol (UFC), late-night salivary cortisol (LNSC) and 1-mg dexamethasone (dex) suppression test (DST) were normal...The patient developed secondary adrenal insufficiency post-delivery requiring hydrocortisone, with recovery of her HPA axis in around 10 weeks...Management of hypercortisolism during pregnancy remains challenging. Metyrapone, a steroidogenesis inhibitor, can be considered for control of hypercortisolemia during pregnancy (off-label) in select cases to prevent maternal and fetal complications.
- |||||||||| dexamethasone / Generic mfg., spironolactone / Generic mfg.
Cardiovascular Risk in Women with Nonclassical Congenital Adrenal Hyperplasia (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_639;
Females with nonclassical congenital adrenal hyperplasia do not present increased CVR using methodologies for precocious detection of atherosclerosis. Although patients receiving dexamethasone therapy for an average of 10 years had increased IL-6 and 8 levels, these data were not associated with radiological markers of atherosclerosis.
- |||||||||| Prezcobix (darunavir/cobicistat) / Gilead, J&J
Iatrogenic Cushing (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_637;
Although patients receiving dexamethasone therapy for an average of 10 years had increased IL-6 and 8 levels, these data were not associated with radiological markers of atherosclerosis. Introduction: The HIV medication Prezcobix contains darunavir, a protease inhibitor which is known to inhibit the hepatic enzyme CYP3A4...Vital signs were remarkable for elevated blood pressure at 165/86 despite taking amlodipine, HCTZ, and carvedilol...His ID physician planned to transition the patient off of Prezcobix and onto Tivicay, so patient was started on hydrocortisone 15mg PO daily at 8AM and 5mg daily at 2PM on the day he switched to Tivicay...Our case demonstrates how the use of Prezcobix with fluticasone may result in iatrogenic Cushing
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Unilateral Adrenal Embolization in Cushing Disease-a Lifesaving Emergent Procedure (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_636;
She was referred to Neurosurgery and was started on Ketoconazole and Paseriotide once-monthly injections...8 am cortisol was 107.6 ug/dl which was suppressed to 16.1 after 8 mg overnight Decadron...Gamma knife radiation treatment was performed a month later after which she was noted to have GWS and required Hydrocortisone 15/10 mg twice daily, which she has been taking to date... Unilateral adrenal artery embolization can be considered a bridging treatment in CD to reduce cortisol burden and improve the metabolic profile following which a more definitive treatment such as repeat surgery or radiotherapy can lead to long-term remission.
- |||||||||| hydrocortisone / Generic mfg., apixaban / Generic mfg.
Bilateral Adrenal Hemorrhage After Laminectomy: A Rare Complication (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_633;
BAH is a rare complication following laminectomy. Clinicians should be aware of this possibility and consider it in the differential diagnosis of postoperative abdominal pain and electrolyte abnormalities, especially hyponatremia.
- |||||||||| dexamethasone / Generic mfg.
A Case of Severe Transient Hypercortisolism In a Patient With Bacterial Meningitis (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_631;
Clinicians should be aware of this possibility and consider it in the differential diagnosis of postoperative abdominal pain and electrolyte abnormalities, especially hyponatremia. Significantly elevated AM cortisol levels persisted despite treatment with high dose dexamethasone as part of the meningitis regimen (20 mg) resulting in unsuppressed AM cortisol of 9.22 ug/dL...This is a rare case of severe transient hypercortisolism with periadrenal congestion (
- |||||||||| Cushing (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_629;
Significantly elevated AM cortisol levels persisted despite treatment with high dose dexamethasone as part of the meningitis regimen (20 mg) resulting in unsuppressed AM cortisol of 9.22 ug/dL...This is a rare case of severe transient hypercortisolism with periadrenal congestion ( He was on three antihypertensives (amlodipine 10 mg, carvedilol 50 mg, and spironolactone 50 mg) with adequate blood pressure control and no hypokalemia...Initial testing for hypersecretion showed an elevated cortisol 8.7 ug/dL (<1.8) after 1 mg dexamethasone with adequate dexamethasone level, aldosterone concentration (PAC) 9 ng/dL (3-16), plasma renin activity (PRA) 0.7 ng/mL/h (0.25-5.82), potassium of 3.8 mmol/L (3.5-5.1), and normal plasma metanephrines...DDAVP stimulation resulted in an increase in cortisol and ACTH suggestive of Cushing
- |||||||||| hydrocortisone / Generic mfg.
Complex Management of Adrenal Insufficiency in Pregnancy: A Challenging Case (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_626;
The use of biochemical testing is limited, given the physiological activation of RAAS and progressive increases in renin, CRH, ACTH (from both pituitary and placental sources), and cortisol during pregnancy. Monitoring mineralocorticoid requirements is further complicated by physiological changes in blood pressure and interstitial fluid status.
- |||||||||| hydrocortisone / Generic mfg.
Bilateral Adrenal Hemorrhages as the Initial Presentation of Poorly Differentiated Bronchogenic Carcinoma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_623;
The patient was discharged from her second hospital admission on hydrocortisone and fludrocortisone...Adrenal hemorrhage is also a rare inciting event resulting in the diagnosis of lung cancer; to date, there are only 29 published cases of spontaneous adrenal hemorrhage as the initial presentation of lung cancer. This case illustrates the importance of careful evaluation for malignancy in patients with spontaneous adrenal hemorrhage and no clear etiology for adrenal bleeding.
- |||||||||| dexamethasone / Generic mfg.
Increased Incidence of Fracture and Predicted Fracture Risk in Patients with Mild Autonomous Cortisol Secretion (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_619;
This case illustrates the importance of careful evaluation for malignancy in patients with spontaneous adrenal hemorrhage and no clear etiology for adrenal bleeding. FRAX, a validated fracture risk stratifying tool, was used to calculated risk scores for all patients aged between 40 and 90 and risk category according to national guidance were also recorded.MACS cohort (mean age 69
- |||||||||| dexamethasone / Generic mfg., progesterone / Generic mfg.
An Uncommon Indolent Form of Adrenocortical Carcinoma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_607;
Androgen levels including DHEA-S, androstenedione, testosterone, and 17 hydroxy-progesterone were all within the normal range... This is an uncommon presentation of adrenocortical carcinoma with patient presenting with weight loss and failure to thrive but without biochemical findings such as elevated cortisol or androgens.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Lysodren (mitotane) / Perrigo Company
Metastatic Adrenocortical Carcinoma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_604;
This is an uncommon presentation of adrenocortical carcinoma with patient presenting with weight loss and failure to thrive but without biochemical findings such as elevated cortisol or androgens. 1 mg overnight dexamethasone suppression study showed non-suppression of cortisol...She was started on pembrolizumab, which was later discontinued due to poor response and then placed on mitotane...Due to tumor
- |||||||||| Lysodren (mitotane) / Perrigo Company
Aldosterone-Producing Adrenocortical Carcinoma With Poor Prognostic Factors Successfully Treated With Multimodal Therapy (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_597;
1 mg overnight dexamethasone suppression study showed non-suppression of cortisol...She was started on pembrolizumab, which was later discontinued due to poor response and then placed on mitotane...Due to tumor Biochemical test revealed hypokalemia 1.3 (3.5 a 5.1 mEq/L), which persisted despite serial corrections, primary aldosteronism - aldosterone levels 73.5 ng/dL (NR 39.2 ng/dL), renin < 4 uUI/mL (up to 39.9 uUI/mL) - and autonomous cortisol secretion - cortisol (08:00 am) 11.8
- |||||||||| dexamethasone / Generic mfg., doxazosin mesylate / Generic mfg.
"My Stomach hurts": A Rare Case of Adrenal Cortical Carcinoma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_593;
Hormonal workup revealed elevated 24-hr urine cortisol 124.2mcg (ref 4.0-50.0mcg/24h), normal aldosterone/renin ratio 10.63ng/dL (ref <30ng/dl), failed low dose dexamethasone suppression test with post-dex AM cortisol 7.20ug/dL (ref <1.8ug/dL), slightly elevated serum total catecholamine 1256pg/mL (242-1125 pg/mL), norepinephrine 1155pg/mL (ref 217-1109 pg/mL), total metanephrine and normetanephrine 341pg/mL (reg <205 pg/mL), normetanephrine 244.1 (ref <210.1pg/mL), elevated 24-hr urine normetanephrine 700ug/L (ref 131-612ug/L), metanephrine 136ug/L (ref 36-209ug/L) and DHEA-s level 285ug/dl (ref 23-266ug/dL)...She was started on doxazosin for alpha blockade and eventually started on beta blockade with Metoprolol...This condition can be life-threatening, hence early diagnosis and intervention can be lifesaving. Prognosis of malignant pheochromocytoma is dependent on tumor size, presence of SDHB gene mutation or visceral metastases.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg., hydrocortisone / Generic mfg.
Adrenocortical Oncocytic Neoplasm Presenting as Cushing's syndrome: A Case Report (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_586;
Prognosis of malignant pheochromocytoma is dependent on tumor size, presence of SDHB gene mutation or visceral metastases. Work-up done: 1-mg dexamethasone suppression test (DST) with unsuppressed 8am cortisol at 948 nmol/L (reference range (RR) 172- 303), ACTH <1.00 pg/ml (RR 3.0
- |||||||||| dexamethasone / Generic mfg.
Primary Hyperaldosteronism and Mild Autonomous Cortisol Secretion (MACS) in Adrenal Incidentaloma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_585;
Laboratory workup revealed high aldosterone, suppressed renin, low normal ACTH and DHEA-S, positive 1-mg overnight dexamethasone suppression test (DST- 2.66 ug/dL) and 8-mg DST (2.26 ug/dL).Additionally, the metabolic panel showed prediabetes and hyperlipidemia.Diagnosis of adrenal macroadenoma with cortisol and aldosterone co-secretion was made.Unilateral adrenalectomy was planned...Recommendation for proper glucocorticoid coverage was given.In conclusion, evaluation of the functional status of adrenal tumors is essential to uncover hidden medical issues, as s well as to properly guide the patient for intra and postoperative management, avoiding the risks of adrenal insufficiency with proper glucocorticoid coverage. Surgical management of hormonally active adrenal incidentalomas, especially larger >2.4 cm, has potential benefit of improving and preventing metabolic abnormalities: hyperglycemia, dyslipidemia as well as comorbidities such as obesity, hypertension and osteoporosis.
- |||||||||| dexamethasone / Generic mfg.
Adrenal Cortical Carcinoma with Vascular Involvement - Complex case requiring life-saving surgery with bovine pericardium- IVC reconstruction. (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_583;
The dexamethasone suppression test confirmed inadequate cortisol suppression...A retrospective case study of 36 venous reconstructions using BPP showed few complications like thrombosis in 14% (versus 11% in autologous venous repair), 11% reoperated, 3-4% developed partial thrombus and hematoma.Our case exemplifies the successful management of challenging ACC with vascular involvement using BPP, which is mostly used for arterial repairs and is now expanding to venous repairs. Outcomes stress the ongoing need for research and collaborative efforts to refine and standardize the ideal approach to ACC patients with IVC thrombosis and the use of BPP in venous repair.
- |||||||||| Mild Autonomous Cortisol Secretion in High Suspicious Adrenal Incidentaloma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_579;
Patient was referred to left-sided laparoscopic adrenalectomy with perioperative glucocorticoid coverage (100 mg hydrocortisone administered IV and again 8 hours later)...However, in the absence of a single test considered as the gold standard, it is necessary to combine the different tests to reach an adequate diagnostic capacity. The indication of surgery in ACS patients should be based mainly on the hormonal evaluation and the comorbidities potentially mediated by cortisol.
- |||||||||| dexamethasone / Generic mfg., nifedipine immediate release / Generic mfg., spironolactone / Generic mfg.
Remnant Aldosterone-producing adenoma identified with 11-C Metomidate post-adrenalectomy (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_568;
His blood pressure was well controlled with nifedipine 30mg daily...1mg overnight dexamethasone was not suppressed at 89 nmol/l with low baseline DHEAs 0.76 umol/l (1.6-12.6) and adrenocorticotrophic hormone 7.2 ng/l, consistent with mild autonomous cortisol secretion...As such, spironolactone 25mg daily was started for PA...Postoperative, there was complete biochemical success (PRA 6.0 ng/ml/hr , Aldosterone 1.1 ng/dl), and complete clinical cure (normal blood pressure without medications) Conclusion Incomplete resection of the adrenal glands may occur, particularly with larger adenomas. Functional imaging with 11C-Metomidate PET-CT can be useful in cases of recurrence / persistent PA post-surgery, as AVS may be risky in post-operative cases.
- |||||||||| ketoconazole / Generic mfg., dexamethasone / Generic mfg., prednisone / Generic mfg.
Cushing (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_554;
Functional imaging with 11C-Metomidate PET-CT can be useful in cases of recurrence / persistent PA post-surgery, as AVS may be risky in post-operative cases. Morning cortisol was elevated at 40.00 ug/dL (4.30
- |||||||||| ketoconazole / Generic mfg., dexamethasone / Generic mfg.
ACTH-Dependent Cushing's Syndrome due to Metastatic Cervical Cancer: A Case Report (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_552;
The dosages of ACTH and cortisol were performed after the dexamethasone suppression test and a pituitary MRI was normal...The patient was initially treated with Etomidate in a continuous infusion, without tolerance and little control of hypercortisolism, after initiating Ketoconazole which was suspended due to hepatotoxicity, and then underwent bilateral adrenalectomy. This case report brings a very rare association of Cushing's syndrome by ectopic ACTH due to cervical cancer, with less than 10 cases reported, in which we highlight the diagnostic difficulty, the complexity of treatment and the high risk of morbidity and mortality.
- |||||||||| Metopirone (metyrapone) / Perrigo Company, Isturisa (osilodrostat) / Novartis, Recordati
A case of ACTH-producing pancreatic neuroendocrine neoplasm associated with Von Hippel-Lindau disease (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_550;
Because osilodrostat effectively reduced urine free cortisol from 301.9 to 30.4 ?g/day, hydrocortisone replacement was used concomitantly...Those two tumors were NENs of different nature. Although this is the second case report of ACTH-producing pancreatic NEN in VHL and is extremely rare, evaluation of ACTH and cortisol is necessary for early diagnosis of CS, as well as evaluation of pancreatic hormones.
- |||||||||| hydrocortisone / Generic mfg., zoledronic acid / Generic mfg.
A Case of Severe Hypercalcemia in Carney's Complex (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_540;
Urinary cortisol was 6.2 mcg per 24-hr (3.5-45), for which she started hydrocortisone 20 mg daily to treat suspected adrenal insufficiency as excess cortisol secretion in PPNAD may be episodic...Repeat chest CT to further characterize these pulmonary findings is planned. This case illustrates a unique constellation of endocrine features associated with severe hypercalcemia in Carney complex.
- |||||||||| dexamethasone / Generic mfg.
Dexamethasone Increases Bone Mass in Mice (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_478;
However, and importantly, absent GR in the osteoclast, DEX increased bone mass significantly, suggesting that its notable anabolic action was mediated by the osteoblast. Our findings challenge the longstanding premise that steroids directly impact the osteoblast to cause bone loss, and that other mechanisms, such as reduced ACTH levels and/or central effects of DEX, may play a key role.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Endocrinologist Perceptions of the Value of Digital Health Tools to Assist in the Management of Insulin Dosing (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_413;
However, this data is often unavailable or unreliable. The survey revealed a gap between their belief that availability of glucose data and insulin dosing data can help them make dosing recommendations and their belief that these will translate into impacting glycemic control of patients.
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