Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


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  • ||||||||||  abiraterone acetate / Generic mfg., docetaxel / Generic mfg.
    Enrollment closed, Trial primary completion date, Metastases:  NU 23U08: Randomized Phase II Study of ADT + Abiraterone vs ADT + Docetaxel + Abiraterone (clinicaltrials.gov) -  May 7, 2024   
    P2,  N=150, Active, not recruiting, 
    Emulgel AP 0.1% could lower the anti-inflammatory agent, which is vital to psoriasis progression. Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2028 --> May 2024
  • ||||||||||  Campath (alemtuzumab) / Sanofi
    Incidence of Rejection in Setting of Weight-Based Alemtuzumab Induction in Kidney Transplantation (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_1635;    
    Thus, peripheral blood DRTC assessment could serve as a tool to stratify patients at higher risk of rejection in the pre- and early post-transplant period. There was no difference in rejection incidence between weight-based and standard-dosing alemtuzumab.
  • ||||||||||  Campath (alemtuzumab) / Sanofi
    Neutropenia Following Weight-Based Alemtuzumab Induction in Kidney Transplantation (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_310;    
    The sensitivity of serum galactomann in detecting aspergillus is poor. The data demonstrated no significant difference of neutropenia and subsequent filgrastim use between the weight-based and standard dosing groups of alemtuzumab.
  • ||||||||||  Campath (alemtuzumab) / Sanofi
    Impact of Weight-Based Alemtuzumab Induction on Infection in Adult Kidney Transplant Recipients (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_306;    
    While weight-based ALEM did not decrease the incidence of infx, it did not have an adverse effect on rejection rates, patient or graft survival at 1-year post-transplant. Our study suggests that weight-based ALEM is a safe approach for induction in kidney transplant.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Nano vitamin E improved the antioxidant capacity of broiler chickens. (Pubmed Central) -  May 6, 2024   
    Similarly, NVE had a higher antioxidant effect in the dexamethasone-constructed oxidative stress model...Additionally, broilers perfused with NVE showed a significant increase in the area under the concentration versus time curve from zero to infinity (AUC0-?), mean residence time (MRT0-?), elimination half-life (t1/2z), and peak concentration (Cmax) of VE in plasma (P < 0.05). In summary, nano-technology provides more effective absorption and persistence of VE in the blood circulation for broilers, which is conducive to the function of VE and further improve the antioxidant performance of broilers.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Prenatal diagnosis and in utero treatment of congenital adrenal hyperplasia: An up-to-date comprehensive review. (Pubmed Central) -  May 6, 2024   
    Diagnosis and treatment before birth are important as irreparable birth defects can be avoided, decreasing the need for surgical intervention later in life, especially regarding genitalia anomalies. Although early implementation of dexamethasone in the prenatal treatment of CAH has been controversial, there is recent evidence that this treatment can reduce long-term complications.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Review, Journal:  Perinuclear Antineutrophil Cytoplasmic Antibody-Associated Ocular Manifestations: Case Series and Literature Review. (Pubmed Central) -  May 6, 2024   
    There was only one patient diagnosed with systemic involvement, presenting as mixed nephrotic and nephritic syndrome, who required a course of intravenous methylprednisolone during the active stage...Anterior segment ocular manifestations are not uncommon and can be the initial presentation of p-ANCA-associated vasculitis (AAV). Therefore, its evaluation should be considered in establishing the diagnosis of AAV, a life-threatening disease.
  • ||||||||||  mycophenolate mofetil / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  A Rare Presentation: Bilateral Necrotizing Scleritis in Primary Sj (Pubmed Central) -  May 6, 2024   
    Further, this case report addresses a gap in the existing literature concerning pSS-related scleritis. It also emphasizes the crucial role of a rheumatologist in the comprehensive management of this condition.
  • ||||||||||  paquinimod (ABR-215757) / Active Biotech, Cubicin (daptomycin) / Merck (MSD)
    Preclinical, Review, Journal:  Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models. (Pubmed Central) -  May 6, 2024   
    HMGB1 inhibitors, matrix metalloproteinase inhibitors, neurotrophins, antioxidants and paquinimod also improved clinical parameters but only in single or small studies...In conclusion, 24 of 54 treatment regimens (44%) tested improved clinically relevant outcomes in experimental pneumococcal meningitis but few were tested in multiple well-designed studies. The most promising new adjunctive treatments are with C5 antibodies or daptomycin, suggesting that these drugs could be tested in clinical trials.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A new anti-inflammatory lupane in Ziziphus jujuba (L.) Gaertn. var. hysudrica Edgew. (Pubmed Central) -  May 6, 2024   
    The activity of Hussainate was found to be comparable to that of dexamethasone (standard)...This study reveals that chloroform extract of the stem's bark of Z. jujuba may be used to prepare standardized anti-inflammatory herbal products using Hussainate as an active analytical marker. Hussainate may be used as a lead to develop anti-inflammatory drugs.
  • ||||||||||  dexamethasone / Generic mfg., progesterone / Generic mfg.
    Postmenopausal Hyperandrogenism due to Rare Ovarian Tumor (205ABC - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_3052;    
    The presented rare case of postmenopausal virilization is even more unique due to the synchronous presence of 2 rare ovarian tumors, both capable of causing hyperandrogenism, including bilateral ovarian Leydig cell tumor, Brenner tumor and adrenal incidentaloma. Despite normal appearing ovaries on imaging studies, BSO was ultimately necessary for diagnosis and management.
  • ||||||||||  dexamethasone / Generic mfg.
    Progressive 11-beta-HSD2 Insufficiency and Mineralocorticoid Receptor Activation as Kidney Function Declines (253ABC - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_3046;    
    A continuum of higher plasma F/E, and biomarkers of MR activation, is observed with lower eGFR in individuals spanning a wide spectrum of kidney function, including those with apparently normal kidney function. These findings support the concept of progressive 11?HSD2 insufficiency as kidney function declines and implicate cortisol-mediated MR activation in the pathophysiology of hypertension and cardiovascular disease in CKD.
  • ||||||||||  dexamethasone / Generic mfg., bleomycin / Generic mfg.
    Des-Ciclesonide: A Novel Selective Glucocorticoid Receptor Modulator With Therapeutic Potential for Bronchopulmonary Dysplasia, a Chronic Lung Disease of Prematurity (153ABC - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_3017;    
    Glucocorticoids (GCs) such as dexamethasone (DEX) have been a mainstay of BPD prevention as they reduce lung inflammation and injury...However, DES is as effective as DEX in reducing the expression of various proinflammatory cytokine mRNAs in neonatal rat lung induced by an 11-day systemic treatment with bleomycin...Furthermore, network pathway analysis illustrated that DES mobility at helix 7/8 uniquely generated a meaningful allosteric signaling pathway between Q642 and NCOA2 peptide. In conclusion, the pharmacokinetic properties of the GR prodrug CIC coupled with the tissue-selective pharmacodynamic properties of its active metabolite DES make this FDA approved drug a potential new therapeutic agent for BPD.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Patient suffering from Laryngeal edema in the setting of Hypothyroidism (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2909;    
    Patients should be screened on admission when they present with unknown cause of airway compromise for hypothyroidism and treated with empiric high dose levothyroxine IV followed by daily IV levothyroxine until symptom improvement and daily TSH and T3/T4 improvement. Treatment with both high dose steroids and racemic epinephrine should be initiated before diagnosis due to feasible alternative or additional causes of airway obstruction.
  • ||||||||||  Alternating Hypothyroidism and Hyperthyroidism Complicated by Thyroid Eye Disease (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2897;    
    Of note, she was diagnosed with breast cancer in 2021 and is now status post mastectomy and on anastrozole therapy...It is presumed that she had a predominance of TSH receptor blocking antibodies that caused her previous hypothyroidism, and then shifted to a predominance of TSH receptor stimulating antibodies causing thyrotoxicosis. Clinician awareness and further research into this disease entity is crucial to elucidate its pathogenic basis and identify risk factors and potential treatment options.
  • ||||||||||  dexamethasone / Generic mfg., progesterone / Generic mfg.
    Postmenopausal Hyperandrogenism due to Rare Ovarian Tumor (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2854;    
    The presented rare case of postmenopausal virilization is even more unique due to the synchronous presence of 2 rare ovarian tumors, both capable of causing hyperandrogenism, including bilateral ovarian Leydig cell tumor, Brenner tumor and adrenal incidentaloma. Despite normal appearing ovaries on imaging studies, BSO was ultimately necessary for diagnosis and management.
  • ||||||||||  triamcinolone acetonide / Generic mfg., hydrocortisone / Generic mfg.
    A Curious Case of Cushing Syndrome (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2833;    
    This case raises the need for early general medical education for clinicians and patients about the potential risks of corticosteroids, administered from any route, even after isolated exposures.Reference: Dickson RR, Reid JM, Nicholson WT, Lamer TJ, Hooten WM. Corticosteroid and Cortisol Serum Levels Following Intra-articular Triamcinolone Acetonide Lumbar Facet Joint Injections.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg., hydrocortisone / Generic mfg.
    Artri King as a Cause of Adrenal Insufficiency (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2829;    
    She was soon placed on hydrocortisone for adrenal insufficiency and was titrated down.The hypothalamic-pituitary-adrenal (HPA) axis can be suppressed with as low as 5 mg prednisone equivalent a day...Many supplements are not regulated and can pose harm to our patients. Adrenal insufficiency due to glucocorticoids may not only occur from steroid injections, long course of prescription glucocorticoids, but can include supplements if it is hidden from the ingredient list.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    A Curious Case of MACS (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2827;    
    The data supporting its use in MACS is sparse. Therefore, it is important to be aware of associated risks of Mifepristone when advising patients.
  • ||||||||||  Cushings Conundrum: Taming the Hormone Hurricane (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2826;    
    Managing ACTH-producing neuroendocrine tumors necessitates a multidisciplinary approach. In severe Cushing
  • ||||||||||  hydrocortisone / Generic mfg.
    Unmasking the Uncommon: A Case of Primary Adrenal Insufficiency Presenting as Severe Hypercalcemia (ENDOExpo PosterArea - BCEC) -  May 5, 2024 - Abstract #ENDO2024ENDO_2816;    
    She was started on stress dose of hydrocortisone, which was then tapered to physiological doses of oral hydrocortisone and fludrocortisone...Her presentation was unique, also due to the fact that her initial symptoms were diagnosed as POTS as well as SIADH. Given the onset of symptoms after a COVID-19 infection a few months ago, there could also be a potential link between the two.