Glucocorticoid Receptor 

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  • ||||||||||  budesonide / Generic mfg.
    Journal:  Treatment for eosinophilic esophagitis. (Pubmed Central) -  Oct 20, 2021   
    Empiric elimination is presently the preferred dietary approach. Swallowed steroids is the standard of care to treat EoE with medication; however, there are several promising drugs currently undergoing clinical trials.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Ex vivo glucocorticoid receptor-mediated IL-10 response predicts the course of depression severity. (Pubmed Central) -  Oct 20, 2021   
    Blood cells were stimulated ex vivo with lipopolysaccharide and the effect was suppressed by increasing dexamethasone (DEX) concentrations...Patients with remitted MDD showed higher logIC TNF-α values (indicating lower GR sensitivity) in comparison to patients with a current MDD at baseline and follow-up. Initially low GR sensitivity measured ex vivo in peripheral blood cells that increases over the course of treatment could serve as a predictive marker for stronger improvement in depression severity.
  • ||||||||||  budesonide / Generic mfg., bezafibrate / Generic mfg.
    Journal:  Primary biliary cholangitis: treatment. (Pubmed Central) -  Oct 20, 2021   
    The measurement of serum dexamethasone following DST reduces the false-positive rate associated with subtherapeutic dexamethasone levels. Patients with PBC need to be evaluated at baseline, and on-treatment, for the risk of progressive disease and eventually treated with second-line therapies in addition to UDCA.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Clinical, Journal:  Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis. (Pubmed Central) -  Oct 20, 2021   
    Our report highlights the importance of multidisciplinary collaborations to guarantee early detection of endocrinopathies in patients with SCFE undergoing surgical interventions in order to avoid potential complications, such as adrenal crisis during surgery. Based on these results, SCS TA injections appear to be a safe and possible effective treatment modality for managing poorly responsive ERU; further clinical study is warranted.
  • ||||||||||  Nasonex (mometasone furoate nasal spray) / Merck (MSD)
    Preclinical, Journal:  Effects and mechanism of Chinese medicine Jiawei Yupingfeng in a mouse model of allergic rhinitis. (Pubmed Central) -  Oct 20, 2021   
    Based on these results, SCS TA injections appear to be a safe and possible effective treatment modality for managing poorly responsive ERU; further clinical study is warranted. JWYPF has a potential therapeutic effect on AR via adjusting the rebalance of T helper 1 and T helper 2.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Abnormal body composition in patients with adrenal adenomas. (Pubmed Central) -  Oct 20, 2021   
    Patients with adrenal adenomas demonstrate a lower muscle mass and a higher proportion of visceral fat when compared to referent subjects, including patients with NFAT. Even a subtle abnormality in cortisol secretion may impact health of patients with adenomas.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    Clinical, Journal:  A case of lupus nephritis flare-up in severe COVID-19 infection. (Pubmed Central) -  Oct 20, 2021   
    The patient's condition continued to improve, and this case illustrates an approach in treating COVID-19 with concomitant active immune-mediated glomerulonephritis. We find that it is safe to institute high dose immunosuppressant in recovered COVID-19 patients two weeks after the illness.
  • ||||||||||  ketamine / Generic mfg.
    Journal:  Pressure-Sensitive Adhesive Combined with Paper Spray Mass Spectrometry for Low-Cost Collection and Analysis of Drug Residues. (Pubmed Central) -  Oct 20, 2021   
    A total of 10 drugs (acetyl fentanyl, fentanyl, clonazolam, cocaine, heroin, ketamine, methamphetamine, methylone, U-47700, and XLR-11) were evaluated and found to be detectable in the picogram range using a benchtop mass spectrometer and in the low nanogram range using a portable ion trap MS. The novel approach demonstrates a simple yet effective sampling strategy, allowing for rapid identification from difficult surfaces via paper spray mass spectrometry.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Low-Frequency Sensorineural Hearing Loss Associated With Iron-Deficiency Anemia. (Pubmed Central) -  Oct 20, 2021   
    Isosorbide and betamethasone were administered orally, and intravenous hydrocortisone tapering was added 1 week later, but these treatments were ineffective...In view of the increase in serum hemoglobin levels after iron therapy, this might have been the most effective treatment in this case. The hearing loss could therefore be associated with the patient's IDA.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Intramural esophageal abscess as a complication of an eosinophilic esophagitis (Pubmed Central) -  Oct 20, 2021   
    The diagnosis of eosinophilic esophagitis, complicated by an intramural abscess of the esophagus, was established. After spontaneous drainage of the abscess, antibiotic therapy and subsequent remission induction of eosinophilic esophagitis with orodispersible budesonide resulted in a good therapeutic outcome.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Clinical, Retrospective data, Review:  Efficacy of COVID-19 Treatments: A Bayesian Network Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) -  Oct 20, 2021   
    Compared with the standard of care, imatinib, intravenous immunoglobulin and tocilizumab led to lower risk of death; baricitinib plus remdesivir, colchicine, dexamethasone, recombinant human granulocyte colony stimulating factor and tocilizumab indicated lower occurrence of mechanical ventilation; tofacitinib, sarilumab, remdesivir, tocilizumab and baricitinib plus remdesivir increased the hospital discharge rate; convalescent plasma, ivermectin, ivermectin plus doxycycline, hydroxychloroquine, nitazoxanide and proxalutamide resulted in better viral clearance...Tocilizumab showed its superiority compared with SOC on preventing severe outcomes such as death and mechanical ventilation as well as increasing the discharge rate, which might be an appropriate treatment for patients with severe or mild/moderate illness. We also found the clinical efficacy of antineoplastic agents, immunostimulants and immunosuppressants with respect to the endpoints of mortality, mechanical ventilation and discharge, which provides valuable information for the discovery of potential COVID-19 treatments.
  • ||||||||||  methylprednisolone oral / Generic mfg., dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures (clinicaltrials.gov) -  Oct 20, 2021   
    P4,  N=200, Recruiting, 
    We also found the clinical efficacy of antineoplastic agents, immunostimulants and immunosuppressants with respect to the endpoints of mortality, mechanical ventilation and discharge, which provides valuable information for the discovery of potential COVID-19 treatments. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
    Enrollment open, Combination therapy:  Venetoclax Plus Inotuzumab for B-ALL (clinicaltrials.gov) -  Oct 19, 2021   
    P1,  N=26, Recruiting, 
    Recruiting --> Completed | Trial completion date: Dec 2022 --> Aug 2021 Not yet recruiting --> Recruiting
  • ||||||||||  Promacta (eltrombopag) / Novartis
    Enrollment open, Trial initiation date, Immunomodulating:  iROM2: Immunomodulation With Eltrombopag in ITP (clinicaltrials.gov) -  Oct 19, 2021   
    P2,  N=24, Recruiting, 
    N=100 --> 40 Not yet recruiting --> Recruiting | Initiation date: Sep 2021 --> Dec 2021
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Intravenous and Perineural Dexamethasone for Brachial Plexus Block in Hand Surgery (clinicaltrials.gov) -  Oct 18, 2021   
    P1,  N=108, Recruiting, 
    Trial primary completion date: Aug 2021 --> Dec 2021 Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022