Glucocorticoid Receptor 

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  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  DABCO-Customized Nanoemulsions: Characterization, Cell Viability and Genotoxicity in Retinal Pigmented Epithelium and Microglia Cells. (Pubmed Central) -  Oct 25, 2021   
    Quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA)...Surfactants with cationic properties have been used to tailor the nanoemulsions' surface for site-specific delivery of drugs to the ocular structure for the delivery of TA. They are tailored for the eye because they have cationic properties that interact with the anionic surface of the eye.
  • ||||||||||  dexamethasone / Generic mfg., cisplatin / Generic mfg.
    Preclinical, Review, Journal:  Nano-Hydroxyapatite as a Delivery System for Promoting Bone Regeneration In Vivo: A Systematic Review. (Pubmed Central) -  Oct 25, 2021   
    The conjugations of drugs or bioactive molecules such as bone-morphogenetic protein-2 (BMP-2), vancomycin, calcitriol, dexamethasone, and cisplatin were able to enhance the osteogenic property of nHA. Thus, nHA is a promising delivery system for a variety of compounds in promoting bone regeneration in vivo.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis
    Journal:  Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 3 Factorial Design and Physicochemical Characterization. (Pubmed Central) -  Oct 25, 2021   
    Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Immunomodulatory Effect of Helleborus purpurascens Waldst. & Kit. (Pubmed Central) -  Oct 24, 2021   
    In the in vivo assay, H2 revealed an immunostimulatory effect in the context of experimentally induced immunosuppression with dexamethasone, a superior effect to levamisole treatment according to the same regimen, in two doses every 24 h. There was no correlation between pharmacological effect and the reference compounds evaluated. (4) The immunomodulatory effect of methanolic and hydroalcoholic hellebore extracts is not due to ecdysones and polyphenolic compounds, but other polar substances, possible steroid glycosides.
  • ||||||||||  BCMA CAR T-cell therapy / Shanghai Unicar
    Enrollment change, CAR T-Cell Therapy:  Study of BiRd Regimen Combined With BCMA CAR T-cell Therapy in Newly Diagnosed Multiple Myeloma (MM) Patients (clinicaltrials.gov) -  Oct 24, 2021   
    P3,  N=20, Recruiting, 
    (4) The immunomodulatory effect of methanolic and hydroalcoholic hellebore extracts is not due to ecdysones and polyphenolic compounds, but other polar substances, possible steroid glycosides. N=30 --> 20
  • ||||||||||  Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva
    CAPTAIN STUDY: EFFECTS OF BASELINE IGE LEVELS ON TRIPLE THERAPY RESPONSE IN INADEQUATELY CONTROLLED ASTHMA (217-219, Ernest N. Morial Convention Center) -  Oct 23, 2021 - Abstract #ACAAI2021ACAAI_636;    
    Treatment: once-daily FF/VI (100/25, 200/25mcg) or FF/UMEC/VI (100/31.25/25, 100/62.5/25, 200/31.25/25, 200/62.5/25mcg) (ELLIPTA)...n = number of patients at baseline for the first vs second treatment groups shown in the preceding column. ACQ, Asthma Control Questionnaire; CI, confidence interval; IgE, immunoglobulin E; FEV 1 , forced expiratory volume in 1 second; FF, fluticasone furoate; ICS, inhaled corticosteroid; LABA, long-acting β 2 -agonist; LAMA, long-acting muscarinic antagonist; MCID, minimal clinically important difference; UMEC, umeclidinium; VI, vilanterol.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Production of osteogenic and angiogenic factors by microencapsulated adipose stem cells varies with culture conditions. (Pubmed Central) -  Oct 22, 2021   
    OM led to the reduction of angiogenic factors; however, the removal of dexamethasone restored angiogenic factor production...BMP2 levels secreted by rbASCs, mouse ASCs (mASCs), and hASCs were independent of the media treatments, while rASCs responded differently in the surrounding media and within the microbeads. In conclusion, microencapsulated ASCs can be treated to produce osteogenic and angiogenic factors for tissue regeneration applications, but outcomes may vary with culture conditions.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Corticosteroids for Neonatal Hypotension. (Pubmed Central) -  Oct 22, 2021   
    Although it is thought to have multiple causes, absolute and relative adrenal insufficiency is considered as the main reason for refractory hypotension. This article focuses on the role of adrenal insufficiency in causing refractory hypotension in preterm and term infants, the different options of corticosteroids available, and their risk/benefit profiles.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  A Biomimetic, Stem Cell-Derived In Vitro Ocular Outflow Model. (Pubmed Central) -  Oct 22, 2021   
    In this study, it is demonstrated that human iPSC-derived TM cells cultured on SU-8 scaffolds exhibit HTM-like cell morphology, extracellular matrix deposition, and drug responsiveness to dexamethasone treatment. These findings suggest that iPSC-derived TM cells behave like primary HTM cells and can thus serve as reproducible and scalable cell sources when using this in vitro system for glaucoma drug screening and further understanding of outflow pathway physiology, leading to personalized medicine.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, IO biomarker:  Euterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB. (Pubmed Central) -  Oct 22, 2021   
    Wistar rats (180-220 g) were orally pretreated with saline (0.3 mL), ASE (10, 30 and 100 mg/kg) and dexamethasone (control group, 1 mg/kg) once daily for 3 days starting before TNBS instillation...ASE 100 mg/kg significantly reduced TNBS-induced expression of the TLR4, COX-2 and NF-κB p65. ASE 100 mg/kg improved macroscopy and histological parameters, inflammation, intestinal barrier integrity and nitric and oxidative stress through the TLR-4/COX-2/NF-κB pathway.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Neurocysticercosis in a Japanese woman with lung cancer who repeatedly visited endemic countries. (Pubmed Central) -  Oct 22, 2021   
    NCC was incidentally discovered on PET scans and, based on her travel history and epidemiological findings; it was diagnosed and successfully treated with ABZ. NCC is endemic in most developing countries and as visits to such countries have increased, NCC must be ruled out in patients with multiple cystic nodular brain lesions.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Infrared thermography is an effective, noninvasive measure of HPA activation. (Pubmed Central) -  Oct 22, 2021   
    We used experimental manipulations of the HPA axis in house sparrows (Passer domesticus), i.e. adrenal tissue responsiveness to exogenous adrenocorticotropin (ACTH) and the efficacy of negative feedback using the synthetic glucocorticoid dexamethasone (DEX), to test whether IRT is an effective tool for measuring HPA reactivity...We show that IRT can be used to measure HPA reactivity but that skin-temperature is not a good index for glucocorticoid secretion at baseline levels. These results suggest that while IRT of skin temperatures is a useful, noninvasive measure of HPA axis reactivity under acute activation, this technique might not be suitable for measuring natural variation of circulating glucocorticoid levels.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Betamethasone versus dexamethasone for inpatient preschool wheezing-A case-control study. (Pubmed Central) -  Oct 22, 2021   
    In preschool children with acute wheezing requiring hospitalization, betamethasone achieved a similar clinical response when compared to dexamethasone, with a lower cumulative steroid dose. Further studies are needed to understand the additional benefits of betamethasone over other steroids or placebo.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells. (Pubmed Central) -  Oct 22, 2021   
    Materials and Mouse bone cells (MLO-Y4) and bone-marrow derived mouse MSCs were exposed to dexamethasone (Dex), hypoxia of 1% oxygen or both in vitro...In contrast, MSC subjected to the same stressors showed preservation of mitochondrial function and reduced oxidative stress. Accordingly, even under conditions sufficiently stressful to cause the osteocytic cell death in vivo, it was thought that the function of MSC could be preserved, suggesting that in the case of osteonecrosis preventative and therapeutic strategies incorporating their intraosseous implantation may be promising.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Observational data, Journal:  Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study. (Pubmed Central) -  Oct 22, 2021   
    Dexamethasone improves survival of patients with COVID-19 acute respiratory distress syndrome, but might shorten the delay between the start of invasive mechanical ventilation and the occurrence of ventilator-associated pneumonia, suggesting possible worsening of COVID-19-induced immune dysfunction with this treatment. In a prospective observational study, we found that mechanically ventilated patients with COVID-19 treated with dexamethasone presented earlier ventilator-associated pneumonia, had significantly lower monocyte Human Leukocyte Antigen-DR expression and number of circulating CD4 + cells after ICU admission, than those not treated with corticoids.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Herpes simplex keratoconjunctivitis in the immediate postoperative period after strabismus surgery. (Pubmed Central) -  Oct 22, 2021   
    The recovery was initially unremarkable, and the standard postoperative drops of dexamethasone and chloramphenicol (non-preservative free) were prescribed...This case highlights the importance of EUA in infections not responding to standard treatment. Although HSK is known to occur after topical steroid use and ocular surgery, we were not able to find any other cases in the literature and believe this is the first reported case of bilateral HSK in the immediate postoperative period after strabismus surgery.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Postnatal steroid management in preterm infants with evolving bronchopulmonary dysplasia. (Pubmed Central) -  Oct 22, 2021   
    This review aims to examine the pharmacologic properties of several corticosteroids, appraise the existing evidence for postnatal corticosteroid use in preterm infants, and assess steroid management strategies to ameliorate BPD. Finally, we aim to provide guidance based on clinical experience for managing adrenal suppression resulting from prolonged steroid exposure since this is an area less well-studied.
  • ||||||||||  dexamethasone / Generic mfg., ondansetron / Generic mfg.
    Clinical, P3 data, Journal, CINV:  Phase III study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in pediatric patients. (Pubmed Central) -  Oct 22, 2021   
    Finally, we aim to provide guidance based on clinical experience for managing adrenal suppression resulting from prolonged steroid exposure since this is an area less well-studied. We demonstrated the efficacy of palonosetron in pediatric patients receiving highly emetogenic chemotherapy or moderately emetogenic chemotherapy and confirmed the appropriateness of the 20 μg/kg dose, regardless of age, considering the safety and pharmacokinetic profiles.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Epicardial fat inflammation response to COVID-19 therapies. (Pubmed Central) -  Oct 22, 2021   
    Dexamethasone therapy was associated with significant reduction of EAT inflammation in COVID-19 patients, whereas SAT showed no changes. Anti-inflammatory therapies targeting visceral fat may be helpful in COVID-19 diseases.