Glucocorticoid Receptor 

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  • ||||||||||  Winrevair (sotatercept-csrk) / BMS, Merck (MSD)
    Trial completion date, Trial primary completion date, Combination therapy:  Sotatercept (ACE-011) With Lenalidomide or Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Oct 29, 2021   
    P1,  N=33, Active, not recruiting, 
    Delayed onset C. acnes endophthalmitis may be triggered by an intravitreal steroid injection in pseudophakic patients. Trial completion date: Mar 2020 --> Jun 2022 | Trial primary completion date: May 2018 --> Jun 2022
  • ||||||||||  Ninlaro (ixazomib) / Takeda
    Trial completion date, Trial primary completion date:  Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome (clinicaltrials.gov) -  Oct 29, 2021   
    P2,  N=34, Recruiting, 
    Active, not recruiting --> Completed | Trial completion date: Aug 2021 --> Mar 2021 Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Oct 2021 --> Oct 2022
  • ||||||||||  Empliciti (elotuzumab) / AbbVie, BMS
    Trial completion date, Trial primary completion date, Combination therapy:  A Study of Elotuzumab With Pomalidomide, Bortezomib, and Dexamethasone in Relapsed Multiple Myeloma (clinicaltrials.gov) -  Oct 29, 2021   
    P2,  N=52, Active, not recruiting, 
    Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Oct 2021 --> Oct 2022 Trial completion date: Sep 2020 --> Jun 2022 | Trial primary completion date: Sep 2020 --> Jun 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Predictors of Anxiolytic Requirement During Radiation Therapy With Thermoplastic Mask Immobilization. (Pubmed Central) -  Oct 29, 2021   
    These factors can be detected in patient charts prior to consultation and therefore have the potential to allow for early identification of individuals who may be at higher risk for anxiety during their radiation experience. Furthermore, patients who required anxiolytics during radiation therapy tended to miss more treatment days, possibly indicating that optimal anxiety management has not yet been achieved.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Reduced Intubation Rates Following Whole-Lung Low-Dose Radiation Therapy (LD-RT) in Patients With COVID-19-Related Pneumonia. (Pubmed Central) -  Oct 29, 2021   
    This study demonstrates that recruitment is readily feasible within the global radiation oncology community, with early results showing a favorable participant experience. In the first, prospective, phase I/II trial of radiotherapy for COVID-19-related pneumonia, a single treatment of whole-lung LD-RT reduced intubation rates by 57% compared to controls in patients receiving supportive care with or without drug therapies (P = 0.05).
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Hemodynamic support of the micropreemie: Should hydrocortisone never be left out? (Pubmed Central) -  Oct 29, 2021   
    Fetal cortisol production is supported by a supply of progesterone from the placenta, and postnatally, adrenal cortisol production in the extremely preterm infant may be inadequate if the infant is placed under excessive stress. This leads to relative adrenal insufficiency which may last for up to several weeks after birth and lead to late-onset circulatory collapse, necessitating treatment with physiological doses of hydrocortisone.
  • ||||||||||  Symbicort (budesonide/formoterol) / AstraZeneca
    Clinical, Journal:  Efficacy and safety of as-needed budesonide-formoterol in adolescents with mild asthma. (Pubmed Central) -  Oct 29, 2021   
    P3
    In adolescents with mild asthma, as-needed BUD-FORM was superior to as-needed terbutaline for severe exacerbation reduction, with similar efficacy to BUD maintenance. As-needed BUD-FORM provides an alternative treatment option for adolescents with mild asthma, without needing daily treatment.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: the COVID STEROID randomised, placebo-controlled trial. (Pubmed Central) -  Oct 29, 2021   
    P3
    Both cervical catheter-directed interlaminar epidural injection and cervical transforaminal steroid injection were effective in reducing pain and disability in the majority of participants with refractory unilateral cervical radiculopathy for up to 1 year. In this trial of adults with COVID-19 and severe hypoxia, we were unable to provide precise estimates of the benefits and harms of hydrocortisone as compared with placebo as only 3% of the planned sample size were enrolled.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Anti-obesity effects of Celastrus orbiculatus extract containing celastrol on canine adipocytes. (Pubmed Central) -  Oct 29, 2021   
    Primary preadipocytes were isolated from the gluteal region of a beagle dog and the primary adipocytes were differentiated into mature adipocytes by adipocyte differentiation media containing isobutylmethylxanthine, dexamethasone, and insulin...In addition, treatment with COE significantly reduced triglyceride content and increased lipolytic activities by 1.5-fold in canine adipocytes. Overall, it was concluded that COE may enhance anti-obesity activity in canine adipocytes by inhibiting lipid accumulation and increasing lipolytic activity.
  • ||||||||||  prednisolone / Generic mfg.
    Clinical, Journal:  A case report about eosinophilic enteritis presenting as abdominal pain. (Pubmed Central) -  Oct 29, 2021   
    Clinicians must be aware that not all patients with EE have a history of allergies. In the management and treatment of the disease, multisite biopsies should be carried out if EE is suspected, and EE is responsive to steroid therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A Neuroprotective Bovine Colostrum Attenuates Apoptosis in Dexamethasone-Treated MC3T3-E1 Osteoblastic Cells. (Pubmed Central) -  Oct 29, 2021   
    Our data support the notion that colostrum may be able to reduce DEX-induced apoptosis possibly via the activation of the ERK pathway and modulation of the Hsp70 system. We provided preliminary evidence on how bovine colostrum, as a complex and multi-component dairy product, in addition to its neuroprotective action, may affect osteoblastic cell survival undergoing apoptosis.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The surface modification of long carbon fiber reinforced polyether ether ketone with bioactive composite hydrogel for effective osteogenicity. (Pubmed Central) -  Oct 29, 2021   
    Thus, a facile surface modification method, using gelatin methacrylate/polyacrylamide composite hydrogel coating (GelMA/PAAM) loading with dexamethasone (Dex) on our newly-developed LCFRPEEK composite via concentrated sulfuric acid sulfonating and ultraviolet (UV) irradiation grafting methods, has been developed to tackle the problem...The in vivo rat cranial defect assay confirms that SCP/GP/Dex boosts bone regeneration/osseointegration, which significantly improves osteogenic fixation between the implant and bone tissue. Therefore, the newly-developed LCFRPEEK modified via GelMA/PAAM/Dex bioactive coating exhibits improved biocompatibility and osteogenic integration capability, which has the basis for an orthopedic implant for clinical application.
  • ||||||||||  Darzalex (daratumumab) / J&J
    Trial completion date, Trial primary completion date:  Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM (clinicaltrials.gov) -  Oct 29, 2021   
    P2,  N=43, Recruiting, 
    Therefore, the newly-developed LCFRPEEK modified via GelMA/PAAM/Dex bioactive coating exhibits improved biocompatibility and osteogenic integration capability, which has the basis for an orthopedic implant for clinical application. Trial completion date: Nov 2024 --> May 2025 | Trial primary completion date: Nov 2023 --> May 2024
  • ||||||||||  prednisolone / Generic mfg.
    Clinical, Journal:  Idiopathic Sudden Sensorineural Hearing Loss in Patients with Obstructive Sleep Apnea. (Pubmed Central) -  Oct 29, 2021   
    Changes in PTA before and after standard treatment with oral prednisolone (1mg/kg/day for 5 days, then tapered) and between participants with OSA and without OSA were compared...Patients with OSA had poorer prednisolone related hearing improvement in high frequencies than patients without OSA. Despite study limitations, OSA-related hypoxia and snoring noise is hazardous to hearing and standard treatments with CPAP is suggested in OSA patients for both holistic and auditory health.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Enrollment open:  Dexamethasone in Total Knee Arthroplasty (clinicaltrials.gov) -  Oct 29, 2021   
    P4,  N=429, Recruiting, 
    Initiation date: Sep 2021 --> Dec 2021 Not yet recruiting --> Recruiting