Glucocorticoid Receptor 

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  • ||||||||||  Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
    Pancytopenia with multiple opportunistic infections in a lupus patient () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_766;    
    She received pulse intravenous (IV) methylprednisolone for presumed haematological flare followed by prednisolone 40 mg daily...She was treated with multiple antibiotics (Levofloxacin, Azithromycin, IV Imipenem and Amikacin for atypical Mycobacterium), anti-tuberculous medications (ethambutol, isoniazid, rifampicin and pyrazinamide), antifungal (amphotericin B, followed by itraconazole and later fluconazole) and anti-viral (ganciclovir) agents...Her prednisolone dose was tapered to 5 mg daily and subsequently converted to replacement hydrocortisone. Opportunistic infections should be considered as a potential cause of pancytopenia especially in lupus patients.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    A case of neuropsychiatric lupus – a double trouble () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_756;    
    CNS and PNS involvement as initial manifestation of SLE is uncommon especially in young women. Prompt diagnosis and treatment are crucial to prevent the complications of the disease.
  • ||||||||||  mycophenolate mofetil / Generic mfg., cyclophosphamide intravenous / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Management of a patient with anti-MDA-5 amyotrophic dermatomyositis with organizing pneumonia - a case report () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_728;    
    We report a case of a patient with anti MDA-5 ADM with organizing pneumonia, treated with glucocorticoids, immunosuppression with Cyclophosphamide followed by Mycophenolate Mofetil (MMF) with significant clinical improvement...He received pulse intravenous (IV) methylprednisolone 500mg daily for 3 days, followed by IV Cyclophosphamide 0.5-0.6 mg/m2 monthly for 6 cycles as induction therapy... Good clinical response can be expected with early and timely immunosuppressive treatment for anti-MDA-5 associated ILD.
  • ||||||||||  dexamethasone / Generic mfg., tacrolimus topical / Generic mfg.
    Juvenile localized scleroderma- Single center experience from India () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_718;    
    Linear scleroderma was the most common subtype in our cohort and extra-cutaneous manifestations were seen in 17.8%. Adjunctive systemic corticosteroid therapy at diagnosis was found to be associated with earlier response, and longer period of remission in patients with JLS.
  • ||||||||||  cyclosporine / Generic mfg.
    Tapering pulse doses of IVMP in the treatment of MAS associated with sJIA in resource – poor settings () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_628;    
    In such situations, a longer duration and tapering dose regimen of intravenous methylprednisolone (IVMP) may be considered to control MAS...MAS in the first case was also managed with oral cyclosporine and IV etoposide... Tapering courses of pulse methylprednisolone may be a useful option to tide over the acute crisis is sJIA with MAS in regions where anakinra not available or the cost is prohibitive.
  • ||||||||||  prednisolone / Generic mfg., naproxen ER / Generic mfg., naproxen / Generic mfg.
    Spontaneous perinephric hematoma in a young boy due to deficiency of adenosine deaminase 2 - an unusual occurrence () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_618;    
    He had history of left wrist and left ankle arthritis 4 years back that responded to naproxen...He was initiated on injection adalimumab (40 mg subcutaneous every 2 weeks) and gradually tapering dose of oral prednisolone (initial dose 2mg/kg/day)... It is prudent to rule out DADA2 in children who develop SPH as it can be a life-threatening manifestation of the disease.
  • ||||||||||  Combination therapy of COVID-19 led to an exacerbation of psoriasis and psoriatic arthritis: a clinical case () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_574;    
    He treated within 2 weeks in the hospital with ceftriaxone 1000 mg/day, azithromycin 500 mg/day, hydroxychloroquine 400 mg x2/day, enoxaparin sodium 0.4 mg/day, baricitinib 4 mg/day, dexamethasone 8 mg/day...The patient initiated therapy with an IL17A inhibitor - secukinumab 300 mg according to the scheme and continued methotrexate 20 mg/week. In the case, we can see the development of exacerbation of PsA after combination therapy of COVID-19, including antibacterial, antimalarial and biological (JAK kinase inhibitor) drugs.
  • ||||||||||  Lamprene (clofazimine) / Novartis
    Severe covid-19 infection in a lupus nephritis patient on treatment for multi-drug resistant disseminated tuberculosis () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_567;    
    She was started on anti-TB regimen in addition to high dose prednisone, whereas MMF and CNI were discontinued...On the 10th month of treatment with clofazimine, cycloserine, p-aminosalicylic acid, and delamanid, she developed fever, dyspnea, chest pain, disorientation accompanied by progressive oxygen desaturation...Oxygen support with high-flow nasal cannula at 60% FiO2, low molecular weight heparin, meropenem, remdesivir, and dexamethasone were given; MDR-TB treatment was temporarily withheld. This case illustrates the management challenges in a lupus nephritis patient with disseminated TB who developed and eventually recovered from severe COVID-19 infection.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Diffuse alveolar hemorrhage in systemic lupus erythematous (sle): a case series () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_549;    
    Early clinical recognition despite the absence of hemoptysis is crucial for prompt institution of intensive therapy. Presence of concomitant infection is challenging, however delivery of intensive immunosuppression is also imperative.Timely institution of appropriate immunosuppression and therapy foresee a better outcome.
  • ||||||||||  prednisolone / Generic mfg.
    Journey of sarcoidosis to sarcoid lymphoma syndrome: a tale of hope and despair () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_541;    
    He responded well to oral prednisolone and over next 2 years the dose was tapered... Unexplained fever with new organomegaly and cytopenia in known sarcoidosis patients needs be taken seriously keeping lymphoma in mind during evaluation.
  • ||||||||||  dexamethasone / Generic mfg.
    A patient of Behcet’s disease complicated with extra-nodal NK/T cell lymphoma () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_522;    
    The symptoms of unexplained ulcers, enlarged lymph nodes, and resistant to corticosteroid and immunosuppressive agents in BD patients may suggest a possibility of complication with ENKL. An EB virus screening and biopsy examination are necessary for early detection of BD with ENKL.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    A bleeding wolf () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_520;    
    He responded well to corticosteroid and immunosuppressive therapy. There is no evidence-based guidelines yet for AvWS management.
  • ||||||||||  methotrexate / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    A rare cause of thrombocytopenia in a patient with uncontrolled Adult Onset Still’s Disease (AOSD) – a case report () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_507;    
    Methotrexate was added as steroid sparing agent however he defaulted...Intravenous methylprednisolone and fresh frozen plasma was given, plasma exchange and hemodialysis were commenced immediately... Persistent raised serum ferritin level in uncontrolled AOSD patient can precipitated TTP and the mortality was high if not identify and treated early.
  • ||||||||||  dexamethasone / Generic mfg.
    Efficacy of Pulse Dexamethasone in non-systemic Juvenile Idiopathic Arthritis: a double-blind randomized controlled trial () -  Nov 7, 2021 - Abstract #APLAR2021APLAR_219;    
    60 treatment-naive children with non-systemic JIA with an active joint count of ≥5 and/or involvement of hip or cervical joints were randomised to receive either pulse dexamethasone (3 mg/kg/day, max:100mg) or placebo (normal saline) for 3 days at 0, 6±2, 12±2 weeks; along with standard therapy (methotrexate and NSAIDs). The addition of pulse dexamethasone to standard treatment may not add any advantage in improving ACR-Pedi 70 scores at short term follow-up.
  • ||||||||||  dexamethasone / Generic mfg.
    [VIRTUAL] CONSERVATIVE THERAPY OF CHRONIC SUBDURAL HEMATOMAS () -  Nov 7, 2021 - Abstract #WSC2021WSC_527;    
    Conservative therapy eliminates the complications related to surgery, some of which are severe. Essentially, dexamethasone therapy involves shorter hospitalization, lower costs, rare severe complications and the possibility for outpatient treatment and follow up.
  • ||||||||||  dexamethasone / Generic mfg., ceftriaxone / Generic mfg., enoxaparin sodium / Generic mfg.
    [VIRTUAL] CEREBRAL VENOUS THROMBOSIS AND ENCEPHALITIS IN A 59-YEAR-OLD FILIPINO WOMAN WITH COVID-19 () -  Nov 7, 2021 - Abstract #WSC2021WSC_372;    
    She self-medicated with Clonidine, thinking that headache was due to hypertension...She was treated with IV Levetiracetam, Ceftriaxone, dexamethasone... COVID-19 hypercoagulability can manifest as cerebral venous thrombosis and multiple ischemic foci, as in our patient.
  • ||||||||||  Cortone (cortisone acetate) / Merck (MSD)
    Clinical, Journal:  What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study. (Pubmed Central) -  Nov 7, 2021   
    Our real-life study demonstrated the influence of etiology of AI on the type of GC used, a weight-based tailoring in sAI, a likely overdosage of GC treatment in pAI women at the start of treatment and the possibility to successfully increase FCA avoiding GC over-treatment. These observations could inform the usual clinical practice.
  • ||||||||||  Empliciti (elotuzumab) / AbbVie, BMS
    Journal:  Elotuzumab in the treatment of relapsed and refractory multiple myeloma. (Pubmed Central) -  Nov 7, 2021   
    Elotuzumab used in combination with lenalidomide/dexamethasone or with pomalidomide/dexamethasone is approved by the US FDA to treat patients with relapsed and/or refractory MM. The article is a summary of the recent knowledge about the possibility of using elotuzumab in the treatment of relapsed and/or refractory MM and shows its potential uses in the future.
  • ||||||||||  dexamethasone / Generic mfg., cisplatin / Generic mfg.
    Clinical, Journal:  Efficacy of 2 Different Intratympanic Steroid Regimen on Prevention of Cisplatin Ototoxicity: An Experimental Study. (Pubmed Central) -  Nov 6, 2021   
    After cisplatin treatment, OAE amplitudes decreased significantly in group 1 and group 4 for all frequencies, while OAE values were protected in methylprednisolone and dexamethasone group (P < .001). In conclusion, it has been shown that both agents have protective effects on cisplatin ototoxicity, with dexamethasone slightly more than methylprednisolone.
  • ||||||||||  Korlym (mifepristone) / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Targeting the glucocorticoid receptor reduces binge-like drinking in High Drinking in the Dark (HDID-1) mice. (Pubmed Central) -  Nov 6, 2021   
    In conclusion, it has been shown that both agents have protective effects on cisplatin ototoxicity, with dexamethasone slightly more than methylprednisolone. These data suggest that the selection process increased sensitivity to GR antagonism on ethanol intake in the HDID-1 mice, and support a role for the GR as a genetic risk factor for high-risk alcohol intake.
  • ||||||||||  budesonide / Generic mfg.
    Retrospective data, Journal:  A meta-analysis of efficacy of topical steroids in eosinophilic esophagitis: From the perspective of histologic, clinical, and endoscopic outcome. (Pubmed Central) -  Nov 6, 2021   
    TPE as an add-on therapy to high-dose steroid injection during an acute attack in NMOSD patients is associated with returning to baseline EDSS at discharge and last follow-up, and a trend to have a lower disability at 6-12 months. Topical steroids were effective in inducing histological, clinical and endoscopic response in the short-term, and the adverse events were almost tolerable; however, we should interpret the result of clinical and endoscopic response with caution.
  • ||||||||||  Atectura Breezhaler (indacaterol/mometasone furoate) / Novartis, Merck (MSD), Asmanex Twisthaler (mometasone furoate) / Merck (MSD)
    PK/PD data, Journal:  Pharmacokinetics of mometasone furoate delivered via two dry powder inhalers. (Pubmed Central) -  Nov 6, 2021   
    After a 6 day hospitalization he recovered remarkably well without major adverse effects. PK characterization in a healthy volunteer PK study and subsequently an asthma study enabled selection of 80 μg (low), 160 μg (medium), and 320 μg (high) delivered via Breezhaler® as MF doses comparable to the 200 μg, 400 μg and 800 μg doses delivered by Twisthaler®, respectively, as part of QMF149 formulation development.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Intratympanic steroid therapy for Bell's palsy with poor prognostic results. (Pubmed Central) -  Nov 6, 2021   
    Concurrent ITST improves the facial nerve outcome in patients with poor electroneurography test results, regardless of whether equivalent or lower glucocorticoid doses were administered. This may be ascribed to a neuroprotective effect of ITST due to a higher dose of steroid reaching the lesion due to dexamethasone transfer in the facial nerve.