Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...407408409410411412413414415416417...10671068»
  • ||||||||||  Atgam (equine anti-thymocyte globulin) / Pfizer
    Trial initiation date:  TRIUMPH: TReatment for ImmUne Mediated PathopHysiology (clinicaltrials.gov) -  Nov 22, 2021   
    P2b,  N=160, Not yet recruiting, 
    CAR-T cells and other cell-surface-targeted therapies also appear promising. Initiation date: Aug 2021 --> Jan 2022
  • ||||||||||  dexamethasone / Generic mfg., budesonide / Generic mfg.
    Journal:  Glucocorticoids Elevate Pseudomonas aeruginosa Binding to Airway Epithelium by Upregulating Syndecan-1 Expression. (Pubmed Central) -  Nov 21, 2021   
    CCAAT-enhancer-binding protein β (C/EBP β) and its phosphorylated form participated in the regulation of glucocorticoid to SDC1 for interfering C/EBP β or inhibiting phosphorylation of C/EBP β by LiCl and BIO, which are inhibitors of glycogen synthase kinase 3β (GSK-3β), and could prevent glucocorticoids from upregulating SDC1 expression. One should be cautious in administering glucocorticoids in chronic lung disease because of their property of increasing the expression of SDC1 and PA binding to the airway epithelium.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Insertion Tendinosis of Stylomandibular Ligament: Ernest Syndrome. (Pubmed Central) -  Nov 21, 2021   
    Complete remission of pain was seen at 12 months of follow up without any recurrence. Craniofacial surgeons involved in the treatment of various head and neck pain should include this less documented syndrome in their differential diagnosis when treating TMJ disorders.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish. (Pubmed Central) -  Nov 21, 2021   
    However, the two baseline chemicals with no known immunotoxic potential, butanol and ethylene glycol, caused significant effects, too. From our results it appears that the in vitro fish leukocyte assay as performed in the present study has only a limited capacity for discriminating between immunotoxicants and non-immunotoxicants.
  • ||||||||||  dexamethasone / Generic mfg.
    PK/PD data, Retrospective data, Journal:  Across-Species Meta-Analysis of Dexamethasone Pharmacokinetics Utilizing Allometric and Scaling Modeling Approaches. (Pubmed Central) -  Nov 21, 2021   
    The a2CM with distribution clearance and central and peripheral volumes scaled allometrically fitted the plasma concentration profiles similarly but required a total of 6 parameters (besides CL). Overall, literature reported DEX CL values exhibit moderate variability (Mean = 0.64 L/h/kg, CV% = 105%), but distribution parameters are largely conserved across most species.
  • ||||||||||  Preclinical, Journal:  Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. (Pubmed Central) -  Nov 21, 2021   
    The mixed glucocorticoid/progesterone receptor antagonist mifepristone and selective GR antagonist CORT113176 have been shown to selectively reduce alcohol consumption in alcohol-dependent rats...The present study tested the effects of the GR modulators CORT118335, CORT122928, CORT108297, and CORT125134 on alcohol self-administration in nondependent (air-exposed) and alcohol-dependent (alcohol vapor-exposed) adult male rats...The present results support the potential of GR modulators for the development of treatments for AUD. Future studies that characterize genomic and nongenomic effects of these GR modulators will elucidate potential molecular mechanisms that underlie alcohol drinking in alcohol-dependent and nondependent states.
  • ||||||||||  budesonide/salbutamol (PT027) / AstraZeneca, Avillion
    Journal:  Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs. (Pubmed Central) -  Nov 21, 2021   
    In the control group, the antiasthmatic budesonide and salbutamol were given in the same model...The anti-remodeling effect of SKF 96365 was mediated via the suppression of IL-4, IL-5, and IL-13 synthesis, and IL-12-INF-γ-TGF-β pathway. The budesonide-related AR suppression had to do with a decrease in proinflammatory cytokines and an increase in the anti-inflammatory IL-10, with negligible influence on growth factors synthesis and mucous glands activity.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  α-Poly-L-lysine functions as an adipogenic inducer in 3T3-L1 preadipocytes. (Pubmed Central) -  Nov 21, 2021   
    While PLL did not activate the glucocorticoid receptor, which is phosphorylated by dexamethasone (DEX), it showed a positive effect on the cAMP signal pathway when preadipocytes were treated with PLL and 3-isobutyl-1-methylxanthine (IBMX)...We also observed that the mitotic clonal expansion phase was the critical stage in adipogenesis for inducing the effects of PLL. These results suggest that PLL functions as an adipogenic inducer in 3T3-L1 preadipocytes and PLL has a direct effect on insulin signaling, one of the main regulatory pathways.
  • ||||||||||  cyclophosphamide intravenous / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Clinical, Review, Journal:  ANCA-associated vasculitis overlaps with systemic sclerosis: a case report and literature review. (Pubmed Central) -  Nov 21, 2021   
    Therefore, it is critical to recognize AAV in the setting of worsening renal function due to SSs and provide appropriate treatment. Several clinical features are suggestive of AAV rather than SRC, but renal biopsy is required for accurate diagnosis.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Sex differences in prenatal programming of hypertension by dexamethasone. (Pubmed Central) -  Nov 21, 2021   
    The present study examined if prenatal programming by maternal injection of dexamethasone on days 15 and 16 of gestation affected the blood pressure comparably in female and male offspring...In conclusion, male but not female offspring have an increase in blood pressure and urinary protein excretion with prenatal dexamethasone. The increase in blood pressure with prenatal programming was not associated with a consistent increase in renal tubular transporter protein abundance, nor plasma renin activity and serum aldosterone.
  • ||||||||||  dexamethasone / Generic mfg., loteprednol etabonate / Generic mfg., cytarabine / Generic mfg.
    Clinical, Journal:  Cytarabine-Induced Corneal Toxicity: Clinical Features and Relief of Symptoms with Loteprednol Etabonate 0.5% in Two Patients (Pubmed Central) -  Nov 21, 2021   
    Although there is no standardized treatment protocol for cytarabine-induced corneal toxicity, dexamethasone 0.1% and prednisolone phosphate 1.0% were reported to be effective in the resolution of discomfort and symptoms. In the two patients we report herein, loteprednol etabonate 0.5% four times daily was also effective in suppressing the symptoms.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Journal:  ANCA-Negative Churg-Strauss Syndrome Presenting as Bilateral Central Retinal Artery Occlusion: A Case Report (Pubmed Central) -  Nov 21, 2021   
    Foot drop and vasculitic purpura improved after 7 days, but there was no further improvement in visual acuity. In conclusion, in the presence of bilateral CRAO and lack of atherosclerotic risk factors, CSS should be considered as a predisposing factor and investigations should be conducted accordingly.
  • ||||||||||  Melflufen (melphalan flufenamide) / Oncopeptides, Mustargen (mechlorethamine) / Recordati
    Review, Journal:  Melphalan Flufenamide (Melflufen): First Approval. (Pubmed Central) -  Nov 21, 2021   
    A multinational clinical study of melphalan flufenamide in amyloid light-chain amyloidosis is underway across several countries, and preclinical studies for various haematological and solid cancers are underway. This article summarizes the milestones in the development of melphalan flufenamide leading to this first approval.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration. (Pubmed Central) -  Nov 21, 2021   
    Conversely, administration of the GR antagonist mifepristone 30 min before ARS produced a partial blockade of Mkp-1 upregulation, suggesting that stress activates MKP-1, at least in part, through upstream GR signaling...In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure. In sum, these findings further demonstrate that MKP-1 is necessary for development of enhanced behavioral emotionality, while also suggesting a role in stress mechanisms linking brain dysfunction and systemic illness such as kidney disease.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  The Cortisol and ACTH response to Dex/CRH testing in Women with and without Perimenopausal Depression. (Pubmed Central) -  Nov 21, 2021   
    Despite reports of increased stress responsiveness in PMD, we observed no abnormalities of HPA axis activity associated with PMD compared with women without depression. These findings suggest that PMD is not uniformly associated with HPA dysregulation and could reflect underlying pathophysiologic processes that are distinct from women with non-reproductive-related depressions.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery. (Pubmed Central) -  Nov 21, 2021   
    In this study, feasibility of sustained release of thermosensitive poloxamer 407 (P407)-based MB gel for US mediation-enhanced inner ear drug (dexamethasone, DEX) delivery was investigated...These are the first results to demonstrate feasibility of US-modified liquid form DEX-P407-MB cavitation for enhancing permeability of round window membrane. Then, a gel form of DEX-P407-MBs was generated and thus prolonged the release of DEX in middle ear to maintain the therapeutic DEX level in inner ear for at least 7 days.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Clinical, Journal:  Preventing Infectious Complications of Immunomodulation in COVID-19 in Foreign-Born Patients. (Pubmed Central) -  Nov 21, 2021   
    Other immunomodulators used in COVID-19 may also increase risk, including interleukin-6 receptor antagonist (e.g., tocilizumab) and kinase inhibitors...Racial and ethnic minorities in North America, including foreign-born persons, who receive immunomodulating agents for COVID-19 may be at risk for reactivation of latent infections. We develop a screening and management pathway for such patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis. (Pubmed Central) -  Nov 21, 2021   
    Others are involved in signaling and signal transduction, including cAMP, cGMP-dependent protein kinase pathway, endocrine system, and thyroid hormone pathway, as based on Kyoto Encyclopedia of Genes and Genomes analysis. The novel findings warrant deeper investigation of the influence of DXM on growth and other pathways in this neglected tropical disease pathogen, particularly in a setting of autoimmune and/or allergic disease, which may require the clinical use of steroid-like hormones during latent or covert strongyloidiasis.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Preclinical, Journal:  Effect of Diabetes and Corticosteroid Injection on Glenohumeral Joint Capsule in a Rat Stiffness Model. (Pubmed Central) -  Nov 21, 2021   
    Future dynamic studies are needed to determine appropriate perioperative and postoperative cortisol requirements in pediatric CAH patients in order to develop optimal stress dose regimens. The diabetic model had a detrimental effect on the development of stiffness by thickening the joint capsule, and an intra-articular steroid injection resolved the thickened joint capsule and restored shoulder motion.
  • ||||||||||  benzesulfonate (PF-562271) / Pfizer
    Preclinical, Journal:  FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice. (Pubmed Central) -  Nov 21, 2021   
    In conclusions, MC degranulation and production of inflammatory mediators in allergic disease may be consequent to FcεRI crosslinking inducing CaMKII-mediated activation of FAK activity. FAK inhibition may represent a new MC-suppressing treatment strategy for the treatment of allergic diseases.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin. (Pubmed Central) -  Nov 21, 2021   
    Consistently UBE2L3 knockdown in Tibialis anterior induced hypertrophy in dexamethasone (Dex)-treated mice, whereas overexpression worsened the muscle atrophy of Dex-treated mice...By contrast with actin that did not alter MuRF1-UBE2L3 affinity, binding of MHC to MuRF1 (K = 8 nM) impeded UBE2L3 binding, suggesting that differential interactions prevail with MuRF1 depending on both the substrate and the E2. Our data suggest that UBE2L3 regulates contractile proteins levels and skeletal muscle atrophy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  Glucocorticoid-Induced Leucine Zipper-Mediated TLR2 Downregulation Accounts for Reduced Neutrophil Activity Following Acute DEX Treatment. (Pubmed Central) -  Nov 21, 2021   
    Here, we sought to explore the regulation of Toll-like receptor 2 (TLR2) by the synthetic glucocorticoid dexamethasone (DEX) on neutrophils and the associated GILZ involvement...A similar modulation of TLR2 expression, impaired phagocytosis, and killing activity was observed in circulating human neutrophils treated in vitro with DEX. These results demonstrate that glucocorticoids reduce the ability of neutrophils to respond to infections by downregulating TLR2 via GILZ, thereby reducing critical functions.
  • ||||||||||  hydrocortisone / Generic mfg., cytarabine / Generic mfg.
    Clinical, Journal:  Stability of high concentrated triple intrathecal therapy for pediatrics and mitigation strategies. (Pubmed Central) -  Nov 21, 2021   
    In case of the hydrocortisone based mixtures, the formation of a precipitate occurred at a slow rate. To improve the physical stability, a better control of the mixture pH (optimal value ≈ 7) is required or the addition of the cytarabine solution to a pre-mixed binary mixture containing MTX and a corticosteroid should be preferred.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Retrospective data, Review, Journal:  Dexamethasone for treating SARS-CoV-2 infection: a systematic review and meta-analysis. (Pubmed Central) -  Nov 21, 2021   
    This study suggests that dexamethasone may significantly improve the outcome among hospitalized patients with SARS-CoV-2 infection and associated severe respiratory complications. -Further studies need to consider both dose-dependent administration and outcomes in early and later stages of the disease.