- |||||||||| dexamethasone / Generic mfg.
IMMUNE THROMBOCYTOPENIA RELAPSE POST COVID-19 VACCINE IN YOUNG MALE PATIENT () - Nov 27, 2021 - Abstract #EHOC2021EHOC_192;
Isa-Kd is a new treatment option for pts with relapsed MM and STP. Case report We report a 28-year-old Asian male patient, known for ITP and in partial remission for eighteen months, who presented to emergency department with ITP relapse (platelets count of 1 × 10^3 /uL), four days after receiving the second dose of Pfizer SARS-CoV-2 vaccine, which required treatment with intravenous immunoglobulins and dexamethasone, we discuss as well the likely underlying pathophysiology and the suggested approach in patients known for ITP who are willing to receive mRNA COVID vaccines.
- |||||||||| Darzalex IV (daratumumab) / J&J
HOW I TREAT NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS? () - Nov 27, 2021 - Abstract #EHOC2021EHOC_188;
Consolidation might be considered if the response previously achieved could be upgraded and maintenance will be able to maintain the response achieved and under the lenalidomide platform, new combinations are emerging like lenalidomide plus either daratumumab or carfilzomib.In the setting of transplant ineligible patients, the old standards of care bortezomib, melphalan and prednisone and continuous therapy with lenalidomide and dexamethasone have been replaced by daratumumab plus either VMP or Rd because the addition of daratumumab significantly improved the responses rate including complete responses and undetectable measurable disease but also the outcomes in terms of progression free and overall survival. Bortezomib, lenalidomide and dexamethasone is another combination maybe of choice for fit patients and the platform to which monoclonal antibodies anti CD38 are going to be added.
- |||||||||| dexamethasone / Generic mfg., methotrexate IV / Generic mfg., methotrexate / Generic mfg.
A CASE OF METHOTREXATE-INDUCED PHOTOSENTIVITY REACTION () - Nov 27, 2021 - Abstract #EHOC2021EHOC_4;
No additional treatment was given, except alkaline hydration and calcium folinate, when the findings were observed...Our case stated that he went to the sea two weeks ago and that the bullae secondary to the sunburn that developed afterwards peeled off after they burst. In conclusion, patients with a history of recent generalized sunburn should have their methotrexate delayed to avoid this complication.
- |||||||||| Opdivo (nivolumab) / BMS
Trial completion date, Trial primary completion date: Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas (clinicaltrials.gov) - Nov 26, 2021
P1/2, N=18, Active, not recruiting,
Not yet recruiting --> Recruiting | Trial completion date: Jan 2027 --> Apr 2027 | Initiation date: Jul 2021 --> Oct 2021 | Trial primary completion date: Jan 2027 --> Apr 2027 Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Nov 2020 --> Dec 2022
- |||||||||| Reolysin (pelareorep) / Oncolytics, Andrus Reo
Enrollment closed, Enrollment change, Trial primary completion date, Combination therapy: Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) - Nov 26, 2021
P1, N=12, Active, not recruiting,
Trial completion date: Dec 2021 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022 Recruiting --> Active, not recruiting | N=28 --> 12 | Trial primary completion date: Oct 2021 --> May 2021
- |||||||||| Zilretta (triamcinolone acetonide ER) / Pacira
Trial completion date, Trial primary completion date: Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease (clinicaltrials.gov) - Nov 26, 2021
P3, N=65, Recruiting,
Recruiting --> Active, not recruiting | N=28 --> 12 | Trial primary completion date: Oct 2021 --> May 2021 Trial completion date: Sep 2022 --> Sep 2024 | Trial primary completion date: Sep 2021 --> Sep 2023
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: The effectiveness of dexamethasone on the prognosis of dialysis patients with severe COVID-19. (Pubmed Central) - Nov 25, 2021
Dexamethasone did not reduce mortality rates and the requirement for intensive care unit in dialysis patients with COVID-19. Larger prospective randomized clinical trials are required to associate personalized medicine with the corticosteroid treatment to select suitable patients who are more likely to show a benefit.
- |||||||||| dexamethasone / Generic mfg., voriconazole / Generic mfg.
Healthcare-associated infections in icu during the Covid-19 pandemic: periodic predisposing factors, agents and antimicrobial sensitivity profiles ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1230;
The second most common isolation site was urinary cultures with a rate of 31% where K.pneumonia and C.albicans were the most commonly isolated pathogens. The antibiotic susceptibility profiles were such that 51.4% of the K.pneumonia cases were pan-resistant and 14.7% were susceptible to fosfomycin;18% of the C.albicans cases were susceptible to fluconazole, voriconazole, caspofungin and micafungin.30% of the A.baumanii cases were pan-resistant and 22% of the cases were susceptible to colistin.39.5% of the MRSA cases were found to be susceptible to vancomycin, daptomycin and linezolid.
- |||||||||| dexamethasone / Generic mfg., midazolam hydrochloride / Generic mfg.
Non - opioid anaesthesia for perioperative use in a patient with a colorectal carcinoma without the use of an epidural nor locoregional blocks – a case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1224;
Non-opioid anaesthesia provides better postoperative Results in relation to pain management, shortened hospitality stay and overall patient satisfaction. Moreover, studies link the cancer recurrence and metastasis progression with the type of anaesthesia applied perioperatively (1).Learning points: Non-opioid agents mixed properly in sufficient doses as a relatively new anaesthetic approach can very fast become a method of choice in interventions that usually use opioids combined with central neuraxial blocks as main anaesthetic technique.
- |||||||||| hydrocortisone / Generic mfg.
Bilateral vocal cord paralysis after anterior cervical spine surgery: a case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1189;
Hydrocortisone 100mg 8/8h was instituted...It is essential that surgeons ensure that the left-sided retractor teeth are placed into the muscles and not in the esophagus and tension on the retractors should be released intermittently [2, 3].Learning points: These complications should be known to the entire team. It is important to establish protocols to minimize the possibility of injury and how to act when it occurs.
- |||||||||| dexamethasone / Generic mfg., pregabalin / Generic mfg.
Chronic postoperative inguinal pain: a stepwise approach for pain control ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1181;
Pregabalin, topical capsaicin and metamizole SOS was started...Evolution to pulsed radiofrequency (pRF) (38º, 120 sec) of nerve II at the right and left (1st - 1 cycle; 8 months interval; 2nd - 2 cycles; 4 months interval; 3rd - 2 cycles), under ultrasound control, with administration of lidocaine 2% 3mL, ropivacaine 0.2% 10mL and dexamethasone 4mg...Learning points: Invasive techniques for the control of CPIP must be part of the therapeutic weapons available to each patient. A diagnostic and therapeutic approach at levels of increasing complexity / risk must be followed.
- |||||||||| ketorolac / Generic mfg., dexamethasone / Generic mfg.
Ehlers-Danlos Syndrome, what now? ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1170;
Currently, there are no guidelines for regional or general anesthesia in patients with EDS. Rare conditions such as EDS can present a clinical conundrum for the anesthetist, nevertheless knowledge of the basic implications of the condition can minimize patient morbidity and mortality without requiring in-depth knowledge of the disease.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
From suspected pulmonary thromboembolism to Tocilizumab: A diagnostic dilemma A case report on severe maternal SARS-CoV-2 ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1126;
Six hours later, with worsening respiratory distress, therapeutic enoxaparin was administered in view of suspected pulmonary embolism...Intravenous dexamethasone was instituted...The affected maternal cohort carries an inherently increased risk of pulmonary thrombosis [2].Learning points: It is prudent to suspect and initiate therapy for SARS-CoV-2 and/or concurrent pulmonary thrombosis in maternal patients presenting with severe hypoxaemia in the current set up, when biochemical dignosis is delayed. Operative or non-operative delivery when indicated and multidisciplinary protocols improve outcomes.
- |||||||||| dexamethasone / Generic mfg.
Anesthetic management of a patient with Takotsubo syndrome undergoing hip fracture repair ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1119;
To our knowledge, there are no reports of intraoperative DEX administration in TTS patients. Our main goal was the control of stress response2,3, performing FICB to facilitate perioperative analgesia and administering DEX, an antiadrenergic agent with sedative and analgesic properties.Learning points: Administration of DEX should be considered in the intraoperative management of patients with TTS, improving patient’s Outcome.
- |||||||||| dexamethasone / Generic mfg.
Successful airway management of a patient with an intrathoracic goiter: a case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1079;
Intraoperatively, antibiotic, dexamethasone and tranexamic acid were administered...During hospitalisation, the patient had a favourable evolution, was extubated in an ICU 24h later and was discharged 9 days later. The anesthesiologist should be able to anticipate difficulties, especially in patients with a clinical history which suggest upcoming Difficulties.
- |||||||||| dexamethasone / Generic mfg.
Anesthetic management of foramen magnum meningiomas (FMM) – a comparison of 2 case reports - the ventral decubitus (VDP) vs the sitting position (SP) ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1076;
Before induction, dexamethasone, mannitol and 20% saline were administered...Propofol and fentanyl were used for induction...Saline 20%, mannitol and awake intubation was the best option for patient 1 due to tumor size, origin and severe compression of brainstem.Learning points:Posterior fossa surgery may require several different positions whose complications should be known, prevented and promptly treated. Tumor size and brainstem compression obligates an additional care during airway management.
- |||||||||| dexamethasone / Generic mfg.
Opioid-sparing intravenous multimodal analgesia/ sedation strategy for non-intubated thoracic surgery: A case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1009;
Before incision the operation site was infiltrated with lidocaine and ropivacaine...In view of the “opioid epidemic” and the related side effects, opioid-sparing regimens have been successfully implemented in traditional thoracic surgery.2 However, to our knowledge, this is the first reported case of a non-intubated thoracic operation under an intravenous opioid-sparing multimodal sedative and analgesic strategy. Learning points: An opioid-sparing strategy could be a suitable alternative in order to achieve sedation and analgesia in non-intubated thoracic surgery.
- |||||||||| dexamethasone / Generic mfg.
Anaesthesia Management of a Patient with Pneumonectomy Undergoing Robotic Bilateral Adrenalectomy: A Case Report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_985;
Robotic bilateral adrenalectomy operation can be performed smoothly in a patient with pneumonectomy, with lung-protective ventilation strategies, neuroprotective steroid administration, and fluid restriction. We recommend that bilateral adrenalectomy surgeries be performed by starting the operation with the surgery on the same side by positioning the intact
- |||||||||| Suicide attempt with Ammonium Hydroxide during pregnancy: a case report ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_966;
She was transferred to the maternal ICU, sedated with propofol and remifentanil...After delivery dexmedetomidine 1mcg/kg/h was added to optimize sedation...(3) Only one publication assessed acute poisonings in pregnant and non-pregnant women (1), but this article is not centered on the management of caustic intoxications in pregnant patients. More data would be necessary to make recommendations in the population of pregnant patients.
- |||||||||| dexamethasone / Generic mfg.
Persistent wrist and forearm pain after admission to the Intensive Care Unit for SARS-CoV-2 pneumonia. What could be the cause? ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_953;
He also underwent periods of prone decubitus (6-8 hours each period) with sedation with dexmedetomidine...The exact number of iatrogenic events that occur is not possible to determine, as some events are minimal and do not cause problems and others are not documented. Learning points: work overload in Critical Care Units during the SARSCoV-2 pandemic situation, as well as the use of personal protective equipment, could increase the incidence of iatrogenic events.
- |||||||||| dexamethasone / Generic mfg.
Journal: Highly bioavailable Berberine formulation improves Glucocorticoid Receptor-mediated Insulin Resistance via reduction in association of the Glucocorticoid Receptor with phosphatidylinositol-3-kinase. (Pubmed Central) - Nov 25, 2021
Here we examined how HGSD treatment attenuated GR-mediated alteration in PI3K signalling and insulin resistance in diabetic rats, dexamethasone-treated mice and in insulin resistant C2C12 skeletal muscle cells...Insulin resistant C2C12 skeletal muscle cells exhibited impaired insulin signalling compared to controls and treatment of HGSD and RU486, an antagonist of GR, restored insulin signalling to that of control cells...Excess GC-induced insulin resistance is mediated by increased association of GR with PI3K and treatment with HGSD attenuates these effects. We hypothesize that HGSD may be a promising candidate drug for the treatment of type 2 diabetes by reducing the association of GR with PI3K in skeletal muscle.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Visualization of the posterior surface of the lens nucleus with triamcinolone acetonide in phacoemulsification. (Pubmed Central) - Nov 25, 2021
Surgical phaco time was shorter in the triamcinolone acetonide-phacoemulsification group than in the phacoemulsification group (157.1 ± 51.7 s vs 225.3 ± 45.1 s; p = 0.006). The triamcinolone acetonide-assisted phacoemulsification procedure is safe and useful for visualizing the posterior surface of the lens nucleus and facilitates removal of the lens nucleus by phacoemulsification.
- |||||||||| dexamethasone / Generic mfg., ibrutinib / Generic mfg.
Journal, PARP Biomarker, IO biomarker: Therapeutic effect and mechanism of ibrutinib combined with dexamethasone on multiple myeloma. (Pubmed Central) - Nov 25, 2021
We found that ibrutinib combined with DXMS increased the apoptosis of MM cell lines through the PI3K/PARP pathway, significantly reduced CD38 expression in MM cells from patients in vitro, and reduced tumor size and increased the survival time in mice model. This study provides a theoretical basis for the treatment of relapsed refractory MM with ibrutinib combined with DXMS, and a potential therapeutic target for MM clinical treatment.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Retinoic acid stimulates transcription of the rat SHARP-2 gene via multiple pathways. (Pubmed Central) - Nov 25, 2021
Then, whether the SHARP-2 mRNA expression is altered by dexamethasone (Dex), insulin, and the combination of RA and Dex or RA and insulin was examined...The RA-induction of SHARP-2 mRNA level was mainly inhibited by LY294002, staurosporine, and actinomycin D, respectively...In addition, this effect was dependent on the retinoic acid receptor and retinoid X receptor. Thus, we conclude that RA stimulated transcription of the SHARP-2 gene via multiple pathways.
- |||||||||| ibuprofen / Generic mfg., dextromethorphan / Generic mfg.
Clinical, Journal: DrugWAS: Drug-wide association studies for COVID-19 drug repurposing. (Pubmed Central) - Nov 25, 2021
In conclusion, this cohort study leveraged EHR data to identify a list of drugs that could be repurposed to improve COVID-19 outcomes. Further randomized clinical trials are needed to investigate the efficacy of the proposed drugs.
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