- |||||||||| dexamethasone / Generic mfg.
PK/PD data, Journal: Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs. (Pubmed Central) - Nov 29, 2021
Dexamethasone, formulated as phenylpropionate combined with sodium phosphate, terminal half-life, was 25.6 h in plasma and approximately 26 h in urine, and at 96 h, plasma hydrocortisone concentrations returned to background with dexamethasone levels in three of the six greyhounds around the LOQ. Critical assessment of the pharmacokinetic and pharmacodynamic data indicated how it might be utilized for medication control in racing greyhounds.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media. (Pubmed Central) - Nov 29, 2021
It might be a potential replacement for glucocorticoid therapy for HLH treatment in children, thereby reducing or avoiding glucocorticoid-related adverse reactions. RNA-Seq demonstrates differential gene expression in MEE from patients with OME compared to healthy controls with important implications for infection susceptibility, hearing loss, and a role for tobacco exposure in the development and/or severity of OME in pediatric patients.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Wasp sting-related allergic encephalitis. (Pubmed Central) - Nov 29, 2021
We provisionally diagnosed wasp sting-related allergic encephalitis and treated this with intravenous methylprednisolone and intravenous immunoglobulin. He recovered uneventfully over several days.
- |||||||||| dexamethasone / Generic mfg.
Journal: Bone Tissue Metabolism in Dynamics of Experimental Knee Osteoarthrosis Induced by Dexamethasone and Talcum. (Pubmed Central) - Nov 29, 2021
Disturbed osteoclastogenesis accompanied by a decrease in the production of fibroblast growth factor-23 and elevation of serum osteoprotegerin and osteocalcin were observed at the early stages of the disease. During progression of degenerative and dystrophic processes in the joint tissues, an increase in sclerostin concentrations, a decrease in osteocalcin content, and changes in the force and direction of correlations between osteoblast processes and osteoclastogenesis as well as hierarchic distribution of the dominating mechanism of subchondral remodeling were revealed.
- |||||||||| triamcinolone acetonide / Generic mfg.
Journal: Pharmacological flap thinning with local injection of triamcinolone acetonide. (Pubmed Central) - Nov 29, 2021
During progression of degenerative and dystrophic processes in the joint tissues, an increase in sclerostin concentrations, a decrease in osteocalcin content, and changes in the force and direction of correlations between osteoblast processes and osteoclastogenesis as well as hierarchic distribution of the dominating mechanism of subchondral remodeling were revealed. No abstract available
- |||||||||| methylprednisolone acetate / Generic mfg.
Clinical, Journal: Musculoskeletal Interventional Radiology in the Pediatric Population: State of the Art. (Pubmed Central) - Nov 29, 2021
Sclerosing agents and where possible, selective arterial embolization are used for treatment of aneurysmal bone cysts and other vascular malformations. In the management of malignant muscoloskeletal tumors, the role interventional radiology is mainly represented by percutaneous biopsies, and by adiuvant selective embolizations in presence of hypervascular lesions to be submitted to surgery.
- |||||||||| budesonide / Generic mfg.
Review, Journal: Microscopic colitis. (Pubmed Central) - Nov 29, 2021
The mainstay of treatment includes the use of budesonide, with or without adjunctive therapies, and withdrawal of offending drugs...MC can have a substantial negative effect on patient quality of life. The outlook for MC includes a better understanding of the immune response, genetics and the microbiome in disease pathogenesis along with progress in disease management through robust clinical trials.
- |||||||||| dexamethasone / Generic mfg.
Journal: Artemisia scoparia promotes adipogenesis in the absence of adipogenic effectors. (Pubmed Central) - Nov 29, 2021
However, ozone alleviates pain much more, enhances the hand functional status, and improves median nerve conduction in study with over six months duration. These data demonstrate the adipogenic capabilities of SCO are similar but not identical to ROSI, thereby warranting further research into SCO as a promising source of therapeutic compounds in the treatment of metabolic disease states.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Clinical, Journal: Acute encephalitis in pediatric multisystem inflammatory syndrome associated with COVID-19. (Pubmed Central) - Nov 29, 2021
Patients with MIS-C may present acute encephalitis characterized by rapid-onset encephalopathy and EEG abnormalities (slow wave activity and/or epileptic abnormalities), in some cases associated with focal neurological signs that disappear with immunomodulatory therapy. The detection through neurological evaluation of sentinel neurological signs and distinctive EEG patterns documentable at disease onset will allow timely diagnosis and treatment of these cases.
- |||||||||| Atectura Breezhaler (indacaterol/mometasone furoate) / Novartis, Merck (MSD)
Retrospective data, Journal: One time a day mometasone/indacaterol fixed-dose combination versus two times a day fluticasone/salmeterol in patients with inadequately controlled asthma: pooled analysis from PALLADIUM and IRIDIUM studies. (Pubmed Central) - Nov 29, 2021
P3
One time a day, single-inhaler, high-dose MF/IND reduced asthma exacerbations and improved lung function versus two times a day, high-dose FLU/SAL in patients with inadequately controlled asthma. Similarly, improved outcomes were seen with one time a day, medium-dose MF/IND and two times a day, high-dose FLU/SAL, but at a lower ICS dose.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Case Report: Bilateral Ciliary Body Detachment in a Patient Taking Oral Diet Pills. (Pubmed Central) - Nov 29, 2021
Extensive publicity and education are needed to ensure that consumers do not abuse diet pills; meanwhile, a timely diagnosis and withdrawal are crucial for a desirable prognosis. Clinicians need to consider the possibility of drug-secondary ocular diseases.
- |||||||||| dexamethasone / Generic mfg.
Journal: Determination of veterinary drugs in microalgae biomass from photobioreactors fed with piggery wastewater. (Pubmed Central) - Nov 29, 2021
Some critical operation parameters of the QuEChERS procedure were optimized by an experimental design but tetracycline, oxytetracycline, doxycycline, marbofloxacin and ciprofloxacin were not detected by the QuEChERS sample preparation...Nine drugs were detected in the samples at relatively low concentration and a proportional relationship between the found concentrations and the octanol/water partition coefficients of the drugs has been outlined. Moreover, a linear ratio between the concentrations measured in biomass and effluent has been observed for most of the drugs.
- |||||||||| dexamethasone / Generic mfg.
Journal: Structure-Based Virtual Screening of Sterols and Triterpenoids Isolated from Ganoderma (Agaricomycetes) Medicinal Mushrooms Shows Differences in Their Affinity for Human Glucocorticoid and Mineralocorticoid Receptors. (Pubmed Central) - Nov 29, 2021
Moreover, the differences between mean BFE values calculated for both receptors suggest that ergosta-7,22-dien-3-one (compound 1), ganodermaside B (compound 2), fungisterol (compound 5), ganoderic acid Ma (compound 9), and cerevisterol (compound 10) might be used as specific ligands for GCR, with a significantly lower affinity for MNR. Finally, it is worth noting that even though this work is exclusively theoretical, the reported bioactivities (either pro- or anti-inflammatory) for those metabolites that were previously studied are consistent with our findings, suggesting that the well-known immunomodulatory effect of Ganoderma triterpenoids and sterols might be attributed, at least partially, to their ability to act as specific GCR ligands.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Multi-joint steroid-induced avascular necrosis in a malignant brain tumor patient. (Pubmed Central) - Nov 29, 2021
This case report describes a 47-year-old female patient with low-grade astrocytoma who was initiated on low-dose dexamethasone for symptom management...This case report highlights the extent to which AVN can occur in patients with brain tumors following a short course of low-dose corticosteroids. Careful evaluation of and monitoring for the development of AVN should occur frequently in patients with brain tumors given the frequent use of corticosteroids for symptom management in this population.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide. (Pubmed Central) - Nov 29, 2021
Since the composition of cell infiltrates coincides with changes in inflammatory patterns of the respiratory mucosa from patients with COVID-19 and in COVID-19-associated enterocolitis, and systemic dexamethasone treatment became standard of care in ventilated intensive care unit patients with COVID-19 infection, we initiated an individualised therapeutic attempt to treat the duodenitis with topical enteral budesonide. Follow-up oesophagogastroduodenoscopies within 4 weeks of enteral budesonide administration revealed a full clinical and histological healing of the duodenal mucosa with marked reduction of neutrophilic and lymphocytic infiltrates.To our knowledge, the current report is the first description of enteral budesonide treatment of duodenitis in a patient with COVID-19 infection and warrants further investigation, whether budesonide might constitute a novel therapeutic strategy for the management of COVID-19-related intestinal mucosal damage.
- |||||||||| dexamethasone / Generic mfg., dasatinib / Generic mfg.
Preclinical, Journal: Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice. (Pubmed Central) - Nov 29, 2021
In conclusion, although VD3 levels significantly altered intestinal mouse Cyp3a in female mice, DEX plasma exposure was only transiently different for orally administered DEX and dasatinib in male mice. Likewise, the small effect size of VD3 deficiency on single oral dose DEX clearance suggests that the clinical significance of VD3 levels on DEX systemic exposure are likely to be limited.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants. (Pubmed Central) - Nov 29, 2021
Longer-term follow-up into late childhood is vital for assessment of important outcomes that cannot be assessed in early childhood, such as effects of early corticosteroid treatment on higher-order neurological functions, including cognitive function, executive function, academic performance, behaviour, mental health, motor function, and lung function. Further RCTs of early corticosteroids, particularly of hydrocortisone, should include longer-term survival free of neurodevelopmental disability as the primary outcome.
- |||||||||| budesonide / Generic mfg.
Retrospective data, Review, Journal: Budding Multi-matrix Technology-a Retrospective Approach, Deep Insights, and Future Perspectives. (Pubmed Central) - Nov 29, 2021
Due to its promising advantages and colon targeting strategy over the other colon targeted drug delivery systems, premier global companies are exploiting its potential. This article review deep insights into the formulation procedures, drug delivery mechanism, advantages, limitations, safety and efficacy studies of various marketed drug formulations of MMX technology including regulatory perspectives and future perspectives.
- |||||||||| cisplatin / Generic mfg.
Journal: Anti-NMDAR encephalitis presenting after immature teratoma resection. (Pubmed Central) - Nov 29, 2021
Given her cancer diagnosis, she underwent treatment with bleomycin, etoposide and cisplatin chemotherapy in addition to 5 days of high-dose steroids (1 g of intravenous methylprednisolone) for the encephalitis. This treatment regimen led to significant clinical improvement 3 weeks after completion of one cycle of chemotherapy.
- |||||||||| triamcinolone acetonide / Generic mfg.
Clinical, Journal: Carboxymethylcellulose excipient allergy: a case report. (Pubmed Central) - Nov 29, 2021
After removal of the port and antibiotic therapy, disease remission was achieved. This case highlights the importance of identifying excipients such as carboxymethylcellulose as causes of allergy, to reduce burden of further hypersensitivity reactions, not just to drugs but to other consumables.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: Characterization of BoHV-1 gG-/tk-/gE- Mutant in Differential Protein Expression, Virulence, and Immunity. (Pubmed Central) - Nov 29, 2021
Moreover, the immunized calves with triple mutant virus showed protection rates of 64.2% and 68.6% against wt BoHV-1 and wt BoHV-5 challenge, respectively, without reactivation of latency after dexamethasone injection. In conclusion, BoHV-1 gG-/tk-/gE- is a safer marker vaccine against IBR although its immunogenicity in calves was decreased when compared to double mutant virus.
- |||||||||| cefepime hydrochloride / Generic mfg., dexamethasone / Generic mfg., ceftazidime / Generic mfg.
Clinical, Journal: Efficacy of Ceftazidime and Cefepime in the Management of COVID-19 Patients: Single Center Report from Egypt. (Pubmed Central) - Nov 29, 2021
Both ceftazidime and cefepime showed very good inhibitory activity towards SARS CoV-2's M, with IC values of 1.81 µM and 8.53 µM, respectively. In conclusion, ceftazidime and cefepime are efficient for the management of moderate and severe cases of COVID-19 due to their potential anti-SARS CoV-2 activity and low side effects, and, hence, the currently used complex multidrug treatment protocol can be replaced by the simpler one proposed in this study.
- |||||||||| prednisolone / Generic mfg., albuterol sulfate / Generic mfg.
Trial completion, Phase classification, Trial completion date, Trial primary completion date: EDSAMS: ED-Initiated School-based Asthma Medication Supervision (clinicaltrials.gov) - Nov 29, 2021
P4, N=90, Completed,
In conclusion, ceftazidime and cefepime are efficient for the management of moderate and severe cases of COVID-19 due to their potential anti-SARS CoV-2 activity and low side effects, and, hence, the currently used complex multidrug treatment protocol can be replaced by the simpler one proposed in this study. Not yet recruiting --> Completed | Phase classification: PN/A --> P4 | Trial completion date: Aug 2021 --> Jan 2021 | Trial primary completion date: Aug 2020 --> Dec 2020
- |||||||||| dexamethasone / Generic mfg.
Journal, IO biomarker: Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells. (Pubmed Central) - Nov 29, 2021
Dexamethasone-resistant (MM.1R) and sensitive (MM.1S) human multiple myeloma cell lines were used in this study...A decrease in β-catenin regulated the impaired cell cycle and especially promoted cyclin D1 and CDK 4/6 reduction. Taken together, these data revealed that BCP might have significant and effective anti-cancer and anti-proliferative effects in MM cells by activating apoptosis, modulating different molecular pathways, and downregulating the cell cycle.
- |||||||||| dexamethasone / Generic mfg.
Journal: Hyaluronan-Cholesterol Nanogels for the Enhancement of the Ocular Delivery of Therapeutics. (Pubmed Central) - Nov 29, 2021
On the other side, the permeation of hydrophobic drugs (i.e., dexamethasone and piroxicam) is strongly dependent on the water solubility of the entrapped molecules. The obtained results suggest that NHs formulations can improve the ocular bioavailability of the instilled drugs by increasing their preocular retention time (hydrophobic drugs) or facilitating their permeation (hydrophilic drugs), thus opening the route for the application of HA-based NHs in the treatment of both anterior and posterior eye segment diseases.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: COVID-19 Advanced Care. (Pubmed Central) - Nov 29, 2021
Consensus suggestions can standardize care, thereby improving outcomes and facilitating future research. This review discusses current evidence regarding the pharmacotherapy of COVID-19.
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