Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...393394395396397398399400401402403...10671068»
  • ||||||||||  triamcinolone acetonide / Generic mfg., hydrocortisone / Generic mfg.
    New trial:  Splint Versus Steroid Randomized Trial (clinicaltrials.gov) -  Dec 21, 2021   
    P=N/A,  N=100, Not yet recruiting, 
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Metastases:  Dexamethasone for Symptom Burden in Advanced Cancer Patients (clinicaltrials.gov) -  Dec 21, 2021   
    P2,  N=132, Active, not recruiting, 
    Trial completion date: Feb 2021 --> Feb 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Enrollment change, Trial termination:  Dexamethasone and Postoperative Delirium (clinicaltrials.gov) -  Dec 21, 2021   
    P4,  N=200, Terminated, 
    Trial completion date: Feb 2021 --> Feb 2022 N=400 --> 200 | Recruiting --> Terminated; Investigator left institution
  • ||||||||||  fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
    Trial completion date, Trial primary completion date:  HORNbILL: Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency (clinicaltrials.gov) -  Dec 21, 2021   
    P3,  N=1092, Not yet recruiting, 
    Phase classification: P4 --> P3 | N=7100 --> 10000 | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2021 --> Dec 2023 Trial completion date: Oct 2025 --> Jan 2026 | Trial primary completion date: Oct 2025 --> Jan 2026
  • ||||||||||  batoclimab (IMVT-1401) / Roivant
    Enrollment open:  A Study of HBM9161 in NMOSD Patients (clinicaltrials.gov) -  Dec 21, 2021   
    P1,  N=12, Recruiting, 
    Trial completion date: Oct 2025 --> Jan 2026 | Trial primary completion date: Oct 2025 --> Jan 2026 Active, not recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Croup Admissions: Can We Shrink the Elephant in the Room? (Pubmed Central) -  Dec 21, 2021   
    Active, not recruiting --> Recruiting There appear to be promising predictors in croup patients presenting to the ED, which might help stratify risk for interventions after the ED encounter and thus reduce the number of potentially avoidable admissions.
  • ||||||||||  Veramyst (fluticasone furoate nasal spray) / GSK
    Clinical, Journal:  Effects of intranasal steroids on continuous positive airway pressure compliance among patients with obstructive sleep apnea. (Pubmed Central) -  Dec 21, 2021   
    DPd as salvage therapy, followed by HDCT and ASCT, demonstrated deep, durable, and clinically meaningful responses with a manageable safety profile in patients with RRMM. The addition of an intranasal steroid decreased the frequency of nasal symptoms, especially rhinorrhea and congestion, among patients with OSA initiating CPAP therapy and increased compliance to CPAP after 90 days of treatment.
  • ||||||||||  dexamethasone / Generic mfg., valsartan / Generic mfg.
    Clinical, Journal:  Surgical treatment outcome of primary aldosteronism assessed using new modified diagnostic tests. (Pubmed Central) -  Dec 21, 2021   
    The present study was a proof-of-concept process to validate two modified diagnostic tests for PA in clinical practice. These tests, used to diagnose a group of patients with PA, successfully assessed their biochemical cure post-adrenalectomy at rates similar to those reported in the literature.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. (Pubmed Central) -  Dec 21, 2021   
    These tests, used to diagnose a group of patients with PA, successfully assessed their biochemical cure post-adrenalectomy at rates similar to those reported in the literature. Our data establish Tregs as a pro-tumorigenic driver during complement inhibition and provide evidence that targeted C3a and C5a receptor inhibition may add therapeutic advantage when coupled with anti-Treg therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, HEOR:  Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. (Pubmed Central) -  Dec 21, 2021   
    In conclusion, QoL domain scores appeared to be comparable to healthy reference populations and higher compared to patients with a chronic illness. QoL was not influenced by genotype, but undertreatment and use of dexamethasone or prednisone were associated with higher QoL.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Determination of the panel of reference genes for quantitative real-time PCR in fetal and adult rat intestines. (Pubmed Central) -  Dec 21, 2021   
    Further, we used the pathological model of prenatal dexamethasone exposure (PDE) to verify the stability of the selected panel of reference genes...The selected panel of reference genes was still stable under pathological conditions. This study determined the optimal panel of reference genes of pre- and post-natal rat intestines and provided reliable reference genes for the qRT-PCR analysis of rat intestines.
  • ||||||||||  dexamethasone / Generic mfg., tranexamic acid oral / Generic mfg.
    Review, Journal:  The critical care literature 2020. (Pubmed Central) -  Dec 21, 2021   
    Furthermore, the emergency physician should not administer tranexamic acid to patients with acute gastrointestinal bleeding or administer the combination of vitamin C, thiamine, and hydrocortisone for patients with septic shock. Finally, the emergency physician should titrate vasopressor medications to more closely match a patient's chronic perfusion pressure rather than target a mean arterial blood pressure of 65 mmHg for all critically ill patients.
  • ||||||||||  Darzalex IV (daratumumab) / J&J
    EXTRAMEDULLARY MYELOMA OF LIVER MASQUERADING AS GALLBLADDER CARCINOMA. (Green Room (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_602;    
    Subsequent relapse treated with carfilzomib and later daratumumab regimen...received V, D, cyclophosphamide and etoposide without cisplatin...He is currently on elotuzumab V and D, but his kappa light chains continue to rise...No prospective studies defining an optimal treatment strategy for exramedullary myeloma. Vemurafenib for BRAF mutation or immune therapies with CAR-T cells have shown promising results in a limited number of EMM patients.
  • ||||||||||  hydrocortisone / Generic mfg.
    LATE PRETERM INFANT WITH POSTNATAL DIAGNOSIS OF RENAL TUBULAR DYSGENESIS. (Promenade Lobby (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_584;    
    Fresh frozen plasma, intravenous hydrocortisone or fludrocortisone, and vasopressin infusion provide transient circulatory support...Perinatal oligohydramnios evolves into acute renal insufficiency, respiratory failure, and refractory hypotension in the neonatal period. Prenatal molecular genetic testing means that RTD is no longer relegated to exclusive postmortem diagnosis and may have a higher incidence than we think.
  • ||||||||||  PERIANAL PSEUDOVERRUCOUS PAPULES AND NODULES PRESENTING AS SUSPECTED CHILD ABUSE. (Promenade Lobby (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_583;    
    The subject was then prescribed topical mupirocin, bacitracin, lidocaine, and oral Keflex at multiple outside ED visits...Patient was discharged on hydrocortisone, ketoconazole, and zinc oxide for four months with significant improvement of lesions...The mainstay of treatment targets the inciting factors, including diaper use, encopresis, and colostomy bag. Therapy should be aimed to restore the skin barrier, eliminate any source of irritations, and treat superimposed infections.
  • ||||||||||  dexamethasone / Generic mfg., ceftriaxone / Generic mfg.
    A RARE CASE OF NEISSERIA MENINGITIDIS PNEUMONIA IN THE ABSENCE OF MENINGITIS. (Carpenter Hall) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_300;    
    She was initially started on Ceftriaxone 1g Q24H and Azithromycin 500 mg Q24H for community acquired pneumonia as well as a 10-day course of dexamethasone for hypoxia associated with SARS-CoV-2...Repeat blood cultures showed no growth and patient was discharged with supplemental oxygen for covid associated hypoxia and oral Amoxicillin/Clavulanic acid to complete a 14 day total course of antibiotics for MP...Early recognition is critical in order to reduce the risk of transmission to close contacts and health care personnel. Finally, given the high mortality rates associated with untreated meningococcal disease, early initiation of appropriate antibiotic therapy is essential in attempting to improve the outcomes of meningococcal disease.
  • ||||||||||  prednisone / Generic mfg., triamcinolone acetonide topical / Generic mfg., fluticasone / Generic mfg.
    ACTINIC GRANULOMA: A RARE CASE OF SUN DAMAGE. (Chapman #4 (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_51;    
    Our patient differed from the typical presentation in that she described intense pruritus associated with her eruption. Solar elastosis and abundant multinucleated foreign body giant cells with ingested elastic fibers
  • ||||||||||  SUPRASELLAR AND SELLAR MENINGIOMA IN PREGNANCY PRESENTING WITH WORSENING VISUAL DEFICITS AND PANHYPOPITUITARISM. (Carmel Women's Club) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_25;    
    This is a rare case of a meningioma resulting in hormonal deficiencies in the anterior and posterior pituitary along with VF deficits which likely developed due to the location and rapid growth of the tumor in the setting of pregnancy. The decision for surgery during pregnancy should be based on clinical presentation and should involve a multidisciplinary team to determine the best management that limits complications to the mother and fetus.
  • ||||||||||  Empliciti (elotuzumab) / AbbVie, BMS
    Trial completion date:  Study of Bortezomib,Lenalidomide,Dexamethasone & Elotuzumab in Newly Diagnosed MM (clinicaltrials.gov) -  Dec 20, 2021   
    P2a,  N=41, Active, not recruiting, 
    The decision for surgery during pregnancy should be based on clinical presentation and should involve a multidisciplinary team to determine the best management that limits complications to the mother and fetus. Trial completion date: Jun 2022 --> Jun 2023