Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Journal:  Use of steroids in COVID-19 patients: A meta-analysis. (Pubmed Central) -  Dec 29, 2021   
    ClinicalTrials.gov Identifier: NCT03248856. The use of steroids in hospitalized COVID-19 patients is useful to reduce deaths.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis
    Preclinical, Journal:  Ex vivo evaluation of retinal cytotoxicity after the use of multiple medical devices in pars plana vitrectomy in porcine eyes. (Pubmed Central) -  Dec 29, 2021   
    This study aimed to evaluate viability of retinal cells after the use of multiple intraoperative devices, namely a vitreal dye (triamcinolone acetonide,TA), a ERM/ILM dye (solution of trypan blue 0.15% and brilliant blue 0.025%), and two intraocular tamponades, namely perfluoro-n-octane, (PFO) and silicone oil (SO 1000 cSt), with minimal and maximal removal of their residues, during a simulated pars plana vitrectomy (PPV) in porcine eyes ex-vivo...No cytotoxicity was detected in retinal samples in groups A, B and E. Samples from eye bulbs that had undergone surgery with minimal removal of residues (group D) and cytotoxic controls (group C) showed high retinal cytotoxicity. The tested conditions indicated that the combined use of TA, ERM/ILM dye, PFO and SO during PPV does not affect retinal cells viability if all the devices are properly removed, whereas the cytotoxicity detected in group D may suggest that the presence and accumulation of the residues of the compounds used intraoperatively could negatively impact retinal viability due to a cumulative and/or synergistic cytotoxic effect between them, supporting the crucial role of an optimal removal of the intraoperative medical devices to ensure a safe vitrectomy to the patient.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Preclinical, Journal:  Use of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits. (Pubmed Central) -  Dec 29, 2021   
    We also propose that measurement of Gilz and Per1 mRNA expression may be useful to evaluate the effectiveness of GR antagonism. The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution (0.9%).
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion date, Trial primary completion date:  Knee Steroid Injection and Blood Sugar Signatur (clinicaltrials.gov) -  Dec 29, 2021   
    P=N/A,  N=45, Enrolling by invitation, 
    The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution (0.9%). Trial completion date: Nov 2022 --> Nov 2023 | Trial primary completion date: Nov 2021 --> Nov 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors. (Pubmed Central) -  Dec 28, 2021   
    In addition, aorta volume was positively correlated with the level of increased TAC Agatston scores in intensity modulated radiation therapy (r = 0.460, p < 0.001). Dexamethasone is associated with a lower risk of the progression of TAC in breast cancer survivors, and there's no correlation between radiotherapy and progression of TAC, but the aorta volume may be a predictor of the severity of progression of TAC.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Current situation in ARDS in the light of recent studies: Classification, epidemiology and pharmacotherapeutics. (Pubmed Central) -  Dec 28, 2021   
    Lung protective mechanical ventilation (low tidal volume, low plateau pressure, low driving pressure) in all ARDS patients, prone position, neuromuscular blockade (cisatracurium) in moderate-severe ARDS patients, and hydrocortisone therapy in sepsis-associated ARDS patients are treatments that contribute to survival. In this review, current changes in the definition and epidemiology of ARDS, recent pharmacotherapeutic research and mesenchymal stem cell therapies will be discussed in the light of newly introduced ARDS phenotypes.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Adrenal function/dysfunction in critically ill patients: a concise narrative review of recent novel insights. (Pubmed Central) -  Dec 28, 2021   
    This implies reduction of hydrocortisone doses when prescribed in ICU...Finally, the Cosyntropin test is not suitable to assess adrenocortical reserve in ICU patients as the test is confounded by increased cortisol distribution volume. These insights necessitate further research focusing on the need, if any, of treating ICU patients with corticosteroids, and timing thereof, outside indications for pharmacological anti-inflammatory drugs.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis
    Journal:  CYSTOID MACULAR EDEMA AFTER FOUR-POINT SCLERAL FIXATION OF INTRAOCULAR LENS. (Pubmed Central) -  Dec 28, 2021   
    In eyes with pseudoexfoliation syndrome and spontaneous IOL dislocation, 4-point Gore-Tex suture IOL ab externo fixation yielded good visual outcomes, although CME was observed more than reported elsewhere. Prophylactic intravitreal triamcinolone acetonide and long-term nonsteroidal anti-inflammatory drugs seem to reduce the risk of postoperative CME.
  • ||||||||||  Alvesco (ciclesonide) / Covis Pharma, Teijin, Korea University Medical Center
    Journal:  Assessment of the effectiveness of early treatment in SARS-CoV-2 infection (Pubmed Central) -  Dec 28, 2021   
    The use of the assessed drugs should take into account the time of onset of SARS-CoV-2 infection and the severity of the disease course, including comorbidities. The presented analysis of the effectiveness of early treatment in patients infected with SARS-CoV-2 requires further clinical trials.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Cytokine storm:  A Closer Look at Dexamethasone and the SARS-CoV-2-Induced Cytokine Storm: In Silico Insights of the First Life-Saving COVID-19 Drug. (Pubmed Central) -  Dec 27, 2021   
    Herein, we demonstrated that dexamethasone binds with high affinity to interlukin-1 (IL-1), IL-6, IL-8, IL-12, IL-21, INF2, TGFβ-1, INF-γ, CXCL8, some of the receptors, IL-1R, IL-21R, IFNGR, INFAR, IL-6αR-gp130, ST2 and the SARS-CoV-2 protein NSP macro X, and 3CLpro, forming stable drug-protein complexes. Our work implied that dexamethasone has the potential to directly neutralize inflammatory markers, further supporting its life-saving potential in patients with severe manifestations of COVID-19.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Clinical data, Journal:  Comparison of Low-Versus High-Dose Steroids in the Clinical Outcome of Hospitalized COVID-19 Patients. (Pubmed Central) -  Dec 27, 2021   
    Dexamethasone = 6 mg/day was found to be a positive predictor of clinical outcome in COVID-19 patients on regression analysis. (4) Low-dose Dexamethasone (6 mg/day) is more effective than high-dose Dexamethasone and Methylprednisolone in improving the survival outcome of severe COVID-19 cases.
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg., carfilzomib / Generic mfg.
    RAPID AND PERSISTENT EFFICACY OF CARFILZOMIBLENALIDOMIDE-DEXAMETHASONE (KRD) IN AGGRESSIVE MULTIPLE MYELOMA DISEASE () -  Dec 25, 2021 - Abstract #SIE2021SIE_151;    
    Preliminary data of EMN12/HO129 trial investigating carfilzomib and lenalidomide-based treatment for PCL showed that KRd induced deep hematologic responses after 4 cycles (≥VGPR in 80% and ≥CR in 33%). Our reported data suggest that KRd regimen could be an excellent choice in a cohort of patients with aggressive disease usually excluded from pivotal registrative studies because of its quick efficacy with an acceptable toxicity profile.