Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Semi-synthetic diversification of coronarin D, a labdane diterpene, under Ugi reaction conditions. (Pubmed Central) -  Jan 4, 2022   
    The potential of the Ugi reaction was further extended to l-phenylalanine, 2-aminopyridine, and d-glucosamine, which afforded Ugi reaction products 3a-f, 4, and 5a-d, respectively. Cytotoxicity studies in RAW cells reveal that compounds 3e and 5b were non-toxic up to 50 µM, and these compounds were able to reduce the LPS stimulated NO production in RAW cells in par with the standard anti-inflammatory drug dexamethasone.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Journal:  Intravenous Methylprednisolone versus Intravenous Methylprednisolone Combined with Inhaled Budesonide in Acute Severe Pediatric Asthma. (Pubmed Central) -  Jan 4, 2022   
    (p = 0.38) PICU and hospital LOS between the 2 groups was similar, median/(QR), 44/(30-64) vs. 46/(30-62), (p = 0.75) and 78/(65-95) vs.72/(58-92), (p = 0.19). Number of patients requiring respiratory support was 22(58%) in Group A and 25(64%) in Group B. (p = 0.19) In critically ill children with ASA, intravenous methylprednisolone combined with inhaled budesonide did not shorten the duration of continuous albuterol inhalation treatment, the PICU and hospital LOS, and the need for respiratory support.
  • ||||||||||  dexamethasone / Generic mfg., amitriptyline / Generic mfg.
    Preclinical, Journal, IO biomarker:  Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway. (Pubmed Central) -  Jan 4, 2022   
    Number of patients requiring respiratory support was 22(58%) in Group A and 25(64%) in Group B. (p = 0.19) In critically ill children with ASA, intravenous methylprednisolone combined with inhaled budesonide did not shorten the duration of continuous albuterol inhalation treatment, the PICU and hospital LOS, and the need for respiratory support. In conclusion, amitriptyline plays an anti-inflammatory role through the suppression of TLR4/pNF-ĸB signaling pathway in the rat model of acute colitis.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Preclinical, Journal:  A new congenital cleft palate New Zealand rabbit model for surgical research. (Pubmed Central) -  Jan 4, 2022   
    Pregnant New Zealand rabbits received 1.0 mg dexamethasone injection intramuscularly once a day from the 13th gestation day (GD13) to GD16...There was no statistically significant difference in maxillary and mandible development between the two groups within one month after birth. This congenital cleft palate model is considered to have more research possibilities with efficient cleft induction, reliable feeding methods, stable anatomical defects, and maxillofacial development similar to those seen in humans.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases. (Pubmed Central) -  Jan 4, 2022   
    Injection of triamcinolone acetonide (TA), an anti-inflammatory steroid drug, directly into the dermis of diseased skin using needle-syringe systems is a long-established procedure for treating recalcitrant lichenified lesions of CISDs, referred to as TA intralesional injection (TAILI)...In an in vivo skin inflammation mouse model, Candlelit-DMN inserted with the applicator effectively alleviates inflammation by suppressing inflammatory cell infiltration and cytokine gene expression, to the same extent as TAILI. This Candlelit-DMN with the applicator arouses the interest of dermatologists, who prefer it to the current TAILI procedure.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Kinetics of hydrocortisone sodium phosphate penetration into the human aqueous humor after topical application. (Pubmed Central) -  Jan 4, 2022   
    Our results support further evaluation of this all-oral regimen in relapsed/refractory MM. Considering the frequent need for prolonged topical steroid therapies and the possible consequent undesirable side effects, ophthalmologists should consider the lowest clinically effective dose of hydrocortisone useful to obtain the desired therapeutic effect and in an adequate time, to minimise the amount of steroids into the anterior chamber and to avoid side effects like intra-ocular pressure increase or cataract development.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Hormesis and stem cells enhancing cell proliferation, differentiation and resilience to inflammatory stress in bone marrow stem cells and their therapeutic implications. (Pubmed Central) -  Jan 4, 2022   
    Such hormetic dose responses are commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g., caffeine, dexamethasone, nicotine), dietary supplements (e.g., curcumin, Ginkgo biloba, green tea extracts...Hormetic dose responses reported here for BMSCs are similar to those induced with other stem cell types [e.g., adipose-derived stem cells (ADSCs), dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), neuro stem cells (NSCs), embryonic stem cells (ESC)], indicating a substantial degree of generality for hormetic responses in stem cells. The paper assesses both the underlying mechanistic foundations of BMSC hormetic responses and their potential therapeutic implications.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Retrospective data, Review, Journal:  Acute haemorrhagic leukoencephalitis (AHLE) - our experience and a short review. (Pubmed Central) -  Jan 4, 2022   
    Prognosis is worse as compared to the classic ADEM, with a high mortality rate. To the best of our knowledge, this is one of the largest series of AHLE to have been reported anywhere in the world.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Retrospective data, Journal:  Smoking status related to Covid-19 mortality and disease severity in a veteran population. (Pubmed Central) -  Jan 4, 2022   
    Gain of Fgf/FGF21 function attenuates the progression of CDDP hepatotoxicity, which may be considered clinically to improve CDDP therapy. Compared to veteran non-smokers with Covid-19, former, but not current smokers with Covid-19 had a significantly higher risk of 30-day mortality.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Review, Journal:  COVID-19-associated optic neuritis - A case series and review of literature. (Pubmed Central) -  Jan 4, 2022   
    All three patients received intravenous methylprednisolone followed by oral steroids according to the Optic Neuritis Treatment Trail ptotocol. Vision recovery was noted in all three patients, which was maintained at 2 months of the last follow up visit.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Glucocorticoids Promote Extracellular Matrix Component Remodeling by Activating YAP in Human Retinal Capillary Endothelial Cells. (Pubmed Central) -  Jan 4, 2022   
    Here, we showed that GC (hydrocortisone) treatment induced ECM component [fibronectin (FN) and type IV collagen (Col IV)] expression and morphological changes in HRCECs via the glucocorticoid receptor (GR), which depended on the nuclear translocation of YAP coactivator...In vivo, YAP was activated in retina vascular ECs of STZ-induced diabetic mice, and TF prediction analysis of published RNA-seq data of dermal vascular ECs from T2DM patients showed that GR and TEAD (the main transcription factor for YAP) were enriched. Together, GCs activate YAP and promote ECM component (FN and Col IV) remodeling in retinal capillary endothelial cells, and the underlying regulatory mechanism may provide new insights into the vascular BM thickening of the retina in the early pathogenesis of DR.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation. (Pubmed Central) -  Jan 4, 2022   
    Compared with CON mice, mice in the DEX and CUMS groups had higher levels of IL-1β in sera and lower levels of glial fibrillary acidic protein (GFAP), Nestin, Synapsin-1 and P2Y12 receptor in the hippocampus. Changes of gut microbiota diversity, intestinal integrity and neuroinflammation in the brain contribute to CUMS-induced depression, whereas pathobionts and excessive immunosuppression with damaged neuronal synapses is a basis of the DEX-induced depression.
  • ||||||||||  dexamethasone / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
    Review, Journal:  Pharmacological Investigations in Glia Culture Model of Inflammation. (Pubmed Central) -  Jan 4, 2022   
    Furthermore, the effects of drugs on glial cell viability, proliferation and astrocytic network were demonstrated. The in vitro astrocyte-microglia co-culture model of inflammation proved to be suitable as unique in vitro model for pharmacological investigations on astrocytes and microglia with future potential (e.g., cancer drugs, antidementia drugs, and toxicologic studies).
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Bioactive fluorescent hybrid microparticles as a stand-alone osteogenic differentiation inducer. (Pubmed Central) -  Jan 4, 2022   
    Both pristine and dexamethasone-loaded PEA-BG microparticles were able to induce osteogenic differentiation of 10T1/2 ​cells in the absence of any media supplement, to a level even higher than standard osteogenic media, as evidenced by the expression of osteogenic markers on gene and protein levels and matrix mineralization. Taken together, the fluorescent PEA-BG hybrid microparticles have the potential to be used as a stand-alone biomaterial for osteogenic differentiation and bone regeneration.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Pattern of medication utilization in hospitalized patients with COVID-19 in three District Headquarters Hospitals in the Punjab province of Pakistan. (Pubmed Central) -  Jan 4, 2022   
    Specifically, dexamethasone was the most commonly used corticosteroid among the included patients (n = 405; 91.2%), irrespective of their clinical severity...Of 444 patients records screened, 399 (89.9%) patients had been discharged, and 45 (10.1%) died. We provided an important glimpse into the utilization patterns of several medications of interest for the treatment of COVID-19, which had not been entirely evidence-based, especially concerning systemic corticosteroids and antibiotics.
  • ||||||||||  Kineret (anakinra) / SOBI
    Enrollment closed, Trial completion date, Trial primary completion date:  Treatment of Macrophage Activation Syndrome (MAS) With Anakinra (clinicaltrials.gov) -  Jan 4, 2022   
    P1,  N=40, Active, not recruiting, 
    We provided an important glimpse into the utilization patterns of several medications of interest for the treatment of COVID-19, which had not been entirely evidence-based, especially concerning systemic corticosteroids and antibiotics. Recruiting --> Active, not recruiting | Trial completion date: Oct 2020 --> Sep 2022 | Trial primary completion date: Sep 2020 --> Sep 2022
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Intracochlear Dexamethasone Application During Cochlear Implantation for Preserving Cochlear Cells (clinicaltrials.gov) -  Jan 4, 2022   
    P=N/A,  N=21, Recruiting, 
    Recruiting --> Active, not recruiting | Trial completion date: Oct 2020 --> Sep 2022 | Trial primary completion date: Sep 2020 --> Sep 2022 Trial completion date: Nov 2021 --> Mar 2022 | Trial primary completion date: Nov 2021 --> Mar 2022
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  EPCSII: EuroPainClinics® Study II (Prospective Trial) (clinicaltrials.gov) -  Jan 3, 2022   
    P=N/A,  N=300, Completed, 
    Initiation date: Nov 2021 --> Feb 2022 Recruiting --> Completed | Trial completion date: Oct 2021 --> Dec 2021 | Trial primary completion date: Sep 2021 --> Dec 2021
  • ||||||||||  fluocinonide / Generic mfg.
    Trial completion date:  Cutaneous Lupus Medication Experience Study (clinicaltrials.gov) -  Jan 3, 2022   
    P=N/A,  N=11, Active, not recruiting, 
    Recruiting --> Completed | Trial completion date: Oct 2021 --> Dec 2021 | Trial primary completion date: Sep 2021 --> Dec 2021 Trial completion date: Dec 2021 --> Apr 2022
  • ||||||||||  Darzalex (daratumumab) / J&J
    Enrollment closed, Enrollment change, Trial primary completion date, Combination therapy:  Daratumumab Plus Gemcitabine, Dexamethasone, Cisplatin in pt R/R CD38+ PTCL-NOS, AITL and TFH (clinicaltrials.gov) -  Jan 3, 2022   
    P2,  N=8, Active, not recruiting, 
    Trial primary completion date: Apr 2021 --> Apr 2022 Recruiting --> Active, not recruiting | N=35 --> 8 | Trial primary completion date: Mar 2023 --> Dec 2021