Glucocorticoid Receptor 

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  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal, Combination therapy:  Combination therapy using multifunctional dissolvable hyaluronic acid microneedles for oral ulcers. (Pubmed Central) -  May 25, 2024   
    The tip layer of the MN patch was loaded with triamcinolone acetonide (TA) and epidermal growth factor (EGF) to inhibit inflammation and promote angiogenesis...In addition, HA exerts a protective effect on the mucous membrane. Owing to these properties, the multifunctional MN patches were found to have good anti-inflammatory, antibacterial, and tissue-healing abilities, indicating that the multifunctional MN patch design successfully promoted the healing of oral ulcers.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Corticosteroids hypersensitivity  (Poster Zone) -  May 25, 2024 - Abstract #EAACI2024EAACI_2870;    
    Additionally, information regarding cross-reactivity among different CST is limited. This emphasizes the importance of conducting a thorough workup to find safe alternatives and avoid unnecessary restrictions.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  NADH Intraperitoneal Injection Prevents Lung Inflammation in a BALB/C Mice Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease. (Pubmed Central) -  May 24, 2024   
    N = 64 mice randomly distributed in eight groups were injected with NADH (two doses of 100 mg/kg or 200 mg/kg) or dexamethasone (2 mg/kg) before being exposed to CSE for up to 9 weeks...Finally, NADH prevented the CSE-induced secretion of cytokines such as Tumor Necrosis Factor alpha (TNF-?), IL-17, and IFN-y (n = 4, p < 0.001). Our study shows, for the first time, the clinical potential of NADH supplementation in preventing key features of COPD via its unique anti-inflammatory and antioxidant properties.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Trismus caused by migration of orthodontic archwire into the infratemporal fossa: a case report. (Pubmed Central) -  May 24, 2024   
    The patient was started on an intravenous (IV) antibiotic and a 2-day course of IV dexamethasone to reduce the muscle inflammation...Soft tissue injuries can be avoided with careful management by the operator with the proper precautions taken. Clinicians should be familiar with the surrounding soft tissue anatomy and be aware of the potential for more severe complications and provide management or referral to the appropriate specialty accordingly.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Resolution of Postoperative Cystoid Macular Edema with a Suprachoroidal Triamcinolone Acetonide Injectable Suspension. (Pubmed Central) -  May 23, 2024   
    Following the operation, the patient began treatment with prednisolone acetate and ketorolac...At 6?months postoperatively, ranibizumab was injected for persistent CME...IOP improved 1 month later with dorzolamide hydrochloride and timolol maleate...Despite the patient's known steroid response with topical steroids, IOP remained within normal limits during the entire follow-up period after injection. SC triamcinolone acetonide injection is indicated for macular edema associated with uveitis; however, treatment for postoperative macular edema with this novel suprachoroidal injection may be considered.
  • ||||||||||  CoronaVac / Sinovac, Bio Farma Indonesia, Vaxzevria (ChAdOx1-S recombinant) / University of Oxford, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca
    Observational data, Journal:  Effect of Corticosteroid on Immunogenicity of SARS-CoV-2 Vaccines in Patients With Solid Cancer. (Pubmed Central) -  May 23, 2024   
    Patients with solid cancer vaccinated against COVID-19 disease while receiving dexamethasone had lower immunogenicity responses than those who got vaccines without dexamethasone. The direct association between the immunogenicity level and steroid dosage, as well as length of duration from vaccination to dexamethasone, was observed.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Clinical efficacy of dexamethasone parabulbar injection in patients with Nonarteritic anterior ischemic optic neuropathy. (Pubmed Central) -  May 23, 2024   
    The present study evaluated the effects of parabulbar dexamethasone injection on visual outcomes in patients with NAAION...Also, fewer side effects were observed in the injection group compared to the control group. The results of this study suggested that dexamethasone parabulbar injection might be a safe and effective intervention for relieving visual acuity and VF in patients with NAAION.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Regulatory effects of microRNAs on monocytic HLA-DR surface expression. (Pubmed Central) -  May 23, 2024   
    Anti-inflammatory glucocorticoid medication Dexamethasone-decreased HLA-DR was significantly restored by hsa-miR-let-7f-2-3p and hsa-miR-5693...In conclusion, novel monocytic HLA-DR microRNA modulators were identified and validated in vitro. Moreover, both the interaction between the microRNAs and anti- and proinflammatory molecules and the up-regulated microRNAs identified in cardiac surgery highlight the potential clinical relevance of our findings.
  • ||||||||||  alendronate / Generic mfg.
    Journal:  Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent. (Pubmed Central) -  May 22, 2024   
    Besides, while 10 mg/mL dexamethasone, 7.6 mM free ALN and ALN-loaded liposomes failed, 50 ?g/mL TL + 2.5 ?g/mL ALN (i.e., nanoARC-Chol(ALN)) reduced the IL-6 and IL-8 levels by, respectively, 75% and 65% in the mild and by, respectively, 60% and 40% in the pronounced inflammation model. This is the first report showing that the endocytosis of nanoARC-Chol(ALN) by HUVECs magnifies the anti-inflammatory activity of ALN even under conditions of intense irritation, not only surpassing that of free ALN but also that of dexamethasone.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Deep eutectic solvent self-assembled reverse nanomicelles for transdermal delivery of sparingly soluble drugs. (Pubmed Central) -  May 22, 2024   
    The results obtained in this study, proposing strategies to improve healing through controlling the behavior of maturing macrophages and present a promising perspective for inflammation control using tissue engineering scaffolds. The present study offers innovative insights into the optimal design of micellar nanodelivery system based on DES combining experiments and computational simulations and provides a promising strategy for developing efficient transdermal delivery systems for sparingly soluble drugs.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal, IO biomarker:  Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma: Challenges and Emerging Strategies. (Pubmed Central) -  May 21, 2024   
    For non-TE NDMM, considering the recent data generated and carefully reviewing those upcoming, quadruplet treatment consisting of anti-CD38 monoclonal antibodies, immunomodulatory agents, proteasome inhibitors, and dexamethasone should also be considered. Future trials integrating BCMA-directed novel generation immunotherapies hold great potential for further advancing the treatment landscape in all NDMM patients with HR disease.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Eco-endocrinological dynamics: Unraveling dexamethasone's influence on the interrenal axis in juvenile carp Cyprinus carpio. (Pubmed Central) -  May 21, 2024   
    These findings shed light on the physiological and molecular responses of juvenile carp to DXE exposure, emphasizing the potential ecological implications of DXE contamination in aquatic environments. Understanding these dynamics is crucial for assessing the environmental impact of glucocorticoid pollutants and developing effective management strategies to mitigate their adverse effects on aquatic ecosystems.
  • ||||||||||  Zevtera (ceftobiprole) / Basilea
    Journal:  Infectious Diseases: What You May Have Missed in 2023. (Pubmed Central) -  May 20, 2024   
    Another article examines differences in all-cause mortality in patients with Clostridioides difficile infection who receive different treatments. Additional articles provide evidence about the treatment of patients with HIV infection: the utility of preexposure prophylaxis to prevent HIV infection, the efficacy of pitavastatin in reducing cardiovascular disease, and the efficacy of dexamethasone for the treatment of tuberculous meningitis in persons with HIV.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Enhanced transgene expression from single-stranded AAV vectors in human cells in (Pubmed Central) -  May 20, 2024   
    Trial completion date: Jun 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026 Here, we describe that (1) purified GR binds to AAV2 D-sequence, and the D-sequence competes with GR binding to its cognate binding site; (2) dexamethasone-mediated activation of GR pathway significantly increases the transduction efficiency of AAV2 vectors in human cells; (3) human osteosarcoma cells, U2OS, which lack expression of GR, are poorly transduced by AAV2 vectors, but stable transfection with a GR expression plasmid restores vector-mediated transgene expression; (4) replacement of the distal 10 nucleotides in the D-sequence of the AAV2 ITR with a full-length GRE consensus sequence significantly enhances transgene expression in human cells in
  • ||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen
    Trial completion date, Trial termination, Trial primary completion date, Gene therapy:  FANCA: Gene Therapy for Fanconi Anemia (clinicaltrials.gov) -  May 20, 2024   
    P1,  N=3, Terminated, 
    Here, we describe that (1) purified GR binds to AAV2 D-sequence, and the D-sequence competes with GR binding to its cognate binding site; (2) dexamethasone-mediated activation of GR pathway significantly increases the transduction efficiency of AAV2 vectors in human cells; (3) human osteosarcoma cells, U2OS, which lack expression of GR, are poorly transduced by AAV2 vectors, but stable transfection with a GR expression plasmid restores vector-mediated transgene expression; (4) replacement of the distal 10 nucleotides in the D-sequence of the AAV2 ITR with a full-length GRE consensus sequence significantly enhances transgene expression in human cells in Trial completion date: Jul 2032 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jul 2032 --> Feb 2024; Study ended early due to end of funding.