Glucocorticoid Receptor 

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  • ||||||||||  methylprednisolone oral / Generic mfg.
    Journal:  Interactions between reinforcement history and drug-primed reinstatement: Studies with MDPV and mixtures of MDPV and caffeine. (Pubmed Central) -  Jan 19, 2022   
    Synthetic cathinones (e.g., 3,4-methylenedioxypyrovalerone [MDPV]) are commonly mixed with caffeine or other cathinones (e.g., 3,4-methylenedioxy-N-methylcathinone [methylone]), and these "bath salts" mixtures (e.g., MDPV + caffeine) can exhibit supra-additive interactions with regard to their reinforcing and discriminative stimulus properties...Together, these results demonstrate that the composition of drug mixtures can impact relapse-related effects of drug mixtures, and "bath salts" mixtures (MDPV + caffeine) may be more effective at promoting relapse-related behaviors than the constituents alone. Further research is needed to determine how other polysubstance reinforcement histories can impact relapse-related behaviors.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Experience in management of burn injury during pregnancy in a Burn Unit. (Pubmed Central) -  Jan 19, 2022   
    Although limited safety information on cerium nitrate or silver sulfadiazine during pregnancy, those were used with no side effects on one of our patients. Obstetrical management should be individualized.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Review, Journal:  Diclofenac Versus Dexamethasone Following Strabismus Surgery: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jan 19, 2022   
    However, a significant difference favoring diclofenac in terms of discomfort, inflammation, conjunctival chemosis, and conjunctival gap was only noted at 2 weeks postoperatively. The authors suggest conducting further studies to support the effectiveness of diclofenac as an alternative to corticosteroids following strabismus surgery.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Autonomous cortisol secretion : Laboratory artifact or disease? (Pubmed Central) -  Jan 19, 2022   
    It is associated with increased mortality and morbidity, especially hypertension, diabetes mellitus type II, dyslipidemia and obesity. Adrenalectomy, as the only specific therapy option, should be considered in an interdisciplinary tumour board.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  New aspects of glucocorticoid substitution in adrenal insufficiency (Pubmed Central) -  Jan 19, 2022   
    Adrenalectomy, as the only specific therapy option, should be considered in an interdisciplinary tumour board. To prevent life-threatening adrenal crisis, patients, their families and medical staff require training.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Morbidity and mortality in Cushing's syndrome (Pubmed Central) -  Jan 19, 2022   
    Biochemical diagnosis is performed in three steps: 1. Confirmation of the diagnosis by 1‑mg dexamethasone suppression test, 24‑h urine free cortisol, and measurement of late-night salivary cortisol...Despite adequate treatment, Cushing's syndrome is associated with increased long-term morbidity and mortality. Interdisciplinary and multimodal therapy management is necessary in the long term to positively influence mortality and reduced quality of life.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Novel electrochemiluminescent assay for the aptamer-based detection of testosterone. (Pubmed Central) -  Jan 19, 2022   
    The selectivity of the proposed assay was assessed by performing two different negative control experiments; i) detection of testosterone with a randomized ssDNA sequence and ii) detection of two other steroids, i.e. deoxycholic acid and hydrocortisone with the TESS.1 aptamer...Furthermore, this important characterization carried out in parallel validates the real functionality of the aptamer (TESS.1) ensuring its use towards selective testosterone binding in further biosensors. This research will pave the way for the development of new aptamer-based assays coupled with ECL sensing for the detection of relevant small molecules.
  • ||||||||||  hydrocortisone / Generic mfg., desmopressin / Generic mfg.
    Journal:  Sport-Related Concussion Preceding Adrenal Insufficiency and Hypopituitarism. (Pubmed Central) -  Jan 19, 2022   
    Her clinical picture suggested chronic subclinical adrenal suppression from inhaled corticosteroids, which was exacerbated by hypopituitarism possibly from concussion combined with diabetes insipidus. Adrenal insufficiency should be considered in athletes with history of corticosteroid use and endocrine-related symptoms after concussion, because this can create significant morbidity and can mimic traditional symptoms of concussion.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Review, Journal:  COVID-19 associated vasculitis: A systematic review of case reports and case series. (Pubmed Central) -  Jan 19, 2022   
    Heparin(n = 2), corticosteroids (n = 6) (methylprednisolone) and intravenous immunoglobulin (n = 4) were prescribed in these patients...Our study discusses vasculitis as one of the complications of COVID-19. Furthermore, the pathophysiology, clinical presentation, and management of COVID-19 associated vasculitis is discussed.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Noradrenergic stimulation increases fear memory expression. (Pubmed Central) -  Jan 18, 2022   
    In contrast to yohimbine, hydrocortisone had no significant effect on fear memory. These findings suggest that noradrenergic arousal strengthens fear memory expression and have important implications for mental disorders in which the overgeneralization of conditioned fear is prominent.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Preclinical, Journal:  Assessment of aversive effects of methylone in male and female Sprague-Dawley rats: Conditioned taste avoidance, body temperature and activity/stereotypies. (Pubmed Central) -  Jan 18, 2022   
    Males displayed a faster onset and females displayed a longer duration of activity (consistent with the analyses considering sex as a factor), while time- and dose-dependent stereotypies did not show consistent pattern differences. Although sex differences were relatively limited when sex was specifically assessed as a factor (or only evident when sex comparisons were made in the patterns of effects), sex as a biological variable in the study of drugs should be made to determine if differences exist and, if evident, the basis for these differences.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Eosinophilic Gastroenteritis: Using Presenting Findings to Predict Disease Course. (Pubmed Central) -  Jan 18, 2022   
    Patients with eosinophilic gastroenteritis may be characterized into 2 forms. Patients with weight loss at time of presentation, hypoalbuminemia at presentation, serosal disease involvement, or anemia at diagnosis were associated with a chronic disease course requiring chronic medications.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone injection / Generic mfg.
    Journal:  COVID-19 Survivors with Calcineurin Inhibitors-Treated Rheumatoid Arthritis. (Pubmed Central) -  Jan 18, 2022   
    Both cases had moderate to severe pneumonia treated with intravenous dexamethasone or in the severe case remdesivir in addition to it. These cases suggest that the use of calcineurin inhibitor may have affected the improvement of severe pneumonia.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Tissue plasminogen activator rescues steroid-induced outflow facility reduction via non-enzymatic action. (Pubmed Central) -  Jan 18, 2022   
    Outflow facility was measured in C57BL/6J mice following triamcinolone acetonide exposure and either transfection of the TM using adenoviral vectors, encoding for enzymatically active and inactive tPA, or administration of the respective proteins...tPA can increase the expression of matrix metalloproteinases in a cytokine-mediated fashion. This cascade of events may eventually lead to extracellular matrix remodeling at the TM, which reverses outflow facility reduction caused by steroids.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2. (Pubmed Central) -  Jan 18, 2022   
    Among patients receiving systemically administered CRTs (e.g., dexamethasone), the use of Vit D was associated with fewer deaths in hospitalized patients (aRR = 0.51) compared with non-hospitalized patients (aRR = 2.5) (P-for-Interaction = 0.0071). Evaluating the effect of modification of these compounds in the context of hospitalization may aid in the management of COVID-19 and provide a better understanding of the pathophysiological mechanisms underlying this and future infectious disease outbreaks.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Maggot extracts promote regulatory T cell differentiation by upregulating Foxp3 in allergic rhinitis. (Pubmed Central) -  Jan 18, 2022   
    Compound glycyrrhizin combined with fractional laser and triamcinolone acetonide injection has good clinical effect in the treatment of vitiligo vulgaris in the stable phase, and its effective mechanism may have nothing to do with T lymphocyte subpopulation. Maggot extracts can inhibit the progression of AR by upregulating the level of Foxp3 and promoting the differentiation of Tregs, thus serving as an alternate treatment for AR.
  • ||||||||||  fluticasone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Clinical, Journal:  Efficacy of tiotropium bromide combined with different doses of fluticasone plus salmeterol DPI in the treatment of stable COPD. (Pubmed Central) -  Jan 18, 2022   
    Maggot extracts can inhibit the progression of AR by upregulating the level of Foxp3 and promoting the differentiation of Tregs, thus serving as an alternate treatment for AR. Tiotropium bromide combined with high dose of salmeterol xinafoate (SX) and fluticasone propionate (FP) powder for inhalation can effectively improve the pulmonary function of patients with moderate to severe stable COPD.