- |||||||||| budesonide/salbutamol (PT027) / AstraZeneca, Avillion
Journal: Efficacy evaluation of budesonide nebulizer as an adjunctive medication in post-rain asthma acute phase attack. (Pubmed Central) - Jan 28, 2022
Experiment data revealed. that due to the significant difference between PEFR and increased FEV1 in the combination of the two drugs and due to the corticosteroid effects of budesonide in reducing and preventing inflammation and swelling of the lungs, nebulizer salbutamol + budesonide has better effects on moderate breath than in nebulizer salbutamol.
- |||||||||| dexamethasone / Generic mfg.
Journal: Steroids in COVID-19: Tailor-made or "one size fits all"? (Pubmed Central) - Jan 28, 2022
The prescribed dose is 6mg dexamethasone or its equivalents for 10 days. However, in clinical practice, there are numerous occasions where the role of steroids cannot be extrapolated from current evidence: patients on immunosuppression, patients with persistent oxygen requirement after ten days of therapy, etc. We highlight the existing caveats and the need for further research and discussion.
- |||||||||| dexamethasone / Generic mfg.
Journal: Successful laparoscopic lavage and drainage for intestinal perforation in a patient with COVID-19: A case report. (Pubmed Central) - Jan 28, 2022
However, in clinical practice, there are numerous occasions where the role of steroids cannot be extrapolated from current evidence: patients on immunosuppression, patients with persistent oxygen requirement after ten days of therapy, etc. We highlight the existing caveats and the need for further research and discussion. Our case suggests that in acute COVID-19 lung infection, careful observation and delayed surgical treatment could prevent worsening of the COVID-19 and reduce the risk of infection to the medical staff.
- |||||||||| triamcinolone acetonide / Generic mfg.
Trial completion date, Trial suspension, Trial primary completion date: PF-RCT: Plantar Fasciitis Randomized Clinical Control Trial (clinicaltrials.gov) - Jan 28, 2022
P=N/A, N=62, Suspended,
Our case suggests that in acute COVID-19 lung infection, careful observation and delayed surgical treatment could prevent worsening of the COVID-19 and reduce the risk of infection to the medical staff. Trial completion date: Aug 2021 --> Dec 2022 | Active, not recruiting --> Suspended | Trial primary completion date: Mar 2021 --> Dec 2022
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
EOSINOPHILIC MYOCARDITIS - A RARE DIFFERENTIAL FOR ACUTE CORONARY SYNDROME (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_6755;
This case highlights EM as a differential for ACS and the usefulness of CMR to reach early diagnosis. Early collaboration between cardiology and rheumatology is essential for timely initiation of immunosuppressive therapy.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
IMMUNE CHECKPOINT INHIBITOR MYOCARDITIS: A CASE OF RECURRENT COMPLETE HEART BLOCK (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_6294;
This case demonstrates the importance of maintaining a high index of suspicion for ICI myocarditis in a patient with cancer on immunotherapy presenting with cardiac abnormalities. Once the diagnosis is made, pulse dose steroids and discontinuation of the offending agent can lead to resolution of arrhythmias and cardiac dysfunction.
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
EOSINOPHILIC MYOCARDITIS AS THE INITIAL PRESENTATION OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGITIS (EGPA) (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_6084;
While many cases of eosinophilic myocarditis are idiopathic or due to hypersensitivity reactions, we must remain vigilante and work up other causes of eosinophilia as they may yield a treatable diagnosis. This is even more critical in patients with EGPA as cardiac involvement is associated with significant morbidity and mortality.
- |||||||||| dexamethasone / Generic mfg.
EXERTIONAL DYSPNEA: MARATHON TO DIAGNOSIS, SPRINT TO TREATMENT (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_6063;
Advancements in imaging modalities such as technetium pyrophosphate scan and cardiac MRI can increase the diagnosis of ATTR and AL cardiac amyloidosis. With new treatment options that can halt disease progression, the need for increased clinical suspicion and early diagnosis from clinicians is imperative.
- |||||||||| dexamethasone / Generic mfg.
ATYPICAL ADULT-ONSET STILL’S DISEASE PRESENTING WITH MYOPERICARDITIS (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_6061;
AOSD is an uncommon disease where diagnosis can be difficult to establish given the complexity of symptoms. It is also an uncommon cause for myopericarditis and should be considered after excluding more common etiologies.
- |||||||||| hydrocortisone / Generic mfg.
LOW BLOOD PRESSURE IN BOTH ARMS:IS THIS A BILATERAL PROBLEM? (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_5936;
Background: Subclavian artery stenosis can be suspected if there is a difference in blood pressure (BP) measured in both arms but diagnosing a bilateral subclavian artery stenosis is challenging and requires high index of suspicion.Case: A 69-year-old woman, smoker with history coronary artery disease (CAD), peripheral vascular disease, adrenal insufficiency on hydrocortisone was hospitalized for non-ST elevation (NSTEMI) with diastolic heart failure... This case emphasizes the importance of physical examination, measuring blood pressure in all four extremities in patients with asymptomatic refractory hypotension.
- |||||||||| Darzalex (daratumumab) / J&J
COINCIDENCE OF CARDIAC AMYLOIDOSIS AND SARCOIDOSIS CAUSING DIASTOLIC HEART FAILURE (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_4826;
This case highlights the importance of appropriate diagnostics to identify these challenging conditions, including tissue sampling. It also rekindles the question about whether there is a possible immunological and pathophysiological relationship between the two conditions.
- |||||||||| dexamethasone / Generic mfg.
IT'S ALL IN YOUR HEAD: A CASE OF NEUROGENIC STRESS CARDIOMYOPATHY (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_4823;
Brain tissue injury can result in neurohumoral activation that can ultimately lead to myocardial damage. Management should consist of correction of the underlying neurological issue with attention also directed toward myocardial protection.
- |||||||||| amiodarone / Generic mfg.
AMIODARONE INDUCED MYXEDEMA COMA PRESENTING WITH CARDIOGENIC SHOCK AND JUNCTIONAL RHYTHM (Complex Clinical Cases Moderated Poster Theater 1_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_4677;
Myxedema coma is a life-threatening emergency that has been reported in a few cases of patients taking amiodarone. It is important to check thyroid function before starting amiodarone and in cases of cardiogenic shock or rhythm disturbances.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
BRUGADA EKG PATTERN IN A PATIENT WITH COVID-19 INFECTION (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_4410;
COVID-19 is associated with various cardiovascular complications; thus, a direct viral precipitation of BEP independent of fever is a possibility. Given the transient nature of BEP in this patient without commonly associated personal or family history, clinicians must maintain a high index of suspicion as prevalence of Brugada might be underestimated.
- |||||||||| cetirizine oral / Generic mfg.
SERONEGATIVE STATIN INDUCED IMMUNE MEDIATED NECROTIZING MYOPATHY (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_4377;
Seronegative IMNM is a rare form thus lacks sufficient data. Muscle biopsy normally shows cell necrosis and degeneration, but it may be infrequent in less severe disease.
- |||||||||| Darzalex (daratumumab) / J&J
A LEFT VENTRICULAR MASS IN A PATIENT WITH MULTIPLE MYELOMA (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_3091;
Solitary LV masses in MM are rare. An approach of watchful waiting and assessment of response to cancer therapy may be appropriate in these patients to avoid unnecessary cardiac surgery.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
NATIVE VALVE ENDOCARDITIS: A COMPLICATION OF TOCILIZUMAB TREATMENT IN COVID-19 PNEUMONIA (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_2982;
We report a case in which COVID-19 pneumonia improved after tocilizumab administration but that was complicated by acquired native valve infective endocarditis.Case: A 66 year-old male was admitted for acute hypoxic respiratory failure secondary to COVID-19 and was treated with dexamethasone and remdesivir. Immunosuppression with tocilizumab may aid with liberation from mechanical ventilation in severe COVID-19 cases, but also lead to superimposed infections, including native valve infective endocarditis.
- |||||||||| dexamethasone / Generic mfg.
RAPID RECOVERY OF COVID-19 RELATED MYOPERICARDITIS (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2593;
COVID-19 associated with elevated LDH can cause myopericarditis and cardiomyopathy, likely due to cytokine-mediated injury to myocytes. Intravenous Immunoglobulin (IVIG) has shown promising results; however, no certain treatment recommendations are available.
- |||||||||| dexamethasone / Generic mfg.
COVID HEARTBREAK (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2589;
Literature shows an increased incidence of TTS in the era of COVID, likely due to complications of the virus or the stressors associated with the pandemic. Thus, it is imperative to keep TTS in mind when evaluating patients for ACS in the midst of the pandemic.
- |||||||||| dexamethasone / Generic mfg.
COVID CORONARY: INTRACORONARY THROMBOLYTICS TO THE RESCUE (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2586;
Large thrombus burden without a focal lesion can reasonably be encountered in the setting of acute Covid infection and presents a significant technical challenge. The use of intracoronary thrombolysis is an effective strategy to achieve optimal results.
- |||||||||| dexamethasone / Generic mfg.
NOT JUST A LUNG DISEASE: A CASE OF RIGHT VENTRICULAR THROMBUS IN A PATIENT WITH COVID-19 (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_2585;
The patient in this case developed a new right ventricular thrombus and likely resultant obstructive shock in the setting of a long period of critical illness secondary to COVID-19. Critical care teams should consider a cardiogenic component in COVID-19 patients who develop worsening shock.
- |||||||||| dexamethasone / Generic mfg.
COVID-19 MYOPERICARDITIS- NEW STORMS, NEW NORMS? (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2566;
COVID-19 induced, cytokine storm-mediated myocardial cellular damage, myopericarditis and cardiogenic shock are rare but emerging complications of COVID-19 infection. Our case highlights the role of prompt use of higher dose of corticosteroids and the utility of IL-6 level as a cardinal prognostic marker.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
COVID-19 INDUCED CARDIOMYOPATHY SUCCESSFULLY TREATED WITH TOCILIZUMAB (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2561;
She received tocilizumab, dexamethasone, and furosemide. This patient’s prompt response to tocilizumab and corticosteroids seems to support the underlying hypothesis that cytokine storm is the primary mechanism by which COVID-19 induces cardiomyopathy and myocardial stunning.
- |||||||||| dexamethasone / Generic mfg.
POST-OPERATIVE MANAGEMENT AFTER CARDIAC SURGICAL REVASCULARIZATION IN A COVID-19 POSITIVE PATIENT (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2559;
A careful evaluation of risks and benefits, understanding the evidence, and understanding the patient is needed to make the best clinical decision on an individual basis. All post-surgical protocols typically exercised in post-CABG patients should be performed unless there are contraindications.
- |||||||||| dexamethasone / Generic mfg.
ELECTRICAL STORM IN A PATIENT WITH BRUGADA SYNDROME AND COVID-19 INFECTION (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2553;
ECG monitoring of COVID-19 patients should be recommended to identify life-threatening arrhythmias during periods of fever and cytokine storm. Treatment for fever induced Brugada syndrome should be focused on aggressive antipyretic management with concomitant pharmacological therapy.
- |||||||||| dexamethasone / Generic mfg.
LEFT VENTRICULAR THROMBUS PRESENTING AS MULTIPLE EMBOLIC SHOWER IN COVID-19 (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_1841;
It presented as an embolic stroke in the setting of COVID-19 infection and metastatic pheochromocytoma. This points to the susceptibility of patients to develop acute arterial thrombotic complications in severe COVID infections.
- |||||||||| Kineret (anakinra) / SOBI
CARDIAC MANIFESTATIONS OF MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN AT A TERTIARY REFERRAL CHILDREN’S HOSPITAL (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_1719;
This points to the susceptibility of patients to develop acute arterial thrombotic complications in severe COVID infections. The results of this retrospective study contribute to a growing knowledge base in the literature that MIS-C can exhibit a wide spectrum of cardiac manifestations further underscoring the importance of thorough cardiac workup and regular outpatient follow-up in patients diagnosed with MIS-C.
- |||||||||| enoxaparin sodium / Generic mfg.
CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME AND CARDIOGENIC SHOCK SUCCESSFULLY MANAGED WITH ECMO (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_87;
Management of CAPS and cardiogenic shock with ECMO in the setting of plasmapheresis and thrombosis remains complicated.Case: 25-year-old pregnant woman with history of APS on lovenox presented with hemolysis elevated liver enzymes and low platelets (HELLP) and hepatic infarcts...She was started on IVIG, solumedrol, and rituxan... Management of ECMO in CAPS and cardiogenic shock remains complicated due to difficulty managing hemodynamics and further research can potentially improve outcomes.
- |||||||||| Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / Eisai, AbbVie
VEDOLIZUMAB FOR REFRACTORY MICROSCOPIC COLITIS: A CASE SERIES () - Jan 28, 2022 - Abstract #CCCongress2022CCCongress_380;
Some patients suffer severe symptoms despite maximum dosage of budesonide, in these cases biologic therapies should be considered...The third patient was transitioned from vedolizumab to adalimumab and is now well controlled symptomatically and the final patient has not reached symptomatic remission of her disease...Due to low volume studies, the data supporting vedolizumab use in refractory microscopic colitis remains limited, and further studies are needed to elucidate the its potential as a first-line therapy. However, based on our experience, we recommend considering vedolizumab for patients suffering from refractory MC.
- |||||||||| mometasone furoate / Generic mfg.
Triplet Fusion Upconversion Nanocapsules for Volumetric 3D Printing (Marriott Grand Ballroom: Section 3 (Marriott Marquis San Diego Marina)) - Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_8789;
The application of upconversion nanocapsules to volumetric 3D printing provides access to the benefits of volumetric printing without the current cost, power, and speed drawbacks. The materials demonstrated here open opportunities for other triplet fusion upconversion-controlled applications.
- |||||||||| Relafen (nabumetone) / GSK
Discovery and characterization of gut microbial enzymes involved in keto-reductive metabolism (Zoom Room 1 (Virtual Room)) - Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_4771;
In addition, we have also identified additional oxidoreductase homologues that have similar ketone-reducing activities from multiple human gut microbial species. Our results expand the gut bacterial enzymatic inventory for the ketone-reduction of pharmaceuticals and dietary chemicals, but it also serves as the basis for elucidating bacteria-chemical interactions and illuminating strategies for future personalized medicines and dietary plans.
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