Glucocorticoid Receptor 

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  • ||||||||||  prednisolone / Generic mfg., cyclophosphamide / Generic mfg., vincristine / Generic mfg.
    A rare case of peripheral T cell lymphoma presenting as peripheral neuropathy & myositis () -  Jan 30, 2022 - Abstract #BSR2022BSR_316;    
    Risk factors include family history of hematological malignancies and smoking. Rashes may be the antecedent finding in about 20% to 50% of angioimmunoblastic T cell lymphoma patients, with skin manifestations ranging from urticarial lesions to nodular tumor.
  • ||||||||||  Giant cell arteritis in an immunocompromised patient with rheumatoid arthritis () -  Jan 30, 2022 - Abstract #BSR2022BSR_314;    
    A 65-year-old Caucasian female with seropositive rheumatoid arthritis (RA) established on 20mg weekly subcutaneous methotrexate and low dose 5mg prednisolone was escalated to her tenth cycle of rituximab with 100mg IVMP for an arthritic flare...Excluding tocilizumab (anti-IL6), a meta-analysis of other biological agents including infliximab, adalimumab, etanercept (anti-TNF) and abatacept (anti-CTLA4) have not been proven to have clinical significance over placebo in GCA... Although rare, clinicians should be vigilant for the development of GCA despite established immunosuppression.
  • ||||||||||  Truxima (rituximab biosimilar) / Teva, Mundipharma, Celltrion, Nippon Kayaku, Indukern, Servier, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Rituximab biosimilar switching shows non-inferior outcomes in routine clinical practice () -  Jan 30, 2022 - Abstract #BSR2022BSR_276;    
    This ‘real-life’ clinical review found similar clinical efficacy of rituximab biosimilar to originator product based on the DAS-28 ESR score. There were no notable safety or infusion differences.
  • ||||||||||  Darzalex IV (daratumumab) / J&J
    TREATMENT PATTERNS AND UNMET NEED IN MULTIPLE MYELOMA IN EUROPE: A REAL-WORLD SURVEY (ePoster Area [VIRTUAL]) -  Jan 30, 2022 - Abstract #EBMT2022EBMT_1226;    
    In 1L-4L there was a clear consensus on the appropriate treatment regimens to use. Later line patients were increasingly tri-exposed and received more individualized treatments, indicating a lack of standard of care and confirming a large unmet treatment need.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    CYTOMEGALOVIRUS IMPACT IN B-CELL LYMPHOMA PATIENTS TREATED WITH CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY (ePoster Area [VIRTUAL]) -  Jan 30, 2022 - Abstract #EBMT2022EBMT_1197;    
     CMV monitoring can be useful during the first 2 months after CAR T-cell therapy, especially in those receiving dexamethasone and/or tocilizumab. CMV replication has doubtful clinical significance in this setting, so treatment should be carefully individualized assessing risk-benefit in terms of toxicity.
  • ||||||||||  dexamethasone / Generic mfg.
    GLUCOCORTICOIDS TRIGGER A CXCR4/PLC-MEDIATED CELL SURVIVAL PATHWAY INVOLVED IN RESISTANCE OF B-ACUTE LYMPHOBLASTIC LEUKEMIA (ePoster Area [VIRTUAL]) -  Jan 30, 2022 - Abstract #EBMT2022EBMT_1078;    
    Applicability of GDP on an outpatient setting also provides advantage over other effective salvage regimen. We recently reported that intracellular Ca2+ or downstream ERK signaling mediates dexamethasone Dex resistance B-ALL cells, and that this could be reversed by Bapta-AM or PD 98059...Furthermore, U73122, AMD3100 and CXCR4 gene silencing were sufficient to overcome GC resistance, leading to a significant increase in Dex-induced reactive oxygen species production, cytochrome c release, caspase-3 activation and eventually apoptosis... Taken together, these data demonstrate that GC paradoxically induce their own resistance in B-ALL cells by stimulating a CXCR4-mediated pro-survival program through the activation of PLC.
  • ||||||||||  dexamethasone / Generic mfg.
    CD19 CAR-T THERAPY IN CHILDREN WITH RELAPSED AND REFRACTORY B-CELL ALL (Forum Hall / Virtual Hall 2) -  Jan 30, 2022 - Abstract #EBMT2022EBMT_949;    
    P1/2
    The proposed risk-adapted strategy of CAR-T dosing allows to achieve high remission rate in all patients. HSCT is likely to be a necessary modality for consolidation and long-term maintenance of remission.
  • ||||||||||  Darzalex IV (daratumumab) / J&J, Sarclisa (isatuximab-irfc) / Sanofi
    Clinical, P1 data, Journal, Combination therapy:  Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma. (Pubmed Central) -  Jan 29, 2022   
    P1b
    The overall response rate was 53.2% in all patients (55.5% in response-evaluable population, 60.0% in daratumumab-naïve patients). Efficacy and safety findings were consistent with data from the isatuximab plus Pd infusion schedule in Part A of this study and also from the phase 3 ICARIA-MM study, and these new data confirm the safety, efficacy, and feasibility of fixed-volume infusion of isatuximab.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Immunomodulatory role and potential utility of various nutrients and dietary components in SARS-CoV-2 infection. (Pubmed Central) -  Jan 29, 2022   
    In this review, various search engines were used to exploit available literature in order to provide a comprehensive review on nutritional and dietary supplements with respect to the viral infections. It will also provide a brief overview on some of the clinical trials that are in progress to assess the role of nutritional supplements, either alone or in combination with other pharmacological drugs, in fight against COVID-19.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes. (Pubmed Central) -  Jan 29, 2022   
    This study, comprising 20 dexamethasone suppression test (DST) non-suppressors and 73 controls, examined the association between the HPA axis dysregulation, shifts in DNA methylation of HPA axis related genes and importantly, gene expression...Methylation levels of cg08636224 (FKBP5) correlated with baseline cortisol and gene expression. Our findings revealed that DNA methylation shifts are involved in the altered mechanism of the HPA axis suggesting that new epigenetic targets should be considered behind psychiatric disorders.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Diagnostic accuracy of the different hormonal tests used for the diagnosis of autonomous cortisol secretion. (Pubmed Central) -  Jan 29, 2022   
    In a retrospective study of patients with AIs ≥ 1 cm, we evaluated the diagnostic reliability and validity of the dexamethasone suppression test (DST), urinary free cortisol (UFC), ACTH, late-night salivary cortisol (LNSC), and dehydroepiandrosterone-sulphate (DHEAS) for the diagnosis of comorbidities potentially related to ACS...The DST test showed the strongest association with comorbidities potentially related to ACS. The definition of ACS based on the combination of elevated DST and LNSC levels improved the identification of patients with increased cardiometabolic risk.
  • ||||||||||  Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
    Journal:  Inhaled indacaterol/glycopyrronium/mometasone furoate fixed-dose combination in moderate-to-severe asthma. (Pubmed Central) -  Jan 29, 2022   
    The recently approved single-inhaler indacaterol/glycopyrronium/mometasone fixed dose combination has demonstrated to significantly reduce exacerbations, improve FEV, symptoms and quality of life compared to ICS/LABA, including, salmeterol/fluticasone combination. Moreover, once-daily dosing may improve adherence.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Twin Mixed Local Anesthesia in Third Molar Surgery - Randomized Controlled Trial. (Pubmed Central) -  Jan 28, 2022   
    Clinicians prescribing antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines, should be aware of the probable risk of drug-drug interaction with COVID-19 medications and may benefit from heeding these recommendations for use to ensure patient safety. Intraoperative and postoperative comfort in both the experimental groups were higher than those for control groups, thereby establishing the clinical efficacy of both modified twin mixes for use in surgical extraction of mandibular third molars.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    Journal:  Vogt-Koyanagi-Harada Disease Associated with COVID-19 mRNA Vaccine. (Pubmed Central) -  Jan 28, 2022   
    Clinical examination and imaging tests were consistent with Vogt-Koyanagi-Hara disease. The patient responded well with a high dose of intravenous methylprednisolone followed by a tapering dose of oral prednisolone.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Intravitreal lupeol: A new potential therapeutic strategy for noninfectious uveitis. (Pubmed Central) -  Jan 28, 2022   
    This reduction was similar to that detected in ARPE-19 cells treated with dexamethasone. The results of the in vivo assay demonstrated that intravitreal lupeol is able to modulate inflammation in the anterior and posterior segment of the rat eyes, indicating that it should be further investigated as a novel potential candidate for management of uveitis.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens. (Pubmed Central) -  Jan 28, 2022   
    A significant reduction was observed in the ovulation rate, follicular size (P < 0.001), ovarian hormones, immunoglobulins, body weight, and food consummation (P ≤ 0.05) by administering GC Fluticasone. Although a relative anti-inflammatory improvement was created by Fluticasone in the ovarian condition, the administration of this glucocorticoid resulted in a considerable reduction in ovarian hormones and functions of commercial aged laying hens.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    Journal:  Pure sensitive chronic inflammatory axonal polyneuropathy following Pfizer COVID-19 vaccine. (Pubmed Central) -  Jan 28, 2022   
    Although a relative anti-inflammatory improvement was created by Fluticasone in the ovarian condition, the administration of this glucocorticoid resulted in a considerable reduction in ovarian hormones and functions of commercial aged laying hens. To the best of our knowledge, this is the first description of CIAP occurring in a close temporal relationship with the administration of Pfizer-BioNTech COVID-19 vaccine.