Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...371372373374375376377378379380381...10671068»
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients. (Pubmed Central) -  Feb 8, 2022   
    This study demonstrates that mOrange2 protein can be an effective alternate to BCECF-AM in measuring intracellular pH (preferred setting Ex520nm, Em 563nm) as affected by NHE3 and DRA activity, with the advantage, compared to AM ester dyes, that genetic expression can provide uniform expression of the pH sensor. In our study, dexamethasone therapy as recommended for COVID-19 was associated with a significant three times increase in the risk of CAPA.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Journal, PD(L)-1 Biomarker, IO biomarker:  Asymptomatic Myocarditis with Mild Cardiac Marker Elevation Following Nivolumab-Induced Myositis. (Pubmed Central) -  Feb 8, 2022   
    Follow-up examination revealed no flare-up of myositis and exacerbation of myocarditis. Since ICI-induced myositis is often complicated by myocarditis, this case report highlights the importance of detecting concurrent myocarditis in patients with ICI-induced myositis through intensive cardiac assessments to improve clinical outcomes.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    METHANOL INDUCED TOXIC OPTIC NEUROPATHY: CASE REPORT () -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_676;    
    Clinicians need to thoroughly question patients, regarding their possible toxic habitudes while investigating cases of optic neuritis. The early use of intravenous steroids may have promising results while managing toxic optic neuritis.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    COMBINED CONJUNCTIVAL AUTOGRAPH TRANSPLANTATION AND AMNIOTIC MEMBRANE OVERLAY IN PTERYGIUM SURGERY () -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_651;    
    Combined conjunctival autograft transplantation and amniotic membrane overlay technique in pterygium surgery can be effective in the immediate post-operative period by reducing pain as well as in the long term outcomes by reducing the rates of pterygium recurrence. Further randomized controlled trials are needed to prove the benefits of this technique over CAT alone.
  • ||||||||||  methylprednisolone acetate / Generic mfg., cyclopentolate hydrochloride / Generic mfg.
    TOXIC ANTERIOR STROMAL KERATITIS AFTER SYSTEMIC ALLERGIC REACTION TO LIDOCAINE () -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_649;    
    The initial perilimbal location of the corneal opacity, adjacent to the terminal capillary loops of the limbal vascular arcades, is compatible with an immune-related etiology, in this case probably related with a hypersensitivity reaction to lidocaine. Corticosteroids are the mainstay of therapy for the most common forms of interstitial keratitis and showed effectiveness in controlling the acute inflammatory symptoms and promoting the resolution of the condition.
  • ||||||||||  Vekacia (ciclosporin ophthalmic) / Santen
    USAGE OF CICLOSPORIN EYE DROPS IN PEDIATRIC AGE: CASE REPORTS (Track 1) -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_331;    
    The usage of immunomodulatory agents such as topical ciclosporin is effective in the long- term treatment, since it is corticosteroid sparing in steroid-dependent patients when other treatments have failed.(3) In Portugal, the commercialized ciclosporin (Ikervis®) is only approved for administration in adults.(4) However, its off-label usage in the pediatric population has shown great benefits...She was treated with tobramycin + dexamethasone and ketotifen with significant improvement...They were both forwarded to a pediatrician specialized in allergies to study them systemically. Conclusion / Take home message: In pediatric patients presenting with corticosteroid dependent VKC the ciclosporin can be a helpful ally in the disease control, avoiding chronic usage of corticosteroids and providing a significant improvement of the clinical status and quality of life of these patients.(3)
  • ||||||||||  prednisolone / Generic mfg.
    UNILATERAL OCULAR CICATRICIAL PEMPHIGOID SECONDARY TO LEVAMISOL-ADULTERED COCAINE CONSUMPTION (Track 1) -  Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_320;    
    Setting: Referral hospital Fundación Jiménez Díaz Report of case: A 48-year-old woman consulted for left eye (LE) vision loss and oral ulcers for the last 6 months. She referred inhaled cocaine consumption through her left nasal fossae. On examination, best corrected visual acuity (BCVA) was 1.0 logMAR in her right eye (RE) and hand movement in LE. The slit- lamp biomicroscopy showed a complete corneal conjunctivalization, shortening of the fornices, temporal symblepharon, cicatricial entropion of the superior eyelid e yelashes with the cornea causing a temporal epithelial defect. Anterior chamber was preserved. On sytemic examination, a well delimited diffuse lingual ulcer that respected the base and the tip of the tongue was found. No other dermatological lesions were observed. A complete blood analysis was perfo rmed to rule out infectious or autoinmune diseases. The conjunctival biopsy showed intersticial linfocite inflammation and was negative for direct immunofluorescence (DIF). The oral biopsy showed acute and chronic inflamation and DIF yielded a linear IgA deposit along the epithelium basal membrane. The indirect immunofluorescence (IIF) detected high circulating I gA levels. Thus, she was diagnosed of ocular mucous membrane pemphigoid, induced by direct contact with Levamisol- adultered cocaine. Metilprednisolone intravenous boluses (12mg/kg/day) were started for 3 days, continued by oral metilp rednisolone 48 mg/day in a tapering schedule and 50mg Azatioprine/day, oral doxicyclin 100mg/day and vitamin C capsule/day. Topical treatment was started with dexametasone/3h, tobramycin/8h, lubricating eye drops and vitamin A enr iched ointment/8h. She underwent an amniotic membrane graft and everting sutures on the left inferior eyelid. At 1- month, ocular and oral symptoms improved, BCVA was counting fingers and the corneal epithelial defect had solved. At 5-months, she is stable under oral Azatoprine 50mg/24h, oral metilprednisolone 32mg/24h,  topical dexamethasone/12h, vitamin A enriched ointment/12h, topical lubric ants/4h and is awaiting for fornix recontruction and lid eversion surgery. Conclusion / Take home message: OCP is a chronic cicatricial disease affecting mucous membranes and skin, which can lead to ankyloblepharon in severe cases. It is an autoimmune response caused by an environmental trigger which leads to inflammation and scarring, in this case the levamisol- adultered cocaine. DIF of conjunctival or oral mucous biopsy is the gold standard to confirm the diagnosis, showing a linear deposition of IgG, IgA, IgM and complement 3 proteins in the epithelial basement membrane. A multidisciplinar management is essential to control the inflammation and halt the progression. Topical treatments alleviate symptoms but only systemic immunosupression stops progression. Surgical interventions can be employed as adjunctive therapy to treat complications.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Retrospective data, Journal:  The comparison of dexamethasone and triamcinolone periarticular administration in total knee arthroplasty: retrospective cohort study. (Pubmed Central) -  Feb 8, 2022   
    Conclusion / Take home message: OCP is a chronic cicatricial disease affecting mucous membranes and skin, which can lead to ankyloblepharon in severe cases. It is an autoimmune response caused by an environmental trigger which leads to inflammation and scarring, in this case the levamisol- adultered cocaine. DIF of conjunctival or oral mucous biopsy is the gold standard to confirm the diagnosis, showing a linear deposition of IgG, IgA, IgM and complement 3 proteins in the epithelial basement membrane. A multidisciplinar management is essential to control the inflammation and halt the progression. Topical treatments alleviate symptoms but only systemic immunosupression stops progression. Surgical interventions can be employed as adjunctive therapy to treat complications. Triamcinolone acetonide periarticular administration provided greater pain relief by reducing inflammation to a greater degree than dexamethasone.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Host Directed Therapies for Tuberculous Meningitis. (Pubmed Central) -  Feb 8, 2022   
    Currently only one HDT, dexamethasone, is proven to improve mortality...Further research on these aspects of its use, as well as alternative HDTs such as aspirin, thalidomide and other immunomodulatory drugs is needed...Here we review existing literature investigating HDTs in TBM, and propose new rationale for the use of novel and repurposed drugs. We also discuss host variable responses and evidence to support a personalised approach to HDTs in TBM.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly, Actemra IV (tocilizumab) / Roche, JW Pharma
    BARICITINIB FOR HIGH-RISK PATIENTS WITH COVID-19: THE PANCOVID RANDOMIZED TRIAL ([VIRTUAL]) -  Feb 7, 2022 - Abstract #CROI2022CROI_1104;    
    Secondary outcomes were disease progression (increase of O[sub]2[/sub] requirements, mechanical ventilation or increase in medical therapy: steroid dose, need for starting tocilizumab) Out of the 355 participants included in the trial 287 (80.8%) were randomized to D (n=142) or DB (n=145), 264 (91.9%) simultaneously with the TDF/FTC randomization and 23 (8.1%) later on...2 comorbidities (most common: 35.9% hypertension, 9.4% diabetes, 1.7 % obesity), 14.3% receiving remdesivir and 49.1% TDF/FTC...In this clinical trial of high-risk patients with COVID-19 all disease outcomes favored baricitinb added to dexamethasone but differences did not reach statistical significance. Overall mortality was unexpectedly low
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    TDF/FTC FOR HIGH-RISK PATIENTS WITH COVID-19: THE PANCOVID RANDOMIZED CLINICAL TRIAL ([VIRTUAL]) -  Feb 7, 2022 - Abstract #CROI2022CROI_1101;    
    2 comorbidities (62.8% hypertension, 9.3% diabetes, 1.7% obesity), median room air SaO2 95% (IQR 94-96), 63% receiving O2 and 11.8% Remdesivir...In this clinical trial of high-risk patients with COVID-19 TDF/FTC did not improve disease outcomes. Overall mortality was unexpectedly low
  • ||||||||||  dexamethasone / Generic mfg.
    METHYLPREDNISOLONE PULSES IN HOSPITALIZED PATIENTS WITH SEVERE COVID-19 PNEUMONIA ([VIRTUAL]) -  Feb 7, 2022 - Abstract #CROI2022CROI_855;    
    Serious adverse events occurred in 9 patients (6.0%) in the methylprednisolone pulse group and in 12 patients (8.0%) in the placebo group. Methylprednisolone pulse therapy in addition to dexamethasone was not of benefit in patients with COVID-19 pneumonia.
  • ||||||||||  dexamethasone / Generic mfg.
    USE OF CORTICOSTEROIDS TO MANAGE HOSPITALIZED PATIENTS WITH COVID-19 IN ZAMBIA ([VIRTUAL]) -  Feb 7, 2022 - Abstract #CROI2022CROI_679;    
    The median duration of treatment with corticosteroids was 3 days (interquartile range: 1 – 6) and 95% of patients received dexamethasone...While our study was not designed to assess the effectiveness of corticosteroids, these results suggest a need to both comprehensively assess their use relative to national guidelines and investigate their benefits in the African context. Important differences in epidemiology and healthcare system capacity could modify the effect of corticosteroids in Zambia relative to countries where the evidence for their use was generated.
  • ||||||||||  budesonide / Generic mfg.
    Autoimmune hepatitis developing after SARS-CoV-2 vaccination: series of three cases (PAVILLON 1; ROOM: BRUSSELS [VIRTUAL]) -  Feb 7, 2022 - Abstract #BWG2022BWG_254;    
    A 57-year-old woman was referred for progressive elevation of liver function tests (LFTs) four weeks following the first dose of Moderna mRNA-1273 vaccination...However, six weeks later budesonide 9mg was initiated for an increase in LFTs (transaminases x10 ULN)...Azathioprine 50mg was associated two weeks later. Currently she is doing well with marginal AST and ALT elevation (
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    Aseptic liver abscesses in newly diagnosed Crohn’s disease (PAVILLON 1; ROOM: ANTWERP [VIRTUAL]) -  Feb 7, 2022 - Abstract #BWG2022BWG_215;    
    Hepatic MRI showed a resolution of the lesions 4 weeks after initiation of the treatment. Aseptic abscess is a rare extra-digestive manifestation of inflammatory bowel disease whose diagnosis is challenging due to its very low prevalence as well as its presentation in immunocompromised patients prone to infectious complications.
  • ||||||||||  dexamethasone sodium phosphate (AVM0703) / AVM Biotechnology
    Trial completion date, Trial primary completion date:  Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS (clinicaltrials.gov) -  Feb 7, 2022   
    P1,  N=16, Not yet recruiting, 
    Trial completion date: Dec 2022 --> Dec 2023 Trial completion date: Jun 2023 --> Mar 2025 | Trial primary completion date: Jun 2022 --> Dec 2024
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation. (Pubmed Central) -  Feb 5, 2022   
    For 21 days, physiological saline solution was treated to the control group and OVA was treated to the groups of OVA, OVA + dexamethasone (Dexa) and OVA + tyrosol groups, intraperitoneally and through inhalation...In addition, it was determined that the number of eosinophils decreased significantly in blood and BALF samples. The obtained results showed that tyrosol possessed antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Clinical, Journal:  Recurrent lupus enteritis in a child-chase the calm before the storm. (Pubmed Central) -  Feb 5, 2022   
    This episode was successfully managed with intravenous methylprednisolone pulse therapy...Diagnostic and therapeutic delays, hence, led to the development of fatal complications. We highlight that a high index of suspicion of LE and a timely aggressive treatment is imperative for optimal outcomes even in rare pediatric cases of recurrent LE that may have normal imaging findings initially and may not be associated with systemic lupus erythematosus disease activity index (SLEDAI).
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
    Review, Journal:  Neuromyelitis Optica Spectrum Disorders in Africa: A Systematic Review. (Pubmed Central) -  Feb 5, 2022   
    Our systemic review shows that data derived from patients living in Africa correspond well to what has been previously published in meta-analyses on patients of African ancestry with NMOSD who live outside of Africa, except for a younger age at onset and a lower proportion of females. We advocate for systematic data collection to adequately capture and monitor the burden of NMOSD, for expansion of research efforts and facilities to perform fundamental and clinical research, and for improved access to health care including diagnostics, treatments, and rehabilitation services for people affected by NMOSD in the African continent.