- |||||||||| triamcinolone acetonide / Generic mfg.
Trial completion date, Trial primary completion date: Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis (clinicaltrials.gov) - Feb 28, 2022
P=N/A, N=140, Recruiting,
Trial completion date: Dec 2025 --> Dec 2028 | Trial primary completion date: Dec 2022 --> Dec 2023 Trial completion date: May 2022 --> Apr 2023 | Trial primary completion date: May 2021 --> Apr 2023
- |||||||||| Atgam (equine anti-thymocyte globulin) / Pfizer
Enrollment open: TRIUMPH: TReatment for ImmUne Mediated PathopHysiology (clinicaltrials.gov) - Feb 28, 2022
P2b, N=160, Recruiting,
Trial completion date: May 2022 --> Apr 2023 | Trial primary completion date: May 2021 --> Apr 2023 Not yet recruiting --> Recruiting
- |||||||||| dexamethasone / Generic mfg.
Journal: Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications. (Pubmed Central) - Feb 27, 2022
The scaffolds were loaded with Dexamethasone-21-phosphate to investigate their efficacy as a drug delivery vehicle, and the full IPN showed a 100% release in 10 days, while the semi-IPN showed a burst release in 6 h. Both scaffolds stimulated the proliferation of rat pheochromocytoma (PC12) and human glioblastoma multiforme (A172) cell cultures and also provided signals for A172 cell migration. Both scaffolds can be used as potential drug delivery vehicles and as artificial extracellular matrices for potential neural regeneration.
- |||||||||| dexamethasone / Generic mfg.
Journal: CoO Nanozymes with Multiple Catalytic Activities Regulate Atopic Dermatitis. (Pubmed Central) - Feb 27, 2022
The side-effects include skin burns, telangiectasias, and even serious drug dependence. CoO nano-enzymes have a low cytotoxicity and its multiple enzyme-like catalytic activities can effectively protect cells and tissues in ROS environments, which proves that CoO nano-enzymes have high application potential in the field of anti-inflammation.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Journal: Haemophilus Influenzae Endogenous Endophthalmitis in an Immunocompetent Host. (Pubmed Central) - Feb 26, 2022
Pediatric endogenous bacterial endophthalmitis is a rare but potentially devastating infection which is often misdiagnosed. Moreover, we want to highlight the importance of an adequate clinical suspicion in cases of H. influenzae to prevent the serious complications seen in this report.
- |||||||||| dexamethasone / Generic mfg., cisplatin / Generic mfg., gemcitabine / Generic mfg.
Clinical, Journal: Reversible renal-limited thrombotic microangiopathy due to gemcitabine-dexamethasone-cisplatin therapy: a case report. (Pubmed Central) - Feb 26, 2022
Drug-induced TMA occurs early after gemcitabine and cisplatin use in renal-limited form and is reversible when detected and managed in a timely manner. Urinalysis, which is simple and inexpensive and can be easily performed, is a beneficial screening tool for early-onset drug-induced TMA among patients who receive gemcitabine-dexamethasone-cisplatin therapy.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal, Polymerase Chain Reaction: The selection and identification of compound housekeeping genes for quantitative real-time polymerase chain reaction analysis in rat fetal kidney. (Pubmed Central) - Feb 26, 2022
Their expression levels in the rat fetal kidney in physiological condition and the intrauterine growth retardation (IUGR) model induced by prenatal dexamethasone exposure (PDE) (0.2 mg/kg·day from gestation Days 9 to 20) was measured...Besides, our results suggest that ACTB + GAPDH were the best compound housekeeping genes for normalization analysis in male fetal kidney studies, and ACTB + YWHAZ in females. This study will provide an experimental evidence basis for the selection of housekeeping genes in the RT-qPCR experiment in renal development toxicology-related models.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Anti-inflammatory effects of kaempferol-3-O-rhamnoside on HSV-1 encephalitis in vivo and in vitro. (Pubmed Central) - Feb 26, 2022
This study will provide an experimental evidence basis for the selection of housekeeping genes in the RT-qPCR experiment in renal development toxicology-related models. In conclusion, K-3-rh had the potential to reduce HSV-1-induced brain injury by reducing the secretion of microglial pro-inflammatory factors, inducing apoptosis of microglia cells, and through cytochrome C and caspase-3 pathway.
- |||||||||| budesonide / Generic mfg.
Journal: Current options and investigational drugs for the treatment of eosinophilic esophagitis. (Pubmed Central) - Feb 26, 2022
These include monoclonal antibodies (including mepolizumab, reslizumab, benralizumab, dectrekumab, cendakimab, and dupilumab), JAK-STAT blockers, and S1PR agonists, among others...Therapies under investigation potentially can target multiple Th2-associated diseases that converge in EoE patients. Therapeutic strategies require a personalized and patient-centered approach to reduce the burden of the disease, and cost-effectiveness analysis to position their use in a complex therapeutic landscape.
- |||||||||| budesonide / Generic mfg.
Journal: Reactive Oxygen Species-Responsive Polyether Micelle Nanomaterials for Targeted Treatment of Ulcerative Colitis. (Pubmed Central) - Feb 26, 2022
It is a self-assembled polyether micelle that can be oxidized at the inflammation site where the concentration of reactive oxygen increases, and effectively release the encapsulated budesonide (Bud)...Molecular mechanism studies have shown that it achieves its therapeutic effects by activating the peroxisome proliferators-activated receptors-γ (PPAR-γ) pathway and inhibiting the nuclear factor (NF)-κB pathway. This study proves that oral nano-micelles have an important impact on improving the efficacy of UC treatment drugs and have far-reaching significance for the targeted treatment of gastrointestinal diseases.
- |||||||||| prednisone delayed-release tablet / Generic mfg.
Journal: The hilum of the lung: Two classical radiological signs to decipher it. (Pubmed Central) - Feb 26, 2022
This article reviews the literature and describes the principal anatomic relations of the lung hilum through illustrative cases to enable the two most important radiologic signs to be identified: "hilum overlay" and "hilum convergence". In the initial imaging evaluation of patients with cardiothoracic disease, knowledge of these basic principles facilitates the three-dimensional location of lesions in a single-plane image, optimizing time and resources.
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg.
Review, Journal, Cancer stem cells: Targeting NF-κB Signaling in Cancer Stem Cells: A Narrative Review. (Pubmed Central) - Feb 26, 2022
Finally, we discuss programmed death-ligand 1 (PD-L1) as an NF-κB target gene and its role in checkpoint therapy. We conclude, that NF-κB inhibition by specific inhibitors of IκB kinase was of no clinical use but inhibition of upstream and downstream targets with drugs or biologicals might be a fruitful way to treat cancer stem cells.
- |||||||||| dexamethasone / Generic mfg.
Journal, IO biomarker: Chemotherapy-Free Targeted Anti-BCR-ABL+ Acute Lymphoblastic Leukemia Therapy May Benefit the Heart. (Pubmed Central) - Feb 26, 2022
These data demonstrate that therapies designed to optimize apoptosis induction in ALL may circumvent cardiac on-target side effects and may even activate cardiac recovery. In the future, combining the careful clinical monitoring of cardiotoxicity in leukemic patients with the further characterization of organ-specific side effects and signaling pathways activated by malignancy and/or anti-tumor therapies seems reasonable.
- |||||||||| dexamethasone / Generic mfg.
Journal: Monitoring Glucose Concentrations in Children with Epilepsy on a Ketogenic Diet. (Pubmed Central) - Feb 26, 2022
Ketogenic diet (KD) and pulsatile dexamethasone therapy (PDT) are commonly used in the treatment of children with drug resistant epilepsy...Improvement of attention and memory performance were reported. FGM during the KD as a treatment for drug resistant epilepsies in childhood is a practical option to explore and to avoid hypoglycemia during the KD and hyperglycemia during PDT.
- |||||||||| diethylpropion / Generic mfg.
Review, Journal: Abuse Potential of Cathinones in Humans: A Systematic Review. (Pubmed Central) - Feb 26, 2022
Cathinone, mephedrone, methylone, and diethylpropion induce a range of desirable and reinforcing effects that may, to some extent, result in abuse potential. Further investigation is needed to minimize and prevent their impact on society and public health.
- |||||||||| dexamethasone / Generic mfg., nifedipine immediate release / Generic mfg.
Journal: A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues. (Pubmed Central) - Feb 26, 2022
We compared the functional performance of EHTs and their histology in three different media and demonstrated that tissues cultured and maintained in maturation medium, containing triiodothyronine (T3), dexamethasone, and insulin-like growth factor-1 (TDI), resulted in a higher force of contraction, sarcomeric organization and alignment, and a higher and lower inotropic response to isoproterenol and nifedipine, respectively. Moreover, in this study, we highlight the importance of integrating a serum-free maturation medium in the EHT platform, making it a suitable tool for cardiovascular research, disease modeling, and preclinical drug testing.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Sex-specific associations between chemotherapy, chronic conditions and neurocognitive impairment in ALL survivors: A report from the Childhood Cancer Survivor Study. (Pubmed Central) - Feb 25, 2022
Moreover, in this study, we highlight the importance of integrating a serum-free maturation medium in the EHT platform, making it a suitable tool for cardiovascular research, disease modeling, and preclinical drug testing. Neurocognitive impairment is associated with methotrexate, dexamethasone and chronic health conditions in a sex-specific manner, highlighting the need to investigate physiological mechanisms and monitor impact through survivorship.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Steroid Sulfatase in the Mouse NIH-3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids. (Pubmed Central) - Feb 25, 2022
This activity was blocked by the STS inhibitors EMATE and STX-64, indicating authentic STS activity...The reduction in STS activity by dexamethasone in whole cells was reversed by the glucocorticoid receptor antagonist RU-486, indicating that glucocorticoid downregulation of STS activity is receptor mediated...This is consistent with the idea that cortisol inhibits STS in NIH-3T3 cells through a regulatory mechanism rather than by substrate inhibition. Our results could have important implications regarding local estrogen production by STS in fibroblasts, which are the most common connective tissue cells in the body, and on possible regulation of local estrogen levels by cortisol.
- |||||||||| Clinical, Review, Journal: Two challenging cases of pituicytoma. (Pubmed Central) - Feb 25, 2022
Pituicytomas are known to be low-grade tumors; because of their rarity, they are a real challenge. These patients should be followed up closely.
- |||||||||| hydroxychloroquine / Generic mfg., dexamethasone / Generic mfg.
Observational data, Journal: COVID-19 treatments sold online without prescription requirements in the United States. (Pubmed Central) - Feb 25, 2022
We document that illegitimate online pharmacies sidestep prescription requirements, skirt pharmacist counselling, and make false claims regarding efficacy in treating COVID-19 infections. Health care professionals must urgently educate the public of the dangers of purchasing drugs from illegitimate websites and highlight the importance of seeking treatment through authentic avenues of care.
- |||||||||| Darzalex IV (daratumumab) / J&J
Clinical, P3 data, Journal: Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study. (Pubmed Central) - Feb 25, 2022
P3
Our study reveals the importance of systemic immunity in regulating PAH-induced skin pigmentation, and provide a new keratinocyte DNA damage response mechanistic target for the prevention or reversal of pollution-associated skin pigmentation. A clear, maintained progression-free survival benefit of KdD over Kd with longer follow-up was confirmed, making KdD an emerging standard-of-care for patients with relapsed or refractory multiple myeloma.
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