Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...355356357358359360361362363364365...10671068»
  • ||||||||||  remifentanil / Generic mfg., dexamethasone injection / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date, Surgery:  Enhanced Recovery After Surgery (ERAS) Pathway for Primary Hip and Knee Arthroplasty (clinicaltrials.gov) -  Mar 8, 2022   
    P=N/A,  N=640, Recruiting, 
    It is important not to neglect symptoms such as a headache, which may seem small, but could serve as a clue in the diagnosis of Waldenstrom's macroglobulinemia. Not yet recruiting --> Recruiting | Trial completion date: Jan 2022 --> Dec 2023 | Trial primary completion date: Jan 2021 --> Jan 2023
  • ||||||||||  dexamethasone sustained-release (TLC599) / Taiwan Liposome Company, Endo
    Trial completion date, Trial primary completion date:  A Phase 2, Open Label, PK Study of TLC599 in Subject With Osteoarthritis of the Knee (clinicaltrials.gov) -  Mar 8, 2022   
    P2,  N=90, Recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Jan 2022 --> Dec 2023 | Trial primary completion date: Jan 2021 --> Jan 2023 Trial completion date: Feb 2022 --> Jun 2022 | Trial primary completion date: Feb 2022 --> Jun 2022
  • ||||||||||  Darzalex (daratumumab) / J&J
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  Daratumumab, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma (clinicaltrials.gov) -  Mar 8, 2022   
    P2,  N=0, Withdrawn, 
    Trial completion date: Feb 2022 --> Jun 2022 | Trial primary completion date: Feb 2022 --> Jun 2022 N=40 --> 0 | Trial completion date: Jun 2025 --> Feb 2022 | Recruiting --> Withdrawn | Trial primary completion date: Jun 2024 --> Feb 2022
  • ||||||||||  dexamethasone injection / Generic mfg., ibuprofen / Generic mfg.
    Trial completion date, Trial primary completion date:  Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity (clinicaltrials.gov) -  Mar 8, 2022   
    P3,  N=300, Recruiting, 
    N=40 --> 0 | Trial completion date: Jun 2025 --> Feb 2022 | Recruiting --> Withdrawn | Trial primary completion date: Jun 2024 --> Feb 2022 Trial completion date: Jun 2023 --> Jun 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  niclosamide nasal spray (UNI91103) / UNION Therap, Institut Pasteur Korea, Alvesco (ciclesonide) / Covis Pharma, Teijin, Korea University Medical Center, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
    Enrollment change, Trial completion date, Trial primary completion date:  PROTECT-V: PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V (clinicaltrials.gov) -  Mar 8, 2022   
    P2/3,  N=5000, Recruiting, 
    Trial completion date: Jun 2023 --> Jun 2024 | Trial primary completion date: Dec 2022 --> Dec 2023 N=1500 --> 5000 | Trial completion date: Mar 2022 --> Oct 2024 | Trial primary completion date: Dec 2021 --> Jul 2023
  • ||||||||||  Blincyto (blinatumomab) / Astellas, Amgen, Opdivo (nivolumab) / BMS, Imbruvica (ibrutinib) / AbbVie, J&J
    Trial completion:  Ibrutinib, Nivolumab and Blinatumomab in Richter Transformation (clinicaltrials.gov) -  Mar 7, 2022   
    P2,  N=10, Completed, 
    Not yet recruiting --> Recruiting Active, not recruiting --> Completed
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Influenza vaccine ANCA-Associated Vasculitis () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_833;    
    RESULTS Influenza-associated vasculitis case reports include new-onset or relapsing ANCA vasculitis.1 Our patient showed high levels of anti-PR3 with pauci-immune pattern. Pauci-immune typifies systemic small-vessel vasculitis which may lead to renal failure or pulmonary hemorrhage.2 We intend to increase awareness of influenza vaccine-associated ANCA vasculitis as rapid detection and treatment lead to optimal outcomes.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    A Case of Worsening Adult-Onset Henoch- Schönlein Purpura Nephritis Despite Corticosteroid Treatment: () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_827;    
    She was discharged with oral prednisone 60 mg daily...Pulse IV methylprednisolone was readministered for three days with resolution of symptoms...Sudden worsening of kidney function despite immunosuppressive therapy making this case unusual. More studies are needed to better understand management guidelines for complicated HSPN.
  • ||||||||||  Fibrillary glomerulonephritis complicating hereditary transthyretin amyloidosis () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_826;    
    Renal function ultimately improves allowing for HD cessation before discharge on prednisone...Of the novel therapies for hATTR, inotersen has been associated with GN, but not patisiran or tafamidis...FGN is often idiopathic, but up to 50% of cases are associated with secondary causes such as malignancy, hep C, autoimmune disease, and dysproteinemia. This is the first reported case of crescentic FGN in a patient with hATTR and may represent a novel association between these two rare conditions.
  • ||||||||||  hydrocortisone / Generic mfg.
    The unusual case of hypopkalemia in a patient with Addison's disease () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_807;    
    She was started on hydrocortisone...A retrospective study that reported presence of such antibodies in patients with APECED has speculated this to be a rare phenomenon and their pathologic significance yet remains to be determined. We need future studies to understand this rare association and know the triggers leading to overt clinical disease in these patients.
  • ||||||||||  remdesivir / Generic mfg.
    Remdesivir Use in a COVID-19 Patient With ESRD on HD () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_735;    
    INTRODUCTION Given that remdesivir and its active metabolite (GS-441524) are primarily (74%) excreted by the kidneys, most studies of its use in COVID-19 patients excluded patients with ESRD, and the FDA advises against using it in patients with a GFR of less than 30 ml/min/1.73m2 unless the potential benefits outweigh the risks...The patient’s oxygen requirement continued to increase despite 96 hours of treatment with dexamethasone...CONCLUSION ESRD does not appear to be an absolute contraindication to remdesivir use. More research involving individuals with renal impairment and those on renal replacement therapy is needed to better understand the safety and mortality advantages of remdesivir in this patient population.
  • ||||||||||  Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
    Refractory Hypertension Caused by Neuroendocrine Tumor in the Lung () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_676;    
    Blood pressure (BP) averaged 140/100 mmHg on maximum dose amlodipine, losartan, chlorthalidone, metoprolol and hydralazine...Dexamethasone failed to suppress morning cortisol and CRH stimulation did not cause ACTH rise, indicating an ectopic ACTH source...Awaiting resection, BP control was achieved by adding eplerenone 50 mg and amiloride 5 mg, both twice a day...Following surgery, the patient started a hydrocortisone taper and antihypertensive requirements went down from 7 to 2 medications in 4 weeks...CONCLUSION Neuroendocrine tumor is rare cause of CS which can result in refractory HTN. In addition to identifying and treating the culprit tumor, mineralocorticoid and RAS blockade are essential to control BP and electrolyte derangement.
  • ||||||||||  Myxedema Coma in End Stage Renal Failure – Pondering a Rare Case () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_665;    
    She had a past medical history of colon cancer status post partial colectomy, stroke, paroxysmal atrial fibrillation on amiodarone, an active herpes zoster infection, recent bilateral pleural effusions, and fecal impaction...Myxedema coma was diagnosed and the patient was initially treated with levothyroxine and hydrocortisone but was later made hospice by the patient’s family which was in line with her wishes...Surprisingly, a TSH was never checked previously, even when the patient developed recurrent borderline exudative pleural effusions and fecal impaction. CONCLUSION We suggest having a low threshold to screen elderly patients with ESRD for hypothyroidism as early treatment may prevent potentially fatal patient outcomes such as myxedema coma.
  • ||||||||||  Hypercalcemia: A Rare Case of Multiple Myeloma During Pregnancy () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_628;    
    In situations where hypercalcemia is life-threatening, pamidronate may be used cautiously...In addition, there are no guidelines regarding the management of MM in pregnancy. Corticosteroids can be initiated in those who require more immediate treatment as the optimal goal is to control the myeloma, prevent fetal toxicity, and achieve successful delivery.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    De Novo Class IV+V Lupus Nephritis after the BNT162b2 COVID-19 Vaccine () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_583;    
    Cases proposing a pathogenic association between autoimmune disease and vaccination describe symptom onset occurring within days to several weeks post-vaccination. Studies that compare the incidence of immune-mediated glomerular diseases in individuals who receive COVID-19 vaccines and unvaccinated individuals are needed to determine if there is a causal relationship.
  • ||||||||||  hydrocortisone / Generic mfg.
    A Case of Hyponatremia due to Secondary Adrenal Insufficiency in a Patient with a Subdural Hematoma () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_579;    
    RESULTS Following the results of the positive cosyntropin stimulation test, patient was started on hydrocortisone 100mcg IV followed by 50 mcg IV every 6 hours with improvement in serum sodium levels and resolution of all symptoms within 24 hours...CONCLUSION It has been noted in previous studies that hypopituitarism often goes undiagnosed, especially in the elderly in whom non-specific symptoms such as generalized weakness or easy fatigability is commonly attributed to aging or other comorbidities, sometimes requiring as many as 5 admissions at different hospitals for correct diagnosis. Hypopituitarism should be ruled out in all patients with an SIADH-like clinical picture without an obvious cause before settling on a diagnosis of SIADH as it is a diagnosis of exclusion.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Rare Case of Lymphoplasmacytic Lymphoma Infiltration of the Kidney Causing Acute Kidney Injury in Waldenström Macroglobulinemia () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_578;    
    CONCLUSION In one study, survival was improved in patients with stable or improved renal function after treatment. Given this knowledge, renal function should be regularly monitored and renal biopsy pursued in those presenting with an unknown cause of AKI and an early renal biopsy remains essential to determine the underlying cause for guiding treatment to maximally preserve renal function and overall survival.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
    Severe Symptomatic Hyponatremia due to Immune Checkpoint Inhibitor induced Secondary Adrenal Insufficiency () -  Mar 6, 2022 - Abstract #NKFSCM2022NKF_SCM_555;    
    Her prior oncologic treatment consisted of 4 cycles of immunotherapy with ipilimumab/nivolumab followed by maintenance nivolumab...Physiologic hydrocortisone was initiated for suspected secondary adrenal insufficiency (AI)...Hyponatremia is variably seen and may be severe. CONCLUSION While hyponatremia may be due to wide range of conditions in patients with malignancies, hyponatremia resulting from ICI induced secondary AI requires timely recognition and treatment for optimal patient outcomes.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    New Onset Refractory Status Epilepticus secondary to HIV CNS Syndrome (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3957;    
    Early diagnosis of HIV CNS escape syndrome requires a change in cART which can potentially change neurological outcomes. Therefore, HIV CNS escape syndrome should be considered early in the investigation of NORSE in HIV patients
  • ||||||||||  dexamethasone / Generic mfg.
    Pediatric COVID Encephalitis: A Case Report (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3676;    
    The temporal improvement in symptoms after administration of convalescent plasma and dexamethasone raises interest in their use for management of SARS-COV-2 infection in pediatric patients. Further research into these findings is important for minority populations which have been disproportionately affected by the pandemic.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
    Identification of Brain and Spinal Cord Abscesses in a Patient with Recently Diagnosed Neurosarcoidosis (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3473;    
    This case provides a unique challenge for the diagnosis of intracranial and intramedullary abscesses in patients with neurosarcoidosis. Abscess should be considered in the differential diagnosis of patients with neurosarcoidosis presenting with acutely worsening neurological symptoms and new intraparenchymal lesions with restricted diffusion on MRI.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Overlapping Autoimmune Neurologic Syndrome, A case report of triple-positive antibody (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3368;    
    Therefore, clinicians need to be vigilant about the overlap neurological syndromes affecting central and peripheral nervous systems to avoid delays in the diagnosis and treatment to prevent poor clinical outcomes. It is equally important to address poor response to the first-line immunosuppressive therapy as the continuation of these therapies may not be effective in some cases.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    The First Ever Report of Morvan’s Syndrome associated with a Pseudopapillary Pancreatic Tumor. (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3359;    
    Treatment with intravenous methylprednisolone along with antiepileptics was instituted. However, her symptoms persisted, following which she received intravenous rituximab and her symptoms improved .Morvan’s syndrome has been associated with tumors of the thymus, lung, colon and prostate.To the best of our knowledge, this is the first case of Morvan syndrome associated with a pseudopapillary pancreatic tumor to be reported. NA
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Case of Leber Hereditary Optic Neuropathy Mimicking Neuromyelitis Optica Spectrum Disorder (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3342;    
    A few similar cases of bilateral optic neuropathy and LETM have been described, and even fewer cases of cord involvement preceding vision symptoms. It is important to consider LHON in the differential for seronegative NMOSD, as both can present with bilateral vision impairment and LETM.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    MOG Antibody Myelitis Following HIV Seroconversion (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3310;    
    HIV has been known to cause myelitis, however this entity is exceedingly rare or underreported. This is the first case report which documents the diagnosis of probable anti-MOG antibody myelitis following period of HIV seroconversion, likely as a post-infectious sequelae of viral infection.