- |||||||||| triamcinolone acetonide / Generic mfg., hydrocortisone / Generic mfg.
Trial initiation date: Splint Versus Steroid Randomized Trial (clinicaltrials.gov) - Mar 9, 2022
P=N/A, N=100, Not yet recruiting,
Initiation date: Feb 2022 --> Jun 2022
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: A Tearfully Painful Darkness. (Pubmed Central) - Mar 8, 2022
Serum studies showed elevated myelin oligodendrocyte glycoprotein (MOG) IgG titer. She was treated with IV methylprednisolone 1000mg daily for 3 days and was discharged on prolonged prednisone taper with return of vision to baseline.
- |||||||||| dexamethasone / Generic mfg., imatinib / Generic mfg.
Journal: Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates. (Pubmed Central) - Mar 8, 2022
Positive compounds showed a high correlation among teratogenic parameters, pointing out at general developmental delay as major cause to explain the physiological/morphological malformations. A more detailed analysis based on deviations from main trends revealed potential specific modes of action for some compounds such as retinoic acid, DEAB, ochratoxin A, haloperidol, warfarin, valproic acid, acetaminophen, dasatinib, imatinib, dexamethasone, 6-aminonicotinamide and bisphenol A. The high degree of predictivity and the possibility of applying mechanistic approaches makes zebrafish a powerful model for screening teratogenicity.
- |||||||||| Avastin (bevacizumab) / Roche
Review, Journal: Treatment of radiation maculopathy and radiation-induced macular edema: a systematic review. (Pubmed Central) - Mar 8, 2022
Intravitreal dexamethasone implant may be an option for those with suboptimal response or contraindications to anti-VEGF agents. Possible preventive treatments that require future study are intravitreal bevacizumab and ranibizumab, peripheral laser photocoagulation, and subtenon triamcinolone acetonide.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Insights into the Regulation on Proliferation and Differentiation of Stem Leydig Cells. (Pubmed Central) - Mar 8, 2022
Among hormones, dexamethasone suppresses SLCs differentiation, while aldosterone suppresses their proliferation...These SLCs in the testis start to proliferate and some of them differentiate into LCs. Thirdly, during the SLCs regeneration period, researchers could explore different function of those factors (pollutants, growth factors, cytokines and hormones) towards SLCs.
- |||||||||| Tecentriq (atezolizumab) / Roche
Clinical, Journal: Anaphylactic shock in a small cell lung cancer patient receiving atezolizumab therapy: a rare but potentially fatal complication. (Pubmed Central) - Mar 8, 2022
After one cycle of treatment, the patient developed a grade 2 rash and recovered after receiving oral methylprednisolone tablets...Then, the patient was scheduled to receive atezolizumab plus carboplatin and etoposide again after three weeks, but approximately three minutes after an intravenous infusion of atezolizumab, the patient developed signs and symptoms of anaphylactic shock, such as dyspnea, cold limbs, and loss of consciousness...Meanwhile, ECG monitoring, supplemental humidified high-flow supplemental 100% oxygen, epinephrine, dopamine, hormone treatment with methylprednisolone, and other anti-shock treatments were carried out...Anaphylactic shock develops rapidly and is also a very severe complication. Prompt detection, diagnosis, and therapeutic intervention are the basics for survival.
- |||||||||| dexamethasone / Generic mfg.
Journal: Multiplexing Nanodrug Ameliorates Liver Fibrosis via ROS Elimination and Inflammation Suppression. (Pubmed Central) - Mar 8, 2022
Herein, an esterase-responsive carbon quantum dot-dexamethasone (CD-Dex) is developed for liver fibrosis therapy to simultaneously target pathological microstructures, scavenge reactive oxygen species (ROS), and suppress inflammation...Antifibrotic experiments demonstrate that CD-Dex significantly alleviates liver injury and collagen deposition, consequently preventing the progression of liver fibrosis. Taken together, these findings suggest that via ROS elimination and inflammation suppression, the newly developed multiplexing nanodrug exhibits great potential in liver fibrosis therapy.
- |||||||||| Darzalex (daratumumab) / J&J
Economic Burden of Relapsed or Refractory Relapse Multiple Myeloma (Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1824;
CONCLUSIONS : The present study concludes that, from patient’s perspective , the economic burden of RRMM patient who are transplant eligible was burdensome and costly . This study helps to inform decisions about the allocation of health care system resources and to achieve better health in the Egyptian population.
- |||||||||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD), Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Health Technology Assessment Landscape for COVID-19 Treatment across the US, Canada, and EU-5 - an Insight into Recommendation Drivers (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1782;
Of all the appraisals made in the above timeframe, only 15 submissions underwent HTA process: 2 ongoing (Remdesivir [NICE] + Sotrovimab [HAS]); 1 planned (multidrug [ICER]) and 12 published...Among the 12 published HTAs, 5 received positive recommendations from HAS (3 dexamethasone; 1 casirivimab + imedvimab; 1 tixagevimab + cilgavimab), 5 received positive recommendation with restrictions (4 remdesivir [HAS, INESS, G-BA, AEMPS]; 1 casirivimab + imedvimab [HAS]), 1 received negative recommendation by HAS (molnupiravir), and 1 received no recommendation from IQWiG (remdesivir)... The prime HTA decision drivers were based on clinical benefit and high unmet need over economic benefit.
- |||||||||| remdesivir / Generic mfg.
Comparison of Remdesivir As Monotherapy or in Combination with Steroids in Treating COVID-19 Patients (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_713;
The study observed that patients treated in combination with steroids had comparatively shorter average length of stay in comparison to those who were treated with Remdesivir alone. Further analysis needs to be done to compare the outcome of these measures on the ICU stay and the need for ventilatory support.
- |||||||||| triamcinolone acetonide / Generic mfg.
Triamcinolone Acetonide Injectable Suspension, for Suprachoroidal Use, for the Treatment of Macular Edema Associated with Uveitis in the United States: A Budget Impact Analysis (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_615;
Brand + brand targeted oncology drug combinations are most likely to receive positive decisions from HTA agencies. Introduction of triamcinolone acetonide injectable suspension, for suprachoroidal use, for treatment of ME associated with NIU in the US, could lead to lower eye-related (inpatient, outpatient, ED), non-eye related, and pharmacy costs, benefitting the US healthcare system.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
US Price Trends over the Drug Life Cycle: Examples and Policy Implications (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_572;
Applying a standardized fixed percent discount from WAC also seems to be an imprecise estimate of actual drug price, given the yearly variability in net price that we observed. Lastly, the drugs of focus in our analysis exemplify price increases pre-LOE and price decreases post-LOE, aligning with policy considerations to limit price increases and enhance competition.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Changes in COVID-19 Treatment Patterns over the Course of 2020 (Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_317;
Medications (azithromycin [sole therapy], corticosteroids [dexamethasone and methylprednisolone], hydroxychloroquine, remdesivir, and tocilizumab), procedures, and mortality outcomes were captured from the medical chart and reported descriptively. Treatment patterns evolved over the course of 2020 with the most variation in care observed 4-7 months after the arrival of SARS-CoV-2 in the US.
- |||||||||| Cost-Effectiveness of Anti-BCMA CAR T-Cell Therapy in Triple-Class Refractory Multiple Myeloma (Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_272;
Ide-cel and cilta-cel are projected to substantively increase life expectancy, but neither is cost-effective at current prices. To meet a $150,000/QALY threshold, the price of ide-cel and cilta-cel need to be reduced by 55% and 23% respectively, and improvements in the cost-effectiveness of subsequent multiple myeloma care are also needed.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Kevzara (sarilumab) / Asahi Kasei, Regeneron, Sanofi
RAPID C-19: Achievements and Challenges of a Collaborative Response to the COVID-19 Pandemic in the UK (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_136;
Key healthcare agencies successfully work together in RAPID C‑19 to bring effective COVID-19 treatments to patients as quickly as possible. This model of collaboration could work in non-COVID settings and in other countries to speed access to beneficial treatments for patients.
- |||||||||| dexamethasone injection / Generic mfg.
Preclinical, Journal: Chronic Systemic Dexamethasone Regulates the Mineralocorticoid/Glucocorticoid Pathways Balance in Rat Ocular Tissues. (Pubmed Central) - Mar 8, 2022
To induce HPA brake, Lewis rats received a systemic injection of dexamethasone daily for five days...The psychological stress induced by the repeated injection of saline also induced HPA axis brake with a trend towards MR pathway activation in RPE/ choroid. HPA axis brake causes an imbalance of corticoid receptors expression in the RPE/choroid towards overactivation of MR pathway, which could favor the occurrence of CSCR.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
Journal, Monotherapy: Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patients. (Pubmed Central) - Mar 8, 2022
SBI incidence was higher in the CS group (13.5% vs. 35.1%, P = 0.02) with a similar LOS (13.4 days vs. 13.4 days, P = 1.00) and similar incidence of MRSA/Pseudomonas infections (13.5% vs. 13.5%, P = 1.00) in both the groups. Therefore, CS-RDV therapy is non-inferior to CS therapy in reducing 28-day all-cause in-hospital mortality but associated with a significant decrease in the incidence of SBI in critically ill COVID-19 patients.
- |||||||||| dexamethasone / Generic mfg.
Journal: PLLA Coating of Active Implants for Dual Drug Release. (Pubmed Central) - Mar 8, 2022
A PLLA coating (containing diclofenac) of medical-grade silicone (containing 5% dexamethasone) was developed and release profiles were determined...This can be overcome by using removable masking on the contacts during the coating process. Dual drug release with different kinetics can be realized by adding drug-loaded coatings to drug-loaded silicone arrays without compromising electrical stimulation.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Review, Journal: Interventions for focal segmental glomerulosclerosis in adults. (Pubmed Central) - Mar 8, 2022
The final study (109 participants) compared sparsentan, a dual inhibitor of endothelin Type A receptor and of the angiotensin II Type 1 receptor, with irbesartan...Treatment with cyclosporin for at least six months was more likely to achieve complete remission of proteinuria compared with other treatments but there was considerable imprecision due to few studies and small participant numbers. In future studies of existing or new interventions, the investigators must clearly define the populations included in the study to provide appropriate recommendations for patients with primary, genetic or secondary FSGS.
- |||||||||| dexamethasone / Generic mfg., temozolomide / Generic mfg.
Retrospective data, Journal: Glucose Influences the Response of Glioblastoma Cells to Temozolomide and Dexamethasone. (Pubmed Central) - Mar 8, 2022
High glucose can influence on GBM progression through the promotion of the following parameters: cell viability, dispersal, InsR expression and cell proliferation (Ki-67). However, this problem needs more studies and explain the mechanism of action studied drugs.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Two Cases of Miliary and Disseminated Coccidioidomycosis Following Glucocorticoid Therapy and Literature Review. (Pubmed Central) - Mar 8, 2022
A 49-year-old man with no significant past medical history received dexamethasone as part of his treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...A 52-year-old man with a past medical history of chronic kidney disease (CKD) was treated with prednisone for focal segmental glomerulosclerosis (FSGS)...Radiology, serology, and lumbar puncture proved a diagnosis of reactivated coccidioidomycosis with miliary pattern and coccidioidomycosis meningoencephalitis with arachnoiditis. Whether treatment with glucocorticoids caused reactivation of coccidioidomycosis is discussed in this case series.
- |||||||||| prednisolone / Generic mfg.
Journal: Clinico-Biochemical Profile and Identification of Independent Risk Factors of Frequent Relapse in Childhood-Onset Steroid-Sensitive Nephrotic Syndrome. (Pubmed Central) - Mar 8, 2022
Children who had no infection were started oral prednisolone at the dose of 2 mg/kg/day for six weeks, followed by 1.5 mg/kg/day on alternate days for six weeks with daily follow-up for evidence of proteinuria till remission...In the relapse group, 41% of the children went into remission within two weeks of initiation of therapy as compared with 80% in the no relapse group. Conclusion The risk factors determined for relapse in SSNS are male sex, younger age, low serum albumin, low serum total protein, and delayed response to steroid therapy.
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