Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone injection / Generic mfg.
    New P1 trial:  SFSS: Spinal Fusions Steroid Study (clinicaltrials.gov) -  Mar 17, 2022   
    P1,  N=70, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hydrogel-mediated local delivery of dexamethasone reduces neuroinflammation after traumatic brain injury. (Pubmed Central) -  Mar 17, 2022   
    Significant reductions in cavity size, inflammatory response, and apoptosis were observed in animals treated with PEG-bis-AA/HA-DXM compared to those receiving PEG-bis-AA/HA and untreated. Animals receiving the PEG-bis-AA/HA-DXM hydrogel also exhibited higher neuronal cell survival and improved motor functional recovery compared to the other two groups.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Journal:  Effects of glucocorticoid and noradrenergic activity on implicit and explicit facial emotion recognition in healthy young men. (Pubmed Central) -  Mar 17, 2022   
    One hundred and four healthy men (mean age = 24.1 years SD 3.5) underwent the Face Puzzle task to test implicit and explicit facial emotion recognition after receiving either 10 mg hydrocortisone or 10 mg yohimbine (an alpha 2-adrenergic receptor antagonist that increases noradrenergic activity) or 10 mg hydrocortisone/10 mg yohimbine combined or placebo...However, there was no effect of separate and combined noradrenergic and glucocorticoid stimulation on implicit and explicit facial emotion recognition performance compared to placebo. Our results do not support an essential role of the glucocorticoid and noradrenergic system in FER in young healthy men.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Hypothalamic-pituitary-adrenal axis regulation and organization in urban and rural song sparrows. (Pubmed Central) -  Mar 17, 2022   
    Further, urban and rural birds had similar reductions in corticosterone following the dexamethasone challenge, suggesting that they do not differ in how quickly they decrease glucocorticoid synthesis and release. Thus, urban and rural song sparrows display similar termination of the glucocorticoid stress response even though urban birds have decreased hippocampal glucocorticoid receptor and 11β-HSD2 abundance.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Sex-specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress. (Pubmed Central) -  Mar 17, 2022   
    Prenatal stress programmes offspring peripheral metabolism in a sex-specific manner, emphasizing that the response to stress in critical periods of development may be sex-specific having each sex different vulnerabilities to psychiatric and metabolic disorders. Considering sex-specificities may provide critical clues for the design of preventive strategies and for early therapeutic intervention.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets. (Pubmed Central) -  Mar 17, 2022   
    Seven-day-old pigs reared by sows received daily intramuscular injections of hydrocortisone 21-acetate (25 mg/kg) or vehicle solution (saline) (n = 10/group)...Collectively, these results suggest an important role for proline oxidase and N-acetylglutamate in regulating citrulline and arginine synthesis from proline in pig enterocytes. Because proline catabolism plays an important role in modulating protein synthesis, cell proliferation, and arginine production, our findings may have important implications for understanding the role of proline oxidase in the growth and health of the mammalian small intestine.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Sex-specific effects of low-dose hydrocortisone on threat detection in HIV. (Pubmed Central) -  Mar 17, 2022   
    This result suggests a role of the HPA axis in sex differences for perception of fearful faces in women with HIV, potentially due to changes in glucocorticoid receptor availability/activity, or improved integration of signals from facial recognition and emotion processing regions. The blunting of this effect in men and in individuals with more severe trauma suggests that the mechanisms underlying threat detection differ by sex and trauma history and warrant further investigation.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation. (Pubmed Central) -  Mar 17, 2022   
    BALB/c mice were sensitized and challenged with ovalbumin and treated with solidagenone orally (30 or 90 mg/kg body weight) or dexamethasone, as a positive control in our in vivo analysis...Histopathological evaluation of lung tissue was performed and morphometrical analyses demonstrated reduction of cellular infiltration and mucus hypersecretion. Altogether solidagenone presented anti-inflammatory activity in vitro and in vivo in the OVA-induced airway inflammation model, suggesting its promising pharmacological use as an anti-inflammatory agent for allergic hypersensitivity.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Relationships between cortisol and urinary androgens in female titi monkeys (Plecturocebus cupreus). (Pubmed Central) -  Mar 17, 2022   
    We validated an assay for plasma and urinary cortisol in this species, showing a strong suppression of cortisol following dexamethasone injection, and a significant but somewhat blunted response to adrenocorticotrophin hormone (ACTH) stimulation...Plasma and urinary cortisol were moderately correlated, whereas urinary cortisol and androgens were only correlated when extreme cortisol values were included. In this study, we laid groundwork for studying the role of glucocorticoids and androgens (and eventually, their interactions with peptides) in the behavioral endocrinology of pair bonds in female titi monkeys.
  • ||||||||||  budesonide/salbutamol (PT027) / AstraZeneca, Avillion
    Clinical, Journal:  Albuterol/budesonide for the treatment of exercise-induced bronchoconstriction in patients with asthma: the TYREE study. (Pubmed Central) -  Mar 17, 2022   
    P3
    In this study, we laid groundwork for studying the role of glucocorticoids and androgens (and eventually, their interactions with peptides) in the behavioral endocrinology of pair bonds in female titi monkeys. In adolescents and adults with asthma and EIB, a single dose of albuterol/budesonide 180/160 µg taken approximately 30 minutes prior to exercise was significantly more effective than placebo in preventing EIB.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows. (Pubmed Central) -  Mar 17, 2022   
    In a previous study, a combination of the long-acting glucocorticoid, triamcinolone acetonide, with a high dose of betamethasone partially normalized the placentomal gene expression during parturition; however, the incidence of retained fetal membrane remained high...Macrophage infiltration in the placentome is known to participate in the detachment of the fetal membrane from the caruncle. Thus, this study raised the possibility that immune cells migrating into the caruncles at parturition may act as a source of ligands that activate interferon signaling.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Crocin attenuates inflammation of lung tissue in ovalbumin-sensitized mice by altering the expression of endoplasmic reticulum stress markers. (Pubmed Central) -  Mar 17, 2022   
    Mice were divided into six groups (n = 5 per group) including control, OVA-sensitized (OVA), OVA-treated crocin (OVA-Cr25, OVA-Cr50, and OVA-Cr100 mg/kg), and OVA-treated dexamethasone (1 mg/kg), (OVA-Dexa) groups...Interestingly, in the OVA-Cr100 group, the suppressive effects on ER stress apoptotic markers were comparable to the OVA-Dexa group. The results suggest that crocin mediates maladaptive ER stress conditions possibly by creating adaptive ER stress status and driving protein folding correctly.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  Stress associated ovarian dysfunctions in a seasonal breeder, Funambulus pennanti: Role of glucocorticoids and possible amelioration by melatonin. (Pubmed Central) -  Mar 17, 2022   
    To elaborate the mechanism(s) involved in stress induced glucocorticoid mediated oxidative damages to the ovary we extended our study by exposing ovaries in vitro to the synthetic glucocorticoid dexamethasone (200 μM)...Therefore, it can be suggested that physical restraint induced glucocorticoid and its receptor activation interfered with the ovarian antioxidant defense mechanism. Melatonin via its receptor MT1 significantly alleviated ovarian damages acting as a cytoprotective agent.
  • ||||||||||  Ninlaro (ixazomib) / Takeda
    Trial completion date, Trial primary completion date:  Trial of Combination of Ixazomib and Lenalidomide and Dexamethasone in Smoldering Multiple Myeloma (clinicaltrials.gov) -  Mar 17, 2022   
    P2,  N=55, Active, not recruiting, 
    Therefore, it seems that tadalafil therapy with dexamethasone did not improve PD compared to verapamil. Trial completion date: Apr 2024 --> Jan 2025 | Trial primary completion date: Apr 2022 --> Jan 2025
  • ||||||||||  dexamethasone / Generic mfg.
    Targeting adipose tissue macrophages ameliorates hepatic injury in a murine model of NAFLD (Poster Area) -  Mar 16, 2022 - Abstract #EASLILC2022EASL_ILC_1644;    
    In vitro modulation of human ATMs by dextran nanocarriers reduce activated phenotype of HSCs. These results demonstrate that modulating the pro-inflammatory phenotype of ATMs might be a good strategy to reduce hepatic fibrosis and inflammation in NAFLD.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Review, Journal:  Signals were broadly positive for months, but never definitive: the tocilizumab story. (Pubmed Central) -  Mar 16, 2022   
    It is key that the effect size is somewhat large (RR > 2), all sources of bias are properly accounted for, and the direct evidence is weighted against these factors. It appears to us that for tocilizumab, not having dismissed the results of carefully designed and analysed observational studies in 2020 could have prevented many deaths over those months.
  • ||||||||||  Ninlaro (ixazomib) / Takeda
    Trial completion date, Trial primary completion date, Combination therapy:  Ixazomib With Pomalidomide, Clarithromycin and Dexamethasone in Treating Patients With Multiple Myeloma (clinicaltrials.gov) -  Mar 16, 2022   
    P1/2,  N=30, Active, not recruiting, 
    Therefore, otolaryngologists performing PITA may not necessarily need to administer dexamethasone in children before surgery. Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jan 2022 --> Sep 2022
  • ||||||||||  Korlym (mifepristone) / Corcept Therap
    Enrollment closed, Trial primary completion date, Metastases:  Abraxane (clinicaltrials.gov) -  Mar 16, 2022   
    P2,  N=64, Active, not recruiting, 
    Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jan 2022 --> Sep 2022 Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2022 --> Aug 2021