Glucocorticoid Receptor 

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  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    DO HIGH-DOSE STEROIDS HAVE BETTER OUTCOMES IN COVID-19 PATIENTS? ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1161;    
    The low dose category was defined as equal to or less than dexamethasone 6 mg/day intravenous or methylprednisolone 120 mg/day intravenous per day dosing in one or divided doses... There is no benefit from using high dose corticosteroids in any disease category of patients than the current recommended dose of 6 mg/day dexamethasone for 10 days duration.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    A RARE INFECTION FOLLOWING COVID-19 PNEUMONIA TREATMENT ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1117;    
    Although our patient had no such exposures, the use of steroids may suppress T-cell function. Additionally, COVID 19 infection has been postulated to cause direct T-cell immune dysfunction thus highlighting the importance of continued vigilance for secondary infections following COVID 19 infection and treatment.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    CORTICOSTEROID TREATMENT RESPONSE IN HOSPITALIZED COVID-19 PATIENTS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1108;    
    Steroid treatment was associated with a significant reduction in CRP; however, its use did not affect PCI. Steroid response was not impacted by use of remdesivir while augmented with tocilizumab.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Spikevax (elasomeran) / Moderna, Takeda
    EVALUATION OF THERAPEUTIC CLINICAL TRIALS INVOLVING GERIATRIC PATIENTS FOR COVID-19 ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1037;    
    More data is needed from randomized clinical trials on the safety and efficacy of therapeutic interventions for COVID-19 in geriatric patients. Based on current data, vaccine use should continue to be encouraged in adults 65 years and older.
  • ||||||||||  dexamethasone / Generic mfg.
    DIABETES INSIPIDUS IN A CRITICALLY ILL POSTPARTUM COVID PATIENT ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1019;    
    She was started on dexamethasone and remdesivir with increasing oxygen requirements, first requiring intubation and then cannulation for venovenous extracorporeal membrane oxygenation (VV-ECMO)...She was treated with intravenous desmopressin, with a post-desmopressin urine osmolality of 397 mOsm/kg, suggesting an appropriate response and thus ruling out nephrogenic DI...Similarly, reports exist of central DI following discontinuation of vasopressin for shock or associated with HELLP or Sheehan syndromes—none of which apply to this patient. This remains the first instance we can find of postpartum central DI in COVID infection.
  • ||||||||||  dobutamine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    ACUTE FULMINANT MYOCARDITIS ASSOCIATED WITH COVID-19 MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1001;    
    Given concern for cardiogenic shock, he was started on dobutamine...After consultation with infectious disease, methylprednisolone and intravenous immunoglobulin were started for possible MIS-A...Diagnosis is based on EKG and cardiac biomarkers and when there is low likelihood of acute coronary syndrome. We emphasize the importance of multidisciplinary care and early recognition of the syndrome and order antibody testing.
  • ||||||||||  dexamethasone / Generic mfg.
    SUCCESSFUL MANAGEMENT OF NOSOCOMIAL OUTBREAK OF SARS-COV-2 AMONG CHRONICALLY VENTILATED CHILDREN ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_997;    
    Early diagnosis based on clinical suspicion, rapid treatment, and a structured approach for containment were key to successful outcomes. This approach could further be extrapolated for use at other institutions for similar viral outbreaks among chronically mechanically ventilated children.
  • ||||||||||  dexamethasone / Generic mfg.
    EHRLICHIOSIS? CHECK FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_961;    
    Doxycycline was started empirically...Treatment was initiated with dexamethasone, etoposide...Given the high mortality rate with HLH, it is imperative to recognize and treat HLH early in Ehrlichiosis. We suggest checking screening ferritin level in suspected cases of Ehrlichiosis would help in early recognition and initiation of treatment HLH.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME AND COVID-19: A CLINICAL CONUNDRUM ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_956;    
    She was given high dose IV methylprednisolone, rituximab, was given 2 doses of IVIG and underwent 5 sessions of plasma exchange...Management involves a combination of anticoagulation, corticosteroids, plasma exchange, cyclophosphamide, and IVIG...Data suggests that patients treated with anticoagulation plus corticosteroids in addition to plasma exchange or IVIG have a survival rate of 70%. Due to the uncommon nature and variable clinical presentation of this disease, high index of suspicion and initiation of aggressive therapy is warranted.
  • ||||||||||  dexamethasone / Generic mfg.
    Enrollment change, Trial completion date, Trial suspension, Combination therapy:  Iontophoresis With Dexamethasone and Physical Therapy to Treat Apophysitis of the Knee in Pediatrics (clinicaltrials.gov) -  Mar 23, 2022   
    P2,  N=46, Suspended, 
    Due to the uncommon nature and variable clinical presentation of this disease, high index of suspicion and initiation of aggressive therapy is warranted. N=147 --> 46 | Trial completion date: Aug 2022 --> Mar 2022 | Recruiting --> Suspended
  • ||||||||||  Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
    Real-World Safety and Effectiveness of Fluticasone Furoate/Vilanterol in Patients with Asthma or Chronic Obstructive Pulmonary Disease: A Post-Marketing Study in Korea (Area G, Hall F (North Building, Exhibition Level), Moscone Center) -  Mar 23, 2022 - Abstract #ATS2022ATS_7206;    
    The reasons for the exclusion of this population and the collected safety data will be fully disclosed by posting a clinical research report on the public register.Research funding source: Funded by GSK (GSK sponsored study 207435).Abstract: (word count 339/400)Disclosures: Eun-Yeong Cho is an employee and shareholder, and Jung-Eun Cho an employee, of GlaxoSmithKline. Seung-Hun Jang and Ki-Eun Hwang declare no relevant conflict of interests1)210 patients were excluded under the Post-Marketing Surveillance Act in Korea.
  • ||||||||||  Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva, Stiolto Respimat (olodaterol/tiotropium FDC) / Boehringer Ingelheim
    The Effect of Inhaled Corticosteroid Withdrawal on Inflammation and the Airway Microbiome in COPD: The INCOGNITO Trial (Room 3001/3003 (West Building, Level 3), Moscone Center) -  Mar 23, 2022 - Abstract #ATS2022ATS_6748;    
    ICS withdrawal did not alter the airway bacterial load but did change the composition of the microbiome. ICS withdrawal altered the exacerbation endotype with a reduction in more severe, bacterial associated exacerbations.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Trial completion date, Trial primary completion date, Combination therapy:  Isatuximab in Combination With Novel Agents in RRMM - Master Protocol (clinicaltrials.gov) -  Mar 23, 2022   
    P1/2,  N=66, Recruiting, 
    N=120 --> 40 | Active, not recruiting --> Terminated | Trial primary completion date: May 2022 --> Nov 2021; Lack of Clinical Benefit Trial completion date: Feb 2026 --> Sep 2026 | Trial primary completion date: Feb 2026 --> Sep 2026
  • ||||||||||  hydrocortisone / Generic mfg.
    Trial completion date, Trial primary completion date:  CareOnTIME: Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (clinicaltrials.gov) -  Mar 22, 2022   
    P4,  N=150, Recruiting, 
    Recruiting --> Active, not recruiting Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  clobetasol propionate topical / Generic mfg., triamcinolone acetonide topical / Generic mfg.
    Successful Treatment of Hypopigmented Mycosis Fungoides in a Pediatric Patient with Excimer Laser () -  Mar 21, 2022 - Abstract #AAD2022AAD_2661;    
    While full body phototherapy has been used to treat MF in the past, this more targeted approach has demonstrated efficacy in our patient and in reported cases in the literature while being a safer option well suited for a pediatric patient. This case highlights the utility of excimer laser in the treatment of pediatric cases of hypopigmented mycosis fungoides.
  • ||||||||||  sirolimus / Generic mfg.
    ASIA Syndrome following deoxycholic acid injection (Poster Presentation Center 2) -  Mar 21, 2022 - Abstract #AAD2022AAD_2436;    
    She continues to follow longitudinally and was recently initiated on mycophenolate mofetil...Historically management of ASIA syndrome was guided by explantation of extraneous substances from the body; however, recent data suggests a role for immunomodulatory and immunosuppressive therapy, including corticosteroids and calcineurin inhibitors. In light of the epidemic of illicit cosmetic procedures, sometimes utilizing counterfeit or contaminated products, dermatologists should educate patients about how to identify appropriate product, technique and practitioners.
  • ||||||||||  prednisone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Melanophages Save the Day: A Case of Generalized Bullous Fixed Drug Eruption (Poster Presentation Center 2) -  Mar 21, 2022 - Abstract #AAD2022AAD_2139;    
    In our patient, we treated aggressively and cautiously with IV methylprednisolone followed by oral prednisone with no disease progression and eventual complete resolution. The clinical findings suggestive of FDE along with dermal melanophages and eosinophils allowed a cautious but confident diagnosis of GBFDE without need for transferring our patient to a burn unit.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    New trial:  Changes After Suprachoroidal Injection. (clinicaltrials.gov) -  Mar 21, 2022   
    P=N/A,  N=30, Recruiting, 
  • ||||||||||  sirolimus / Generic mfg.
    Trial initiation date:  Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease (clinicaltrials.gov) -  Mar 21, 2022   
    P2,  N=60, Not yet recruiting, 
    This case demonstrates how rapid clinical diagnosis of KHE and prompt workup may improve patient outcomes and avoid this life-threatening complication. Initiation date: Jan 2022 --> Jan 2023
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Enrollment closed, Trial primary completion date, Surgery:  STRESS: STeroids to REduce Systemic Inflammation After Infant Heart Surgery (clinicaltrials.gov) -  Mar 21, 2022   
    P3,  N=1200, Active, not recruiting, 
    Initiation date: Jan 2022 --> Jan 2023 Recruiting --> Active, not recruiting | Trial primary completion date: Jan 2022 --> May 2022
  • ||||||||||  Stelara (ustekinumab) / J&J
    A Case Of Severe Amicrobial Pustulosis Of The Folds Unresponsive To Ustekinumab Treatment () -  Mar 20, 2022 - Abstract #INDERCOS2022INDERCOS_8;    
    Oral methylprednisolone 40 mg was started...Topical and systemic corticosteroids, oral antibiotics, zinc supplementation, colchicine, hydroxychloroquine, dapsone, cyclosporine, and methotrexate are reported as treatment options in literature...Diagnosing and treating APF is hard since it is rarely encountered in routine practice and treatment methods are mainly anecdotal. Further cases will aid clinicians to find a more suitable treatment protocol in the future.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates. (Pubmed Central) -  Mar 19, 2022   
    In contrast, diabetic animals transplanted with either islets alone or islets in bioscaffolds without DEX microplates were not able to regain glycemic control during basal conditions with overall poor islet function. Taken together, our data show that coating PDMS bioscaffolds with collagen, and enriching them with DEX-microplates, significantly prolongs and enhances islet function and survival.
  • ||||||||||  dexamethasone / Generic mfg., tamoxifen / Generic mfg.
    Journal:  HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. (Pubmed Central) -  Mar 19, 2022   
    Taken together, our data show that coating PDMS bioscaffolds with collagen, and enriching them with DEX-microplates, significantly prolongs and enhances islet function and survival. In summary, our study identifies HAND2 as a novel obesity-linked adipocyte transcription factor, highlighting new mechanisms of GR-dependent adipogenesis in humans and mice.