Glucocorticoid Receptor 

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  • ||||||||||  Journal:  Aseptic pyomyositis in rheumatoid arthritis treated with corticosteroid and DMARDs. (Pubmed Central) -  Jun 11, 2024   
    The diagnosis was made as rheumatoid arthritis with autoimmune pyomyositis, and the patient was treated with oral prednisolone 1mg/kg body weight in tapering dose, cs DMARDS, (methotrexate 25 mg once a week, and leflunomide 20mg daily hydroxychloroquine 200 mg daily orally) and another supportive treatment along with surgical drainage of pus was done. There was complete resolution of the initial lesion and remission of the primary disease in 3 months.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  Total Alkaloids of Sophora alopecuroides Linn. Attenuates Rheumatoid Arthritis Through Regulating Follicular Helper T Cells. (Pubmed Central) -  Jun 11, 2024   
    Between days 15 and 45 following the first immunization, the mice were treated intraperitoneally with saline, TASA (100, 50, and 25 mg/kg), and dexamethasone (DXM) for 30 days...Total alkaloids of Sophora alopecuroides Linn. may down-regulate the frequency and function of Tfh cells and inhibit GCB cells via TLRs/NF-?B signal pathway to relieve the immune-pathological progression of CIA mice.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Outcomes following cochlear implantation with eluting electrodes: A systematic review. (Pubmed Central) -  Jun 10, 2024   
    Eluting electrodes included dexamethasone (16 studies), aracytine (1 study), nicotinamide adenine dinucleotide (1 study), the growth factors insulin-like growth factor 1 (IGF1) and hepatocyte growth factor (HGF) (1 study), and neurotrophin-3 (1 study)...Eluting electrodes have shown promise in animal studies in preserving residual hearing following cochlear implantation and in reducing impedance, though data from human studies remain lacking. Further in-human studies will be required to determine the clinical usefulness of drug-eluting cochlear implants as a future treatment for sensorineural hearing loss.
  • ||||||||||  zoledronic acid / Generic mfg.
    Review, Journal:  Posterior scleritis following a single infusion of zoledronate for osteoporosis: A case report and literature review. (Pubmed Central) -  Jun 10, 2024   
    Treatment with methylprednisolone 80?mg intravenous infusion twice daily led to gradual symptom improvement and eventual resolution of inflammation. This report, based on a review of relevant literature, investigates the treatment and outcomes of zoledronic acid-induced scleritis, emphasizing the importance for clinicians to promptly identify and manage this rare and serious ocular adverse reaction.
  • ||||||||||  Rituxan (rituximab) / Roche
    Journal:  Rituximab Therapy for Double Seronegative Neuromyelitis Optica Spectrum Disease. (Pubmed Central) -  Jun 10, 2024   
    Non-steroid treatments include azathioprine, mycophenolate mofetil, and rituximab...Rituximab targets the CD20 antigen in B cells and is thought to reduce the risk of relapse and the severity of NMOSD. The patient's Barthel index score, expanded disability status scale score, and motor examination improved after two cycles of rituximab.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Diagnosis and management of secondary adrenal crisis. (Pubmed Central) -  Jun 8, 2024   
    In diagnosed patients, preventive education in sick-day rules adjustment of glucocorticoid replacement and hydrocortisone parenteral self-administration must be performed repeatedly by trained health care providers. Strategies to improve the adequate preventive education in patients at risk for secondary AI should be promoted in collaboration with various medical specialist societies and patients support associations.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  What is the materno-fetal prognosis of adrenal insufficiency and pregnancy in low-resource setting? a case report. (Pubmed Central) -  Jun 7, 2024   
    Treatment consisted to an obstetrical and endocrinological follow-up and corticosteroid replacement therapy with hydrocortisone...Through this case, the authors discuss the therapeutic and prognostic aspects of adrenal insufficiency in our setting. With the introduction of gluco-corticosteroid replacement therapy, pregnancy in adrenal insufficiency can progress normally.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Anti-CASPR2 Antibody-Associated Syndrome Presenting With Episodic Ataxia. (Pubmed Central) -  Jun 7, 2024   
    In conclusion, the neurological manifestations that led to the diagnosis of anti-CASPR2 antibody-associated syndrome were intermittent self-limiting episodes of ataxia, often triggered by concurrent stress-inducing factors. This case supports the aim of other authors to add paroxysmal cerebellar ataxia to the spectrum of the anti-CASPR2 antibody syndrome.
  • ||||||||||  Opdivo (nivolumab) / BMS, Rituxan (rituximab) / Roche
    Enrollment open, Enrollment change:  Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma (clinicaltrials.gov) -  Jun 6, 2024   
    P1,  N=47, Recruiting, 
    This case supports the aim of other authors to add paroxysmal cerebellar ataxia to the spectrum of the anti-CASPR2 antibody syndrome. Suspended --> Recruiting | N=32 --> 47
  • ||||||||||  Padcev (enfortumab vedotin-ejfv) / Astellas, Pfizer
    Journal, Adverse events:  Enfortumab Vedotin Drug Eruption: Cutaneous Adverse Events and Histopathologic Findings. (Pubmed Central) -  Jun 6, 2024   
    The histologic findings of EV associated skin eruptions can aid in correctly identifying the culprit drug and assist in management. This case provides insights for dermatologists by highlighting the common cutaneous side effects of EV and the associated histologic findings as this targeted therapy becomes increasingly utilized in the treatment of refractory neoplasms.
  • ||||||||||  Sylvant (siltuximab) / Jazz
    Journal:  Idiopathic multicentric Castleman disease and connective tissue disorder successfully treated by siltuximab: a pediatric case report. (Pubmed Central) -  Jun 6, 2024   
    A male pediatric patient was diagnosed with CTD in October 2019 and had been receiving regular treatment with tocilizumab and glucocorticoid or methotrexate since April 2020...He received 4 doses of rituximab and then a combination of thalidomide and dexamethasone for about 1 year...We reported a pediatric case diagnosed as CTD and iMCD, whose inflammation finally be well controlled by siltuximab. Hopefully, our work will add insight into such rare situations and it is undoubtedly that the pathophysiological mechanism of CD and CTD coexistence and prediction models of treatment response remains to be explored to facilitate the clinical management and optimal treatment.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Optimal management of radiation pneumonitis: Findings of an international Delphi consensus study. (Pubmed Central) -  Jun 5, 2024   
    Hopefully, our work will add insight into such rare situations and it is undoubtedly that the pathophysiological mechanism of CD and CTD coexistence and prediction models of treatment response remains to be explored to facilitate the clinical management and optimal treatment. This Delphi study achieved consensus recommendations and provides practical guidance on diagnosis and management of RP.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Transient Bacillary Layer Detachment During the Disease Course of Primary Vitreoretinal Lymphoma. (Pubmed Central) -  Jun 5, 2024   
    A 50?year-old woman was referred to us with a 2-month history of vitritis in both eyes, poorly responding to oral prednisolone...During the disease course, optical coherence tomography of the macula showed a BALAD in the right eye, which resolved during follow-up. Our case indicates that BALAD is a possible rare manifestation of PVRL, and this should be considered in the differential diagnosis process in order to avoid diagnostic delays.
  • ||||||||||  prednisolone / Generic mfg., methotrexate / Generic mfg.
    Journal, FDG PET:  A Case of Large Vessel Giant Cell Arteritis Presenting With Cough and Diagnosed Using an FDG-PET Scan. (Pubmed Central) -  Jun 5, 2024   
    This case exemplifies the unusual manifestation of LV-GCA and verifies that recurring symptoms may differ from the original presentation. While dry cough is not commonly listed as a symptom of LV-GCA, it can be present as a manifestation or the sole presentation in certain patients, particularly when inflammatory markers are consistently high and there is no pulmonary disease.
  • ||||||||||  pregabalin / Generic mfg., epinephrine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  A Novel Approach in Treating Phantom Limb Pain Using Erector Spinae Plane Block. (Pubmed Central) -  Jun 5, 2024   
    In literature, ESP block has been used as a regional technique for shoulder disarticulation surgery and other neuropathic pain conditions, but no account has shown its use for PLP treatment. The procedure was successfully done to alleviate the upper extremity phantom limb pain, significantly reduce analgesic requirements, and improve tolerance of physical therapy and overall quality of life.