Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg., olanzapine / Generic mfg.
    Journal, HEOR, CINV:  Cost-effectiveness of palonosetron and dexamethasone-based triple and quadruple regimens in preventing highly emetogenic chemotherapy-induced nausea and vomiting. (Pubmed Central) -  Apr 2, 2022   
    In term of rate of absence of nausea, the PAL + NK-1-RA + DEX + OLA was associated with the highest rate of absence of nausea among all the treatment regimens at base case ICERs of $2,291 versus PAL + DEX, $1,304 versus NK-1-RA + PAL + DEX, $2,657 versus OLA + PAL + DEX. from an economic perspective, our study revealed that whether to use overall CR or/and rate of absence of nausea as determinants in the antiemetic decision for the CINV patients, the CR-based-, and rate of absence of nausea-based cost-effectiveness analyses, showed negotiable ICER estimates for the treatment PAL + NK-1-RA + DEX + OLA over the combinations PAL + DEX, NK-1-RA + PAL + DEX, and OLA + PAL + DEX regimens.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Journal:  Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis. (Pubmed Central) -  Apr 2, 2022   
    from an economic perspective, our study revealed that whether to use overall CR or/and rate of absence of nausea as determinants in the antiemetic decision for the CINV patients, the CR-based-, and rate of absence of nausea-based cost-effectiveness analyses, showed negotiable ICER estimates for the treatment PAL + NK-1-RA + DEX + OLA over the combinations PAL + DEX, NK-1-RA + PAL + DEX, and OLA + PAL + DEX regimens. No abstract available
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  SFTPB regulates PTGS2 and inflammation in chronic obstructive pulmonary disease. (Pubmed Central) -  Apr 1, 2022   
    A549 cells were induced using 10% cigarette smoke extract (CSE) and treated with dexamethasone to investigate the effect of inflammation on SFTPB expression, and the effect of SFTPB overexpression and silencing on inflammatory cytokines was measured using real-time PCR and enzyme-linked immunosorbent assay...SFTPB levels were significantly reduced in the lung tissue of a mouse model of COPD compared to controls. Reduced SFTPB levels may induce PTGS2 and inflammatory responses in COPD and could be a key protein for evaluation of COPD progression.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Influence of Secretome of Different Functional Phenotypes of Macrophages on Proliferation, Differentiation, and Collagen-Producing Activity of Dermal Fibroblasts In Vitro. (Pubmed Central) -  Apr 1, 2022   
    We studied the effect of conditioned media of GM-CSF-differentiated human macrophages polarized in M1(LPS), M2a(IL-4), M2c(dexamethasone), and M2(low serum) phenotypes on proliferation, differentiation, and collagen-producing activity of dermal fibroblasts...On the contrary, M2(low serum) generated under conditions of growth factors deficiency had a pronounced stimulating effect on the differentiation of fibroblasts and production of type I collagen by these cells, but moderately stimulated the fibroblast proliferation. Thus, the secretory activity of various functional phenotypes of macrophages is an important mechanism of fibrogenesis regulation.
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Review, Journal:  2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde. (Pubmed Central) -  Apr 1, 2022   
    In this paper, experts from the European Myeloma Network describe current biological and clinical knowledge on SMM, focusing on novel insights into its molecular pathogenesis, new prognostic scoring systems proposed to identify SMM patients at higher risk of early transformation, and updated results of completed or ongoing clinical trials. Finally, some practical recommendations for the real-life management of these patients, based on Delphi consensus methodology, are provided.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Trial primary completion date:  Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography (clinicaltrials.gov) -  Apr 1, 2022   
    P=N/A,  N=10, Recruiting, 
    Finally, some practical recommendations for the real-life management of these patients, based on Delphi consensus methodology, are provided. Trial completion date: Jun 2021 --> Nov 2023 | Trial primary completion date: Jun 2021 --> Nov 2022
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Trial completion date, Trial primary completion date, Combination therapy:  SAR650984 (Isatuximab), Lenalidomide, and Dexamethasone in Combination in RRMM Patients (clinicaltrials.gov) -  Apr 1, 2022   
    P1b,  N=60, Active, not recruiting, 
    Trial completion date: Jun 2021 --> Nov 2023 | Trial primary completion date: Jun 2021 --> Nov 2022 Trial completion date: Jun 2022 --> Dec 2022 | Trial primary completion date: Jun 2022 --> Dec 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Induction of parturition in horses - from physiological pathways to clinical applications. (Pubmed Central) -  Apr 1, 2022   
    Repeated daily dexamethasone treatment in late gestation results in birth of mature foals but the time from initiation of treatment to foaling is highly variable and complications such as dystocia have been reported...Mares selected on clinical criteria receive 1 dose of 2.5 to 3.5 IU of oxytocin. Mares not responding to oxytocin are judged not yet ready for foaling and treatment is repeated the earliest after 24 h. This protocol at present is the most reliable and safest way to induce parturition in mares.
  • ||||||||||  ketamine / Generic mfg., alprazolam / Generic mfg., amphetamine / Generic mfg.
    Journal:  Wastewater analysis for psychoactive substances at music festivals across New South Wales, Australia in 2019-2020. (Pubmed Central) -  Apr 1, 2022   
    Amphetamine, cocaine, ketamine, methylone, MDMA, MDA, alprazolam, diazepam, etizolam, oxazepam and temazepam were found in almost all samples from all festivals...A norfentanyl (a fentanyl metabolite) and n-ethylpentylone were found at 2/6 and 1/6 festivals...The detection of highly toxic substances such as N-ethylpentylone and norfentanyl may warrant public health alerts. If provided close to real time, wastewater analysis at festivals could be complemented with information sources such as drug checking, on-site surveys, medical presentations and intelligence from peer networks to feed into early warning systems, public health alerts and peer-based harm reduction education during the festival season.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Journal:  Effects of dexamethasone on catheter-related bladder discomfort and emergence agitation: A prospective, randomized, and controlled trial. (Pubmed Central) -  Apr 1, 2022   
    Before induction of anesthesia, the dexamethasone group received 10 mg (2 ml) of dexamethasone intravenously, while the control group received 2 ml of saline in the same manner...The incidence and severity of EA in the operating room and PACU also showed no difference between the groups. Dexamethasone (10 mg) administered before induction of anesthesia did not further reduce the incidence or severity of CRBD or EA in patients undergoing urological surgery.
  • ||||||||||  budesonide/salbutamol (PT027) / AstraZeneca, Avillion
    Preclinical, Journal:  In-vitro in-vivo correlation (IVIVC) of inhaled products using Twin Stage Impinger. (Pubmed Central) -  Apr 1, 2022   
    The design, with optimum drug deposition, was adopted for the dissolution study of budesonide and salbutamol...The similarity factors for PBS and PB were 47.6 and 69.7, respectively, using SLF as a reference, whereas the similarity factor for salbutamol dissolution between PB and SLF was 81.3, suggesting PB is a suitable substitute. Comparison using both the predicted and actual in vivo pharmacokinetics (PK) values of the two drugs, as well as the pattern of their Concentration-Time (c-t) profiles, showed good similarity, which gave an indication of the validity of this in vitro dissolution method.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat. (Pubmed Central) -  Apr 1, 2022   
    The synthetic GC dexamethasone (DEX) did not significantly affect the magnitude of depressor responses but increased BRS and impaired the effect of IC stimulation on the BR. The results obtained confirm the hypothesis put forward and suggest that GC can attenuate the inhibitory effects of the IC on the BR arc, thereby enhancing the sensitivity of the BR.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Review, Journal:  Anesthesia in Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Apr 1, 2022   
    Liposomal bupivacaine is comparable with non-liposomal local anesthetic agents with respect to pain relief, the opioid-sparing effect, and adverse effects in the first 48 hours after total shoulder arthroplasty. Perioperative dexamethasone administration improves postoperative pain control, decreases perioperative opioid requirements, and reduces postoperative nausea.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity. (Pubmed Central) -  Apr 1, 2022   
    Triamcinolone acetonide was added either directly or by encapsulating within the poly(lactic-co-glycolic acid) nanoparticles...Finally, the drug loaded hydrogel patches were demonstrated antifungal activity against Aspergillus fumigatus and Aspergillus flavus. These results provide that the novel modified kappa-carrageenan and pectin based buccal delivery system has promising antifungal property, and could have advantages compared to conventional buccal delivery systems.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. (Pubmed Central) -  Apr 1, 2022   
    Dexamethasone (Dex) is a widely used anti-inflammatory corticosteroid medication that is structurally similar to cholesterol, a key component of LNPs...Reduction of inflammation using this strategy improved in vivo mRNA expression in mice by 1.5-fold. Thus, we envision that our Dex-incorporated LNPs could potentially be used to broadly to reduce the inflammatory responses of LNPs and enhance protein expression of a range of mRNA therapeutics.
  • ||||||||||  dimethyl fumarate / Generic mfg.
    Journal:  A patient with multiple sclerosis who developed bilateral optic neuritis and central trigeminal myelin lesion (Pubmed Central) -  Apr 1, 2022   
    After intravenous methylprednisolone pulse therapy, her visual impairment and facial sensory disturbance gradually improved...This patient showed a high T signal at the trigeminal nerve 3 mm from the pons on MRI, suggesting the involvement of a central trigeminal myelin lesion. Findings of a central trigeminal myelin lesion on MRI may aid in differentiating between MS and seronegative neuromyelitis optica spectrum disorder.
  • ||||||||||  hydrocortisone / Generic mfg.
    Preclinical, Journal:  H NMR serum metabolomics and its endogenous network pharmacological analysis of gushudan on kidney-yang-deficiency-syndrome rats. (Pubmed Central) -  Apr 1, 2022   
    Firstly, the KYDS rat model was achieved by hydrocortisone induction, and the efficacy of GSD on KYDS model rats was assessed by the pharmacodynamic indicators...In addition, the potential biomarkers-targets-pathways-disease metabolic network was further investigated for deeper understanding the preventive effects of GSD on KYDS rats and its mechanism, which was further obtained for the important targets related to biomarkers and diseases such as NOS3, PTGS2 and CXCL8, and important metabolic pathways such as glyoxylate and dicarboxylate metabolism, arginine and proline metabolism, and microbial metabolism in diverse environments. Finally, compared with our previous anti-osteoporosis study of GSD, it suggested that some similar metabolic pathways, which would provide some scientific reference of the existence of the kidney-bone axis under the traditional Chinese medicine (TCM) theory of "kidney dominates bone".
  • ||||||||||  hydrocortisone / Generic mfg.
    Retrospective data, Journal, HEOR:  The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment. (Pubmed Central) -  Apr 1, 2022   
    Replacement of hydrocortisone was commonly associated both in young and middle-aged group (P =0.04), and in older group (P =0.02)...In older patients, arthropathy and higher BMI were associated with poor QoL. These suggest the importance of early diagnosis and appropriate treatment in preventing arthropathy in acromegaly.
  • ||||||||||  fluticasone propionate controlled release (EP-104) / Eupraxia Pharma
    Trial completion date, Trial primary completion date:  Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee (clinicaltrials.gov) -  Apr 1, 2022   
    P2,  N=300, Recruiting, 
    This study confirmed that T-CD90@NP promoted chondrocyte proliferation and anti-inflammation, improving the effects of a clinical glucocorticoid treatment plan. Trial completion date: Oct 2022 --> Mar 2023 | Trial primary completion date: Oct 2022 --> Mar 2023
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Journal:  Comparison of ultrasound guided pulsed radiofrequency of genicular nerve with local anesthetic and steroid block for management of osteoarthritis knee pain. (Pubmed Central) -  Apr 1, 2022   
    Thirty patients with OA knee were randomly allocated to receive either ultrasound-guided PRF of the genicular nerve (PRF group) or nerve block with bupivacaine and methylprednisolone acetate (local anesthetic steroid [LAS] group)...Both ultrasound-guided PRF of the genicular nerve and blocks of genicular nerve with local anesthetic and a steroid provided comparable pain relief without any complications. However, PRF of the genicular nerve is a procedure that takes much more time and equipment than the genicular nerve block.