Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Retrospective data, Journal:  Description and Early Results of the Kaiser Permanente Southern California COVID-19 Home Monitoring Program. (Pubmed Central) -  Apr 5, 2022   
    Initial data suggest it can serve as an alternative to hospitalization, decreasing hospital length of stay when patients receive therapies in the ambulatory setting otherwise reserved for the hospital. Initial results of this Home Monitoring program appear to be promising, and a longer term prospective study is warranted.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Very late intubation in COVID-19 patients: a forgotten prognosis factor? (Pubmed Central) -  Apr 5, 2022   
    Description of all consecutive critically ill COVID 19 patients hospitalized in ICU in University Hospital of Guadeloupe and outcome according to delay between steroid therapy initiation and mechanical ventilation onset. Very late mechanical ventilation defined as intubation after day 7 of dexamethasone therapy was associated with grim prognosis and a high mortality rate of 87%.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal. (Pubmed Central) -  Apr 5, 2022   
    Group I, control, and group II received methylprednisolone sodium succinate injection preoperatively, group III received hyaluronic acid applied in extraction socket, and group IV received preoperative methylprednisolone sodium succinate injection and topical hyaluronic acid in the socket...There was less pain and analgesic dose reported in group IV than other groups. Combined use of methylprednisolone sodium succinate and hyaluronic acid significantly decrease postoperative complications than using each agent alone.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  One Year Into the Pandemic: Evolving COVID-19 Outcomes in Lung Transplant Recipients, a Single-center Experience. (Pubmed Central) -  Apr 5, 2022   
    The overall 90-d mortality decreased from 34% to 17% from the first cohort to the second (adjusted odds ratio, 0.26; 95% confidence interval, 0.08-0.85; P = 0.026). Although COVID-19-associated mortality rate in lung transplant recipients at our center has decreased over time, COVID-19 continues to be associated with significant morbidity and mortality.
  • ||||||||||  resiniferatoxin (MCP-101) / Sorrento
    Enrollment open, Trial completion date:  Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis (clinicaltrials.gov) -  Apr 5, 2022   
    P2,  N=112, Recruiting, 
    Although COVID-19-associated mortality rate in lung transplant recipients at our center has decreased over time, COVID-19 continues to be associated with significant morbidity and mortality. Not yet recruiting --> Recruiting | Trial completion date: Jan 2023 --> Nov 2023
  • ||||||||||  Jakafi (ruxolitinib) / Novartis, Incyte, BGP-15 - N / Gene, vamorolone (VBP15) / Santhera
    Review, Journal:  Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications. (Pubmed Central) -  Apr 5, 2022   
    In recent years, promising methods for early and confirmatory diagnosis of CIM have been developed, but still need validation. Experimental studies on novel pharmacological interventions show promising results in terms of preventive CIM treatments, but future clinical studies will be needed to study the effectiveness and safety of these drugs.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis. (Pubmed Central) -  Apr 5, 2022   
    Congenital adrenal hyperplasia (CAH) is the most common form of adrenal insufficiency in childhood; it requires cortisol replacement therapy with hydrocortisone (HC, synthetic cortisol) from birth and therapy monitoring for successful treatment...Deterministic simulations of the different cortisol binding/association fractions demonstrated that with higher blood cortisol concentrations, saturation of cortisol binding to CBG was observed, leading to an increase in all other cortisol binding fractions. In conclusion, a mathematical PK model was developed which links DBS measurements to plasma exposure and thus allows for quantitative interpretation of measurements of DBS samples.
  • ||||||||||  fluticasone / Generic mfg.
    Clinical data, Journal:  Technologies for Type 1 Diabetes and Contact Dermatitis: Therapeutic Tools and Clinical Outcomes in a Cohort of Pediatric Patients. (Pubmed Central) -  Apr 5, 2022   
    One patient reported benefit from the off-label use of fluticasone propionate nasal spray...Our study confirms the severity of this dermatological complication that may hinder the spread of new technologies for the management of diabetes. Finally, our findings highlight the importance of establishing close collaboration both with pediatric allergy specialists to prescribe the most suitable treatment and with manufacturing companies to ensure that adhesives of technological devices are free of harmful well-known sensitizers.
  • ||||||||||  zidovudine / Generic mfg., budesonide / Generic mfg.
    Journal:  Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease. (Pubmed Central) -  Apr 5, 2022   
    Both licensed medications, estramustine (DB01196) and quinestrol (DB04575), were found to be similar to Chevalone E, with prediction scores of 0.818 and 0.856, respectively. In addition, cholic acid (DB02659), acitretin (DB00459), and mupirocin (DB00410) are similar to Sterolic acid, zidovudine (DB00495), imipenem (DB01598), and nadolol (DB01203) are similar to Brocazine A, and budesonide (DB01222) and colchicine (DB01394) are related to Brevione K. These findings suggest that these could be feasible dengue virus treatment options, meaning that more research is needed.
  • ||||||||||  Cingal (hyaluronic acid/triamcinolone) / Anika Therap
    Trial completion date, Trial primary completion date:  ECHO: A Prospective Evaluation of the Cingal Injection for Hip Osteoarthritis (clinicaltrials.gov) -  Apr 5, 2022   
    P=N/A,  N=100, Recruiting, 
    In addition, cholic acid (DB02659), acitretin (DB00459), and mupirocin (DB00410) are similar to Sterolic acid, zidovudine (DB00495), imipenem (DB01598), and nadolol (DB01203) are similar to Brocazine A, and budesonide (DB01222) and colchicine (DB01394) are related to Brevione K. These findings suggest that these could be feasible dengue virus treatment options, meaning that more research is needed. Trial completion date: Sep 2022 --> Sep 2023 | Trial primary completion date: Jan 2022 --> Jan 2023
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Enrollment closed, Trial initiation date:  ISABEL: A Trial for Relapsed Multiple Myeloma Patients (Isatuximab-dexamethasone) (clinicaltrials.gov) -  Apr 5, 2022   
    P2,  N=50, Active, not recruiting, 
    Initiation date: Mar 2022 --> Jun 2022 Not yet recruiting --> Active, not recruiting | Initiation date: Dec 2021 --> Mar 2021
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    INDUCIBLE REGULATORY SYNOVIAL MACROPHAGES: A PROOF-OF-CONCEPT STUDY FOR A CELL-BASED TARGETED THERAPY FOR RHEUMATOID ARTHRITIS (Poster Tour Auditorium 5) -  Apr 4, 2022 - Abstract #EULAR2022EULAR_1098;    
    Our findings demonstrate that inflammatory SF cells are indeed able to polarise to regulatory, CD206 + MerTK + macrophages in vitro . The findings provide further mechanistic insights into the basis for the therapeutic benefits of glucocorticoids and TNF inhibitors, as well as providing initial proof-of-concept in the use of regulatory macrophages as a cellular-based therapy or therapeutic target for patients with RA.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Breakthrough infections and predicting severe COVID outcomes during rituximab therapy in autoimmune rheumatic diseases (Auditorium 10) -  Apr 4, 2022 - Abstract #EULAR2022EULAR_915;    
    The high vaccination uptake in our cohort was effective in preventing severe infection despite the termination of national shielding programme in March 2021 and the spread of the Delta and Omicron variants. Individualised risk–benefit assessment should be undertaken in those with comorbidities, low IgG and unvaccinated when scheduling rituximab therapy.
  • ||||||||||  dexamethasone / Generic mfg., mirtazapine / Generic mfg., dronabinol oral / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date, HEOR:  Nutrition and Pharmacological Algorithm for Oncology Patients Study (clinicaltrials.gov) -  Apr 4, 2022   
    P4,  N=1, Terminated, 
    N=30 --> 1 | Trial completion date: Dec 2021 --> Apr 2021 | Recruiting --> Terminated | Trial primary completion date: Dec 2021 --> Apr 2021; The trial was closed after 4 months due to slow to accrual. Only 1 participant was enrolled.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, MetaBlok (lsalt peptide) / Arch Biopartners
    Phase classification, Trial completion date, Trial primary completion date:  CATCO: Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (clinicaltrials.gov) -  Apr 4, 2022   
    P3,  N=2900, Recruiting, 
    Trial completion date: Apr 2022 --> Dec 2022 | Trial primary completion date: Apr 2022 --> Dec 2022 Phase classification: P2 --> P3 | Trial completion date: May 2022 --> May 2024 | Trial primary completion date: Mar 2022 --> Mar 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date:  Erector Spinae Plane Blocks for Adolescent Idiopathic Scoliosis (clinicaltrials.gov) -  Apr 4, 2022   
    P=N/A,  N=24, Enrolling by invitation, 
    Phase classification: P2 --> P3 | Trial completion date: May 2022 --> May 2024 | Trial primary completion date: Mar 2022 --> Mar 2023 Trial completion date: Feb 2022 --> Jun 2022 | Trial primary completion date: Jan 2022 --> May 2022
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Journal:  White Cord Syndrome and Acute Tetraplegia After Posterior Cervical Decompression: A Case Report. (Pubmed Central) -  Apr 2, 2022   
    We diagnosed WCS in our patient through postoperative examination consisting of acute tetraplegia and magnetic resonance imaging revealing increased signal in the cord. In this case, we used intravenous dexamethasone and mean arterial pressure above 90 mm Hg resulting in markedly improved clinical examination.