- |||||||||| Empliciti (elotuzumab) / AbbVie, BMS
Journal: Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma. (Pubmed Central) - Apr 7, 2022
P2
While correlating with serum-free light chains and bone marrow, cfDNA additionally discriminated patients with poor PFS among those with the same response by IMWG criteria. In summary, detectability of MM-derived cfDNA, as a measure of substantial tumor burden with therapy, independently predicts poor PFS and may provide refinement for standard-of-care response parameters to identify patients with poor response to treatment earlier than is currently feasible.
- |||||||||| Arokaris (fosnetupitant) / Helsinn, Otsuka, netupitant (Ro 67-3189) / Helsinn, Otsuka
Clinical, P3 data, Journal: A phase 3 safety study of fosnetupitant as an antiemetic in patients receiving anthracycline and cyclophosphamide: CONSOLE-BC. (Pubmed Central) - Apr 7, 2022
In summary, detectability of MM-derived cfDNA, as a measure of substantial tumor burden with therapy, independently predicts poor PFS and may provide refinement for standard-of-care response parameters to identify patients with poor response to treatment earlier than is currently feasible. FosNTP demonstrated a favorable safety profile with a very low risk of ISRs in the AC/EC setting.
- |||||||||| dexamethasone / Generic mfg.
Retrospective data, Journal: Postoperative CT scans after resection of brain metastases: neurosurgical routine or added value? (Pubmed Central) - Apr 7, 2022
We showed that it is well-tolerated at the dosage schedule that we describe, with no serious adverse effects throughout the study period. Following resection of brain metastases, a routine postoperative CT scan has low diagnostic yield and did not change patient management in any cases examined in this work.
- |||||||||| prednisolone / Generic mfg., doxycycline / Generic mfg.
Journal: Onchocerca lupi in imported dogs in the UK: implications for animal and public health. (Pubmed Central) - Apr 7, 2022
Moreover, the progression of infection can be highly aggressive and recalcitrant to both surgical intervention and anthelminthic treatment. Increasingly, former stray dogs of unknown infection status are entering the UK, raising both veterinary and public health concerns.
- |||||||||| dexamethasone / Generic mfg.
Journal: Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity. (Pubmed Central) - Apr 7, 2022
It was found that the derivatives functionalized with a di-substituted phenyl group at the 2-position of GA generally displayed high antimicrobial activity against Gram-positive bacteria (MIC down to 2.5 μM) and potent anti-inflammatory effects (inhibition of NO production up to 55%, comparable to dexamethasone)...The anti-inflammatory mechanism may involve the inhibition of NF-κB, MAPKs and PI3K/Akt related inflammatory signaling pathways and activation of Nrf2/HO-1 signaling pathway. The results demonstrated that GA-O-02 and GA-O-06 possess great application potential as potent antimicrobial and anti-inflammatory agents.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspring. (Pubmed Central) - Apr 7, 2022
We also confirmed that dexamethasone upregulates the expression of miR-98-3p in vitro and shows targeted inhibition of JAG1/Notch1 signaling, leading to poor osteogenic differentiation of bone marrow mesenchymal stem cells. In conclusion, maternal dexamethasone exposure caused low bone mass in female rat offspring with a multigenerational inheritance effect, the mechanism of which is related to the inhibition of JAG1/Notch1 signaling caused by the continuous upregulation of miR-98-3p expression in bone tissues transmitted by F2 and F3 oocytes.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Glucocorticoid Induces Atrial Arrhythmogenesis via Modification of Ion Channel Gene Expression in Rats. (Pubmed Central) - Apr 7, 2022
To test a hypothesis that one of the stress-induced hormones, glucocorticoid, is involved in the pathogenesis of stress-induced AF, we investigated whether the glucocorticoid could alter the temporal profile of cardiac ion channels gene expression, thereby leading to atrial arrhythmogenesis.Dexamethasone (DEX, 1.0 mg/kg) was injected subcutaneously in Sprague-Dawley rats...Simultaneously, electrophysiological study in isolated perfused hearts showed significantly increased number of repetitive atrial responses induced by single atrial extrastimulus (3.2 ± 2.4 to 26.7 ± 16.4, P = 0.004) with shorting of the refractory period (36.4 ± 4.6 to 27.4 ± 5.5 ms, P = 0.049) after DEX injection.Glucocorticoid immediately modified Kv1.5 and Kir2.2 gene expression at pretranslational levels, thus leading to effective refractory period shortening that could be arrhythmogenic. These results implied that transient glucocorticoid-induced biochemical modification of cardiac ion channels might be one of the mechanisms underlying the stress-induced paroxysmal AF.
- |||||||||| dexamethasone / Generic mfg.
Journal, Cytokine storm: Systematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological analyses. (Pubmed Central) - Apr 7, 2022
BALB/c Mice in each group were first orally administered medicines (0.9% saline solution for the control group, 0.5 mg/kg Dexamethasone, or 1.3, 2.6, 5.2 g/kg QFXYW), after 4 h, the groups were injected LPS (1.0 mg/kg) to induce ALI, then the same medicines were administered repeatedly...The results of RT-PCR, ELISA, and protein chip assay revealed that QFXYW could effectively inhibit ALI via multiple key targets and the cytokine-cytokine signalling pathway. This study showed that QFXYW decreased the number of leukocytes and neutrophils by attenuating inflammatory response, which provides an important basis for the use of QFXYW in the treatment of ALI.
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
Journal: Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients. (Pubmed Central) - Apr 7, 2022
In the logistic regression analysis, SLE vasculitis was independently associated with juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher scores of SLEDAI at disease onset (p<0.05). Juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher SLEDAI scores at disease onset may be associated with the development of vasculitis in SLE patients.
- |||||||||| Ryaltris (olopatadine/mometasone) / Glenmark, Nasonex (mometasone furoate nasal spray) / Merck (MSD)
Enrollment change, Trial withdrawal, Trial primary completion date: Impact of RYALTRIS® Nasal Spray on Patients' Reported Outcomes (clinicaltrials.gov) - Apr 7, 2022
P=N/A, N=0, Withdrawn,
Juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher SLEDAI scores at disease onset may be associated with the development of vasculitis in SLE patients. N=100 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Dec 2021 --> Mar 2022
- |||||||||| Trial completion date, Trial primary completion date: TEIAS: Transforaminal Epidural Injection in Acute Sciatica (clinicaltrials.gov) - Apr 7, 2022
P=N/A, N=142, Recruiting,
N=100 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Dec 2021 --> Mar 2022 Trial completion date: Dec 2020 --> Dec 2024 | Trial primary completion date: Dec 2020 --> Dec 2023
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg., Ninlaro (ixazomib) / Takeda
Clinical, Real-world evidence: Suzanne Fanning, DO, and Joshua Richter, MD, discuss clinical implications of a real-world study of ixazomib, lenalidomide, and dexamethasone compared with lenalidomide and dexamethasone in patients with relapsed/refractory #mmsm. @JoshuaRichterMD https://t.co/Syi7jWY0wD (Twitter) - Apr 7, 2022
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg., azacitidine / Generic mfg.
P1 data, Journal, Combination therapy, Epigenetic controller: DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. (Pubmed Central) - Apr 6, 2022
The median number of prior lines of therapy was 5 (1-11) and 81% (34) were refractory to len and/or pomalidomide (pom)...Two of the len refractory pts achieved longer disease control than with any prior regimen and 1 responded immediately after progression on len, bortezomib, and prednisone...The study demonstrated tolerability of twice a week SC aza at 50 mg/m with len and dex in RRMM and suggested aza may help overcome the len/pom refractory state, possibly by activating differentiation pathways. Relatively low response rates and association of clinical benefit with low plasma levels of the aza inactivating enzyme CDA suggest the aza regimen will need to be optimized further and pt selection may be required to maximize benefit.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: The safety and efficacy of dexamethasone in the perioperative management of glioma patients. (Pubmed Central) - Apr 6, 2022
Combined pre- and postoperative dexamethasone use may increase the risk of postoperative wound infection, and dexamethasone use, specifically preoperative use, may negatively impact survival. These findings highlight the potential for serious negative consequences with dexamethasone use.
- |||||||||| Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
Journal: Indacaterol/Glycopyrronium/Mometasone fixed dose combination for uncontrolled asthma. (Pubmed Central) - Apr 6, 2022
IND/GLY/MF was superior to both IND/MF and salmeterol/fluticasone (SAL/FLU), a well-established LABA/ICS combination improving lung function in uncontrolled asthma. Moreover, IND/GLY/MF, delivered through the Breezhaler inhaler in a single inhalation, is the first inhaled therapy prescribed alongside a digital companion, a sensor and the Propeller app, allowing for improved treatment adherence, reduced rescue inhaler usage and hospitalizations, increased patient satisfaction and asthma control.
- |||||||||| hydrocortisone / Generic mfg.
Clinical, Journal, HEOR: The Impact of Adherence and Therapy Regimens on Quality of Life in Patients with Congenital Adrenal Hyperplasia. (Pubmed Central) - Apr 6, 2022
Moreover, IND/GLY/MF, delivered through the Breezhaler inhaler in a single inhalation, is the first inhaled therapy prescribed alongside a digital companion, a sensor and the Propeller app, allowing for improved treatment adherence, reduced rescue inhaler usage and hospitalizations, increased patient satisfaction and asthma control. A poor adherence rate to therapy regimens, rather than type of glucocorticoid was associated with impaired QoL in adolescents and adults with CAH.
- |||||||||| dexamethasone / Generic mfg.
Clinical, Journal: Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study. (Pubmed Central) - Apr 6, 2022
Adults with asthma who have required two or more courses of oral corticosteroids in the previous 2 years or a hospital admission for asthma before March 1, 2020, are at increased risk of both COVID-19 hospitalisation and ICU admission or death. Patients with a recent asthma attack should be considered a priority group for booster COVID-19 vaccines.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Advantages and drawbacks of dexamethasone in glioblastoma multiforme. (Pubmed Central) - Apr 6, 2022
Unfortunately, steroids are associated with various undesirable side effects, including severe immunosuppression and metabolic changes like hyperglycemia, which may impair the survival of GBM patients. Current ideas and concerns about Dex's effects on GBM cerebral edema, cell proliferation, migration, and its clinical outcomes were investigated in this study.
- |||||||||| Feraheme (ferumoxytol injection) / Covis Pharma
Journal, Adverse events: Analysis of Adverse Events and Intravenous Iron Infusion Formulations in Adults With and Without Prior Infusion Reactions. (Pubmed Central) - Apr 6, 2022
Type of intravenous iron formulation and concurrent administration of diphenhydramine, epinephrine, famotidine, and/or hydrocortisone, used as surrogate maker of infusion reaction...Among 35 737 unique iron infusions (12 237 patients [9480 (77.5%) women; 717 (5.9%) Black; 10 250 (83.7%) White; mean (SD) age of 51 (20) years]), comprising 22 309 iron sucrose doses, 9067 iron dextran total doses (1771 preceded by test dose, 56 test doses alone), 3147 ferumoxytol doses, and 1214 ferric carboxymaltose doses, incidence of adverse events was 3.9% (n = 1389; 95% CI, 3.7%-4.1%)...Among 873 patients with history of infusion reaction who underwent readministration, the majority received the same formulation, which was associated with significantly higher reaction rate particularly if premedication was administered (68% [95% CI, 64%-72%] vs 32% [95% CI, 26%-41%], respectively), compared with those who received an alternate formulation (21% [95% CI, 11%-35%] vs 5% [95% CI, 2%-12%], respectively) (P < .001). These data, and the preponderance of published evidence, suggest that intravenous iron is generally well tolerated with exceedingly low risk of severe reaction, use of premedication and test doses are unnecessary, and that optimal prevention and management of infusion-related reactions warrant further study.
- |||||||||| dexamethasone / Generic mfg.
Journal: Nausea and vomiting in end-of-life care: managing this debilitating symptom in the community. (Pubmed Central) - Apr 6, 2022
Conversely, careful consideration of the use of dexamethasone for the management of N&V in EOLC should be taken, due to known side effects (Ferrel and Paice, 2019). This case study will use a systematic approach to critically appraise the management of N&V, experienced by a community patient receiving EOLC from the district nurses.
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