Glucocorticoid Receptor 

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  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Renal Medullary Angiitis Associated with Cutaneous Leukocytoclastic Vasculitis: A Case Report. (Pubmed Central) -  Jun 16, 2024   
    An immunofluorescence analysis was negative, and electron microscopy revealed no immune-dense deposits, ruling out immunoglobulin A vasculitis. Intravenous methylprednisolone for three days and plasma exchange followed by oral prednisolone improved his general condition.
  • ||||||||||  pantoprazole / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Sinus Node Dysfunction Triggered by Tonsillar Abscess: Effects of Vagal Nerve Compression. (Pubmed Central) -  Jun 16, 2024   
    Clinicians must remain vigilant for such extrinsic causes, particularly in patients with chronic sore throat and cardiac symptoms. Further research and case reports are needed to deepen our understanding of this rare yet significant association.
  • ||||||||||  Journal, Metastases:  Patient perceptions of advanced practice radiation therapists prescribing medication in radiation therapy. (Pubmed Central) -  Jun 16, 2024   
    The study revealed that although patients were happy with the process of prescribing medication, they all agreed that having an advanced practice radiation therapist prescribe would improve care. Patient responses further demonstrated the need for future research in regards to side effect management as a whole by APRTs as well as how role clarification can impact patient perceptions of APRTs.
  • ||||||||||  PK/PD data, Review, Journal, CINV:  Pharmacokinetics, pharmacodynamics, safety, and tolerability of dopamine-receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. (Pubmed Central) -  Jun 16, 2024   
    Eight D2,3-RAs, amisulpride, domperidone, droperidol, haloperidol, metoclopramide, metopimazine, olanzapine and prochlorperazine are reviewed focusing on pharmacokinetics, pharmacodynamics, antiemetic effect and side effects...It should be emphasized, that most of these drugs are not selective for dopamine receptors.The multi-receptor targeting agent, olanzapine, is recommended in the prophylaxis of HEC-induced CINV as part of a four-drug antiemetic regimen, including a 5-HT3-RA, dexamethasone and a NK1-RA...Domperidone and metoclopramide are prokinetics, whereas metopimazine delays gastric emptying and haloperidol does not influence gastric motility. Many D2,3-RAs increase the risk of prolonged QTc interval; other side effects include sedation and orthostatic hypotension.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism. (Pubmed Central) -  Jun 15, 2024   
    Collectively, our study reveals that the microenvironment influences the susceptibility of PDAC cells to GCs and provides unprecedented evidence for the anti-proliferative activity of budesonide on PDAC cells in 3D conditions, in vitro and in vivo. Our findings may explain, at least in part, the reason for the lower occurrence of pancreatic cancer in asthmatic patients and suggest a potential suitability of budesonide for clinical trials as a therapeutic approach to fight pancreatic cancer.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Retrospective data, Review, Journal:  Juvenile dermatomyositis with central nervous system involvement: two case reports from a retrospective single-center cohort, with literature review. (Pubmed Central) -  Jun 14, 2024   
    Salvage therapies like intravenous methylprednisolone (IVMP) pulse therapy and/or plasma exchange were administered successfully...Herein, our cases and the literature indicate that it typically occurs within the first 10 months of the disease course and manifests as seizures, often accompanied by active cutaneous vasculitis, with fatal outcomes. Timely implementation of salvage therapies, like IVMP pulse therapy and plasma exchange, may significantly impact patient outcomes.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Journal:  Case report: Autoimmune encephalomyelitis following cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. (Pubmed Central) -  Jun 14, 2024   
    Here we report a case of possible AE following CMV viremia after allo-HSCT, which was successfully treated with high-dose pulsed methylprednisolone and intravenous immunoglobulins (IVIg)...The patient developed CMV viremia on day 36 after transplantation, and serum CMV-DNA remained positive after initiating ganciclovir antiviral therapy, turning negative one month later...The mechanisms of AE after allo-HSCT and the relationship with CMV infection should be further studied. Therefore, reporting this and similar cases will improve our awareness and understanding of the underlying disease mechanisms.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Botulinum toxin injection shows promise in nail psoriasis: A comparative randomized controlled trial. (Pubmed Central) -  Jun 14, 2024   
    To compare the efficacy of botulinum toxin A (BoNT-A) injection, triamcinolone acetonide (TA) injection, topical combination of vitamin D/steroid (VitD/steroid) and placebo in improving nail psoriasis...Relatively small sample size; hand hygiene during the COVID-19 pandemic may interfere NAPSI score evaluation. BoNT-A injection emerges as a promising and effective therapy for nail psoriasis, providing sustained efficacy lasting up to 6
  • ||||||||||  Onpattro (patisiran) / Alnylam, Sanofi
    Journal:  Coexistence of variant-type transthyretin and immunoglobulin light-chain amyloidosis: a case report. (Pubmed Central) -  Jun 14, 2024   
    Despite the administration of patisiran, her condition exhibited progressive deterioration...Although treatment with melphalan and dexamethasone was started, she passed away 24 months after the initial visit...Coexistence of ATTRv and AL within cardiac amyloidosis is extremely uncommon. In situations where incongruities arise between the amyloid type determined via immunohistochemistry findings and the amyloid type assumed based on other clinical findings, mass spectrometry should be considered.
  • ||||||||||  Clinical, Journal, Surgery:  Opioid-free versus opioid-based anesthesia in major spine surgery: a prospective, randomized, controlled clinical trial. (Pubmed Central) -  Jun 13, 2024   
    All patients received intraoperative sevoflurane, propofol, rocuronium, ketamine, dexamethasone, ondansetron and postoperative paracetamol and patient-controlled analgesia device set to deliver intravenous morphine for 48 hours after surgery...OFA can be an alternative to OBA in patients undergoing multilevel spine fusion surgery. OFA reduces opioids consumption in the first 24 hours and PONV.
  • ||||||||||  Avastin (bevacizumab) / Roche
    Journal, Metastases:  A Rare Case of Insulin-Like Growth Factor (IGF-2) Induced Hypoglycemia Associated With Metastatic Colon Cancer. (Pubmed Central) -  Jun 13, 2024   
    Using quality improvement methodology, we successfully decreased the time from ED arrival to administration of dexamethasone in asthma exacerbation patients from 59 to 38 minutes over 10 months. Here is a case of a 66-year-old man with stage IV colon cancer who presented to the emergency department with breathlessness during chemotherapy (Bevacizumab plus FOLFOX4 regimen)...IGF-1 levels were undetectable (10), confirming IGF-2 mediated NICTH.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Dexamethasone in Total Knee Arthroplasty (clinicaltrials.gov) -  Jun 12, 2024   
    P4,  N=404, Active, not recruiting, 
    Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting | Trial completion date: Jul 2024 --> Oct 2024 | Trial primary completion date: May 2024 --> Aug 2024
  • ||||||||||  Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie
    Journal:  Subretinal Fibrosis Developing 10 Years After First Presentation with Chronic Ocular Sarcoidosis in a Child. (Pubmed Central) -  Jun 12, 2024   
    Ultimately, the patient's intraocular inflammation was successfully controlled by using intravitreal steroids (Triamcinolone and Fluocinolone acetonide implant)...The index case progressed to sight-robbing bilateral subretinal fibrosis, a rare complication of ocular sarcoidosis despite a combination of conventional and biologic anti-inflammatory therapies. There is a pressing need to develop new treatment agents for refractory non-infectious uveitis.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections: A Review. (Pubmed Central) -  Jun 12, 2024   
    A randomized clinical trial of 6425 patients hospitalized with COVID-19 who required supplemental oxygen or noninvasive or invasive mechanical ventilation reported that dexamethasone 6 mg daily for 10 days decreased 28-day mortality (23% vs 26%)...Treatment with low-dose corticosteroids is associated with decreased mortality for patients with severe COVID-19 infection, severe community-acquired bacterial pneumonia, and moderate to severe Pneumocystis pneumonia (for patients with HIV). Low-dose corticosteroids may also benefit critically ill patients with respiratory infections who have septic shock, acute respiratory distress syndrome, or both.
  • ||||||||||  dexamethasone / Generic mfg., tamoxifen / Generic mfg.
    Journal:  Dexamethasone-Tamoxifen combination exerts synergistic therapeutic effects in tamoxifen-resistance breast cancer cells. (Pubmed Central) -  Jun 12, 2024   
    Combining DEX with TAM led to synergistic inhibition of TAMR-1 cell proliferation and migration, induced apoptosis, reduced SOX-2 and E2F3 expression and was also associated with S and G2-M phase arrest. Therefore, combining DEX with TAM may present an effective therapeutic option to overcome TAM resistance, by targeting the E2F3/SOX-2/Wnt signaling pathway, in addition to its anti-inflammatory effect.
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Laryngeal Foreign Body Aspiration in Infancy: A Diagnostic Challenge. (Pubmed Central) -  Jun 12, 2024   
    axis inhibition. He was suspected of having croup and treated with dexamethasone and racemic nebulized epinephrine, which led to temporary clinical improvement.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Posterior spinal fusion for adolescent idiopathic scoliosis and the impact of postoperative intravenous dexamethasone supplementation. (Pubmed Central) -  Jun 12, 2024   
    The initial retrospective epidural cohort (EPI) (n?=?59) had surgeon placed epidural catheters with infusion of ropivacaine 0.1% postoperatively for 18-24?h...Compared to the LB cohort, the LB?+?D cohort demonstrated statistically significant decreases in oral milligram morphine equivalents per kilogram at 0-24, 24-48, and 48-72?h...The LB?+?D cohort's median length of stay in hours was significantly less compared to the LB cohort (52?h vs. 70?h, p?<?0.0001). Postoperative intravenous dexamethasone was added to an established postoperative care pathway for patients undergoing posterior spinal fusion for idiopathic scoliosis resulting in decreased VAS pain scores, opioid consumption, and shorter length of stay.
  • ||||||||||  relacorilant (CORT125134) / Corcept Therap
    Enrollment closed, Trial completion date, Trial primary completion date:  GRADIENT: Efficacy and Safety of Relacorilant in Patients with Cortisol-Secreting Adrenal Adenomas (clinicaltrials.gov) -  Jun 11, 2024   
    P3,  N=130, Active, not recruiting, 
    Postoperative intravenous dexamethasone was added to an established postoperative care pathway for patients undergoing posterior spinal fusion for idiopathic scoliosis resulting in decreased VAS pain scores, opioid consumption, and shorter length of stay. Recruiting --> Active, not recruiting | Trial completion date: Mar 2024 --> Sep 2024 | Trial primary completion date: Mar 2024 --> Sep 2024
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Chronic TNF exposure induces glucocorticoid-like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia. (Pubmed Central) -  Jun 11, 2024   
    Dusp1 is known to be responsible for glucocorticoid-mediated immune suppression, and dexamethasone treatment increased Dusp1 and Ptprs expression in cells and recapitulated the ADMD phenotype...TNF-neutralizing antibody reduced Dusp1 and Ptprs levels in AM from aged mice and reduced pneumonia severity following bacterial challenge. We conclude that chronic exposure to TNF increases the expression of the glucocorticoid-associated MAPK signaling suppressors, Dusp1 and Ptprs, which inhibits AM activation and increases susceptibility to bacterial pneumonia in older adults.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Short-term aerobic exercise prevents development of glucocorticoid myopathic features in aged skeletal muscle in a sex-dependent manner. (Pubmed Central) -  Jun 11, 2024   
    Within their respective groups, mice were randomized to either daily treatment with dexamethasone (DEX) or saline...Glucocorticoid-induced changes to aged muscle contractile properties coincide with sex-specific differences in the content of calcium handling proteins. Aerobic exercise prevents glucocorticoid-induced fatigue only in aged females and coincides with differences in the content of mitochondrial quality control proteins and glucocorticoid receptors.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Triamcinolone acetonide has minimal effect on short- and long-term metabolic activities of cartilage. (Pubmed Central) -  Jun 11, 2024   
    After both acute and sustained inflammatory challenges, TA reduced the catabolic activities in cartilage, reducing nascent glycosaminoglycan loss and maintaining cartilage mechanical properties. Overall, at physiologically relevant doses, TA had minimal negative impact on chondrocytes when maintained within their native ECM.