Glucocorticoid Receptor 

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  • ||||||||||  pemetrexed / Generic mfg.
    Review, Journal:  Mechanisms, Management and Prevention of Pemetrexed-Related Toxicity. (Pubmed Central) -  Apr 21, 2022   
    There are several experimental options to prevent or manage pemetrexed-related toxicity, such as the use of standard folinic acid, hemodialysis, antidotes such as thymidine, hypoxanthine, and glucarpidase, and the use of therapeutic drug monitoring. These strategies still need clinical evaluation before implementation, but could enable treatment with pemetrexed for patients who are at risk for toxicity, such as in renal impairment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The association between adrenal adenoma size, autonomous cortisol secretion and metabolic derangements. (Pubmed Central) -  Apr 21, 2022   
    Even though the study was terminated early prior to completion of enrollment, the results indicate that this may be a promising therapeutic approach for high-risk RRMM patients, which warrants further study. There is a quantitative positive mild correlation between AI size and both cortisol autonomy and metabolic parameters.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, Cancer stem cells:  Dexamethasone promotes breast cancer stem cells in obese and not lean mice. (Pubmed Central) -  Apr 21, 2022   
    GC transcriptionally regulated genes were not altered in the dexamethasone-treated groups compared to treatment controls. In summary, these results provide initial evidence that obesity presents a higher risk of GC-induced cancer stemness via non-genomic GC signaling which is of potential translational significance.
  • ||||||||||  prednisolone / Generic mfg., itraconazole / Generic mfg.
    Journal:  Kerion Celsi caused by Microsporum gypseum in a Chinese child, a case report. (Pubmed Central) -  Apr 21, 2022   
    Our results provide strong evidence for enhancing existing treatment regimens and developing novel combination therapy to improve TBM treatment efficacy. We presented the first case of kerion Celsi infection secondary to M gypseum that was probably transmitted from a guinea pig.
  • ||||||||||  dexamethasone / Generic mfg., bleomycin / Generic mfg.
    A High-Throughput Cell Culture Model of Idiopathic Pulmonary Fibrosis (IPF) for Gene Therapy Applications (Poster Board Number: Tu-126; Hall D) -  Apr 20, 2022 - Abstract #ASGCT2022ASGCT_760;    
    Use of the bleomycin-induced mouse model has identified some potential therapeutic compounds but few have shown beneficial effects in clinical trials...Human H441 cells grown in transwells with basal culture media lacking dexamethasone were air-lifted to differentiate at the ALI to allow the cells to acquire a phenotype similar to alveolar Type II (ATII) cells in the lung parenchyma...Our human ALI culture model of lung parenchyma provides a new platform for modelling aspects of the formation and progression of IPF at the molecular (RNA and protein) level. It may also provide an opportunity to develop opportunities for screening of novel antifibrotic agents and validating gene therapy interventions.
  • ||||||||||  diphenhydramine / Generic mfg., hydrocortisone / Generic mfg., paracetamol / Generic mfg.
    TO PREMEDICATE OR NOT? A CLOSER LOOK AT PREMEDICATIONS FOR BLOOD PRODUCT TRANSFUSIONS AT MSK KIDS () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_456;    
    Despite the low overall incidence of transfusion reactions in our cohort, most patients still received premedication, even without a history of transfusion reactions, with no clear benefit. Standardization of an evidence-based algorithm and provider education is needed for blood product transfusion premedication in pediatric oncology patients.
  • ||||||||||  dexamethasone / Generic mfg., cyclosporine / Generic mfg.
    RECURRENT CYTOPENIAS IN A CHILD WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_368;    
    Chronic or multi-lineage disease should prompt testing for decreased production or secondary causes of autoimmune cytopenias, including infectious, SLE, ALPS, and common variable immune deficiency. One should keep in mind that immunosuppressive drugs can influence diagnostic tests, and if possible, should perform diagnostic tests off these agents.
  • ||||||||||  dexamethasone / Generic mfg., vinblastine / Generic mfg.
    RARE PRESENTATION OF A DEEP XANTHOGRANULOMATOUS PROCESS WITH EPIDURAL MASS AND NOVEL FUSION PROTEIN () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_360;    
    One should keep in mind that immunosuppressive drugs can influence diagnostic tests, and if possible, should perform diagnostic tests off these agents. JXGtypically has an indolent course but in rarecases withmultisystem andCNSinvolvementmayhave amore aggressivecoursewithbenefit from systemic therapy.Ourpatientwith a deepxanthogranulomatousprocesswith unusualfeatures,a novelMYH9-FLT3 fusion protein, and an epidural massshowed radiological improvementand clinical stabilityafter6 weeksofvinblastine and dexamethasone.Further research is warranted on profiling histiocytic disorders to determine relevant genetics and optimize treatment strategies.
  • ||||||||||  prednisone / Generic mfg., sirolimus / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    MEDICAL HISTORY: FRIEND OR FOE? A CASE OF TWO TYPES OF ANEMIA IN THE SAME PATIENT () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_272;    
    However, there are subtleties among the different types that can make it difficult to diagnose. This case emphasizes the importance for clinicians to have a high index of suspicion for a secondary process if a patients symptoms evolve over time and no longer fit with the initial diagnosis.
  • ||||||||||  Gamifant (emapalumab) / SOBI
    LIVER FAILURE IN A NEWBORN WITH DOWN SYNDROME () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_259;    
    This case emphasizes complexities in diagnosing TAM in the setting of pancytopenia and is the first report of this entity with the comorbid hyper-inflammatory syndrome of HLH. This novel association is in keeping with the association of other myelopoiesis abnormalities and HLH.
  • ||||||||||  dexamethasone / Generic mfg.
    KIKUCHI FUJIMOTO DISEASE MIMICKING LYMPHOMA IN AN ADOLESCENT FEMALE () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_252;    
    KFD is especially challenging to diagnose because viable tissue must be obtained from a lymph node biopsy to confirm the diagnosis. We highlight the benefit of using a PET scan in such time-sensitive cases where attaining viable lymph nodes may be difficult due to widespread lymph node necrosis which is a common finding in this rare disease
  • ||||||||||  HYPONATREMIA ASSOCIATED WITH INDUCTION CHEMOTHERAPY REGIMENS FOR LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_210;    
    These data may provide further evidence that hyponatremia is associated with steroid use instead of vincristine use as SIADH was not a common diagnosis in our patient population. Given the frequency of severe hyponatremia and the variable approach for assessment and management, future directions include creating an algorithm in collaboration with nephrology to standardize the approach to assessment and management of hyponatremia during induction.
  • ||||||||||  CASE SERIES: DIAMOND-BLACKFAN ANEMIA WITH A DE NOVO RPS19 MUTATION IN A CRITICALLY ILL CHILD () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_113;    
    These two cases illustrate two novel genotypic-phenotypic correlation of DBA and further demonstrating variability in treatment response. Moreover, these two cases emphasize the utility of genetic testing in cases of aplastic crisis due to the confounding effects of critical illness that may distort the underlying etiology.
  • ||||||||||  Xalkori (crizotinib) / Pfizer
    ACUTE RESPIRATORY FAILURE DUE TO RELAPSED INFILTRATIVE ANAPLASTIC LARGE CELL LYMPHOMA () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_55;    
    Our single patient experience demonstrates the importance of considering this phenomenon in a patient with ALCL and respiratory distress, as well as the importance of swift treatment if an alternative cause is not identified. It also highlights the utility of crizotinib in the treatment of relapsed ALCL.
  • ||||||||||  measles vaccine / Generic mfg.
    A RARE CASE OF SECONDARY HLH DUE TO VACCINE-STRAIN MEASLES IN A YOUNG CHILD WITH HEPATOBLASTOMA () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_43;    
    Although therearerareindividualreports of HLH secondary toprimarymeasles infection,to our knowledgethis is the first report of secondary HLH due to vaccine-strain measles[1].Uncontrolledreplicationof vaccine-strain measlesishighly unusualand can bedifficultto diagnose when presentation is atypical.This case highlights an exceptionallyrare complicationofimmunosuppressive therapy in a patient with recentlive vaccination.We hope greater awareness can lead to earlier recognition andimproved outcomes.1.LagousiT,KorovessiP,PanagouliE,TsagrisV,KostaridouS.ARare Case of Measles-Associated HemophagocyticLymphohistiocytosisin an Infant.Cureus. 2020; 12(5):e8246.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    A RARE CASE OF PAEDIATRIC B-CELL LYMPHOMA PRESENTING WITH SPINAL CORD COMPRESSION () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_41;    
    Although rare, SCC can be an initial presentation of malignancy, including NHL, neuroblastoma, Langerhan cell histiocytosis and sarcomas.Previous studies in adults have reported that 1.8% of all diffuse large B-cell lymphomas occur in the spinal epidural location3, and the frequency in children is has not been specifically studied.Pediatric patients presenting with back pain with or without neurologic symptoms require prompt imaging assessment to rule out a spinal mass.References:1. Pui, Journal of Pediatrics, 19852.
  • ||||||||||  dexamethasone / Generic mfg., etoposide IV / Generic mfg.
    A CASE OF FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS PRESENTING WITH CORONARY ARTERY DILATION () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_18;    
    His HLH was cured with chemotherapy and allogeneic hematopoietic stem cell transplant. This case report illustrates the potential for overlap in patients with Kawasaki-like disease and HLH and the importance of avoiding premature closure when caring for patients with systemic immune inflammation.[1] Jordan, et.
  • ||||||||||  ceftriaxone / Generic mfg., methylprednisolone sodium succinate / Generic mfg., enoxaparin sodium / Generic mfg.
    A CASE OF EVALI PRESENTING WITH COAGULOPATHY IN THE SETTING OF A RECENT COVID-19 INFECTION () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_17;    
    Understanding of COVID-9-associated coagulopathy and thrombosis has evolved. Coagulopathy associated with vaping has also been described; vitamin E acetate, as an additive to THC-containing e-cigarette, can lead to antagonism of Vitamin K. It is important to keep EVALI on the differential diagnosis given appropriate history, even when COVID-19 related disease is a primary concern.
  • ||||||||||  Veramyst (fluticasone furoate nasal spray) / GSK
    Clinical, Review, Journal:  Risk of diabetes mellitus during regular long-term inhaled glucocorticoid treatment in COPD patients: narrative review of the literature. (Pubmed Central) -  Apr 20, 2022   
    The inhaled glucocorticoids administered were: fluticasone propionate (7 studies), budesonide (6 studies), mometasone furoate (3 studies), beclomethasone dipropionate (1 study), triamcinolone acetonide (1 study), and fluticasone furoate (1 study) respectively. Only 3 out of the 19 trials identified in our narrative review reported data on diabetes mellitus, and in these the incidence of diabetes mellitus was not significantly different in both treatment arms (inhaled glucocorticoids and placebo), regardless of the type of glucocorticoid used.