Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...329330331332333334335336337338339...10671068»
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway. (Pubmed Central) -  Apr 27, 2022   
    Cells were cultured in an osteogenic medium (OST) (α-MEM, 15% fetal bovine serum, L-glutamine, penicillin, streptomycin, amphotericin B, dexamethasone, and beta-glycerophosphate)...PI3K blockage did not affect the gene expression of CEMP1 at any experimental time (p > 0.05). We concluded that CEMP1 gene expression increased by PAR1 activation is MAPK/ERK-dependent and PI3K independent, suggesting that PAR1 may regulate cementogenetic differentiation of hPDLSCs.
  • ||||||||||  Aerospan (flunisolide HFA) / Viatris, AbbVie
    Journal:  Targeted glucocorticoid analysis using ion mobility-mass spectrometry (IM-MS). (Pubmed Central) -  Apr 27, 2022   
    Despite the relatively modest resolution of isomer pairs under standard conditions (i.e., nitrogen drift gas, sodiated ions, etc.), improvements were observed for alkaline earth and transition metals (notable barium adducts) and in carbon dioxide drift gas. In summary, LC-IM-MS offers potential as a clinical method due to its ease of coupling with traditional LC-MS methods and its promise for tuning separations to better resolve targeted and/or global isomers in complex biological samples.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Peri-operative Analgesic Efficacy and Safety of Erector Spinae Plane Block in Posterior Cervical Spine Surgery - A Double blinded, Randomized Controlled Study. (Pubmed Central) -  Apr 27, 2022   
    After anesthesia and prone position, case patients received ultrasound-guided ESPB at the T1 level using 15ml of 0.25% bupivacaine and 8mg Dexamethasone bilaterally while the control patients received only standard postoperative multimodal analgesia...The Modified Observer Alertness/Sedation Score (MOASS) score and satisfaction scores also showed significant differences between the case and control groups (p<0.001). The mean time required to ambulate (sitting/walking) was statistically less in cases (15.81±6.15/ 20.72±4.02 hours) when compared to controls (16.86±6.18/ 23.05±8.88 hours) (p<0.001) In patients undergoing PCSS, ESPB is a safe and effective technique with better outcomes than standard multi-modal analgesia alone, in terms of reduced intra-operative opioid requirements and blood loss, better postoperative analgesia and early mobilization.
  • ||||||||||  azelastine intranasal / Generic mfg., fluticasone / Generic mfg.
    Enrollment open:  Efficacy and Safety of On-demand and Continuous Administration of Nasal Spray in the Treatment of Allergic Rhinitis (clinicaltrials.gov) -  Apr 26, 2022   
    P4,  N=150, Recruiting, 
    The mean time required to ambulate (sitting/walking) was statistically less in cases (15.81±6.15/ 20.72±4.02 hours) when compared to controls (16.86±6.18/ 23.05±8.88 hours) (p<0.001) In patients undergoing PCSS, ESPB is a safe and effective technique with better outcomes than standard multi-modal analgesia alone, in terms of reduced intra-operative opioid requirements and blood loss, better postoperative analgesia and early mobilization. Not yet recruiting --> Recruiting
  • ||||||||||  azathioprine / Generic mfg.
    New P3 trial:  MOGwAI: Azathioprine in MOGAD (clinicaltrials.gov) -  Apr 26, 2022   
    P3,  N=126, Not yet recruiting, 
  • ||||||||||  Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
    Biomarker, Journal:  OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema. (Pubmed Central) -  Apr 26, 2022   
    Pretreatment EZ integrity and the presence of central subfield cystoid spaces or subretinal fluid each predict improved therapeutic response to treatment in eyes with NIU. In CLS-TA treated eyes, longitudinal modeling shows CST improvement preceding BCVA improvement.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Tuning surface charges of peptide nanofibers for induction of antigen-specific immune tolerance: an introductory study. (Pubmed Central) -  Apr 26, 2022   
    Dexamethasone, an immunosuppressive glucocorticoid drug, and the ovalbumin-derived OVA323-339 peptide that binds to I-A(d) MHC Class II were covalently linked at either end of the peptide sequences...Dendritic cell culture assays suggested that nanofiber of less negative ζ-potential can augment the antigen-specific tolerogenic response. Our findings illustrate a molecular approach to calibrate the tolerogenic response induced by peptide nanofibers, which pave the way for better design of future tolerogenic immunotherapies.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice. (Pubmed Central) -  Apr 26, 2022   
    St6gal1 expression was greatest in the duodenum, where it was mediated by the P1 promoter and efficiently inhibited by dexamethasone. Our data show that the inability to produce α2,6-sialyl ligands contributes to microbiome-dependent Th17 inflammation, highlighting a pathway by which the intestinal glycosylation regulates mucosal immunity.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells. (Pubmed Central) -  Apr 26, 2022   
    We used the synthetic glucocorticoid analogue dexamethasone to address glucocorticoid effects on adipose tissue fibrosis, in particular involving macrophage to preadipocyte communication...Our data suggest that macrophages promote adipose tissue fibrosis by directly interfering with preadipocyte differentiation and stimulating gene expression of pro-fibrotic factors. Excess glucocorticoid exposure also has pro-fibrotic effect on adipose tissue, but this requires the presence of macrophages.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Enhancing health span: muscle stem cells and hormesis. (Pubmed Central) -  Apr 26, 2022   
    Hormetic dose responses were observed following administration of a broad range of agents, including dietary supplements (e.g., resveratrol), pharmaceuticals (e.g., dexamethasone), endogenous ligands (e.g., tumor necrosis factor α), environmental contaminants (e.g., cadmium) and physical agents (e.g., low level laser). The paper assesses both putative mechanisms of hormetic responses in muscle stem cells, and potential therapeutic implications and application(s) of hormetic frameworks for slowing muscle loss and reduced functionality during the aging process.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis. (Pubmed Central) -  Apr 26, 2022   
    Dexamethasone and an IL-1β inhibitor partially diminished RHE degeneration caused by Oα-Syn. These findings suggest that Oα-Syn induces epidermal inflammation and decreases keratinocyte proliferation, and therefore might contribute to epidermal degeneration observed in human skin aging.
  • ||||||||||  Journal:  Bilateral Vitreous Hemorrhage in a Young Man with Pustular Psoriasis. (Pubmed Central) -  Apr 26, 2022   
    Topical medication (eye drop atropine 1%, timolol 0.5%, moxifloxacin and dexamethasone combination) and oral prednisolone (60 mg per day for 2 weeks) were prescribed but were later withdrawn in view of no response and worsening of skin condition. In the past, he had received various treatments, including phototherapy, acitretin, methotrexate, apremilast, cyclosporine, and mycophenolate mofetil; however, his condition was recalcitrant.
  • ||||||||||  budesonide/formoterol / Generic mfg.
    Journal:  First Symbicort Generic Gains Approval. (Pubmed Central) -  Apr 26, 2022   
    It raised the concern that whether steroids are safe in elderly patients with septic shock. No abstract available
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Clinical Profile and Treatment Outcome in MOGAD: A Single-Center Case-Series Study in Guiyang, China. (Pubmed Central) -  Apr 26, 2022   
    Intravenous methylprednisolone (IVMP) was administrated for 85% of the attacks while both IVMP and intravenous immunoglobulin were for 6% of the attacks...Among them, six patients were treated with mycophenolate mofetil, three patients were treated with prednisone, rituximab, and teriflunomide, respectively...The long-term outcome of MOGAD seems benign. Further studies are warranted to determine the risk factors of relapse and identify the optimal steroid-sparing agents.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Continuous flow process for preparing budesonide. (Pubmed Central) -  Apr 26, 2022   
    In another aspect, particle size optimization studies are also performed to get the desired budesonide solid product. A continuous flow process for preparation of budesonide is identified from the present research investigation which can be readily transferred to industrial scale up.
  • ||||||||||  thyroxine / Generic mfg.
    Journal:  Initial treatment of myxedema coma using oral levothyroxine: a case report from Tanzania. (Pubmed Central) -  Apr 26, 2022   
    Although diagnostic and scoring criteria based on clinical, laboratory, and imaging features have been proposed, no consensus has been reached. This article shows an alternative treatment option for myxedema coma using oral levothyroxine, which led to a favorable outcome.
  • ||||||||||  dexamethasone / Generic mfg.
    Anterior Chamber Versus Intravitreal Administration of Dexamethasone 9% Suspension in Cataract Patients with and without Glaucoma (WEWCC - Level 1, 143C) -  Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_1480;    
    MethodsRetrospective data were collected from patients who received dexamethasone 9% suspension (DEXYCU®; EyePoint Pharmaceuticals) either via anterior chamber administration (on-label) or intravitreal injection (off-label) after cataract surgery, with/without minimally invasive glaucoma surgery (MIGS)...All patients were given intracameral moxifloxacin at the time of surgery...1 patient in the IVD required rescue medications compared to 8 patients in the ACD group (p<0.01). Conclusion Administration of IVD or ACD does not impede the intraocular pressure reduction produced by cataract surgery combined with MIGS.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Comparative Analysis of Two Different Concentration of Intraoperative Sub-Conjunctival Depot Steroid in Cataract Surgery (WEWCC - Level 1, 143C) -  Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_1479;    
    ConclusionPatients who received a higher concentration of subconjunctival triamcinolone acetonide had a lower incidence of post op iritis compared to lower dose while IOP spike was comparable in the two groups. 6mg in 0.15ml sunconjunctival depot steroid 6 mm from the limbus was effective in controlling post-operative pain and inflammation.
  • ||||||||||  dexamethasone / Generic mfg.
    Scleraxis Expressing Scleral Cells in Respond to Inflammatory Stimulation (WEWCC - Level 1, 143B) -  Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_1304;    
    moreover,IL1_ß stimulation resulted in significantly collagen degegradation.Addition of dexamethasone siginficantly reduced the response of IL1_ß stimulation. Conclusion With this work we show for the first time that scleral fibroblast cells express the tendon associated marker Scleraxis._x000D_ _x000D_ Organotypic, in vitro exposure to IL1-ß induces inflammation- and fibrosis associated events in these cells._x000D_ _x000D_ This is a novel in vitro model of scleritis, allowing to study early mechanisms in scleral inflammation.
  • ||||||||||  dexamethasone / Generic mfg., bromfenac ophthalmic solution / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Effect of 0.09% Topical Bromfenac in Managing Discomfort Following Photorefractive Keratectomy (WEWCC) -  Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_381;    
    The bromfenac group (121 cases) showed better pain management compared to the control group (134 cases) : mean score 1.5 to 3.2, 96 cases from group B required at least one dose of Lonarid and 75 an IM injection of paracetamole-none from group A. mean epitheliazation day was 3.5 vs. 3.6 and was not statistical significant between the 2 groups ConclusionAdjunct treatment with 0.09% bromfenac ophthalmic solution showed good efficacy for preventingearly postoperative pain following PRK. It maybe considered as primary adjunct treatment to corticosteroids, as it improves dramatically patient comfort and adaptability to the procedure.
  • ||||||||||  dexamethasone / Generic mfg., bromfenac ophthalmic solution / Generic mfg.
    Effect of 0.09% Topical Bromfenac in Preventing Macular Edema after Cataract Surgery (WEWCC) -  Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_380;    
    there were no cases of CME diagnosed in group A, while 8 cases in group B (6 cases with OCT identified ERM and 2 cases with DM, mean age 59 (42-75)), necessitating further management with dexamethasone and bromfenac for up to an additional 6 months and significant patient morbidity. Conclusion Adjunct treatment with 0.09% bromfenac ophthalmic solution showed good efficacy for preventing cystoid macular edema early after cataract surgery.It may be considered as primary adjunct treatment to corticosteroids following cataract surgery in younger and/or diabetic patients or when epiretinal membrane has been identified on OCT pre-operatively.