Glucocorticoid Receptor 

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  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Linear Leucoderma Following Intralesional Steroid Injection. (Pubmed Central) -  Jun 21, 2024   
    Linear leukoderma following intralesional steroid is a rare but known complication. Here, we report a case of a 23-year-old female presented with cutaneous linear depigmentation along the volar aspect of her left forearm developed three months following a single episode
  • ||||||||||  Filspari (sparsentan) / Travere Therap
    Review, Journal, IO biomarker:  Drugs in Development to Treat IgA Nephropathy. (Pubmed Central) -  Jun 20, 2024   
    Other new possible strategies include spleen tyrosine kinase inhibitors, anti-CD40 ligands and anti-CD38 antibodies. In an era increasingly characterised by 'personalised medicine' and 'precision therapy' approaches and considering that the potential therapeutic armamentarium for IgA nephropathy will be very broad in the near future, the identification of biomarkers capable of helping the nephrologist to select the right drug for the right patient should be the focus of future studies.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, Epigenetic controller:  DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans. (Pubmed Central) -  Jun 20, 2024   
    The animal model also recapitulated effects of dexamethasone on DNAm, especially in peripheral blood and to a lesser extent effects of genotype on DNAm. The humanized mouse model could thus assist in reverse translation of human findings in psychiatry that involve genetic and epigenetic regulation in non-coding elements.
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Improving croup management at a pediatric emergency department. (Pubmed Central) -  Jun 20, 2024   
    The primary outcome of this QI initiative was to reduce nebulized epinephrine (NE) use among children with mild croup by 50% over 7?months...Other outcomes included the administration of dexamethasone to all children with croup, reduction of antibiotics, laboratory tests, and revisits, and shortening the duration between physical examination to dexamethasone and NE treatments, and the length of stay (LOS) at the PED...With this QI intervention,decreases in the rate of administration of NE to mild croup cases, antibioticprescription, X-ray, laboratory blood and respiratory PCR panel tests in allcroup cases were achieved without an increase in revisits. However, unnecessaryNE, antibiotic, and X-ray rates are still high.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Biomarker, P3 data, Clinical Trial,Phase III, Journal:  Houde CA, Khan A, Jacobus SJ, et (Pubmed Central) -  Jun 20, 2024   
    However, unnecessaryNE, antibiotic, and X-ray rates are still high. No abstract available
  • ||||||||||  budesonide / Generic mfg.
    Clinical data, Retrospective data, Journal:  Factors associated with long-term clinical outcome in microscopic colitis. (Pubmed Central) -  Jun 20, 2024   
    In the present cohort of patients with microscopic colitis, a favourable response to budesonide was significantly associated with long-term clinical remission, and all patients achieving histological remission were able to maintain clinical remission without further medical therapy. Larger studies are required to confirm these findings.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Avastin (bevacizumab) / Roche
    Journal:  Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide. (Pubmed Central) -  Jun 20, 2024   
    Inflammation and cellular osmohomeostasis rather than VEGF suppression appear to play important roles in BRVO-induced retinal neurodegeneration, enhanced in both BEV- and TA-treated retinas. Inner retinal neurodegeneration seen in this acute model of BRVO appears to be mediated by inflammation and alterations in osmohomeostasis rather than VEGF inhibition, which may have implications for more specific treatment modalities in the acute phase of BRVO.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Fibrin Hydrogels Reinforced by Reactive Microgels for Stimulus-Triggered Drug Administration. (Pubmed Central) -  Jun 20, 2024   
    Microgels can be additionally used as carriers for active drugs, as demonstrated for dexamethasone...The cytocompatibility of the microgel-reinforced fibrin-based hydrogels is demonstrated by LIVE/DEAD staining experiments using human mesenchymal stem cells. The microgel-reinforced hydrogels are a promising material for tissue engineering, owing to their superior mechanical performance and stability, possibility of drug release, and retained biocompatibility.
  • ||||||||||  dexamethasone sodium phosphate-loaded RBC (EDS-EP) / Erydel
    Enrollment open:  NEAT: Evaluate the Neurological Effects of EryDex on Subjects With A-T (clinicaltrials.gov) -  Jun 20, 2024   
    P3,  N=106, Recruiting, 
    The microgel-reinforced hydrogels are a promising material for tissue engineering, owing to their superior mechanical performance and stability, possibility of drug release, and retained biocompatibility. Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    The crosstalk between insulin resistance and tau pathology (Exhibit (Pennsylvania Convention Center); In-Person) -  Jun 19, 2024 - Abstract #AAIC2024AAIC_3863;    
    Tau aggregates may increase the likelihood of insulin resistance by impairing the insulin signaling pathway, ultimately resulting in Type 2 diabetes. The findings suggest that impaired insulin signaling in the brain could contribute to tau pathogenesis by decreasing GLUT4 expression, leading to hyperglycemia and cellular hypertrophy.
  • ||||||||||  Tavneos (avacopan) / Amgen, Rituxan (rituximab) / Roche
    Therapeutic Decisions in Glomerular Diseases: Updating the Algorithms (Room 6A, Convention Center |) -  Jun 19, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_225;    
    This session reviews these challenging therapeutic decisions and provides insights from experts. Learning Objective(s) Summarize current evidence for use of avacopan, plasmapheresis, and rituximab in ANCA-associated vasculitis Describe the current therapeutic options for maintenance therapy in lupus nephritis Explain appropriate use of endothelin receptor antagonists, targeted-release formulation budesonide, and SGLT2 inhibitors in the management of IgAN Discuss alternatives to corticosteroids and their application in management of minimal change disease Learning Pathway(s) Glomerular Diseases
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., tranylcypromine / Generic mfg.
    Preclinical, Journal:  Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation. (Pubmed Central) -  Jun 19, 2024   
    To validate the in silico studies, the inhibitory activity of phenolic compounds was compared to the clinically approved inhibitor tranylcypromine...Using a cell culture model system with corticosteroid-stimulated human BJ fibroblast cells, the results demonstrate the attenuation of dexamethasone- and hydrocortisone-induced MAO activity by phenolic compounds...Overall, the results indicate the inhibition of flavin adenine dinucleotide (FAD)-dependent amine oxidases by olive phenolics. More generally, our findings further support at least a partial mechanism accounting for the antidepressant effects associated with EVOO and the Mediterranean diet.
  • ||||||||||  Adcetris (brentuximab vedotin) / Takeda, Pfizer, Opdivo (nivolumab) / BMS, Matulane (procarbazine hydrochloride) / Leadiant Biosci
    Review, Journal, Metastases:  Treatment Strategies in Advanced-Stage Hodgkin Lymphoma. (Pubmed Central) -  Jun 19, 2024   
    Lately, a significant advancement has been made by the integration of checkpoint inhibitors in the first-line treatment, with preliminary results demonstrating the superiority of anti-PD1 combined with chemotherapy (nivolumab-AVD) compared to the BV-AVD regimen. This review aims to analyze recently published studies whose findings could change the treatment practice in advanced-stage HL.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Chronic Stress Related to Cancer Incidence, including the Role of Metabolic Syndrome Components. (Pubmed Central) -  Jun 19, 2024   
    When including age as a confounder and gender as a moderator, LogHairE was statistically significantly associated with cancer incidence (HR: 6.403, 95%CI: 1.110-36.92). In a population-based cohort, chronic biological stress, measured by HairE, was associated with cancer incidence, after controlling for age and gender.
  • ||||||||||  dexamethasone / Generic mfg., docetaxel / Generic mfg.
    Retrospective data, Journal:  Evaluation of the impact of systemic dexamethasone dosage on docetaxel-induced hand-foot syndrome in patients with breast cancer. (Pubmed Central) -  Jun 19, 2024   
    Logistic regression analysis suggested higher DEX dosage as an independent preventive factor (adjusted odds ratio 0.35; 95% confidence interval 0.14-0.86, P?=?0.02 for all cycles; 0.26, 0.11-0.63, P?=?0.003 for the first cycle). Our study suggests that systemic DEX prevents the occurrence of docetaxel-induced HFS in patients with breast cancer in a dose-dependent manner in a real-world setting.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Mechanistic understanding of dexamethasone-mediated protection against remdesivir-induced hepatotoxicity. (Pubmed Central) -  Jun 19, 2024   
    Collectively, our findings suggest a molecular mechanism by which DEX modulates the GR-DUSP1-MAPK regulatory axis to alleviate the adverse actions of RDV in the liver. Significance Statement The research uncovers the molecular mechanisms by which dexamethasone safeguards against remdesivir-associated liver damage in the context of COVID-19 treatment.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Anti-inflammatory activity of plant sterols in a co-culture model of intestinal inflammation: focus on food-matrix effect. (Pubmed Central) -  Jun 17, 2024   
    The pharmacological interaction between samples and budesonide (1 ?M, 90 min) was evaluated...This study demonstrates the potent intestinal anti-inflammatory activity of a PS-FS, positioning it as a promising nutraceutical product for the management of inflammatory bowel diseases. However, the food matrix of the milk-based fruit beverage and rye bread appear to interfere with the anti-inflammatory activity of PS.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Bioactive prenylated c6-c3 derivatives from the roots of Illicium brevistylum. (Pubmed Central) -  Jun 17, 2024   
    Compounds 3 and 4 exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC50 values of 20.57 and 12.87??M respectively, which were greater than those of dexamethasone (positive control). Compounds 1 and 4-6 exhibited weak activity against Coxsackievirus B3, with IC50 values ranging from 25.87 to 33.33??M.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, BioNTech, Promacta (eltrombopag) / Novartis, Rituxan (rituximab) / Roche
    Review, Journal:  COVID-19-induced immune thrombocytopenia management approach: A case report and literature review. (Pubmed Central) -  Jun 17, 2024   
    In the following weeks, we attempted several other lines of therapy to treat his ITP, including anti-RhD immunoglobulin, which, unfortunately, caused moderate hemolysis requiring packed red blood cell transfusion, intravenous immunoglobulin (given at a subtherapeutic dose of 0.4?g/kg for only 1?day since it was not available), rituximab, and eltrombopag...More in-depth research is needed to delineate standard guidelines for the management of such cases. This report underscores the importance of resorting to vincristine and eltrombopag as great options for severe and refractory ITP related to the COVID-19 vaccine.
  • ||||||||||  acyclovir / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Herpes Zoster Optic Neuritis: A Catastrophe of a Disease. (Pubmed Central) -  Jun 17, 2024   
    He was treated with one week of intravenous methylprednisolone 1 g/day, followed by a tapering dose of oral prednisolone (1 mg/kg/day) together with oral acyclovir 800 mg five times a day for another week. His visual acuity remained poor with a slight improvement in vision to hand motion.