Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia. (Pubmed Central) -  May 3, 2022   
    Trial completion date: Jun 2022 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023 Among patients with COVID-19 and severe hypoxaemia, dexamethasone 12 mg compared with 6 mg did not result in statistically significant improvements in mortality or HRQoL at 180 days, but the results were most compatible with benefit from the higher dose.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  The diagnosis and management of Cushing's syndrome in pregnancy. (Pubmed Central) -  May 3, 2022   
    Dexamethasone administration fails to fully suppress cortisol in pregnant women without CS...Close communication is a necessity with the patient placed at the centre of all decisions, with risks, benefits, and uncertainties around any investigation and management carefully discussed. Care should be delivered by an experienced, multidisciplinary team, with the resources and expertise available to manage such a rare and challenging condition during pregnancy.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Committee report: Questionnaire survey on the treatment of COVID-19 in patients receiving dialysis therapy. (Pubmed Central) -  May 3, 2022   
    Furthermore, some facilities used a polymethylmethacrylate membrane during dialysis, nafamostat as an anticoagulant, and continuous hemodiafiltration in severe cases...Our survey revealed a variety of treatment practices in each facility. Further evidence and innovations are required to improve the prognosis of patients with COVID-19 receiving dialysis therapy.
  • ||||||||||  Oncocort (pegylated liposomal dexamethasone) / Enceladus
    Preclinical, Journal:  Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice. (Pubmed Central) -  May 3, 2022   
    The liposomal dexamethasone was mainly distributed into the monocyte/macrophages as a major cell population for inducing the cytokine storm in the lungs. Taken together, the intranasal delivery of liposomal dexamethasone may serve as a novel promising therapeutic strategy for the treatment of influenza A-induced pneumonia.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  An assessment of asthma exacerbations in pediatric patients using a long-acting B2-agonist plus inhaled corticosteroid versus an inhaled corticosteroid alone. (Pubmed Central) -  May 3, 2022   
    The majority (n = 480, 81.9%) of the patients received fluticasone (Flovent)® as the standard of care ICS treatment for controlling asthma, and a small proportion (n = 106, 18.1%) were treated with a combination of LABA and ICS...Moderate to severe exacerbations were significantly higher in the ICS group compared to the combination group (95.6% versus 84.5%, respectively, p = 0.0005). The current results confirm the substantial efficacy of the LABA/ICS combination therapy in reducing the incidence and severity of asthma exacerbations in pediatric patients, compared to ICS alone.
  • ||||||||||  hydrocortisone / Generic mfg.
    Retrospective data, Journal, Adverse drug reaction:  Hydrocortisone for Preventing Adverse Drug Reactions to Snake Antivenom: A Meta-Analysis. (Pubmed Central) -  May 3, 2022   
    However, the substantial beneficial effect of prehydrocortisone combinations with premedications (injectable antihistamines or adrenaline) used against ADRs cannot be excluded. Therefore, the use of prehydrocortisone combinations with premedications (injectable antihistamines or adrenaline) as a prophylaxis may reduce the ADRs to antivenom.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Is Cryptosporidium a hijacker able to drive cancer cell proliferation? (Pubmed Central) -  May 3, 2022   
    To explore the dynamics of Cryptosporidium infection, an animal model of cryptosporidiosis using corticoid dexamethasone-treated adult SCID (severe combined immunodeficiency) mice, orally infected with C. parvum or Cryptosporidium muris oocysts was implemented...If Cryptosporidium is able to hijack signal transduction, then is very likely that this contributes to transformation of its host cell. More research in the field is required in order to identify mechanisms and molecular factors involved in this process and to develop effective treatment interventions.
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Enrollment change:  Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study (clinicaltrials.gov) -  May 3, 2022   
    P3,  N=864, Recruiting, 
    More research in the field is required in order to identify mechanisms and molecular factors involved in this process and to develop effective treatment interventions. N=1616 --> 864
  • ||||||||||  triamcinolone acetonide topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Fractional Ablative Laser Treatment for Skin Grafts (clinicaltrials.gov) -  May 3, 2022   
    P=N/A,  N=29, Recruiting, 
    Recruiting --> Active, not recruiting Trial completion date: Mar 2022 --> Jun 2022 | Trial primary completion date: Mar 2022 --> Jun 2022
  • ||||||||||  vilanterol (GW642444H) / GSK, Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
    Enrollment open, Trial completion date, Trial primary completion date, Head-to-Head:  Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults (clinicaltrials.gov) -  May 2, 2022   
    P2/3,  N=130, Recruiting, 
    Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting | Trial completion date: Dec 2021 --> Mar 2023 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Enrollment open, Trial initiation date:  Medrol Dosepak for Outpatient Total Knee Arthroplasty (clinicaltrials.gov) -  May 1, 2022   
    P4,  N=420, Recruiting, 
    Excluded are patients who are planned for an autologous-stem- cell-transplantation following induction, who are intolerable to IMiDs or Carfilzomib, are NYHA-class >II, present with PS ≥ 2, CrCl ≤ 30 ml/min, and/or neuropathy grade ≥ 2. Not yet recruiting --> Recruiting | Initiation date: Nov 2021 --> Mar 2022
  • ||||||||||  Darzalex (daratumumab) / J&J, Tecvayli (teclistamab-cqyv) / Genmab, J&J
    Trial completion date, Trial initiation date, Trial primary completion date:  MASTER-2: Sequential Therapy in Multiple Myeloma Guided by MRD Assessments (clinicaltrials.gov) -  May 1, 2022   
    P2,  N=300, Not yet recruiting, 
    Not yet recruiting --> Recruiting | Initiation date: Nov 2021 --> Mar 2022 Trial completion date: Dec 2026 --> Apr 2027 | Initiation date: Apr 2022 --> Aug 2022 | Trial primary completion date: Dec 2025 --> Apr 2026
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Cardiometabolic Health in Adolescents and Young Adults with Congenital Adrenal Hyperplasia. (Pubmed Central) -  May 1, 2022   
    CAH patients had higher BMI, VAT and frequency of elevated BP compared to controls. Doses of glucocorticoids were related directly to LDL-cholesterol and inversely to lean body mass in CAH females, but not associated with body composition, insulin sensitivity and BP in the whole cohort of CAH patients.
  • ||||||||||  methylprednisolone acetate / Generic mfg., epinephrine / Generic mfg.
    Journal:  Peripheral sensitization is demonstrated in subacromial pain syndrome, with central sensitization found only in females. (Pubmed Central) -  May 1, 2022   
    CLINICAL SIGNIFICANCE -: Neuropathic components are likely present in some patients with subacromial pain syndrome, and female patients may be particularly at risk for presenting with neuropathic pain. These findings are applicable towards understanding the heterogeneous etiology underlying subacromial pain syndrome and informing clinical management.