Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. (Pubmed Central) -  May 7, 2022   
    RAW264.7 mouse macrophages cultured with a mixture of macrophage colony-stimulating factor, interleukin-4, and dexamethasone increased LYVE-1 expression, whereas lipopolysaccharide-stimulation decreased LYVE-1 expression...Lyve1-expressing macrophages promoted the migration and tube formation of human umbilical vein endothelial cells. In conclusion, LYVE-1 tissue-resident M2-like macrophages in dental pulp showed dynamism in response to pulp injury, and possibly play an important role in angiogenesis during wound healing and tissue remodeling.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Review, Journal:  Steroid therapy and antiviral treatment in SARS-CoV-2 pneumonia: clinical contexts and indications. (Pubmed Central) -  May 7, 2022   
    With respect to the effectiveness of remdesivir, the ACTT-1 trial found that the drug conferred a benefit on time to clinical improvement. The subgroup analysis in the clinical trial also showed a benefit per mortality in patients requiring supplemental oxygen, albeit not those in need of mechanical ventilation.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Low-dose Perioperative Dexamethasone Improves 24-hour Post-Operative Pain after Anterior Cruciate Ligament Reconstruction. (Pubmed Central) -  May 7, 2022   
    Patients in the D treatment group were given the first dose of 10mg of intravenous dexamethasone intravenously intraoperatively and the second dose on transferring of the patient to the inpatient department...No adverse side effect, like osteonecrosis of the hip, was detected. The pain following anterior cruciate ligament reconstruction is severe during the first 24 hours and perioperative administration of dexamethasone can decrease the post-operative pain substantially.
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Trial completion date, Trial primary completion date:  Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment (clinicaltrials.gov) -  May 6, 2022   
    P4,  N=260, Recruiting, 
    The pain following anterior cruciate ligament reconstruction is severe during the first 24 hours and perioperative administration of dexamethasone can decrease the post-operative pain substantially. Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2022 --> Dec 2024
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. (Pubmed Central) -  May 6, 2022   
    The GR was activated with the synthetic glucocorticoid dexamethasone, and the effects were mapped using single-cell transcriptomics across development...These findings suggest that excessive glucocorticoid exposure could interfere with neuronal maturation in utero, leading to increased disease susceptibility through neurodevelopmental processes at the interface of genetic susceptibility and environmental exposure. Cerebral organoids are a valuable translational resource for exploring the effects of glucocorticoids on early human brain development.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
    Clinical, Journal, IO biomarker:  ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically lll COVID-19 Patients. (Pubmed Central) -  May 6, 2022   
    Daratumumab and lenalidomide combination therapy could be a valuable treatment option for patients requiring dialysis when bortezomib may be hesitate to use due to severe heart disease. Immune assessment resulted in favorable anakinra responses among critically ill patients with COVID-19 and features of MALS.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease. (Pubmed Central) -  May 6, 2022   
    With initiation of corticosteroid treatment in VKH disease patients, choroidal blood flow improved and was maintained for 2 years. However, the presence of SGF should be taken into consideration when interpreting MBR results in VKH disease patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Using Dexamethasone Wisely in Invasively Ventilated Preterm Infants. (Pubmed Central) -  May 6, 2022   
    However, the presence of SGF should be taken into consideration when interpreting MBR results in VKH disease patients. In this month's issue, O'Connor et al investigate factors associated with successful extubation in preterm infants exposed to dexamethasone.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Clinical response predictors of tocilizumab therapy in patients with severe COVID-19 (Poster View 9) -  May 6, 2022 - Abstract #EULAR2022EULAR_2659;    
    Objectives: To identify predictors of clinical response to tocilizumab (TCZ) added to dexamethasone in patients hospitalized with severe COVID-19. Administration of TCZ early in severe disease, with moderate IL-6 concentration and low organ damage indices is most beneficial in patients with severe COVID-19, especially in younger patients without respiratory and cardiac comorbidities.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Progressive multifocal leukocencephalopathy in a patient with a background of lupus nephritis and cerebral lupus. (Poster View 11) -  May 6, 2022 - Abstract #EULAR2022EULAR_1971;    
    Her longstanding lymphopenia with low CD4 counts were attributed to the combined consequences of active lupus and her cumulative immunosuppressive burden. CD4 lymphopenia is associated with PML in the HIV population, and may provide information about which patients on immunosuppressive treatments are at risk of developing PML (3).
  • ||||||||||  dexamethasone / Generic mfg., tranexamic acid oral / Generic mfg.
    Clinical, Journal:  National survey on the current practice and attitudes toward the management of chronic subdural hematoma. (Pubmed Central) -  May 6, 2022   
    However, this is considered not to be insurmountable when implementing evidence-based treatments. This baseline inventory on current clinical practice and current attitudes toward CSDH-treatment is a stepping-stone in the eventual development and implementation of a national guideline.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Sepsis and Septic Shock: Evolving Evidence, Evolving Paradigms. (Pubmed Central) -  May 6, 2022   
    Conflicting data exist regarding the impact of corticosteroids on mortality in septic shock. However, these reports indicate that adjunctive hydrocortisone can lead to more rapid shock reversal.
  • ||||||||||  remdesivir / Generic mfg.
    Journal, HEOR:  The Cost-Effectiveness of Remdesivir for Hospitalized Patients With COVID-19. (Pubmed Central) -  May 6, 2022   
    With the current evidence available, remdesivir's price is too high to align with its expected health gains for hospitalized patients with COVID-19. Results from this study provide a rationale for iterative health technology assessment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone as risk-factor for ICU-acquired respiratory tract infections in severe COVID-19. (Pubmed Central) -  May 6, 2022   
    Results from this study provide a rationale for iterative health technology assessment. Patients treated with dexamethasone for severe COVID-19 had a higher risk of developing ICU-acquired respiratory tract infections after adjusting for days of invasive mechanical ventilation and ICU length of stay, suggesting a cautious use of this treatment.
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates: An Umbrella Review of Systematic Reviews and Meta-analyses. (Pubmed Central) -  May 6, 2022   
    Patients treated with dexamethasone for severe COVID-19 had a higher risk of developing ICU-acquired respiratory tract infections after adjusting for days of invasive mechanical ventilation and ICU length of stay, suggesting a cautious use of this treatment. A multipronged approach of delivery room continuous positive airway pressure, early selective surfactant administration with less invasive surfactant administration, early hydrocortisone prophylaxis in high-risk neonates, inhaled corticosteroids, and volume-targeted ventilation for preterm neonates requiring invasive ventilation may decrease the combined risk of BPD or mortality at 36 weeks' PMA.