Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...321322323324325326327328329330331...10671068»
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Review, Journal:  Glucocorticoids in Myositis: Initiation, Tapering, and Discontinuation. (Pubmed Central) -  May 10, 2022   
    Steroid-related myopathy and osteoporosis are glucocorticoid side effects that are particularly relevant in myositis. The optimal dose and duration of glucocorticoid therapy in myositis currently remain elusive, and this review emphasizes the need for better quality studies in this area.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Bone Marrow Mesenchymal Stem Cells Overexpressing HIF-1α Prevented the Progression of Glucocorticoid-Induced Avascular Osteonecrosis of Femoral Heads in Mice. (Pubmed Central) -  May 10, 2022   
    BMMSCs isolated from wild-type (WT) mice were treated with dexamethasone (Dex) and the results showed that Dex repressed the expression of COX-2...Implantation of BMMSCs overexpressing HIF-1α into femoral heads of AOFH mice significantly reduced osteonecrotic areas and enhanced bone repair, thus largely preserving the structural integrity of femoral heads. Our studies provide strong rationales for early intervention with core decompression and implantation of modified BMMSCs for GC-induced AOFH, which may spare patients from expensive and difficult surgical procedures.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics. (Pubmed Central) -  May 10, 2022   
    Bulk and single-cell transcriptomic analyses confirmed dampened inflammatory cell recruitment into lungs upon dexamethasone treatment, and identified a specifically responsive subpopulation of neutrophils, thereby indicating a potential mechanism of action. Our analyses confirm the anti-inflammatory properties of dexamethasone and suggest possible mechanisms, validate anti-viral effects of anti-SARS-CoV-2 antibody treatment, and reveal synergistic effects of a combination therapy, thus informing more effective COVID-19 therapies.
  • ||||||||||  cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Paraneoplastic cerebellar degeneration with anti-Yo antibodies and an associated submandibular gland tumor: a case report. (Pubmed Central) -  May 10, 2022   
    Although tumor detection was delayed, early tumor detection, diagnosis, and PCD treatment are essential because any delay can result in the progression of the disorder and irreversible neurological damage. Therefore, we recommend that the possibility of a salivary gland tumor should be considered, and whole-body dual-modality CT, including the head and neck, and FDG-PET should be performed at the earliest for patients with well-characterized paraneoplastic antibodies when conventional imaging fails to identify a tumor.
  • ||||||||||  prednisone delayed-release tablet / Generic mfg.
    Journal:  Mónico Sánchez Moreno: A pioneer in radiologic technology. (Pubmed Central) -  May 10, 2022   
    Her efforts made it possible to have an affordable device made in Spain that would allow radiological examinations to be done in places where it would have been otherwise unthinkable. In conclusion, Mónico Sánchez Moreno was a self-made woman who deserves to be remembered for her pioneering role in portable radiology.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  A Case Report of FLAMES with Elevated Myelin Basic Protein Followed by Myelitis. (Pubmed Central) -  May 10, 2022   
    His symptoms and imaging abnormalities were improved after intravenous methylprednisolone therapy...Myelin basic protein (MBP) was elevated in CSF. The high MBP value in the CSF in the present case suggested that demyelination as well as inflammation can occur in some FLAMES patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation. (Pubmed Central) -  May 10, 2022   
    We describe the design and application of a light responsive red blood cell (RBC) conveyed dexamethasone (Dex) construct that enables targeted drug delivery upon illumination of the inflamed site...In addition, a single dose of light-targeted Dex delivery is 5-fold more effective in suppressing inflammation than the parent drug, delivered serially over multiple days. These results are consistent with the notion that the circulatory system be used as an on-command drug depot, providing the means to therapeutically target diseased sites both efficiently and effectively.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, IO biomarker:  Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway. (Pubmed Central) -  May 10, 2022   
    We obtained gene expression profile of osteoblasts subjected to dexamethasone (Dex) treatment from the Gene Expression Omnibus (GEO) database...Dex induces osteoblast apoptosis via the PI3K/AKT/FOXO1 signaling pathway. Our research offers new insights into the underlying molecular mechanisms of glucocorticoid-induced osteonecrosis in SONFH and proposes FOXO1 as a therapeutic target for this disease.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Dexamethasone-Loaded biodegradable magnetic microparticles for treatment of CFA-induced chronic pain in rats. (Pubmed Central) -  May 10, 2022   
    b) Therapeutic effect: the treatment effect of dexamethasone-PLGA magnetic microspheres + magnetic therapy was substantially better than that observed for other groups on day 4, as monitored by appearance, mechanical pain threshold, and histological analysis. This type of carrier could be a suitable magnetically retainable local drug delivery system for treating chronic pain.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Journal:  Clinical Efficacy of Gandakang Tablets plus Methylprednisolone in Patients with Systemic Lupus Erythematosus. (Pubmed Central) -  May 10, 2022   
    Patients given Gandakang tablets plus methylprednisolone had higher mental health, emotional role, physical role, social functioning, and bodily pain scores versus those receiving the monotherapy of methylprednisolone (P < 0.05). Gandakang tablets plus methylprednisolone is effective in the treatment of SLE by enhancing the patients' immunity, mitigating the inflammatory response, eliminating negative emotions, and improving their quality of life.
  • ||||||||||  dexamethasone / Generic mfg.
    New P4 trial, Surgery:  MIDCAB (Mid-Calf Block) for Foot Surgery (clinicaltrials.gov) -  May 10, 2022   
    P4,  N=20, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Sorghum (Sorghum bicolor) Extract-Induced Adipogenesis Is Independent of PPARγ Ser273 Phosphorylation in 3T3-L1 Adipocytes. (Pubmed Central) -  May 9, 2022   
    Previously we showed that the water-soluble fraction of sorghum extract (SE) improves adipogenesis in 3-isobutyl-1-methylxanthine (IBMX)/dexamethasone/insulin (MDI)/thiazolidinedione (TZD)-induced 3T3-L1 preadipocytes but downregulates genes related to peroxisome proliferator-activated receptor γ (PPARγ) and adipogenesis in both MDI- and MDI/TZD-induced 3T3-L1 adipocytes...SE downregulated PPARγ expression in MDI-induced 3T3-L1 adipocytes and did not affect its phosphorylation at Ser273 in MDI- and MDI/Tro-induced 3T3-L1 adipocytes. Therefore, SE likely promotes adipogenesis and lipid metabolism in 3T3-L1 preadipocytes by cooperating with Tro independent of PPARγ Ser273 phosphorylation.
  • ||||||||||  triamcinolone acetonide topical / Generic mfg., doxycycline / Generic mfg.
    Journal:  Prurigo pigmentosa in a patient with newly diagnosed type one diabetes with diabetic ketoacidosis. (Pubmed Central) -  May 9, 2022   
    Histopathological findings consistent with the clinical findings suggested the diagnosis of prurigo pigmentosa. After treatment with topical triamcinolone and oral doxycycline along with resolution of his ketosis after insulin administration, the patient's rash healed with reticulate hyperpigmentation.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Less Traditional Interventions Lead to Dramatic Changes for Young Woman with Neuromyelitis Optica (Gaylord National Resort & Convention Center - Prince George's Exhibit Hall) -  May 9, 2022 - Abstract #CMSC2022CMSC_26;    
    Ellie received 5 days IV Solumedrol with prednisone taper...Solumedrol infusion was repeated in July 2021 and Rituximab infusion just prior to OP discharge September 2021... Incorporating less traditional treatment interventions, along with a carefully coordinated schedule and team communication contributed to Ellie's relatively quick progress.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Enrollment closed, Combination therapy, IO biomarker:  Multi-center, Open-label, Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov) -  May 9, 2022   
    P1b,  N=56, Active, not recruiting, 
    Incorporating less traditional treatment interventions, along with a carefully coordinated schedule and team communication contributed to Ellie's relatively quick progress. Recruiting --> Active, not recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date:  Erector Spinae Plane Blocks for Adolescent Idiopathic Scoliosis (clinicaltrials.gov) -  May 9, 2022   
    P=N/A,  N=24, Enrolling by invitation, 
    Trial completion date: Mar 2022 --> Dec 2022 | Trial primary completion date: Mar 2022 --> Nov 2022 Trial completion date: Jun 2022 --> Sep 2022 | Trial primary completion date: May 2022 --> Aug 2022
  • ||||||||||  Onon dry syrup (pranlukast) / Ono Pharma
    Journal:  The Effects of Combined Therapeutic Protocol on Allergic Rhinitis Symptoms and Molecular Determinants. (Pubmed Central) -  May 8, 2022   
    Allergic symptoms (nasal rubbing and sneezing), serum Igs (IgG1, total and OVA-specific IgE), eicosanoids (LTB4 and LTC4), histamine, TSLP, and IL-4 as well as gene expressions of MUC5a, Caspase-1, NLR3, HRH1, and CysLT1R were reduced in the animals receiving each of the therapeutic regimens; however, more pronounced effects were seen in the group treated with the triple combined protocol (loratadine + fluticasone + pranlukast). The combination of the loratadine, fluticasone, and pranlukast can effectively control the symptoms of AR probably via modulating several related mechanisms at early and late phases of allergic responses.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  miR-455-5p regulates circadian rhythms by accelerating the degradation of Clock mRNA. (Pubmed Central) -  May 7, 2022   
    In conclusion, miR-455-5p is essential for maintaining a normal circadian rhythm via regulating Clock mRNA stability. Our study reveals a new mutual regulatory mechanism between CLOCK protein, Clock mRNA, and miR-455-5p, which regulates circadian rhythms in cells.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Mini-review: pump therapy in endocrinology & metabolism beyond diabetes. (Pubmed Central) -  May 7, 2022   
    A systematic literature search has been conducted on PubMed database seeking articles published until May 2021 using a combination of the following Medical Subject Headings terms and keywords: pump "OR" continue infusion "AND" (adrenal insufficiency "OR" Addison "OR" hydrocortisone "OR" hypoparathyroidism "OR teriparatide" "OR" somatostatin "OR" hypogonadism "OR" hypoglycemia "OR" endocrinology "OR" hormone replacement). In addition, the reference publications in the identified articles have also been reviewed.