Glucocorticoid Receptor 

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  • ||||||||||  Journal:  A Rare Cyclic Cushing Syndrome Mystery Illustrates Diagnostic Principles. (Pubmed Central) -  Jun 25, 2024   
    This case underscores the importance of considering pheochromocytoma in ACTH-dependent hypercortisolism with elevated metanephrines and an adrenal mass. Timely diagnosis and treatment can reduce morbidity and improve quality of life.
  • ||||||||||  Zynyz (retifanlimab-dlwr) / Incyte
    Journal:  Secondary adrenocortical insufficiency after treatment with retifanlimab: a case report. (Pubmed Central) -  Jun 25, 2024   
    The vomiting resolved, and the electrolyte levels were corrected after 3 days of treatment with glucocorticoids (hydrocortisone, intravenous, 200 mg/day). When patients present with gastrointestinal symptoms, such as poor appetite and nausea, not only symptomatic treatment but also a search for the etiology behind the symptoms is needed, especially in immunotherapy patients who should undergo a thorough evaluation of the endocrine system and be alert for adrenocortical insufficiency.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Enrollment closed, Enrollment change:  Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis (clinicaltrials.gov) -  Jun 25, 2024   
    P1,  N=11, Active, not recruiting, 
    When patients present with gastrointestinal symptoms, such as poor appetite and nausea, not only symptomatic treatment but also a search for the etiology behind the symptoms is needed, especially in immunotherapy patients who should undergo a thorough evaluation of the endocrine system and be alert for adrenocortical insufficiency. Recruiting --> Active, not recruiting | N=25 --> 11
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  CLINICAL CHARACTERISTICS AND MULTIMODAL IMAGING FINDINGS IN UNILATERAL FROSTED BRANCH ANGIITIS: A CASE REPORT. (Pubmed Central) -  Jun 24, 2024   
    Multimodal imaging is crucial to correctly diagnose and treat frosted branch angiitis. To the best of our knowledge, the use of optical coherence tomography angiography as a complementary tool to the diagnostic process in frosted branch angiitis has been described in literature just once as a photographic essay of cytomegalovirus-related frosted branch angiitis 1 and it might be of great value for better characterizing clinical features of this disorder and for following disease activity in a noninvasive fashion.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg.
    Journal:  Outcomes of a Dexamethasone-Prednisone Combination Treatment Course for Status Asthmaticus. (Pubmed Central) -  Jun 24, 2024   
    Dexamethasone and combination therapy were not associated with increased 30-day ED reutilization/hospital readmissions compared to prednisone (p?>?0.05).ConclusionsIn our study, most patients hospitalized for status asthmaticus received combination therapy. Despite the differences in severity between steroid groups, outcomes of combination therapy and dexamethasone monotherapy, as measured by frequency of ED reutilizations/hospital readmissions, are comparable to prednisone monotherapy.
  • ||||||||||  Nucala (mepolizumab) / GSK
    Journal:  Case report: eosinophilic myocarditis in hypereosinophilic syndrome: a journey to heart transplantation. (Pubmed Central) -  Jun 24, 2024   
    Treatment involved Solu-Medrol for HES and heparin for ventricular thrombi, leading to initial clinical improvement...Management includes standard heart failure treatments, steroids, and emerging therapies like Mepolizumab...Advancements in the detection of complications, surgical management, and therapeutic options have improved outcomes in HES. Ongoing research is essential to further understand and address the diagnostic and therapeutic challenges of HES and EM.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction. (Pubmed Central) -  Jun 24, 2024   
    Dexamethasone was used in about 1 in 4 eligible mSBO admissions with high variability of use between tertiary academic centers. This multicenter retrospective cohort study suggested an association between dexamethasone use and lower rates of nonelective surgery, representing a potential opportunity for quality improvement.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Transient Neonatal Hypocortisolism in Neonates with Hypoglycemia - Coexistence or Cause? (Pubmed Central) -  Jun 24, 2024   
    Four of the five babies were started on oral hydrocortisone, to which they responded well with the resolution of hypoglycemia...While the non-specific use of glucocorticoids is not advocated, the role of therapeutic glucocorticoids among at-risk neonates with documented hypocortisolism during hypoglycemia should be an area for research. Close follow-up of these neonates for spontaneous recovery of cortisol levels is warranted.
  • ||||||||||  dexamethasone / Generic mfg., acyclovir / Generic mfg.
    Journal:  A case of Hemophagocytic syndrome due to reactivation of Epstein-Barr virus after novel coronavirus infection. (Pubmed Central) -  Jun 24, 2024   
    Here, we report a case of a 73-year-old man with EBV reactivation after novel coronavirus infection, who was diagnosed with hemophagocytic syndrome after bone marrow aspiration and died after being treated with acyclovir, dexamethasone. the aim of this report is to increase clinical awareness of this type of disease for early recognition and treatment.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Split Dose of Prednisolone in the Treatment for Erythema Nodosum Leprosum: A Case Series. (Pubmed Central) -  Jun 24, 2024   
    Oral prednisolone is the drug of choice, with doses ranging from 0.5 to 1 mg/kg...Results Eight cases of ENL (three nodular, three necrotic, one pustular, and one nodulcerative) had a dramatic response to split-dose therapy without any relapse and HPA axis suppression. Conclusion A split-dosing regimen can be a good treatment option in ENL with better control, less steroid dependency, and a lower relapse rate.
  • ||||||||||  Tevimbra (tislelizumab-jsgr) / BeiGene
    Review, Journal:  Treatment of Tislelizumab-Induced Toxic Epidermal Necrolysis and Agranulocytosis: A Case Report and Literature Review. (Pubmed Central) -  Jun 24, 2024   
    Effective management of severe immune-related side effects from tislelizumab, including TEN and agranulocytosis, can be partly achieved through steroids, gamma globulin, GCSF, and antibiotics. This strategy not only alleviates these adverse effects, but also potentially improves tumor conditions, highlighting the crucial role of vigilant monitoring and management in immunotherapy.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis. (Pubmed Central) -  Jun 23, 2024   
    For example, the abundance of Oscillibacter was strongly correlated with gut microflora-related metabolites (Icosenoic acid, Lysosulfatide, and fluticasone) and liver differential genes (Grin3b, Lifr, and Spta1). Together, IMI exposure resulted in significant changes in microbial composition, along with alterations in certain metabolites and genes associated with metabolic process, which may promote gestational hyperglycemia.
  • ||||||||||  Skyclarys (omaveloxolone) / Biogen
    Journal:  Omaveloxolone ameliorates glucocorticoid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis. (Pubmed Central) -  Jun 22, 2024   
    The results demonstrate that OMA promotes DEX-induced osteogenesis, HUVECs migration, angiogenesis, and anti-apoptosis in hBMSCs by inhibiting the STING/NF-?B signaling pathway. This experimental evidence underscores the potential of OMA in regulating DEX-induced osteogenesis, HUVECs migration, angiogenesis, and anti-apoptosis in hBMSCs through the STING/NF-?B pathway, thereby offering a promising avenue for improving the progression of SONFH.
  • ||||||||||  dexamethasone / Generic mfg., gentamicin sulfate / Generic mfg.
    Retrospective data, Review, Journal:  Pharmacological Interventions for Meni (Pubmed Central) -  Jun 22, 2024   
    Pharmacological intervention is more effective than placebo in treating MD. Although gentamicin treatment shows significant effects in treating vertigo, corticosteroid combination therapy is markedly superior to gentamicin in controlling hearing loss and vertigo symptoms.
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  Pre vs Post Block in Total Knee Arthroplasty (TKA) (clinicaltrials.gov) -  Jun 21, 2024   
    P4,  N=84, Completed, 
    The findings suggest that increasing the resistance of MSCs to stress by preconditioning them via dexamethasone or hypoxia exposure could result in more rapid differentiation into osteoblasts following transplantation. Trial completion date: Jul 2024 --> Jan 2024 | Recruiting --> Completed | Trial primary completion date: Jul 2024 --> Jan 2024