Glucocorticoid Receptor 

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  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Cortisol promotes breast-to-brain metastasis through the blood-cerebrospinal fluid barrier. (Pubmed Central) -  May 26, 2022   
    Our findings indicate, for the first time that increased cortisol levels facilitate breast-to-brain metastasis through the BCSFB-a vulnerable point of entry which has been typically overlooked in brain metastasis. Our study suggests cortisol plays a pro-metastatic role in breast-to-brain metastasis and thus caution is needed when using glucocorticoids to treat breast cancer patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  DAMPening Severe COVID-19 with Dexamethasone. (Pubmed Central) -  May 26, 2022   
    Our study suggests cortisol plays a pro-metastatic role in breast-to-brain metastasis and thus caution is needed when using glucocorticoids to treat breast cancer patients. No abstract available
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Postinfectious SARS-CoV-2 Opsoclonus-Myoclonus-Ataxia Syndrome. (Pubmed Central) -  May 26, 2022   
    In this case report, we report 1 patient with elevated CSF neuronal specific enolase, macrosaccadic oscillations, ocular flutter, and OMAS as a SARS-CoV-2 postinfectious complication. Opsoclonus emerged predominantly with fixation block and suppressed with fixation, providing support to modern theories on the mechanism responsible for these ocular oscillations involving cerebellar-brainstem pathogenesis.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Great balls of fire! The basal ganglia on fire. (Pubmed Central) -  May 26, 2022   
    He was treated with intravenous methylprednisolone and rituximab, and made a remarkable recovery. Magnetic resonance imaging of the brain was normal, although positron emission tomography - computed tomography showed striking basal ganglia changes.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly
    Journal:  Discovery of new drug indications for COVID-19: A drug repurposing approach. (Pubmed Central) -  May 25, 2022   
    The docking results suggested that doxorubicin showed the least binding energy compared to reference drugs. Their practical utility as anti-SARS-CoV-2 drugs, either individually or in combination, warrants further investigation.
  • ||||||||||  Nasonex (mometasone furoate nasal spray) / Merck (MSD)
    Trial completion:  Anti-Inflammatory Agent in Sinusitis (clinicaltrials.gov) -  May 25, 2022   
    P2a,  N=43, Completed, 
    Eight out of nine cases had a favorable outcome. Enrolling by invitation --> Completed
  • ||||||||||  dexamethasone injection / Generic mfg.
    Mechanistic link between central serous and glucocorticoids (Main Room) -  May 25, 2022 - Abstract #Macula2022Macula_102;    
    The fact that intraocular injection of glucocorticoids does not increase the risk of CSCR suggests that the consequences of the HPA axis regulations on ocular tissues may be involved. Our results are in line with this hypothesis, and they suggest that it could be rather a lack of activation of the glucocorticoid pathway in the eye and an imbalance in favor of activation of the mineralocorticoid pathway in RPE/ choroid, observed in response to the HPA axis brake that could favor CSCR.
  • ||||||||||  hydrocortisone / Generic mfg.
    Trial completion, Enrollment change:  Investigating the Central and Peripheral Mechanisms by Which Glucocorticoids Affect Hunger (clinicaltrials.gov) -  May 25, 2022   
    P1,  N=28, Completed, 
    Our results are in line with this hypothesis, and they suggest that it could be rather a lack of activation of the glucocorticoid pathway in the eye and an imbalance in favor of activation of the mineralocorticoid pathway in RPE/ choroid, observed in response to the HPA axis brake that could favor CSCR. Active, not recruiting --> Completed | N=16 --> 28
  • ||||||||||  dexamethasone / Generic mfg., carboplatin / Generic mfg., fosaprepitant / Generic mfg.
    Trial completion date, Trial suspension, Trial primary completion date:  Low Dose Aprepitant for Patients Receiving Carboplatin (clinicaltrials.gov) -  May 25, 2022   
    P2,  N=50, Suspended, 
    Active, not recruiting --> Completed | N=16 --> 28 Trial completion date: Aug 2021 --> Aug 2022 | Recruiting --> Suspended | Trial primary completion date: Jul 2021 --> Jul 2022
  • ||||||||||  Darzalex (daratumumab) / J&J, Neupogen (filgrastim) / Kyowa Kirin, Amgen
    Trial completion date, Trial primary completion date:  MUKnineb: MUK Nine b: OPTIMUM Treatment Protocol (clinicaltrials.gov) -  May 25, 2022   
    P2,  N=95, Active, not recruiting, 
    Trial completion date: Aug 2021 --> Aug 2022 | Recruiting --> Suspended | Trial primary completion date: Jul 2021 --> Jul 2022 Trial completion date: Dec 2022 --> Jun 2023 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  JNJ-1887 / J&J
    Trial completion:  AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) -  May 25, 2022   
    P1,  N=25, Completed, 
    Active, not recruiting --> Completed Active, not recruiting --> Completed
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal, Adverse events:  Adverse effects of prenatal dexamethasone exposure on fetal development. (Pubmed Central) -  May 25, 2022   
    In addition, we strongly support the application of dexamethasone as a pharmaceutical therapy in pregnant women with coronavirus disease 2019 before a better therapy is developed. However, the adverse side effects that may arise also cannot be ignored.
  • ||||||||||  Journal:  Drug treatment strategies for eosinophilic esophagitis in adults. (Pubmed Central) -  May 25, 2022   
    Finally, the authors briefly look at the value of monoclonal antibodies targeting IL-5RA, IL-13, IL-4 or Siglec8, and oral S1PR agonists to the treatment of EoE...Investigational therapies that target several Th2-associated diseases seem useful in EoE. Comparative effectiveness and cost-utility analyses will help to position them in a complex therapeutic scenario.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Murine model of steroid-resistant neutrophilic bronchial asthma as an attempt to simulate human pathology. (Pubmed Central) -  May 25, 2022   
    Moreover, this pathology developed through Th1- and Th17-dependent mechanisms and mice with induced neutrophilic BA phenotype responded poorly to dexamethasone treatment, that coincide to clinical observations. The established mouse model could be useful both for studying the pathogenesis and for testing novel approaches to control neutrophilic BA.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells. (Pubmed Central) -  May 25, 2022   
    The core clock genes and clock-related genes showed high-amplitude robust circadian messenger RNA (mRNA) expression rhythms in cHCECs after treatment with dexamethasone, and 329 genes that exhibited circadian mRNA expression rhythms were identified (i.e., genes involved in various physiological processes including glycolysis, mitochondrial function, antioxidative systems, hypoxic responses, apoptosis, and extracellular matrix regulation, which represent the physiological functions of HCECs). Our findings revealed that cHCECs have a robust and functional circadian clock, and our discovery that a large number of genes exhibit circadian mRNA expression rhythms in cHCECs suggests a potential contribution of circadian regulation to fine-tune HCEC functions for daily changes in the environment.
  • ||||||||||  Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
    Trial initiation date, Trial suspension:  STARR: Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease (clinicaltrials.gov) -  May 25, 2022   
    P1,  N=10, Suspended, 
    Our findings revealed that cHCECs have a robust and functional circadian clock, and our discovery that a large number of genes exhibit circadian mRNA expression rhythms in cHCECs suggests a potential contribution of circadian regulation to fine-tune HCEC functions for daily changes in the environment. Initiation date: Mar 2022 --> Sep 2022 | Recruiting --> Suspended
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Assessing recovery of adrenal function in glucocorticoid-treated patients: Our strategy for screening and management. (Pubmed Central) -  May 24, 2022   
    All patients had received GC therapy for longer than 3 weeks before switching to hydrocortisone substitution, for various indications...We demonstrated the positive correlation between serum cortisol peak levels after stimulation and body mass index. The study supports that basal cortisol level, the duration of corticoid cessation and the type of stimulation test can predict the response of cortisol to stimulation tests.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis. (Pubmed Central) -  May 24, 2022   
    The efficacy was comparable to that of dexamethasone, but without appreciable side effects...Moreover, the Fer-1-NPs treatment showed no signs of cytotoxicity, hematologic toxicity, or visceral organ damage, which further confirmed the biocompatibility. Overall, Fer-1-NPs provide a new prospect for safe and effective therapy for corneal alkali burn.
  • ||||||||||  dexamethasone / Generic mfg.
    Results of routine patch testing with 10 allergens not included in 2015 and 2019 European baseline series () -  May 24, 2022 - Abstract #EAACI2022EAACI_2232;    
    Eight allergens not listed in 2015 nor 2019 EBS had ≥ 0.5% prevalence rate (ie, cocamidopropyl betaine, thimerosal, disperse blue mix (106/124), 2-bromo-2-nitropropane-1,3-diol, propylene glycol, compositae mix, diazolidinyl urea, and dexamethasone)...Our study also shows the importance of late readings since relatively high frequencies of pos. reactions would have been missed if such readings had not taken place.
  • ||||||||||  dexamethasone / Generic mfg., montelukast / Generic mfg.
    Carboplatin and oxaliplatin desensitization in six patients: an interdisciplinary experience () -  May 24, 2022 - Abstract #EAACI2022EAACI_2105;    
    Conclusion The interdisciplinary approach facilitated the management of problems during the robotic preparation and administration of chemotherapeutics in the intensive care unit. Interdisciplinary teams may increase the success rates of desensitization protocols for platinum-based chemotherapy, where the concentration and application of drugs differ from standard procedures.