- |||||||||| Henletor (torsemide) / Orchid
Journal: Minimal Change Disease in an Adult: A Case Report. (Pubmed Central) - Jun 5, 2022 Hence, minimal change disease should also be considered as a differential diagnosis in adults presenting with the features of nephrotic syndrome. electron microscopy; minimal change disease; nephrotic syndrome; prednisolone.
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
Breakthrough SARS-CoV-2 Infections in Fully Vaccinated Kidney Transplant Recipients: A Series of Two Cases (Exhibit and Poster Hall) - Jun 4, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_3251; Despite treatment with remdesivir, baricitinib, and intravenous methylprednisolone, she developed multiorgan dysfunction (MOD). This case series demonstrates that further investigation is required to develop a safe way to effectively immunize KT patients currently on immunosuppressive therapy against COVID-19.
- |||||||||| nanocrystalline form of fluticasone (AC-155) / Nicox, Vyzulta (latanoprostene bunod) / Bausch Health, Nicox, nitric oxide (NO)‑donating bimatoprost analog (NCX 470) / Nicox
Nicox (Theater 3) - Jun 4, 2022 - Abstract #BIO2022BIO_203; Our ophthalmic pipeline includes two programs in clinical development, NCX 470 targeting glaucoma and NCX 4251 targeting dry eye disease. We also have two products which are commercialized in the U.S., VYZULTA® (latanoprostene bunod ophthalmic solution) 0.024% and ZERVIATE® (cetirizine ophthalmic solution) 0.24%, for use in patients with open-angle glaucoma and ocular allergic conjunctivitis, respectively.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal, Epigenetic controller: Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. (Pubmed Central) - Jun 4, 2022 In this study, cultured hippocampal neurons treated with NMDA or dexamethasone showed an increased of DNA methyltransferase 3b (DNMT3b) mRNA expression, which was blocked by pre-treatment with nNOS inhibitor n -propyl-l-arginine (NPA)...The NOS inhibitors 7-NI and aminoguanidine (AMG) decreased the number of escape failures in LH, and counteracted the changes in hippocampal DNMT3b mRNA induced in this behavioral paradigm. Altogether, our data suggest that NO produced in response to NMDAr activation following stress upregulates DNMT3b in the hippocampus.
- |||||||||| Journal, Adverse drug reaction: Managing Multiple Myeloma in the Face of Drug-Induced Adverse Drug Reaction. (Pubmed Central) - Jun 4, 2022
Other proteasome inhibitors are available for multiple myeloma treatment. When starting chemotherapy, it is important to be aware of medications that cause a rise in liver enzymes, potential drug interactions, and how best to manage the clinical consequences.
- |||||||||| fluticasone / Generic mfg.
Review, Journal: Fluticasone/Formoterol compared withother ICS/LABAs in asthma: A systematic review. (Pubmed Central) - Jun 4, 2022 The present systematic review was undertaken to compare the clinical efficacy and safety of formoterol fluticasone (FF) to other ICS/LABA combinations in asthmatics...Only trials comparing the efficacy and safety of FF in comparision with Salmeterol/fluticasone (SF) or Budesonide/Formoterol (BF) were selected...Pneumonia risk was least with FF usage.ConclusionFF provides faster onset of action, numerically superior improvement in lung function and comparable asthma control than other ICS-LABA formulations. FF has better safety evidenced by lower occurrence of pneumonia.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Cortisol promotes the cognitive regulation of high intensive emotions independent of timing. (Pubmed Central) - Jun 4, 2022 Eighty-five healthy men received either 10 mg hydrocortisone or a placebo in a double-blind, randomized design 30 or 90 min prior to an emotion regulation paradigm, in which they were asked to downregulate their emotional responses towards low and high intensive negative pictures via reappraisal or distraction...Cortisol significantly reduced arousal ratings when downregulating high intensive negative emotions via distraction and (at a trend level) via reappraisal, independent of timing, demonstrating a beneficial effect of cortisol on subjective regulatory outcomes. Taken together, this study provides initial evidence suggesting that cortisol promotes the cognitive control of high intensive negative emotions both, 30 and 90 min after treatment.
- |||||||||| fluocinolone acetonide / Generic mfg.
Journal: Non-infectious uveitis affecting the posterior segment treated with fluocinolone acetonide intravitreal implant: 3-year fellow eye analysis. (Pubmed Central) - Jun 4, 2022 P3 In the three countries evaluated, total treatment costs with regular twice-daily FP/salm were consistently lower than with budesonide/formoterol MART due to lower direct healthcare costs. In subjects with bilateral NIU-PS, continuous, low-dose corticosteroid with 0.2 μg/day FAi reduced recurrence and adjunctive medication requirements, and improved vision over 36 months, providing greater protection against ocular inflammation than a reactive approach using standard of care.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Retrospective data, Journal: Effectiveness and safety of R-GCD (rituximab, gemcitabine, carboplatin, and dexamethasone) for transplant-ineligible relapse/refractory diffuse large B-cell lymphoma and grade 3a follicular lymphoma: a retrospective analysis comparing with R-GDP (rituximab, gemcitabine, cisplatin, and dexamethasone). (Pubmed Central) - Jun 4, 2022 No abstract available No abstract available
- |||||||||| Darzalex (daratumumab) / J&J
P2 data, Journal, HEOR: Pomalidomide, dexamethasone, and daratumumab immediately after lenalidomide-based treatment in patients with multiple myeloma: updated efficacy, safety, and health-related quality of life results from the phase 2 MM-014 trial. (Pubmed Central) - Jun 4, 2022 P2 Health-related quality of life was preserved or trended toward improvement through 12 treatment cycles. Pomalidomide, dexamethasone, and daratumumab given immediately after early-line lenalidomide-based treatment continues to demonstrate safety and efficacy, supporting pomalidomide-dexamethasone as a foundation of combination therapy in RRMM and providing evidence that the immunomodulatory agent class delivers benefit after lenalidomide treatment failure.
- |||||||||| Review, Journal: Premedication Protocols to Prevent Hypersensitivity Reactions to Chemotherapy: a Literature Review. (Pubmed Central) - Jun 4, 2022
Most premedication regimens have been derived empirically rather than determined through randomized trials. Based on the available evidence, we provide an update on likely HSR mechanisms and a practical guide for classifying systemic HSR. The evidence indicates that a combination of prevention strategies using newer antihistamines, H2 antagonists, leukotriene receptor antagonists, and corticosteroids and other interventions used judiciously reduces the occurrence and severity of HSR and improves safety.
- |||||||||| Ocrevus (ocrelizumab) / Roche, Biogen
Journal: Impact of immunotherapies on COVID-19 outcomes in multiple sclerosis patients. (Pubmed Central) - Jun 4, 2022 Severity of disability, MS clinical phenotype, age, and comorbidities, along with the use of intravenous methylprednisolone and anti-CD20 treatments, are risk factors for COVID-19 severity...COVID-19 vaccination is safe in MS, and its efficacy could be reduced in fingolimod- and ocrelizumab-treated patients...Impact of emerging DMTs on COVID-19 should be investigated. More data and longer follow-up are needed to characterize long-term efficacy and safety profile of vaccinations in pwMS.
- |||||||||| dexamethasone / Generic mfg., celecoxib oral / Generic mfg.
Journal: Prenatal Activation of Glucocorticoid Receptors Induces Memory Impairment in a Sex-Dependent Manner: Role of Cyclooxygenase-2. (Pubmed Central) - Jun 4, 2022 Prenatal exposure to dexamethasone (DEX) results in long-lasting effects on cognitive functions such as learning and memory impairment...A different cohort of adult male and female rat offspring was given daily injections of either vehicle or a specific COX-2 inhibitor (celecoxib 10 mg/kg, i.p.) for 5 consecutive days and was subsequently subjected to Morris water maze memory test...This study suggests that prenatal activation of glucocorticoid receptors stimulates COX-2 gene and protein expression and impairs hippocampal-dependent spatial memory in female but not male rat offspring. Furthermore, COX-2 selective inhibitors can be used to alleviate the long-lasting deleterious effects of corticosteroid medication during pregnancy.
- |||||||||| dexamethasone / Generic mfg., ropivacaine / Generic mfg., dexmedetomidine / Generic mfg.
Retrospective data, Journal: The feasibility and safety of cocktail treatment of triple anti-inflammatory agents loaded with gelatin sponge promotes early recovery after posterior percutaneous endoscopic cervical discectomy. (Pubmed Central) - Jun 4, 2022 In conclusion, this study found significantly lower IOPs levels at 18 and 24 months of follow-up and higher complete success rates until 18 months of follow-up, with the use of subtenon TAAC as an adjuvant to standard MMC-TRABs in non-inflammatory glaucoma patients. Cocktail treatment, in which a drug sustained-release material made of gelatin sponge was impregnated with dexamethasone, ropivacaine, dexmedetomidine and vitamin B12, facilitates pain relief and early postoperative recovery after PPECD.
- |||||||||| hydrocortisone / Generic mfg.
Clinical, Review, Journal: Adrenal insufficiency and pregnancy. (Pubmed Central) - Jun 4, 2022 These data are in agreement with those of a previously published study and also confirm the statements made by the recent guidelines. Prospective data are needed aiming to develop precise therapeutic protocols during each trimester of pregnancy according to the different causes of adrenal insufficiency.
- |||||||||| dexamethasone / Generic mfg.
Journal: Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks. (Pubmed Central) - Jun 4, 2022 Additionally, the pancreatic exocrine clock responded differently to treatments with insulin and the glucocorticoid analog dexamethasone in vitro...In summary, our data suggest that misaligned meals impair the clock in the exocrine part of the pancreas by uncoupling insulin and corticosterone rhythms. These findings suggest a new mechanism by which adverse dietary habits, often associated with shift work in humans, may impair the clock in the exocrine pancreas and potentially contribute to exocrine pancreatic insufficiency.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Review, Journal: Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review. (Pubmed Central) - Jun 4, 2022 The perfusate commonly used in clinical practice consisted of leukocyte-depleted, packed red blood cells suspended in Ringer's lactate solution with Mannitol, dexamethasone, heparin, sodium bicarbonate and a specific nutrient solution supplemented with insulin, glucose, multivitamins and vasodilators...Current evidence demonstrates safety with the aforementioned widely used protocol, however, extracellular base solutions with adequate oxygenation, supplemented with nutrient and metabolic substrates, show promise by providing a suitable environment for prolonged preservation and resuscitation. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021231381, identifier PROSPERO 2021 CRD42021231381.
- |||||||||| dexamethasone / Generic mfg.
Journal: Detecting patients with Cushing's syndrome: The importance of initial test selection. (Pubmed Central) - Jun 4, 2022 The recommended initial tests for suspected Cushing's syndrome are late-night salivary cortisol (LNSC), 24-hour urinary free cortisol (UFC) and the 1 mg overnight dexamethasone suppression test (ONDST)...In 214 of 272 cases (78.7%; 95% confidence interval: 73.2%, 83.3%) initial testing was by measurement of serum cortisol alone. The relatively infrequent selection of the higher sensitivity tests (ONDST, UFC and LNSC) for investigation of suspected Cushing's syndrome signifies a risk of delayed or missed diagnosis, with important implications for morbidity and mortality.
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg., carfilzomib / Generic mfg.
Clinical, Retrospective data, Journal: Carfilzomib combined with lenalidomide and dexamethasone (KRd) as salvage therapy for multiple myeloma patients: Italian, multicenter, retrospective clinical experience with 600 cases outside of controlled clinical trials. (Pubmed Central) - Jun 4, 2022 The most frequent side effects were hematological (anemia 49.3%, neutropenia 42.7%, thrombocytopenia 42.5%) and cardiovascular (hypertension 14.5%, heart failure 2.5%, arrhythmias 3.6%). Our study confirms the safety and efficacy of KRd in the real-life setting of RRMM patients and encourages its use in clinical practice.
- |||||||||| dexamethasone / Generic mfg., cisplatin / Generic mfg.
Retrospective data, Journal: Control and Risk Factors of Nausea and Vomiting in Patients With Cervical Cancer Receiving Radiotherapy. (Pubmed Central) - Jun 4, 2022 Antiemetic prophylaxis should be considered for younger patients with cervical cancer undergoing radiotherapy alone. Further, neurokinin-1 receptor antagonist should be added to 5-hydroxytryptamine type-3 receptor antagonist and dexamethasone as antiemetic prophylactic therapy for patients with cervical cancer undergoing radiotherapy with concomitant weekly doses of 40 mg/m cisplatin.
- |||||||||| dexamethasone / Generic mfg.
Journal: A potential harmful effect of dexamethasone in non-severe COVID-19: results from the COPPER-pilot study. (Pubmed Central) - Jun 4, 2022 Olanzapine was cost-effective in the four-drug antiemetic therapy for Japanese patients treated with highly emetogenic cisplatin-containing chemotherapy. This study suggests caution when prescribing systemic corticosteroids to patients with #COVID19 who show mild-to-moderate pulmonary symptoms because a harmful effect cannot be excluded https://bit.ly/3P4nOjQ.
- |||||||||| dexamethasone / Generic mfg., favipiravir / Generic mfg.
Journal: Clinical characteristics, risk factors, and rate of severity of a nationwide COVID-19 Saudi cohort. (Pubmed Central) - Jun 4, 2022 The data shows that comorbidity is associated with hospitalization among COVID-19 patients, which indicates the level of severity. Infection during the winter season (November), male gender, elderly, and those with pre-existing diabetes mellitus or obesity were associated with higher COVID-19 clinical severity.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: The Impact of Initial COVID-19 Episode Inflammation Among Adults on Mortality Within 12 Months Post-hospital Discharge. (Pubmed Central) - Jun 4, 2022 Elevated CRP was associated other indicators of severity of the COVID-19 hospitalization including, supplemental oxygen and intravenous dexamethasone...Hyperinflammation present with severe COVID-19 is associated with an increased mortality risk after hospital discharge. Although suggestive, treatment with anti-inflammatory medications like steroids upon hospital discharge is associated with a decreased post-acute COVID-19 mortality risk.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Bioactive phenolics fraction of Hedera helix L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress. (Pubmed Central) - Jun 4, 2022 The animals were divided into seven groups randomly (each group containing 10 mice): control negative (saline only), control positive (LPS group), standard (Dexamethasone 2 mg/kg), ethanolic ivy leaves extract (EIE, 100 mg/kg), ethanolic ivy leaves extract (EIE, 200 mg/kg), saponin rich fraction (SRF, 100 mg/kg) and phenolic rich fraction (PRF, 100 mg/kg)...Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.
- |||||||||| ketorolac / Generic mfg., dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Journal: Perioperative Pain Management After Primary Palate Repair: A 3-Surgeon Retrospective Study. (Pubmed Central) - Jun 4, 2022 The authors advise careful consideration of NCA due to the potential for increased narcotic utilization that we found in our institution. Based on our promising findings, further studies are warranted to assess risks, benefits, and costs of performing peripheral nerve blocks at the time of palatoplasty.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review. (Pubmed Central) - Jun 4, 2022 HA was used as a standalone preparation in 31 studies, in two studies it was injected with platelet-rich plasma (PRP) and with either low-level laser therapy (LLLT), triamcinolone (TA), betamethasone (CS), poly deoxyribonucleotide (PDRN) or dexamethasone (DX) in one study each...The combination formulations with corticosteroids or PRP or MSCs show better results than HA alone. Combining HA with newer molecules such as peptides or diclofenac for sustained and disease-modifying effects requires more studies in the future.
- |||||||||| fluticasone / Generic mfg.
Journal, Real-world evidence: Tiotropium Add-On and Treatable Traits in Asthma-COPD Overlap: A Real-World Pilot Study. (Pubmed Central) - Jun 4, 2022 A 12-week open-label cross-over pilot study was conducted in patients with ACO to investigate the effect of tiotropium bromide (TIO) 5 µg/day add-on therapy to fluticasone propionate/formoterol fumarate (FP/FM) 500/20 µg/day compared with FP/FM 500/20 µg/day alone...FEV values after the TIO add-on therapy FP/FM period were significantly higher than those after the run-in period (p < 0.01). TIO add-on therapy to FP/FM in patients with ACO, considered difficult to treat because of the presence of both asthma and COPD, resulted in improvements in lung function parameters in this real-world pilot study, indicating the potential value of TIO add-on therapy as a "treatable traits" option for standard treatment for ACO.
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