- |||||||||| mometasone furoate / Generic mfg.
Microblading reaction as a first manifestation of a systemic sarcoidosis (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_251;
She was prescribed a topical treatment for cutaneous involvement with mometasone furoate ointment twice per week with good response...Additionally, all patients with sarcoidosis, should be informed of possible skin sequalae after aesthetic procedures with infiltration of dermis or subcutis. In conclusion, sarcoidosis should be suspected in patients with chronic, especially papulonodular lesions at the site of extrinsic material skin infiltration.
- |||||||||| CoronaVac / Sinovac, Bio Farma Indonesia
Bilateral Localized Acneiform Eruption Due to Coronavac Vaccine (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_209;
Oral antihistamine drugs, triamcinolone acetonide and topical treatments were given symptomatically. As a result, fixed and acneiform drug eruption due to Coronavac has not been previously reported in the literature.
- |||||||||| vancomycin / Generic mfg., prednisolone / Generic mfg.
Linear Ig A bullous dermatosis following Oxford Astrazenaca COVID-19 vaccine (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_194;
Discussion There are multiple reports in the literature on drugs that cause LABD, particularly vancomycin.Drug-induced LABD is defined by its polymorphic clinical features, which are more severe than in spontaneous forms...Vaccination is a rare trigger for this condition. While this case may be a simple coincidence, it is worth keeping in mind that COVID-19 vaccination could induce immune-mediated bullous disease in susceptible people
- |||||||||| Vaxzevria (ChAdOx1-S recombinant) / Oxford Biomedica, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca, University of Oxford
New-onset leukocyclastic vasculitis following ChAdOx1 nCoV-19 COVID-19 vaccine (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_190;
No systemic involvement was described in all of these cases and clinical course was rapidly regressive when treated with tapering doses of oral prednisolone. As reports of similar cutaneous eruptions add-up, health care providers must be aware of such manifestations after COVID-19 vaccines.
- |||||||||| Tinea corporis after T lymphocyte infusion for COVID infection (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_171;
We report a case of a 65-year-old man with severe COVID-19 pneumonia, initially treated with soulbactam+ampicillin, dexamethasone and fondaparinux...The clinical diagnosis of tinea corporis was conformed by the cure of the exanthema after four weeks of 200 mg daily per os therapy with itraconazole...Respectively, a pre-existing ringworm may expand after treatment of COVID-19 infection, especially with systemic antibiotics and recently, T cell infusion. Diagnosing coinfections is complex and essential in the best of circumstances and because there is a desire to avoid diagnostic procedure and minimize the exposure of COVID-19 to health-care workers, diagnosing potential mycotic skin infection during COVID-19 has been challenging.
- |||||||||| Silverzine Tulle (Silver Sulfadiazine) / MinaPharm, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Treatment barriers in a patient with severe pemphigus of the scalp (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_120;
While her lesions on the body progressively remitted under therapy, her scalp was still refractory to treatment. Discussion Despite the wide variety of available treatment possibilities nowadays, when it comes to patients with multiple comorbidities, options are limited, thus maintaining a remission status of the disease becomes a challenging journey.
- |||||||||| cytarabine / Generic mfg.
Cutaneous toxicity associated with cytarabine infusion in a child (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_57;
Most cytarabine-related skin reactions resolve without sequelae. Co-administration of dexamethasone rapidly improves the rash, allowing chemotherapy to continue and suggesting the beneficial effect of corticosteroids.
- |||||||||| Ibrance (palbociclib) / Pfizer, Kisqali (ribociclib) / Novartis, Verzenio (abemaciclib) / Eli Lilly
Cutaneous reactions to cyclin-dependent kinase 4/6 inhibitors (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_50;
Introduction Three cyclin-dependent kinase 4/6 inhibitors, palbociclib, ribociclib and abemaciclib, are currently used in positive hormone receptor and negative human epidermal growth factor receptor-2 metastatic breast cancer, associated with endocrine therapy...The patient was treated with a course of oral prednisolone with marked improvement...Discussion Considering the increasing use of these molecules and the prevalence of breast cancer, it’s important for both dermatologists and oncologists to know the associated skin toxicities and the symptoms management. Scarce information exists about this topic, so the presented cases help to elucidate the skin manifestation of the cyclin- dependent kinase 4/6 inhibitors.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Follicular occlusion tetrad with urological complications (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_16;
Taking into account no marked improvement several attempts of short course oral prednisolone 50 mg/day had been tried in combination with isotretinoin with positive effect on hidradenitis suppurativa, however when the daily dosage was reduced to 20 mg per day exacerbations occurred...The patient was recommended adalimumab with the standard dosing schedule...Discussion Due to the severity of the condition, the duration of the course and the disease burden in patients with follicular occlusion syndrome, the earliest possible therapy with biological agents is indicated. Prolongation of isotretinoin, combination therapy and dose increase is ineffective.
- |||||||||| Empliciti (elotuzumab) / AbbVie, BMS
Enrollment open: Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD) (clinicaltrials.gov) - Jun 13, 2022
P2, N=75, Recruiting,
Trial completion date: Sep 2026 --> Aug 2027 | Trial primary completion date: Jul 2022 --> Apr 2024 Active, not recruiting --> Recruiting
- |||||||||| Darzalex (daratumumab) / J&J, Blenrep (belantamab mafodotin-blmf) / GSK
Enrollment open: Belantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple Myeloma (clinicaltrials.gov) - Jun 13, 2022
P1/2, N=12, Recruiting,
Active, not recruiting --> Recruiting Suspended --> Recruiting
- |||||||||| dexamethasone / Generic mfg.
Dexamethasone? (Twitter) - Jun 13, 2022
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: Effect of Soak and Smear on [14C]-Hydrocortisone In Vitro Human Skin Percutaneous Penetration. (Pubmed Central) - Jun 11, 2022
Water soaking (≤20 min) induced skin hydration increases [C]-hydrocortisone absorption and retention into the upper skin layer but not deep layers. This could support the proposed hypothesis of clinical dermatological treatment of hydrocortisone to local skin inflammations should the epidermis be found to be a key target for atopic dermatitis therapy.
- |||||||||| hydrocortisone / Generic mfg.
Clinical, Journal: A novel SCNN1A variation in a patient with autosomal-recessive pseudohypoaldosteronism type 1. (Pubmed Central) - Jun 11, 2022
A 41-day-old female who presented with recurrent adrenal crisis did not adequately respond to hydrocortisone and required mineralocorticoid therapy...Adrenal crisis during the neonatal period highlights the importance of early screening for PHA1. Genetic testing could help to anticipate the prognosis, severity, onset of the disease, and the mode of inheritance, especially with its extensive phenotype.
- |||||||||| fluvastatin / Generic mfg.
Journal: Therapeutic effect of fluvastatin on medication-related osteonecrosis of the jaw. (Pubmed Central) - Jun 11, 2022
Genetic testing could help to anticipate the prognosis, severity, onset of the disease, and the mode of inheritance, especially with its extensive phenotype. This study suggests that a single topical administration of fluvastatin may be a novel treatment for medication-related osteonecrosis of the jaw.
- |||||||||| fentanyl citrate / Generic mfg., methylprednisolone oral / Generic mfg., methamphetamine / Generic mfg.
Journal: Paper-based monolith extraction of psychoactive substances from biological fluids. (Pubmed Central) - Jun 11, 2022
Urine and serum certified reference materials were employed in the validation of the proposed methodology, providing results statistically comparable. The developed approach is simple and straightforward for the determination of psychoactive substances in urine and serum samples.
- |||||||||| dexamethasone / Generic mfg.
Journal: Leukocyte cytokine responses in adult patients with mitochondrial DNA defects. (Pubmed Central) - Jun 11, 2022
In a small cohort of healthy controls (n = 21) and patients (n = 12) with either the m.3243A > G mutation or single, large-scale mtDNA deletions, we examined (i) cytokine responses (IL-6, TNF-α, IL-1β) in response to acute lipopolysaccharide (LPS) exposure and (ii) sensitivity to the immunosuppressive effects of glucocorticoid signaling (dexamethasone) on cytokine production...Leukocytes of patients with mtDNA deletions are more sensitive to glucocorticoid-mediated IL-6 suppression. Work in larger cohorts is needed to delineate potential immune alterations in mitochondrial diseases.
- |||||||||| dexamethasone / Generic mfg.
Journal: Primary pigmented nodular adrenal disease presenting as hypertensive crisis. (Pubmed Central) - Jun 11, 2022
On evaluation for Cushing syndrome (CS), her cortisol concentration was high, showed a paradoxical cortisol rise on dexamethasone suppression and the adrenocorticotropic hormone (ACTH) was low...Our case highlights the rare aetiology of PPNAD as a cause of CS resulting in a hypertensive crisis. To the best of our knowledge, this is the youngest case of ACTH independent CS presenting as hypertensive encephalopathy.
- |||||||||| QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva
Journal, PD(L)-1 Biomarker, IO biomarker: Prediction of Adrenocortical Carcinoma Relapse and Prognosis with a Set of Novel Multigene Panels. (Pubmed Central) - Jun 11, 2022
Sig27var25 and SigIQvar8 were derived from a prostate cancer (PC) and clear cell renal cell carcinoma (ccRCC) multigene signature, respectively; SigCmbnvar5 and SigCmbn_B are combinations of both panels, revealing close relationships of ACC with PC and ccRCC. The origin of these four panels from PC and ccRCC favors their prognostic potential towards ACC.
- |||||||||| fluocinolone acetonide / Generic mfg.
Journal: Polymeric Micelles Enhance Mucosal Contact Time and Deposition of Fluocinolone Acetonide. (Pubmed Central) - Jun 11, 2022
In contrast, the FPM without SPA penetrated and passed through all layers. The FPM with extended mucoadhesion, improved drug-mucosal retention time, and increased FA permeation and deposition were successfully developed, and could be a promising innovation for increasing the efficiency of mouth rinses, as well as other topical pharmaceutical and dental applications.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Construction of an HLA Classifier for Early Diagnosis, Prognosis, and Recognition of Immunosuppression in Sepsis by Multiple Transcriptome Datasets. (Pubmed Central) - Jun 11, 2022
Results of qRT-PCR validated the higher expression level of B2M as well as lower expression level of HLA-DQA1, HLA-DPA1, TAP1, and TAP2 in sepsis samples compared to control sample. Based on five HLA genes, a diagnostic and prognostic model, namely the HLA classifier, was established, which is closely correlated with responses to hydrocortisone and immunosuppression status and might facilitate personalized counseling for specific therapy.
- |||||||||| dexamethasone / Generic mfg., ceftriaxone / Generic mfg., amoxicillin / Generic mfg.
Journal: A large cluster of human infections of Streptococcus suis in Bali, Indonesia. (Pubmed Central) - Jun 11, 2022
A prompt and early response, as well as early treatment of patients, is paramount in case finding to enable a favourable outcome of full recovery. Additionally, the implementation of the "One Health" approach provides a comprehensive picture of the management of S. suis infection in humans.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Trial completion, Surgery: STRESS: STeroids to REduce Systemic Inflammation After Infant Heart Surgery (clinicaltrials.gov) - Jun 10, 2022
P3, N=1200, Completed,
Additionally, the implementation of the "One Health" approach provides a comprehensive picture of the management of S. suis infection in humans. Active, not recruiting --> Completed
- |||||||||| dexamethasone / Generic mfg.
Journal: 3,3',4,5'-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress. (Pubmed Central) - Jun 10, 2022
The potential anti-diabetic effect of resveratrol derivative, 3,3',4,5'-tetramethoxy-trans-stilbene (3,3',4,5'-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated...Furthermore, 3,3',4,5'-TMS significantly suppressed levels of reactive oxygen species (ROS) with up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) expression. To conclude, the beneficial effect of 3,3',4,5'-TMS against insulin resistance to increase glucose consumption and glycogen synthesis was mediated through activation of IRS/PI3K/Akt signaling pathways in the IR-HepG2 cells, accomplished with anti-oxidative activity through up-regulation of Nrf2.
- |||||||||| pemetrexed / Generic mfg.
Phase classification, Enrollment change: Intrathecal Pemetrexed for Leptomeningeal Metastasis (clinicaltrials.gov) - Jun 9, 2022
P1/2, N=40, Recruiting,
To conclude, the beneficial effect of 3,3',4,5'-TMS against insulin resistance to increase glucose consumption and glycogen synthesis was mediated through activation of IRS/PI3K/Akt signaling pathways in the IR-HepG2 cells, accomplished with anti-oxidative activity through up-regulation of Nrf2. Phase classification: P1 --> P1/2 | N=12 --> 40
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