- |||||||||| dexamethasone / Generic mfg.
Journal: BdRCN4, a Brachypodium distachyon TFL1 homologue, is involved in regulation of apical meristem fate. (Pubmed Central) - Jun 28, 2024
Although further molecular studies will be necessary, the evidence in B. distachyon support the idea that a balance between LFY and BdRCN4/TFL1 seems to be essential for activating AP1 expression and initiating floral organ identity gene expression. This study also demonstrates interesting conservation through the molecular pathways that regulate flowering meristem transition and identity across the evolution of monocot and dicot plants.
- |||||||||| budesonide / Generic mfg.
Journal: Lymphocytic Colitis With Enterocolic Lymphocytic Phlebitis. (Pubmed Central) - Jun 28, 2024
Colonoscopic examination revealed normal-appearing mucosa, but biopsy findings revealed lymphocytic colitis with coexisting enterocolic lymphocytic phlebitis. The patient was started on oral budesonide and responded to the treatment with symptomatic and histopathological resolution.
- |||||||||| Mycamine (micafungin) / Astellas, Noxafil (posaconazole) / Merck (MSD)
Journal: Endogenous Endophthalmitis Caused by Aspergillus lentulus in an Immunocompromised Patient with Lung Cancer. (Pubmed Central) - Jun 28, 2024
Vitreous culture confirmed the presence of Aspergillus lentulus, and he was treated with intravitreal amphotericin-B and voriconazole injections together with systemic amphotericin-B, voriconazole, posaconazole, and micafungin therapy...Timely ocular examination is crucial for any immunocompromised patient having ocular symptoms. High level of suspicion for a fungal etiology is a must in these patients.
- |||||||||| Dipentum (olsalazine sodium) / Viatris, UCB, Humira (adalimumab) / AbbVie
Journal: Refractory Crohn's Disease Responsive to Dietary Therapy: A Case Report. (Pubmed Central) - Jun 28, 2024
In conclusion, for patients whose disease is refractory to different treatments, or who develop antibodies to the medication, AIDs may offer a solution to reduce disease symptoms and progression. Education of healthcare professionals and patients alike is vital in order for Crohn's patients to gain the benefits from dietary therapy.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Iclusig (ponatinib) / Takeda, Otsuka
Trial completion: NCI-2018-01100: Venetoclax, Ponatinib, and Dexamethasone in Participants With Philadelphia Chromosome or BCR-ABL Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia (clinicaltrials.gov) - Jun 28, 2024
P1/2, N=11, Completed,
The efficacy of the KRD combination in advanced-stage MCL patients who are R/R to BTKi is unsatisfactory and too toxic. Active, not recruiting --> Completed
- |||||||||| dexamethasone / Generic mfg.
Journal, PARP Biomarker, IO biomarker: NAD+ Supplementation Improves Mitochondrial Functions and Normalizes Glaucomatous Trabecular Meshwork Features. (Pubmed Central) - Jun 27, 2024
In this study, primary TM cells treated with dexamethasone were used to simulate glaucomatous changes, showing abnormal cellular cytoskeleton, increased expression of extracellular matrix, and disrupted mitochondrial fusion and fission dynamics...Supplementation of NAD+ restored mitochondrial function and cellular viability in GTM3 cells. Therefore, we propose that the aberrant mitochondrial function in glaucomatous TM cells may be attributed to increased NAD+ consumption dependent on CD38 and PARP1, and NAD+ supplementation could effectively ameliorate mitochondrial function and improve TM function, providing a novel alternative approach for glaucoma treatment.
- |||||||||| dexamethasone / Generic mfg., celecoxib oral / Generic mfg.
Journal, Stroma: Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis. (Pubmed Central) - Jun 27, 2024
Experiments with PGE2 treatment or the inhibitor celecoxib or specific receptor antagonists demonstrated that PGE2, although driven by prohypertrophic signals, exerted broad autocrine antihypertrophic effects. This chondroprotective effect makes PGE2 not only a promising option for future combinatorial approaches to direct MSC tissue engineering approaches into chondral instead of endochondral development but could potentially have implications for the use of COX-2-selective inhibitors in osteoarthritis pain management.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing. (Pubmed Central) - Jun 27, 2024
In simulating the human gut barrier, the PreD chip demonstrates highly enhanced sensitivity in tests for dexamethasone toxicity and is highly effective in assessing drug transport across the human blood-brain barrier. These findings emphasize the potential of the PreD chip in advancing organ chip-based drug testing methodologies.
- |||||||||| dexamethasone injection / Generic mfg.
Retrospective data, Journal: Therapeutic Efficacy of Ultrasound-Guided Selective Nerve Block on Chronic Cervical Radiculopathy. (Pubmed Central) - Jun 27, 2024
Ultrasound-guided SNRB effectively manages chronic CR, providing substantial symptom relief and potentially reducing the need for surgical intervention. This technique offers a promising conservative treatment option, especially given its real-time visualization advantages and minimal radiation exposure.
- |||||||||| dexamethasone / Generic mfg.
Journal: The Association between Broiler Litter Microbiota and the Supplementation of Bacillus Probiotics in a Leaky Gut Model. (Pubmed Central) - Jun 27, 2024
We investigated the influence of probiotic supplementation and a leaky gut challenge induced using dexamethasone (DEX) on the litter microbial community and litter parameters...In terms of litter quality, the birds in the DEX groups had a significantly higher moisture content, indicating successful leaky gut challenge, while probiotic supplementation did not significantly affect the moisture levels. These findings provide comprehensive insights into the distinct microbiota characteristics of litter.
- |||||||||| Clinical, Journal: Molecular Long-Term Analysis of the GMMG-HD4 Trial in Multiple Myeloma-Patterns of Association of Chromosomal Aberrations with Response and Proliferation Determining Survival in Selecting Treatments in View of Limited Resources in Low- and Middle-Income Countries. (Pubmed Central) - Jun 27, 2024
Based on the lack of differences in progression-free and overall survival after a median follow-up of 93 months in our HOVON-65/GMMG-HD4 trial (German part; n = 395) randomizing VAD induction (vincristin/adriamycin/dexamthasone)/tandem-transplantation/thalidomide-maintenance vs. PAD induction (bortezomib/adriamycin/dexamethasone)/tandem transplantation/bortezomib maintenance, we discern how chromosomal aberrations determine long-term prognosis by different patterns of association with proliferation and treatment-dependent response, whether responses achieved by different regimens are equal regarding prognosis, and whether subpopulations of patients could be defined as treatable without upfront "novel agents" in cases of limited resources, e.g., in low- or middle-income countries...Significantly fewer patients reach a near-complete response or better with "conventional" (VAD) vs. bortezomib-based treatment after induction or high-dose melphalan...Associations with faster and deeper responses can be deceptive in the case of prognostically adverse aberrations 1q21+ and t(4;14). Far from advocating a return to "outdated" treatments, if resources do not permit state-of-the-art-treatment, normal renal function and/or molecular profiling identifies patient subpopulations doing well without upfront "novel agents".
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Ninlaro (ixazomib) / Takeda
Trial completion date, Trial primary completion date, IO biomarker: Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis (clinicaltrials.gov) - Jun 27, 2024
P1, N=24, Recruiting,
Far from advocating a return to "outdated" treatments, if resources do not permit state-of-the-art-treatment, normal renal function and/or molecular profiling identifies patient subpopulations doing well without upfront "novel agents". Trial completion date: Jun 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, idasanutlin (RG7388) / Roche
Trial primary completion date, Combination therapy: A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors (clinicaltrials.gov) - Jun 27, 2024
P1/2, N=38, Active, not recruiting,
Trial completion date: Jun 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026 Trial primary completion date: Dec 2025 --> Jun 2024
- |||||||||| indomethacin / Generic mfg., hydrocortisone / Generic mfg.
Journal: Preparation and Application of Decanoic Acid/Arginine Hydrogels to a Transdermal Formulation. (Pubmed Central) - Jun 26, 2024
On the other hand, the flux of IM decreased with increasing arginine concentration, likely due to the acid-base interaction between Arg and IM in C10/Arg gel. Adequate drug skin permeation enhancement by C10/Arg gel requires optimizing the gel composition for each specific drug.
- |||||||||| dexamethasone / Generic mfg.
Journal: Investigating the effects of dexamethasone on pulmonary surfactant lipids based on lipidomics studies. (Pubmed Central) - Jun 26, 2024
We observed a decrease in lipids, such as phosphatidylcholine, phosphatidylglycerol and phosphatidylethanolamine, and an increase in ceramide, fatty acid, diacylglycerol and monoglyceride, which may impact lung health. This study revealed the influence of dexamethasone on pulmonary surfactant lipids, offering new insights into adverse reactions in clinical settings.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: In Vitro/Ex Vivo Release Study of a Ground Umbilical Cord Matrix Loaded with Dexamethasone. (Pubmed Central) - Jun 26, 2024
A low dose of dexamethasone along with a single dose of mannitol and antiseizures prophylaxis might be useful for reducing both overall and early mortality in pneumococcal meningitis in adult patients. We studied the release kinetic of 100 mg of biomaterial loaded with 100
- |||||||||| Rybelsus (semaglutide oral) / Novo Nordisk
Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3036;
Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?$$graphic_{9CA3D4AD-3357-477A-921A-4E0D00A82435}$$$$graphic_{1D86D868-9821-42AC-A5FF-6985D06287C1}$$
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Levemir (insulin detemir rDNA origin) / Novo Nordisk
Stressful Dose Steroids: When Should I Worry About Perioperative Adrenal Insufficiency? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2551;
Abstract is embargoed at this time. Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Levemir (insulin detemir rDNA origin) / Novo Nordisk
Stressful Dose Steroids: When Should I Worry About Perioperative Adrenal Insufficiency? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1591;
Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient
- |||||||||| An Awake Craniotomy at 4 P.M.! What a Way to End the Day! (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1437;
The patient reports intermittent headaches which have improved since initiating oral dexamethasone one week ago. She is also taking levetiracetam for seizure prophylaxis...An 18-gauge intravenous catheter is placed and standard American Society of Anesthesiologists (ASA) monitors applied.1.Outline an appropriate anesthetic plan for this patient.2.Discuss additional monitoring and/or intravenous access needs.3.How can the airway best be managed during
- |||||||||| An Awake Craniotomy at 4 P.M.! What a Way to End the Day! (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1076;
The patient reports intermittent headaches which have improved since initiating oral dexamethasone one week ago. She is also taking levetiracetam for seizure prophylaxis...An 18-gauge intravenous catheter is placed and standard American Society of Anesthesiologists (ASA) monitors applied.1.Outline an appropriate anesthetic plan for this patient.2.Discuss additional monitoring and/or intravenous access needs.3.How can the airway best be managed during
- |||||||||| Dynastat (parecoxib) / Pfizer
A Four-Year-Old Child Scheduled for Elective Outpatient Adenotonsillectomy: Avoiding the Pitfalls (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_924;
She is also taking levetiracetam for seizure prophylaxis...An 18-gauge intravenous catheter is placed and standard American Society of Anesthesiologists (ASA) monitors applied.1.Outline an appropriate anesthetic plan for this patient.2.Discuss additional monitoring and/or intravenous access needs.3.How can the airway best be managed during Case continuation: After the usual monitors are applied you proceed with a sevoflurane inhalation induction and you notice that the patient
- |||||||||| Rybelsus (semaglutide oral) / Novo Nordisk
Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_479;
Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?
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