Glucocorticoid Receptor 

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  • ||||||||||  Oncaspar liquid (pegaspargase) / Servier
    Journal:  DDGP followed by radiotherapy vs VIPD followed by radiotherapy in newly diagnosed early NK/T-cell lymphoma. (Pubmed Central) -  Jun 19, 2022   
    A single dose of intravenous dexamethasone used preoperatively in single-level and multilevel ACDF can significantly improve symptoms of dysphagia and odynophagia early on postoperatively. In patients newly diagnosed with early NK/T-cell lymphoma, those treated with DDGP followed by radiotherapy had a higher CRR and ORR and longer PFS than those treated with VIPD followed by radiotherapy, and adverse reactions were tolerable.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone should not be given to people with a chronic subdural haematoma. (Pubmed Central) -  Jun 19, 2022   
    Trial of dexamethasone for chronic subdural haematoma. N Engl J Med 2020;383:2616-27.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/dexamethasone-should-not-be-used-chronic-subdural-haematoma/.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  BMP-2/CPC scaffold with dexamethasone-loaded blood clot embedment accelerates clinical bone regeneration. (Pubmed Central) -  Jun 18, 2022   
    On these bases, a pilot clinical trial was carried out and the Dex/blood/BMP-2/CPC scaffold was demonstrated to accelerate fracture healing, improve therapeutic quality, and eliminate local inflammation compared to current bone regenerative treatment. Taken together, this work designed an immunoregulatory and osteoinductive Dex/blood/BMP-2/CPC scaffold, which might provide new insights for future biomaterial development (Trial registration: ChiCTR2100047693).
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study. (Pubmed Central) -  Jun 18, 2022   
    We conducted two observational studies in patients with COVID-19 hospitalised at Charité - Universitätsmedizin Berlin, Germany before (from March 1 to 26, 2020, n=30) and after (from April 4 to November 19, 2020, n=164) dexamethasone became standard of care...This study was further supported by the BMBF grant NaFoUniMedCOVID-19 - NUM-NAPKON, FKZ: 01KX2021. The study was co-funded by the UK's innovation agency, Innovate UK, under project numbers 75594 and 56328.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Review, Journal:  Pharmacologic and Acute Management of Spinal Cord Injury in Adults and Children. (Pubmed Central) -  Jun 18, 2022   
    Subsequent analysis of the National Acute Spinal Cord Injury Study (NASCIS) II and NASCIS III trials have demonstrated potentially serious complications from intravenous methylprednisolone with limited benefit...Rapid assessment and intervention involve focused neurological examination, targeted imaging, and surgical intervention when indicated. There are currently no evidence-based recommendations for pathomechanistically targeted therapies.
  • ||||||||||  dexamethasone / Generic mfg.
    Polycystin-1 Regulates Calcium Handling And Contractility In Human IPSC-derived Ventricular Cardiomyocytes (Salon B, Lower Level) -  Jun 18, 2022 - Abstract #BCVS2022BCVS_113;    
    Because hiPSC-CMs have several limitations due to their immature state, we employed a well-validated method to improve their maturation that utilizes a Matrigel mattress and hormone supplementation (dexamethasone; Dexa / thyroid hormone; T3; PMID: 28974554; developed by Dr...In this model, PC1 knockdown also decreased action potential duration and impaired Ca2+ transients and decreased contractility measured as fractional shortening. Altogether, this evidence shows for the first time that PC1 regulates human cardiomyocyte physiology and suggests that cardiac alterations in patients with autosomal dominant polycystic kidney disease may emerge as a result of impaired cardiomyocyte contractile function.
  • ||||||||||  Anaesthetic management of a kidney transplantation in an adult with multiple drug allergy syndrome (Poster eBoard 1) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1449;    
    Haemodynamic and oxygenation stability was attained throughout the surgery and diuresis occurred spontaneously after ureterovesical anastomosis and administration of furosemide 80mg...Prophylactic treatments with corticosteroids and H1 antagonists are still debated, albeit they seem to be beneficial. Implementation of preventive measures (allergens avoidance), vigilance for allergic reactions recognition and readiness to deal with them are the cornerstones that contribute to an optimal outcome, as in our case.
  • ||||||||||  hydrocortisone / Generic mfg., diazepam / Generic mfg.
    TURP syndrome: a rare presentation with an unexpected difficult airway management (Poster eBoard 1) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1446;    
    A laryngeal mask airway (LMA) was placed and IV hydrocortisone plus intramuscular adrenaline were administered...Anaesthesia for transurethral resection of the prostate. Continuing Education in Anaesthesia Critical Care & Pain,2009.
  • ||||||||||  Tavegil (clemastine) / GSK
    Postoperative ​​​​ACE inhibitor-induced angioedema (Poster eBoard 2) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1084;    
    Ibuprofen and lisinopril were discontinued...It may be triggered by anesthesia/surgery, typically occurring within 1-8 hours. It is the most likely diagnosis.In anaesthesia/surgery, there are several possible triggers for ACEI induced angioedema, such as trauma, airway irritation and surgical stress.
  • ||||||||||  Case series of Kawasaki disease and MIS-C: treatment options (Poster eBoard 4) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_853;    
    Corticosteroids (methylprednisolone and dexamethasone) were administered in 8 patients...Heparin, enoxaparin, and fondaparinux were used in 1 patient each...One child died due to a rupture of left-ventricular aneurism as a complication of KD. Our case series presents additive information for growing data in this field.
  • ||||||||||  dexamethasone / Generic mfg., ondansetron / Generic mfg.
    Study of a simplified algorithm for prevention of postoperative nausea and vomiting in an oncological hospital: a quasi experimental study (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_691;    
    We established a simplified algorithm for PONV prophylaxis: patients who had history of CINV receiving triple antiemetics (dexamethasone, ondansetron and droperidol) and patients who had no history of CINV receiving double treatment (dexamethasone and ondansetron). A simplified algorithm using CINV as a risk factor for PONV did not reduce the incidence of PONV in this study population, but did reduce it considerably in patients who had both a history of CINV and an Apfel score 3 or 4.
  • ||||||||||  hydrocortisone / Generic mfg.
    Efficacy of vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_603;    
    Background and goal of study: Marik, et al showed in 2017 promising results in terms of mortality of septic shock patients with hydrocortisone, vitamin C, and thiamine1...Hospital LOS was longer in the treatment group.The principal strengths of our study were the homogeneity of the patients between the groups, the severity of illness (SAPS II average 50 and 51.4 in control and treatment groups respectively), and the predominant abdominal source of infection (114 out of 120 patients). The main limitation is the limited number of patients enrolled.Conclusion(s): Our study did not show differences in 28- day mortality but it showed an increased ICU survival and increased hospital LOS in the treatment group.Further studies are needed for the surgical population.
  • ||||||||||  Erector spinae plane block, a viable option for terminal patients with refractory liver metastasis pain (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_590;    
    The patient was admitted to the intensive care unit due to uncontrolled pain and was started on transdermal fentanyl (25mcg/hour), dexamethasone (8mg/day), and morphine, 3mg as needed...With the patient’s consent, an echo-guided ESP block was performed at T9 level, with 20mL 0,5% ropivacaine...Hepatic or renal dysfunction limit analgesic options, due to the altered pharmacokinetics. In these cases, regional analgesia plays an important role and should be considered in palliative care patients.
  • ||||||||||  Pituitary apoplexy, the role of anesthesia: a case report (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_562;    
    In the operatory room, total intravenous anesthesia was performed with propofol, fentanyl, and rocuronium infusions...To prevent cerebral edema, hyperventilation (pCO2 30-35 mmHg) was used and intravenous (I.V.) dexamethasone 8 mg and mannitol (1g/kg) were administrated...Preoperative optimization of systemic repercussions of pituitary involvement must be achieved. Management includes adrenocortical replacement therapy with I.V. fluids and hydrocortisone, followed by urgent transsphenoidal decompression.
  • ||||||||||  Contrast-induced encephalopathy following cerebral angiography: a case report (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_554;    
    This case report evidences the rare potential for development of contrast-induced encephalopathy (CIE) following administration of iodinated contrastand bolsters awareness of its management.83-year-old female, 65kg, ASA III, with hypertension which underwent carotid cavernousfistula and unruptured aneurysm embolization.ASA standardmonitoring was established, GA was induced (fentanyl 0.1mg, propofol 120mg, rocuronium 80mg, dexamethasone 8mg) and the procedure performed using iohexol 120mL, without complications.Upon admission on ICU, patient was somnolent and poorly collaborative...Levetiracetam, midazolam, propofol, fentanyl perfusions were initiated...Early identification and diagnosis augment a favorable outcome. Further studies are needed to define risk factors and mechanism of the iodinated contrast neurotoxicity, which may help minimize severe complications.
  • ||||||||||  Opioid sparing effect of transversus abdominis plane (TAP) block in open ventral hernia repair: case series (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_492;    
    Total opioid consumption during surgery in all patients was 150 µgr fentanyl and none of the patients received opioids in the postoperative period. Pain in open ventral hernia repair operations is from somatic origin and can lead to high pain scores in the postoperative period, bigger opioid consumption and prolonged stay in hospital.1Bilateral TAP block is ideal for treatment of somatic pain and given together with dexamethasone can prolong analgesia in first 48 hours after surgery.
  • ||||||||||  Vecuron (vecuronium) / Sun Pharma
    Anesthetic and perioperative management in a patient with Bernard Soulier syndrome undergoing total abdominal hysterectomy (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_455;    
    Gentle laryngoscopy was done and trachea was intubated with cuffed endotracheal tube no.7.5 and maintained via isoflurane 1- 1.5% in 40% O2 in N2O.During the 3 hour surgical repair, HLA matched platelets -6 units, fresh whole blood – 3 units and 2 Lt...Tranexamic acid can be used prophylactically as well as in perioperative/postoperative period along with platelets.General anesthesia is superior to regional anesthesia2. Hypothermia and hemodilution should be avoided.
  • ||||||||||  Opioid free anaesthesia in oncologic gynaecological surgery. Is there any benefit? Retrospective observational study (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_451;    
    Patients in both groups received a regional block when possible, dexamethasone 8 mg at induction and paracetamol 1g plus dexketoprofen 50mg at the end of surgery...No significant differences were found for postoperative SIRS (C- Reactive Protein (P=0.116)), total hospitalization time (Control: 4.9+ 6.0 days; OFA: 5.4+5.7 days, P=0.145), disease progression at 6 months (Control: 19.7%; OFA: 16.7%, P=0.822) and 12 months (Control:28.8%; OFA: 28.8%, P=1) and mortality at 12 months between groups (Control: 4.5%; OFA:4.5%, P=1).Conclusion(s): Patients receiving OFA for MGOS may develop less postoperative infections than others undergoing anesthesia including opioids. No effect was observed for hospital stay, disease progression after 6 and 12 months and 1 year mortality.
  • ||||||||||  Emestop (ramosetron hydrochloride) / Samyang Group
    A prospective, randomized, double blind, comparative study of ramosetron 0.3mg v/s combination of ondansetron 4 mg and dexamethasone 8mg for prevention of postoperative nausea and vomiting in patients undergoing elective middle ear surgery (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_449;    
    The study population was randomly assigned to two groups with eighty seven patients in each group.Patients were randomly allocated to receive a combination of dexamethasone 8 mg andondansetron 4 mg considered as group DO or ramosetron 0.3 mg (near the end of surgery) considered as group R by a computer-generated randomization.Primary efficacy variables assessed were the incidence of nausea, retching and vomiting in the first 48h after the surgery.Results and  The comparison table shows that the incidence of vomiting in group DO and group R during first 24 hour postoperative period. During 0-2 hours and 2-24hours the p value was 0.7805 and 0.5891 respectively which were statistically insignificant.It also shows that the incidence of nausea during 0-2 hour interval ,2-24 hour interval and 24-48 hours,the p value was 0.6544 and 0.5235 and 0.3694 respectively which was found to be statistically insignificant.Conclusion(s): Ramosetron 0.3mg is effective in preventing postoperative nausea and vomiting in elective middle ear surgeriesThe need for rescue antiemetics in early as well as delayed postoperative period (within 48 hours) is reduced with Ramosetron 0.3mg.Ramosetron 0.3mg is equally effective and comparable to combination of Dexamethasone 8mg and Ondansetron 4mg for prevention of early and late PONV in patients undergoing elective middle ear surgeries
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Allergic contact dermatitis from dipropylene glycol in hydrocortisone lotion. (Pubmed Central) -  Jun 15, 2022   
    The RCTs examined suggest that prophylactic administration of corticosteroid agents and NAC can reduce the severity of pancreatitis as indicated by histopathologic markers, serum amylase and IL-6 levels. No abstract available
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Marginaols G-M, anti-inflammatory isopimarane diterpenoids, from the rhizomes of Kaempferia marginata. (Pubmed Central) -  Jun 15, 2022   
    When compared to the standard drug dexamethasone (IC 4.7 μM), marginaol G, H, and 6β-acetoxysandaracopimaradien-1α,9α-diol had an intriguing anti-inflammatory effect on NO inhibition in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with IC values ranging from 4.5 to 7.3 μM and being less cytotoxic to the cells. The anti-inflammatory action of these isopimarane diterpenoids from K. marginata supports the use of Thai traditional medicine for inflammation treatment.