- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, idasanutlin (RG7388) / Roche
Trial completion, Trial completion date, Combination therapy: A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors (clinicaltrials.gov) - Jul 3, 2024
P1/2, N=38, Completed,
In patients with ASUC, combination of tofacitinib and corticosteroids improved treatment responsiveness and decreased the need for rescue therapy. Active, not recruiting --> Completed | Trial completion date: Dec 2025 --> May 2024
- |||||||||| dexamethasone / Generic mfg., clarithromycin / Generic mfg., pomalidomide / Generic mfg.
Trial completion date, Trial primary completion date: Autologous Stem Cell Transplant With Pomalidomide (CC-4047 (clinicaltrials.gov) - Jul 3, 2024
P2, N=23, Active, not recruiting,
Active, not recruiting --> Completed | Trial completion date: Dec 2025 --> May 2024 Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
- |||||||||| dordaviprone (ONC201) / Chimerix
Trial termination: Oral ONC201 in Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) - Jul 3, 2024
P1/2, N=17, Terminated,
Active, not recruiting --> Terminated; This study was terminated due to a change in corporate priorities. The decision to terminate the study was not based on any safety concerns.
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Trial completion date, Trial primary completion date, Minimal residual disease, Post-transplantation: EMAT: Elimination of Minimal Residual Disease After Transplant (clinicaltrials.gov) - Jul 3, 2024
P2, N=31, Recruiting,
The decision to terminate the study was not based on any safety concerns. Trial completion date: Sep 2027 --> Jul 2026 | Trial primary completion date: Sep 2026 --> Jun 2026
- |||||||||| dexamethasone / Generic mfg.
Journal: Hydroxypropyl Cellulose-Based Orally Dissolving Film Loaded with Insoluble Dexamethasone for Treatment of Oral Ulcers. (Pubmed Central) - Jul 3, 2024
The findings demonstrated that the ODF@Dex exerted significant antiulcer effects by modulating the PI3K/Akt signaling pathway, thus contributing to ulcer resolution. In conclusion, our study underscores the potential of HPC-based ODFs formulated with ethanol as a solvent as a promising platform for delivering insoluble drugs, offering a viable strategy for the clinical management of oral ulcers.
- |||||||||| hydrocortisone / Generic mfg.
Retrospective data, Journal: Easily misdiagnosed X-linked adrenoleukodystrophy. (Pubmed Central) - Jul 3, 2024
In addition, infection, as a hit factor, may aggravate demyelinating lesions of CCALD. Thus, patients should be protected from external environmental factors to delay the progression of cerebral adrenoleukodystrophy.
- |||||||||| dexamethasone / Generic mfg.
Trial completion date, Trial primary completion date: De-Tox: Dexamethasone for Cerebral Toxoplasmosis (clinicaltrials.gov) - Jul 3, 2024
P2, N=138, Recruiting,
The elevated preoperative HbA1c, but not the dexamethasone regimens were the risk factor for FBG???140 Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Apr 2024 --> Apr 2025
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats. (Pubmed Central) - Jul 2, 2024
Apigenin (30 mg/kg) decreased the level of TNF-a, at all three time points (4 hr; p<0.05, 12 hr; p<0.01, and 24 hr; p<0.01), and the level of IL-1b (p<0.01), 24 hr and the level of IL-6 at 4 hr (p<0.05), and 24 hr (p<0.01) after LPS injection. Apigenin can suppress serum inflammatory cytokines, similar to dexamethasone.
- |||||||||| dexamethasone / Generic mfg., acyclovir / Generic mfg.
Dengue-induced acute cerebellitis (A4) - Jul 2, 2024 - Abstract #EAN2024EAN_2762;
Cerebellar syndrome in children after or during dengue fever is a rare case, being one of the first cases to be reported in the literature until this report was produced. Therefore, it is important to recognize atypical clinical conditions so that the best measures can be taken early without leaving consequences.
- |||||||||| dexamethasone / Generic mfg.
Role of dexamethasone as a possible protective factor against long-COVID headache (B2) - Jul 2, 2024 - Abstract #EAN2024EAN_2754;
Patients with administered dexamethasone had a statistically lower probability of developing long-COVID headache. This has relevant implications into clinical practice, as long-COVID headache remains a therapeutic challenge worldwide with specific recommendations and a tailored approach needed.
- |||||||||| Tysabri (natalizumab) / Biogen, Royalty
Liver injury in patients with multiple sclerosis: a case series (B5) - Jul 2, 2024 - Abstract #EAN2024EAN_2604;
Vigilant monitoring and a multidisciplinary approach are fundamental. Liver biopsy can contribute in differential diagnosis and informing therapeutic decisions.
- |||||||||| dexamethasone / Generic mfg., prochlorperazine maleate / Generic mfg., sumatriptan succinate / Generic mfg.
Assessing the Relative Utility of a Two Headache "Rescue Rooms" and Their Respective Treatment Protocols (B2) - Jul 2, 2024 - Abstract #EAN2024EAN_2428;
"A" involved primarily intramuscular (IM) administration of droperidol, and (B) involved an evidence-based sequence of therapies beginning with subcutaneously administered sumatriptan and proceeding as needed to intravenous ketorolac, metoclopramide, DHE/prochlorperazine, metoclopramide, magnesium, divalproex sodium and dexamethasone. An outpatient headache
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Neurophysiological evidence on the intravenous methylprednisolone use in spinal surgery (A4) - Jul 2, 2024 - Abstract #EAN2024EAN_876;
An outpatient headache This current study is the first to investigate the effects of IVMP on the deterioration degree of MEP waves, and it further explores the impact of IVMP on postoperative motor outcomes in relation to the degree of MEP deterioration.
- |||||||||| Review, Journal: Renal failure in multiple myeloma: Specific management issues (Pubmed Central) - Jul 1, 2024
Adding Cyclophosphamide or the immunomodulator Lenalidomide may improve the hematological response, but with a poorer tolerance...Because of improvement in global survival, kidney transplantation remains an option to consider in selected patients. Collaboration between hematologists and nephrologists is essential throughout the course of the disease.
- |||||||||| Triesence (triamcinolone acetonide injectable suspension) / Novartis
Journal, Surgery: Intravitreal versus Oral Steroids for Inflammation Control in Uveitic Patients Undergoing Cataract Surgery. (Pubmed Central) - Jul 1, 2024
This prospective experimental study was conducted on 40 eyes of 40 patients with complicated uveitic cataracts to compare a single intraoperative intravitreal injection of triamcinolone acetonide (IVTA) with oral steroids for inflammation control after cataract extraction...Five patients in the oral steroid group had IOP >21?mmHg post-operatively. A single injection of 4?mg IVTA has similar efficacy to peri-operative oral steroid administration.
- |||||||||| Journal: Patterns of paternal medication dispensation around the time of conception. (Pubmed Central) - Jul 1, 2024
Thus, NR has promising potential as a therapeutic candidate for GIG treatment. More than a third of fathers filled at least one prescription medication in the preconception period, and several of them are known to be embryotoxic, emphasizing the necessity for further investigation into the potential teratogenicity of paternal exposure.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: An Acellular, Self-Healed Trilayer Cryogel for Osteochondral Regeneration in Rabbits. (Pubmed Central) - Jul 1, 2024
Bioactive molecules (Y27632 and dexamethasone) are respectively loaded in the top and bottom layers to form the Y27632/dexamethasone-loaded trilayer cryogel (Y/DEX-TC)...The synergistic effect of cryogel and acupuncture on immunomodulation is verified with a ?7.3-fold enhancement of the M2-/M1-macrophage population ratio by treatment of Y/DEX-TC combining acupuncture, significantly greater than ?1.5-fold increase by acupuncture or ?2.2-fold increase by Y/DEX-TC alone. This novel strategy using acellular drug-loaded cryogel and accessible acupuncture shows promise in treating osteochondral defects of joint damage.
- |||||||||| mercaptopurine / Generic mfg., prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: Two Cases of Behcet's Disease-Like Syndrome with Gene Deficiency in ELF4 (Pubmed Central) - Jul 1, 2024
The patient 2 was successively treated with corticosteroids combined with enteral nutrition, as well as oral mercaptopurine. Subsequently, both patients showed improvements in symptoms and were discharged.
- |||||||||| cyclophosphamide / Generic mfg.
Preclinical, Journal: Therapeutic effects of Medicago sativa against cyclophosphamide-induced toxicity in rats. (Pubmed Central) - Jul 1, 2024
Administering M. sativa extract (400 mg/kg) significantly enhanced platelet count, and SOD and CAT activities and inhibited all of the CP toxic effects, while dexamethasone improved platelet count and oxidative stress markers compared to the CP group (p<0.05 to p<0.001). The extract of M. sativa (400 mg/kg) showed therapeutic effects against the CP-induced myelosuppression and thrombocytopenia and improved oxidative stress markers which were comparable to the effect of dexamethasone.
- |||||||||| prednisolone / Generic mfg., acyclovir / Generic mfg.
Journal: Varicella Zoster Virus Vasculopathy: An Under-Recognized Entity. (Pubmed Central) - Jul 1, 2024
Early recognition and appropriate intervention offer promise in ameliorating outcomes for affected patients. This case emphasizes the importance of including VZV vasculopathy in the differential diagnosis of neurological deficits, especially within high-risk populations.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: Consequences of Hyponatremia: Central Pontine and Extrapontine Myelinolysis in a Chronic Alcohol User. (Pubmed Central) - Jul 1, 2024
Treatment with intravenous dexamethasone, intravenous immunoglobulin (IVIG), and methylprednisolone led to gradual neurological improvement. The patient showed significant recovery after two months, highlighting the importance of early recognition and cautious management of electrolyte disturbances in high-risk individuals to prevent devastating neurological complications.
- |||||||||| chlorpheniramine / Generic mfg., budesonide / Generic mfg., epinephrine / Generic mfg.
Clinical, Journal: Age-related off-label drug prescribing in pediatric patients in South Korea and consistency of labeling compared to the United States, Europe, and Japan. (Pubmed Central) - Jul 1, 2024
However, the degree of agreement between South Korea, the United States, and Japan (0.09, 0.06-0.11) and South Korea, Europe, and Japan (0.08, 0.05-0.10) was low. This study highlights the need for South Korean regulatory agencies to consider introducing pediatric legislation to prescribe evidence-based drugs for safe and effective use.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Journal: Incitement to misuse of corticosteroids by Arab YouTubers in a local context. (Pubmed Central) - Jun 29, 2024
The common focus on weight gain as an objective underscores the importance of educating content creators and viewers about responsible corticosteroid use. Targeted interventions are needed to promote safe and informed medication practices within this online environment.
- |||||||||| Darzalex (daratumumab) / J&J
Journal, IO biomarker: Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management. (Pubmed Central) - Jun 29, 2024
In patients who are candidates for autologous stem cell transplantation, induction therapy consists of anti-CD38 monoclonal antibody plus bortezomib, lenalidomide, dexamethasone (VRd) followed by autologous stem cell transplantation (ASCT)...Frail patients who not candidates for transplant are treated with VRd for approximately 8-12?cycles followed by maintenance or alternatively with daratumumab, lenalidomide, dexamethasone (DRd) until progression...A triplet regimen is usually needed at relapse, with the choice of regimen varying with each successive relapse. Chimeric antigen receptor T (CAR-T) cell therapy and bispecific antibodies are additional options.
- |||||||||| Darzalex (daratumumab) / J&J
Observational data, Reimbursement, Retrospective data, US reimbursement, Journal, HEOR, Medicare: Clinical and economic burden of medicare beneficiaries with multiple myeloma and renal impairment: An observational study. (Pubmed Central) - Jun 28, 2024
In the RI MM cohort, the mean all-cause total cost increased from 1L to 4L ($14,549-$18,667 per person per month) and was higher than that of the general MM cohort. RI MM patients presented higher clinical and economic burdens across 1L to 4L than the general MM patients in real-world clinical practice.
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