Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Characterization of the Pathophysiologic Spectrum of Subclinical Primary Aldosteronism in Normotension (In Person in Atlanta A404-A405) -  Jul 16, 2022 - Abstract #ENDO2022ENDO_908;    
    Methods : Normotensive participants with obesity, metabolic syndrome, and/or high-normal untreated blood pressure underwent dietary sodium loading and restriction protocols (to maximally suppress and stimulate angiotensin II-mediated aldosterone production), dexamethasone suppression and cosyntropin stimulation protocols (to maximally suppress and stimulate ACTH-mediated aldosterone production), and 24h ambulatory blood pressure monitoring...Conclusions : Dynamic phenotyping studies in normotensive individuals demonstrate a continuum of non-suppressible and renin-independent aldosterone production that parallels higher blood pressure, greater kaliuresis, increased 18-hybrid steroid production indicative of dysregulated CYP11B2 expression, and increased uEV excretion indicative of renal mineralocorticoid receptor activation. This pathophysiologic continuum of normotensive primary aldosteronism provides phenotypic support for histopathology studies showing ectopic CYP11B2 expression within adrenal glands of normotensive humans, and for epidemiologic studies demonstrating renin-independent aldosterone production in normotensive populations increases risk for developing hypertension.
  • ||||||||||  hydrocortisone / Generic mfg.
    Chair (In Person in Atlanta A411) -  Jul 16, 2022 - Abstract #ENDO2022ENDO_741;    
    Discuss the rational of emergency dose of hydrocortisone. Present the tools of patients education for the prevention of adrenal crisis.
  • ||||||||||  hydrocortisone / Generic mfg.
    Chair (In Person in Atlanta A411) -  Jul 16, 2022 - Abstract #ENDO2022ENDO_740;    
    Discuss the rational of emergency dose of hydrocortisone. Present the tools of patients education for the prevention of adrenal crisis.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Role of C3a as a Novel Regulator of 25(OH)D to 1α, 25-Dihydroxyvitamin D Metabolism in Upper Airway Epithelial Cells. (Pubmed Central) -  Jul 16, 2022   
    In summary, in this article, we describe for the first time a novel relationship between complement activation and local vitamin D metabolism in airway epithelial cells. The presence of elevated C3/C3a in patients with asthma and/or chronic rhinosinusitis with nasal polyps may account for their impaired HSNEC 25(OH)D to 1,25(OH)D metabolism and explain why they receive limited therapeutic benefit from oral vitamin D supplementation.
  • ||||||||||  vancomycin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Two entities in pulmonary nodules of a diabetic patient receiving corticosteroid therapy for bullous pemphigoid: an autopsy case report. (Pubmed Central) -  Jul 16, 2022   
    The presence of elevated C3/C3a in patients with asthma and/or chronic rhinosinusitis with nasal polyps may account for their impaired HSNEC 25(OH)D to 1,25(OH)D metabolism and explain why they receive limited therapeutic benefit from oral vitamin D supplementation. Although similar features of nodules with cavitation on CT imaging were shared with SPE and IPA, this case demonstrated that these heterogeneous diseases can occur within the lungs and the distinctly different transitions of CT imaging are helpful for suspecting the presence of multiple pathogeneses.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Punctate inner choroidopathy immediately after COVID-19 infection: a case report. (Pubmed Central) -  Jul 16, 2022   
    Although similar features of nodules with cavitation on CT imaging were shared with SPE and IPA, this case demonstrated that these heterogeneous diseases can occur within the lungs and the distinctly different transitions of CT imaging are helpful for suspecting the presence of multiple pathogeneses. We experienced an extremely rare case of PIC immediately after COVID-19 infection and showed the potential safety and effectiveness of oral prednisolone in treating PIC in the active phase after the disappearance of the general COVID-19 infection symptoms.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The 1 mg overnight dexamethasone suppression test: a danger to the adrenal gland? (Pubmed Central) -  Jul 16, 2022   
    We experienced an extremely rare case of PIC immediately after COVID-19 infection and showed the potential safety and effectiveness of oral prednisolone in treating PIC in the active phase after the disappearance of the general COVID-19 infection symptoms. An ONDST cutoff of 1.8 mcg/dl (50 nmol/l) in patients with no clinical features of Cushing's syndrome will produce false positive results and a diagnosis of MACS that could result in unnecessary adrenalectomy.
  • ||||||||||  hydrocortisone / Generic mfg.
    Retrospective data, Journal:  Effects of postnatal hydrocortisone on cytokine profile in extremely preterm infants. (Pubmed Central) -  Jul 16, 2022   
    Work should be done to improve the impact of guidelines, understand why they are not followed and, once published, ensure they translate into changed practice. Although the postnatal hydrocortisone treatment provided for respiratory deterioration did not prevent the BPD development, hydrocortisone treatment might suppress IL-6 overproduction in extremely preterm infants.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort. (Pubmed Central) -  Jul 16, 2022   
    From this group, 18 with a safety index greater than 2 are also marketed drugs, making them suitable for further study as potential therapies against COVID-19. Our result supports the idea that a systematic approach to repurposing is a valid strategy to accelerate the necessary drug discovery process.
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
    Journal, PD(L)-1 Biomarker, IO biomarker:  Ipilimumab- and nivolumab-induced myocarditis in a patient with metastatic cholangiocarcinoma: a case report. (Pubmed Central) -  Jul 16, 2022   
    Moreover, the emerging combination of immune checkpoint inhibitors with non-immune checkpoint inhibitor therapies with potential synergistic cardiotoxic side effects (for example, tyrosine kinase inhibitors) will further complicate the diagnosis of immune-related cardiotoxicity. This case highlights the urgent need for predictive biomarkers to stratify patients at risk and to develop a standardized and multidisciplinary management approach for early diagnosis and treatment of this severe immune-related adverse event.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation (clinicaltrials.gov) -  Jul 15, 2022   
    P1,  N=75, Recruiting, 
    This case highlights the urgent need for predictive biomarkers to stratify patients at risk and to develop a standardized and multidisciplinary management approach for early diagnosis and treatment of this severe immune-related adverse event. Trial completion date: Jun 2022 --> Mar 2023 | Trial primary completion date: Jun 2022 --> Jan 2023
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Clinical, Journal:  Is methylprednisolone acetate-related insulin resistance preventable in cats? (Pubmed Central) -  Jul 15, 2022   
    Also, at T15, reduced levels (p < 0.05) of eosinophils, lymphocytes, and creatinine were documented in all groups. An MPA single dose induced changes in insulin sensitivity in cats; however, neither metformin nor O&D feeding used in this study was effective as protective factors against MPA-related insulin resistance.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Prenatal glucocorticoid administration accelerates the maturation of fetal rat hepatocytes. (Pubmed Central) -  Jul 15, 2022   
    Furthermore, additional investigation may reveal that polarising tumour-associated macrophages to M1 and eliminating the M2a or particularly the M2c subtype are effective anti-cancer strategies. The results suggest that prenatal GC administration leads to hepatocyte maturation via expression of HNF4α and HGF in preterm fetuses.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy. (Pubmed Central) -  Jul 15, 2022   
    In this study, using micelles formed by CUR conjugated hydroxyethyl starch (HES) as vehicles, dexamethasone (DEX)-loaded HES-CUR nanoparticles (DHC NPs) with desirable size, negative surface charge, good stability in the harsh gastric environment, and excellent ROS scavenging activity are developed as a colon-targeted oral formulation for treating IBD...Importantly, in vivo studies reveal that the DHC NPs are capable of targeting the inflamed colon induced by dextran sulfate sodium (DSS), and the targeted and combination therapy enhances the efficacy of free DEX and significantly relieves the impairment caused by DSS-induced ulcerative colitis. Incorporating the merits of targeted drug delivery and combined therapy with an anti-inflammatory drug and ROS scavenger, the DHC NPs are promising for developing novel oral formulations for IBD therapy.
  • ||||||||||  fluticasone / Generic mfg.
    Review, Journal:  A review of the efficacy and safety of fluticasone propionate/formoterol fixed-dose combination. (Pubmed Central) -  Jul 15, 2022   
    Extensive study of several trials has established the superior efficacy of FP/FORM combination therapy over FP or FORM monotherapy, comparable efficacy with FP+FORM and non-inferiority to other ICS/LABA fixed-dose combinations. The safety profile of FP/FORM has also been found to be comparable with respect to its mono-components and their concurrent use, and also other ICS/LABA combinations such as formoterol/budesonide and fluticasone/salmeterol.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes. (Pubmed Central) -  Jul 15, 2022   
    The TA-NEs safety profile was evaluated using in vitro and in vivo ocular tolerance tests. Out of the two formulations, the one showing no irritant effects was screened in vivo demonstrating capacity to ameliorate ocular inflammation in New Zealand rabbits significantly, specially to reduce the risk of ocular inflammation processes, with antiangiogenic activity, and can therefore be exploited as a suitable formulation to avoid inflammatory reactions upon ocular surgical procedures, such as cataracts.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Controlled Bioactive Delivery Using Degradable Electroactive Polymers. (Pubmed Central) -  Jul 15, 2022   
    Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP)...10-30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.
  • ||||||||||  Tetralysal (lymecycline) / Galderma
    Maculopapular cutaneous mastocytosis mimicking seborrhoeic folliculitis () -  Jul 15, 2022 - Abstract #BAD2022BAD_756;    
    This had been widely investigated and managed as follicular eruption with long-term antibiotics in the past (lymecycline and doxycycline)...Urgent skin biopsies were carried out using lidocaine without adrenaline...He was started on fexofenadine 180 mg twice daily with topical mometasone furoate 0·1% cream, which resulted in a slight improvement...Gastrointestinal symptoms are second only to pruritus and seen in 60–80% of patients with systemic disease. This case report highlights the importance of re-evaluation, a high degree of clinical suspicion and clinicopathological correlation in arriving at a diagnosis of a rare skin disease with variable presentations as they are often misdiagnosed and underdiagnosed.